ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "CyTOF"

  • Abstract Number: 2734 • 2019 ACR/ARP Annual Meeting

    Signaling Lymphocytic Activation Molecule Family (SLAMF) Receptors Deregulation Is Implicated in the Altered Function of NK Cells in Systemic Lupus Erythematosus

    Morgane Humbel 1, Florence Bellanger 1, Craig Fenwick 2, Alice Horisberger 3, Camillo Ribi 3 and Denis Comte1, 1Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Epalinges, Vaud, Switzerland, 2Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Epalinhes, Vaud, Switzerland, 3Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Vaud, Switzerland

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by quantitative and qualitative deficiencies of immune cells. Natural killer (NK) cells are innate…
  • Abstract Number: 99 • 2019 ACR/ARP Annual Meeting

    Mass Cytometry Immunophenotyping of Synovial Fluid from Checkpoint Inhibitor Related Arthritis

    Runci Wang1, Karmela Kim Chan 2, Amy Cunningham-Bussel 3, Laura Donlin 4, Gregory Vitone 2, Aidan Tirpack 2, Caroline Benson 2, Gregory Keras 3, Anna Helena Jonsson 5, Michael Brenner 6, Anne Bass 7 and Deepak Rao 1, 1Brigham and women's hospital, Boston, MA, 2Hospital For Special Surgery, New York, 3Brigham and women's hospital, Boston, 4Hospital For Special Surgery, New York, NY, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 6Brigham and Women’s Hospital:, Boston, 7Hospital for Special Surgery/Weill Cornell Medicine, New York, NY

    Background/Purpose: Anti-PD-1/PD-L1 checkpoint inhibitor therapies have produced remarkable results in stimulating immune responses against tumors. Checkpoint inhibitor therapy can also trigger a variety of autoimmune…
  • Abstract Number: 1033 • 2019 ACR/ARP Annual Meeting

    Mass Cytometric Immunophenotyping Highlights a Dysregulated T cell-B Cell Axis in Patients with New-onset Lupus

    Ye Cao1, Stephen Alves 2, Corine Sinnette 3, Cameron Speyer 3, Gregory Keras 1, Yujie Qu 2, Joshua Keegan 4, James Lederer 4, Deepak Rao 3 and Karen Costenbader 3, 1Brigham and Women's Hospital, Boston, 2Merck, boston, 3Brigham and Women's Hospital, Boston, MA, 4BWH, Boston

    Background/Purpose: The immune cell subsets most altered early in SLE disease course remain unclear. Defining abnormalities in lymphocyte populations in patients with new-onset SLE may…
  • Abstract Number: 135 • 2018 ACR/ARHP Annual Meeting

    High Dimensional Analysis By Mass Cytometry and RNA-Sequencing Reveals Altered Frequency and Exhausted Features of CD4 T and MAIT Cells in Systemic Sclerosis

    Bhairav Paleja1, Andrea Hsiu Ling Low2, Pavanish Kumar1, Suzan Saidin1, Ahmad Lajam2, Camillus Chua3, Liyun Lai1 and Salvatore Albani4, 1Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, 2Singapore General Hospital, Singapore, Singapore, 3Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 4Translational Immunology Institute, Singhealth/Duke-NUS Acedemic Medical Centre, Singapore, Singapore

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterised by excessive fibrosis of skin and internal organs, and vascular dysfunction. Association of T and B…
  • Abstract Number: 1104 • 2018 ACR/ARHP Annual Meeting

    Mass Cytometry Analysis Detects Dysregulated T Cell Complement Responses in Diffuse Cutaneous Systemic Sclerosis

    Giuseppina Arbore1, Shahram Kordasti2, Claudia Kemper3,4,5, Dennis Hourcade6, Benedetta Costantini2, Leo Placais3, Lynne Mitchell6, Richard Ellis4, Christopher P. Denton7, David Abraham8 and Voon H. Ong8, 1Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy, 2Systems Cancer Immunology Lab, King's College London, London, United Kingdom, 3Laboratory of Molecular Immunology and the Immunology Center, National Institutes of Health, Washington, WA, 4School of Immunology and Microbial Sciences, King's College London, London, United Kingdom, 5Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany, 6Division of Rheumatology, Washington University School of Medicine, St Louis, WA, 7UCL Division of Medicine, Royal Free Campus, London, United Kingdom, 8Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Aberrant CD4+ T cell activation is implicated in disease progression in systemic sclerosis (SSc). Activated T cells release various cytokines that may drive inflammation,…
  • Abstract Number: 1832 • 2018 ACR/ARHP Annual Meeting

    Proteomic and Transcriptomic Profiling of Cells in Ankylosing Spondylitis Patients Identifies a Novel, Synovial-Resident CD8+ T Cell

