Abstracts tagged "Crystal-induced arthritis"

Abstract Number: 2896 • 2017 ACR/ARHP Annual Meeting
Human Cartilage Influences the Crystallization of Monosodium Urate; Understanding the Link between Gout and Osteoarthritis
Ashika Chhana¹, Bregina Pool², Ally Choi¹, Ryan Gao¹, Mark Zhu¹, Jillian Cornish², Jacob Munro³ and Nicola Dalbeth⁴, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Orthopaedics, Auckland City Hospital, Auckland, New Zealand, ⁴University of Auckland, Auckland, New Zealand
Background/Purpose: Monosodium urate (MSU) crystal deposition and gout flares frequently affect joints that have been damaged or are affected by osteoarthritis. The aim of…
Abstract Number: 249 • 2017 ACR/ARHP Annual Meeting
Where to Look for Uric Acid Crystals? Results from a Norwegian Ultrasound Study
Hilde B Hammer¹, Lars Karoliussen², Lene Terslev³, Espen A. Haavardsholm⁴, Tore K Kvien⁵ and Till Uhlig⁴, ¹Rheumatology, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵On behalf of the NOR-DMARD registry, Oslo, Norway
Background/Purpose: Ultrasound (US) has received an increasing attention in detecting uric monosodium urate (MSU) deposits, and is included in the ACR/EULAR classification criteria for gout.…
Abstract Number: 1132 • 2017 ACR/ARHP Annual Meeting
Compensated Polarized Microscopy for Crystal Identification Shows High Reliability Among Multiple Observers
José Antonio Bernal¹, Mariano Andrés^2,3, Salvador López-Salguero⁴, Vega Jovaní⁵, Paloma Vela^3,6 and Eliseo Pascual⁷, ¹Reumatología, Hospital Universitario del Vinalopó, Elche, Spain, ²Reumatología, Hospital General Universitario Alicante, Alicante, Spain, ³Universidad Miguel Hernández, Elche, Spain, ⁴Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ⁵Reumatología, Hospital general universitario de Alicante, Alicante, Spain, ⁶Reumatología, Hospital General Universitario de Alicante. Alicante. Spain, Alicante, Spain, ⁷Emeritus Professor, Universidad Miguel Hernández, Elche, Spain
Background/Purpose: The gold standard for crystal-related arthritis diagnosis remains synovial fluid analysis by a microscope fitted with compensated polarized filters as it has been shown…
Abstract Number: 2055 • 2017 ACR/ARHP Annual Meeting
Omeract Ultrasonographic Criteria for the Diagnosis of Calcium Pyrophosphate Deposition Disease at the Metacarpal-Phalangeal, Wrist, Acromion-Clavicular and Hip Joints: An Inter-Observer and Intra-Observer Reliability Study
Pascal Zufferey¹, Georgios Filippou², Carlo Alberto Scirè³, Nemanja Damjanov⁴, MA D'Agostino⁵, George A. W. Bruyn⁶, Antonella Adinolfi², Greta Carrara⁷, Valentina Di Sabatino⁸, Andrea Delle Sedie⁹, Tomas Cazenave¹⁰, Carlos Pineda¹¹, Francesco Porta¹², Daryl K. MacCarter¹³, Emilio Filippucci¹⁴, Frédérique Gandjbakhch¹⁵, Ingrid Moller¹⁶, Anthony Reginato¹⁷, Mihaela Cosmina Micu¹⁸, Mohamed Mortada¹⁹, Gaël Mouterde²⁰, Lene Terslev²¹, Esperanza Naredo²², Valentina Picerno², Wolfgang A. Schmidt²³, Violeta Vlad²⁴, Florentin Ananu Vreju²⁵ and Annamaria Iagnocco²⁶, ¹Department of Rheumatology, University Hospital Lausanne, Lausanne, Switzerland, ²University of Siena, Siena, Italy, ³Epidemiology Unit -Italian Society for Rheumatology, Milano, Italy, ⁴Institute of Rheumatology, Belgrade University School of Medicine, Belgrade, Serbia, ⁵Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁶Rheumatology, MC Groep, Loenga, Netherlands, ⁷Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy, ⁸CMV, Grosseto, Italy, ⁹University of