ACR Meeting Abstracts

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Abstracts tagged "cytokines and systemic sclerosis"

  • Abstract Number: 36 • 2017 ACR/ARHP Annual Meeting

    GM-CSF-Producing B Cells: A Novel B Cell Subset Involved in the Pathogenesis of Systemic Sclerosis

    Kazuhiko Higashioka1, Yuri Ota1, Tsuyoshi Nakayama1, Koji Mishima1, Masahiro Ayano1, Yasutaka Kimoto2, Hiroki Mitoma1, Mitsuteru Akahoshi1, Yojiro Arinobu1, Koichi Akashi1, Takahiko Horiuchi3 and Hiroaki Niro4, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 4Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Background/Purpose: Systemic sclerosis (SSc) is a T helper type 2 (Th2)-driven autoimmune disease characterized by vasculopathy and fibrosis. There are still unmet needs in the…
  • Abstract Number: 2980 • 2017 ACR/ARHP Annual Meeting

    Chemokine CCL21 As a Potential Serum Biomarker for Pulmonary Arterial Hypertension in Systemic Sclerosis

    Anna-Maria Hoffmann-Vold1, Roger Hesselstrand2, Håvard Fretheim1, Thor Ueland1, Arne K Andreassen1, Oyvind Midtvedt1, Torhild Garen1, Pål Aukrust1, John A Belperio3 and Øyvind Molberg1, 1Oslo University Hospital, Oslo, Norway, 2Lund University, Lund, Sweden, 3University of California, Los Angeles, Los Angeles, CA

    Background/Purpose : Systemic sclerosis (SSc) is a major cause of pulmonary arterial hypertension (PAH). Murine models indicate key roles of chemokines CCL19/21 and their receptor…
  • Abstract Number: 3250 • 2016 ACR/ARHP Annual Meeting

    Serum MCP-1 Levels Predict Long-Term Progression of Interstitial Lung Disease in Systemic Sclerosis

    Minghua Wu1, Murray Baron2, Marie Hudson3, Marvin J. Fritzler4, Claudia Pedroza5, Jun Ying1, Gloria Salazar1, Julio Charles6, Maureen D Mayes1 and Shervin Assassi1, 1Department of Internal Medicine - Rheumatology, University of Texas-McGovern Medical School, Houston, TX, 2Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, 3Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, 4Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 5Pediatrics, University of Texas-McGovern Medical School, Houston, TX, 6Internal Medicine-Rheumatology, University of Texas-McGovern Medical School, Houston, TX

    Background/Purpose:  Currently available clinical biomarkers are not reliable predictors of long-term progression of interstitial lung disease (ILD) in the context of systemic sclerosis (SSc) A previous…
  • Abstract Number: 1914 • 2015 ACR/ARHP Annual Meeting

    Oncostatin M As a Potential Molecular Target in Systemic Sclerosis

    Maria Feeney1, Farhat Syed2, Korsa Khan3, Xu Shiwen4, Katherine Sully5, Sarah Trinder6, Paul Wilson7, David Abraham6,8, Alan M. Holmes6 and Christopher P. Denton9, 1Biopharm Research, GlaxoSmithKline, Stevenage, United Kingdom, 2Immuno-Inflammation, GlaxoSmithKline, Stevenage, United Kingdom, 3Centre For Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 4UCL Medical School, London, United Kingdom, 5Biopharm Translational Medicine, GlaxoSmithKline, Stevenage, United Kingdom, 6Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 7Quantitative Sciences, GlaxoSmithKline, Stevenage, United Kingdom, 8Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 9Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom

    Background/Purpose:   Oncostatin M (OSM) is a pleiotropic member of the gp130/ IL-6 cytokine family, produced by a variety of immune cells, including macrophages, neutrophils…
  • Abstract Number: 900 • 2015 ACR/ARHP Annual Meeting

    A Multidimensional  Immunomics Approach Annotates an Immunome Shaped By the Interplay Between the Periphery and the Skin Microenvironment in Systemic Sclerosis

    Hari Balaji Venkatanarayanan1,2, Andrea Low3, Raymond Ong Jr.4, Liyun Lai1,2, Juntao Li2,5, Chie Hwee Ang1,2, Suzan Saidin1,2, Camillus Chua1,2, Jing Yao Leong1,2, Agnieszka Maliszewska1,2, Lakshmi Ramakrishna1,2, Julian Thumboo6 and Salvatore Albani1,2, 1SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 2Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, 3Division of Rheumatology, Singapore General Hospital, Singapore, Singapore, 4Singhealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, 5SingHealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, 6Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore

    Background/Purpose: Systemic sclerosis (SSc), is a chronic autoimmune disorder of the connective tissue. There is an unmet need to define precise immune correlates involved in…
  • Abstract Number: 1513 • 2012 ACR/ARHP Annual Meeting

    TSLP Receptor Deficiency Reduces IL-13 Expression and Prevents Fibrosis in Experimental Scleroderma

    Alicia Usategui1, Vanessa Miranda1, Gabriel Criado2, Manuel J. Del Rey1, Elena Izquierdo1, Warren J. Leonard3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 3Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. Although SSc shares pathogenetic features with other…
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ACR Pediatric Rheumatology Symposium 2020

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