    Zoya Qaiyum1, Eric Gracey2, Yuchen Yao2 and Robert D Inman3, 1Department of Immunology, University of Toronto, Toronto, ON, Canada, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada

    Background/Purpose: Current data suggests that immune events in the gut may impact on joint inflammation in ankylosing spondylitis (AS) but what directs cells in the…
  • Abstract Number: 2029 • 2018 ACR/ARHP Annual Meeting

    Extended Phenotypic Immunome Characterization (EPIC): A Web-Based Immune Reference Atlas

    Joo Guan Yeo1,2, Pan Lu1, Thaschawee Arkachaisri1,2, Su Li Poh1, Fauziah Ally1, Jing Yao Leong3, Kee Thai Yeo1,2, Loshinidevi D/O Thana Bathi1, Yun June Angela Tan2, Seck Choon Elene Lee2 and Salvatore Albani1,4, 1Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 2KK Women's and Children's Hospital, Singapore, Singapore, 3Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, 4Translational Immunology Institute, Singhealth/Duke-NUS Acedemic Medical Centre, Singapore, Singapore

    Background/Purpose: An atlas of the developing immune system will aid in our understanding of its normal maturation and identification of disease-associated cell subsets. The availability…
  • Abstract Number: 2837 • 2018 ACR/ARHP Annual Meeting

    Diminished STAT-3 Phosphorylation and Associated Cell Pathways Characterize MMF-Treated Systemic Lupus Erythematosus Patients

    Samantha Slight-Webb1, Joel M. Guthridge1, Eliza Chakravarty1, Hua Chen1, Rufei Lu2, Krista M. Bean1, Holden T. Maecker3, Paul J. Utz4 and Judith A. James5, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Stanford University, Stanford, CA, 4Medicine, Stanford University School of Medicine, Stanford, CA, 5Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Mycophenolate mofetil (MMF) is a commonly used medication to treat major organ involvement in SLE, specifically in patients with lupus nephritis. The safety and…
  • Abstract Number: 2903 • 2018 ACR/ARHP Annual Meeting

    Single Cell Association Testing Identifies an Expanded Th1-Skewed Cytotoxic Effector CD4+ T Cell Subset in Rheumatoid Arthritis

    Chamith Fonseka1, Deepak Rao2, Nikola Teslovich3, Ilya Korsunsky4, Susan Hannes5, Kamil Slowikowski1, Michael Gurish6, Laura T. Donlin7, James A. Lederer8, Michael Weinblatt9, Elena Massarotti9, Jonathan Coblyn9, Simon Helfgott10, Derrick J. Todd11, Vivian P. Bykerk12, Elizabeth Karlson13, Joerg Ermann14, Yvonne C. Lee15, Michael Brenner16 and Soumya Raychaudhuri1,17, 1Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Human Immunology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Division of Genetics and Rheumatology, Department of Medicine, Harvard Medical School, Boston, MA, 4Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 6Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 8Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 9Brigham and Women's Hospital, Boston, MA, 10Division of Rheumatology, Brigham and Women’s Hospital, Boston, MA, 11Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 12Deptartment of Rheumatology, Hospital for Special Surgery, New York, NY, 13Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 14Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 15Northwestern University Feinberg School of Medicine, Chicago, IL, 16Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 17Program in Medical and Population Genetics, Broad Institute, Boston, MA

    Background/Purpose: Defining the precise CD4+ T cell subsets that are dysregulated in RA patients is critical to deciphering pathogenesis. Here we present Mixed effects modeling…
  • Abstract Number: 2946 • 2018 ACR/ARHP Annual Meeting

    T Peripheral Helper Cells Are Expanded in the Circulation of Active SLE Patients and Correlate with CD21low B Cells

    Deepak Rao1, Alexandra Bocharnikov2, Chamith Fonseka3, Joshua Keegan2, Betty Diamond4, Jennifer Anolik5, Peter Nigrovic1, Soumya Raychaudhuri3,6, James A. Lederer7 and Michael Brenner8, 1Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, 5Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 6Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, 7Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 8Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Pathologic T cell-B cell interactions and production of autoantibodies are hallmark features of SLE. T follicular helper (Tfh) cells are generally considered the principal…
  • Abstract Number: 2949 • 2018 ACR/ARHP Annual Meeting

    African American and European American SLE Patients with Variable Disease Activity Reveal Distinct Differences in B Cells and TLR7/8 Pathways

    Samantha Slight-Webb1, Miles C. Smith1, Holden T. Maecker2, Paul J. Utz3, Joel M. Guthridge1 and Judith A. James4, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Stanford University, Stanford, CA, 3Medicine, Stanford University School of Medicine, Stanford, CA, 4Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder with a heterogeneous clinical presentation and periods of waxing and waning disease. Heterogeneity in SLE is…
  • Abstract Number: 1406 • 2017 ACR/ARHP Annual Meeting