Pisa, Rheumatology Unit, Pisa, Italy, ¹⁰Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ¹¹Biomedical Research, Instituto Nacional de Rehabilitacion, Mexico City, Mexico, ¹²Hospital of Pistoia, Pistoia, Italy, ¹³Coeur d'Alene Arthritis Clinic, Coeur d'Alene, ID, ¹⁴Clinical Reumatologica, Universita Politecnica delle Marche, Ancona, Italy, ¹⁵Service de Rhumatologie, GH Pitié-Salpétrière, MD, Paris, France, ¹⁶Instituto de Poal, Barcelona, Spain, ¹⁷Rheumatology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, ¹⁸Division of Rheumatology, Department of Rehabilitation II, Clinical Rehabilitation Hospital, Cluj Napoca, Romania, ¹⁹zagazig university, Zagazig, Egypt, ²⁰Rheumatology Department, Hopital Lapeyronie, Montpellier, France, ²¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ²²Rheumatology Department, Hospital Gregorio Marañón, Madrid, Spain, ²³Med Ctr Rheumatology Berlin Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, ²⁴RCRD Research Center, Bucharest, Romania, ²⁵University of Medicine and Pharmacy, Department of Rheumatology, Craiova, Romania, ²⁶Academic Rheumatology Unit, Università degli Studi di Torino, Torino, Italy
Background/Purpose: The OMERACT US subtask force “US in CPPD” has recently created the definitions for US identification of crystal deposits in joints and tested the…
Abstract Number: 2081 • 2017 ACR/ARHP Annual Meeting
Synovial Fluid Leukocyte Count and Its Association with Crystal Deposition in Asymptomatic Hyperuricemia
Mariano Andrés^1,2, José Antonio Bernal³, María Dolores Arenas⁴ and Eliseo Pascual^1,5, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ³Reumatología, Hospital Universitario del Vinalopó, Elche, Spain, ⁴Unidad de Nefrología, Hospital Vithas Perpetuo Socorro, Alicante, Spain, ⁵Emeritus Professor, Universidad Miguel Hernández, Elche, Spain
Background/Purpose: Articular and periarticular deposits of monosodium urate (MSU) crystals in asymptomatic hyperuricemia (AH) may associate with more severe forms of atherosclerosis [Andrés 2016]. This…
Abstract Number: 222 • 2016 ACR/ARHP Annual Meeting
Role of Synovial Biopsy in Diagnosis of Crystal Arthropathies
Viju Moses¹, Jaya Asirvatham², Jonathan McHugh² and Robert Ike¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Pathology, University of Michigan, Ann Arbor, MI
Title: Role of Synovial Biopsy in Diagnosis of Crystal Arthropathies Background/Purpose: Diagnosis of crystal arthropathies (CAs) can be challenging. Advances in arthroscopy and ultrasound guided…
Abstract Number: 223 • 2016 ACR/ARHP Annual Meeting
Clinical Predictors of Acute Gout Flares within Hospitalized Patients at a Tertiary Care Center in New York
Lara El Khoury¹, Mohamad Yasmin^1,2, Nabil Zeineddine¹, Joseph Saabiye¹, Saleha Riaz¹, Sami Arnaout¹, Talal El Imad¹, Suzanne El-Sayegh³ and Rita Obeid⁴, ¹Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, NY, ²Infectious Diseases, Case Western Reserve University, Cleveland, OH, ³Internal Medicine, Program Director, Staten Island University Hospital, Northwell Health, Staten Island, NY, ⁴Psychology, The Graduate Center, CUNY, New York, NY
Background/Purpose: Gout is the most prevalent inflammatory arthritis worldwide. Within the healthcare setting, gout flares contribute to substantial morbidity and complicated hospital stays. Identifying risk…
Abstract Number: 2260 • 2016 ACR/ARHP Annual Meeting
Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4) in Monosodium Urate (MSU)-Crystal Induced Arthritis.