    Methods for Generating Multiple High-Dimensional Analyses of Cryopreserved Synovial Tissue Developed By the Accelerating Medicines Partnership RA/SLE Network

    Deepak Rao1, Laura T. Donlin2, Kevin Wei3, Nida Meednu4, Jason Turner5, Mandy J. McGeachy6, Fumitaka Mizoguchi7, Joshua Keegan8, James Lederer9, Maria Gutierrez-Arcelus10, Kamil Slowikowski11, Kaylin Muskat12, Joshua Hillman12, Cristina Rozo13, Edd Ricker14, Thomas Eisenhaure15, David Lieb15, Shuqiang Li15, Edward Browne15, Chad Nusbaum15, William H. Robinson16, Stephen Kelly17, Alessandra B. Pernis18, Lionel Ivashkiv19, Susan M. Goodman20, Ellen M. Gravallese21, Michael Holers22, Nir Hacohen23, Costantino Pitzalis17, Peter Gregersen24, Vivian P. Bykerk25, Larry W. Moreland26, Gary Firestein27, Soumya Raychaudhuri28, Andrew Filer29, David L. Boyle30, Michael Brenner10 and Jennifer H. Anolik4, 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 3Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 5Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 6Medicine, University of Pittsburgh, Pittsburgh, PA, 7Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 8Brigham and Women's Hospital, Boston, MA, 9Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 10Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 11Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, 12University of California, San Diego, San Diego, CA, 13Hospital for Special Surgery, New York, NY, 14Weill Cornell Graduate School of Medical Sciences, New York, NY, 15Broad Institute, Cambridge, MA, 16Stanford University School of Medicine, Stanford, CA, 17Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 18David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 19Medicine, Hospital for Special Surgery, New York, NY, 20Medicine, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 21Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA, 22Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, 23Harvard Medical School, Boston, MA, 24The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, 252-005, Mt Sinai Hospital, Toronto, ON, Canada, 26Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 27EGG, St Cloud, France, 28Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 29Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, 30University of California San Diego, La Jolla, CA

    Background/Purpose: Detailed analyses of cells from rheumatoid arthritis (RA) synovium may identify cell phenotypes and functions that drive tissue pathology and joint damage. The AMP…
  • Abstract Number: 1577 • 2017 ACR/ARHP Annual Meeting

    Deciphering the Role of the Tissue Microenvironment in Shaping the Immune Landscape in Psoriatic Arthritis

    Jin Hui Sherlynn Chan1, Ying Ying Leung2, Warren Fong2, Yi Wei Yeo2, Bhairav Paleja1, Liyun Lai1, Suzan Saidin1, Camillus Chua1, Sharifah Nur Hazirah1, Su Li Poh1, Andrea Hsiu Ling Low2 and Salvatore Albani1,3, 1SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, 2Singapore General Hospital, Singapore, Singapore, 3KK Women's and Children's Hospital, Singapore, Singapore

    Background/Purpose: Psoriatic arthritis (PsA) occurs in a third of patients with psoriasis (Ps) and up to 30% of patients with PsA do not have an…
  • Abstract Number: 1736 • 2017 ACR/ARHP Annual Meeting

    Deep Immunophenotyping of T-Lymphocytes with a 37-Channel Mass Cytometry (CyTOF) Panel for the Identification of Pathological Cell Functions and the Prediction of Response to Biologic Drugs in Rheumatoid Arthritis

    Ben Mulhearn1,2,3, Darren Plant2, Ann W. Morgan4,5, Anthony G. Wilson6, John D Isaacs7,8, Jane Worthington9, Soumya Raychaudhuri9,10,11,12, Tracy Hussell1, Anne Barton13,14 and Sebastien Viatte2, 1Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom, 2The University of Manchester, Arthritis Research UK Centre for Genetics and Genomics, , Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Medicine, Biology and Health, Manchester, United Kingdom, 3Kellgren Centre for Rheumatology, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4Section of Musculoskeletal Disease, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 6UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, 7Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom, 8National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom, 9Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 10Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 11Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, 12Partners Center for Personalized Genetic Medicine, Boston, MA, 13Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK, Manchester, United Kingdom, 14The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom

    Background/Purpose: Pathogenic immune cell types and functions have not been identified yet in rheumatoid arthritis (RA). This is explained by the impact of disease heterogeneity…
  • Abstract Number: 1941 • 2017 ACR/ARHP Annual Meeting

    Microenvironmental and Systematic Evaluation of the Immunome in Osteoarthritis

    Bhairav Paleja1, Ying Ying Leung2, Pavanish Kumar1, Suzan Saidin1, Ahmad Lajam2, Liyun Lai1 and Salvatore Albani1, 1SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, 2Singapore General Hospital, Singapore, Singapore

    Background/Purpose: Osteoarthritis is the most common joint disease and involves whole joint, including degeneration of articular cartilage and surrounding tissues. Although widely prevalent, the exact…
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