Anthony M. Reginato¹, Marwa Qadri², Changqi Sun³, Tannin Schmidt⁴, Nicole Yang⁵, Khaled Elsaid⁶ and Gregory Jay⁷, ¹Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Department of Pharmaceutical Science, School of Pharmacy, MCHS University, Boston, MA, ³Division of Rheumatology, Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ⁴Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ⁶Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, ⁷Emergency Medicine, Brown University, Providence, RI
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including…
Abstract Number: 2269 • 2016 ACR/ARHP Annual Meeting
Proteinaceous Amorphous Calcium Carbonates As a Novel Family of Crystals in Synovial Fluid from Symptomatic Joints
Bolan Li¹, Nora Singer^2,3 and Ozan Akkus^3,4, ¹Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, ²Medicine and Pediatrics, MetroHealth System, Cleveland, OH, ³Case Western Reserve University School of Medicine, Cleveland, OH, ⁴University Hospitals Case Medical Center, Cleveland, OH
Background/Purpose: There are many types of particulate matter in synovial fluid, and specific identification of these particles are challenging. We assessed synovial fluid samples from…
Abstract Number: 3126 • 2016 ACR/ARHP Annual Meeting
Computational Polarizing Microscopy: A Novel Method to Detect Birefringent Crystals Using Lens-Free on-Chip Microscopy
Seung Yoon Lee¹, Yibo Zhang², Daniel E. Furst¹, Ann Rosenthal³, Ralph Schumacher⁴, John FitzGerald¹ and Aydogan Ozcan², ¹Division of Rheumatology, Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Electrical Engineering Department, University of California Los Angeles, School of Engineering, Los Angeles, CA, ³Division of Rheumatology, Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, ⁴Division of Rheumatology, Department of Internal Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
Background/Purpose: A compensated polarizing microscopy has been used for detecting monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals to confirm the diagnosis of gout…
Abstract Number: 215 • 2015 ACR/ARHP Annual Meeting
Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ –Induced Anti-Osteoclastogenic Signaling in Human Osteoclast Precursors
Geraldine M. McCarthy¹, Clare C. Cunningham², Emma M. Corr³ and Aisling Dunne³, ¹University College Dublin, Dublin, Ireland, ²School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular calcium hydroxyapatite (HA) crystals are present in the majority of osteoarthritic (OA) joints. They activate macrophages, synovial fibroblasts and articular chondrocytes, resulting in…
Abstract Number: 224 • 2015 ACR/ARHP Annual Meeting
Silent Monosodium Urate Crystals Deposits in Asymptomatic Hyperuricemia Lead to a Higher Need for Coronary Revascularization
Mariano Andrés¹, María Amparo Quintanilla², Francisca Sivera³, José Sánchez-Payá⁴, Juan M Ruiz-Nodar⁵, Eliseo Pascual^1,6 and Paloma Vela^1,6, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Sección de Cardiología, Hospital General Universitario de Elda, Alicante, Spain, ³Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ⁴Servicio de Medicina Preventiva, Hospital General Universitario de Alicante, Alicante, Spain, ⁵Servicio de Cardiología, Hospital General Universitario de Alicante, Alicante, Spain, ⁶Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: Increased cardiovascular (CV) risk in gout relates to crystal-driven inflammation. In a preliminary, cross-sectional study we found that silent deposits of monosodium urate (MSU)…
Abstract Number: 225 • 2015 ACR/ARHP Annual Meeting
Gout Patients Present Carotid Plaques at Presentation in Spite of Low-Risk Cardiovascular Score
Mariano Andrés¹, Francisca Sivera², José Antonio Bernal¹, Neus Quilis¹, Loreto Carmona³, Paloma Vela^1,4 and Eliseo Pascual^1,4, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ³Instituto de Salud Musculoesquelética, Madrid, Spain, ⁴Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain
Gout patients present carotid plaques at presentation in spite of low-risk cardiovascular score.Background/Purpose: Gout is associated with an increased cardiovascular (CV) risk related to high…
Abstract Number: 245 • 2015 ACR/ARHP Annual Meeting
Seasonal Variation in Acute Gouty Arthritis: Data from Nationwide Inpatient Sample
Paras Karmacharya¹, Ranjan Pathak², Madan Aryal², Smith Giri³ and Anthony Donato⁴, ¹Internal Medicine, Reading Health System, WEST READING, PA, ²Internal medicine, Reading Health System, West Reading, PA, ³Internal medicine, University of Tennessee Health Science Center, Memphis, TN, ⁴Internal, Reading Health System, Salt Lake, UT
Background/Purpose: Studies describing seasonal variations in acute gouty arthritis note a seasonal trend, but disagree on timing, with most showing a peak in spring months…
Abstract Number: 2148 • 2014 ACR/ARHP Annual Meeting
Dual Energy CT Scanning: Variable Sensitivity for Gout in Non-Tophaceous and Tophaceous Disease and in Individual Erosions
Tracie Kurano¹, Uma Thakur², Gaurav Thawait³, Elliot Fishman⁴, Mara McAdams-DeMarco⁵, Janet W. Maynard⁶, Matthew Fuld⁷, John A. Carrino⁸ and Alan N. Baer⁹, ¹Medicine-Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Musculoskeletal Radiology Section, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ³Musculoskeletal Radiology Section, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Research Collaborations - Computed Tomography R&D, Siemens Medical Solutions USA, Inc., Baltimore, MD, ⁸Radiology, Hospital for Special Surgery, New York, NY, ⁹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Dual energy computed tomography (DECT) is emerging as a diagnostic tool for gout, but its sensitivity has not been established. We assessed the sensitivity…

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