Abstracts tagged "Crystal-induced arthritis"

Abstract Number: 223 • 2016 ACR/ARHP Annual Meeting
Clinical Predictors of Acute Gout Flares within Hospitalized Patients at a Tertiary Care Center in New York
Lara El Khoury¹, Mohamad Yasmin^1,2, Nabil Zeineddine¹, Joseph Saabiye¹, Saleha Riaz¹, Sami Arnaout¹, Talal El Imad¹, Suzanne El-Sayegh³ and Rita Obeid⁴, ¹Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, NY, ²Infectious Diseases, Case Western Reserve University, Cleveland, OH, ³Internal Medicine, Program Director, Staten Island University Hospital, Northwell Health, Staten Island, NY, ⁴Psychology, The Graduate Center, CUNY, New York, NY
Background/Purpose: Gout is the most prevalent inflammatory arthritis worldwide. Within the healthcare setting, gout flares contribute to substantial morbidity and complicated hospital stays. Identifying risk…
Abstract Number: 2260 • 2016 ACR/ARHP Annual Meeting
Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4) in Monosodium Urate (MSU)-Crystal Induced Arthritis.
Anthony M. Reginato¹, Marwa Qadri², Changqi Sun³, Tannin Schmidt⁴, Nicole Yang⁵, Khaled Elsaid⁶ and Gregory Jay⁷, ¹Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Department of Pharmaceutical Science, School of Pharmacy, MCHS University, Boston, MA, ³Division of Rheumatology, Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ⁴Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ⁶Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, ⁷Emergency Medicine, Brown University, Providence, RI
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including…
Abstract Number: 2269 • 2016 ACR/ARHP Annual Meeting
Proteinaceous Amorphous Calcium Carbonates As a Novel Family of Crystals in Synovial Fluid from Symptomatic Joints
Bolan Li¹, Nora Singer^2,3 and Ozan Akkus^3,4, ¹Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, ²Medicine and Pediatrics, MetroHealth System, Cleveland, OH, ³Case Western Reserve University School of Medicine, Cleveland, OH, ⁴University Hospitals Case Medical Center, Cleveland, OH
Background/Purpose: There are many types of particulate matter in synovial fluid, and specific identification of these particles are challenging. We assessed synovial fluid samples from…
Abstract Number: 3126 • 2016 ACR/ARHP Annual Meeting
Computational Polarizing Microscopy: A Novel Method to Detect Birefringent Crystals Using Lens-Free on-Chip Microscopy
Seung Yoon Lee¹, Yibo Zhang², Daniel E. Furst¹, Ann Rosenthal³, Ralph Schumacher⁴, John FitzGerald¹ and Aydogan Ozcan², ¹Division of Rheumatology, Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Electrical Engineering Department, University of California Los Angeles, School of Engineering, Los Angeles, CA, ³Division of Rheumatology, Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, ⁴Division of Rheumatology, Department of Internal Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
Background/Purpose: A compensated polarizing microscopy has been used for detecting monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals to confirm the diagnosis of gout…
Abstract Number: 224 • 2015 ACR/ARHP Annual Meeting
Silent Monosodium Urate Crystals Deposits in Asymptomatic Hyperuricemia Lead to a Higher Need for Coronary Revascularization
Mariano Andrés¹, María Amparo Quintanilla², Francisca Sivera³, José Sánchez-Payá⁴, Juan M Ruiz-Nodar⁵, Eliseo Pascual^1,6 and Paloma Vela^1,6, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Sección de Cardiología, Hospital General Universitario de Elda, Alicante, Spain, ³Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ⁴Servicio de Medicina Preventiva, Hospital General Universitario de Alicante, Alicante, Spain, ⁵Servicio de Cardiología, Hospital General Universitario de Alicante, Alicante, Spain, ⁶Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: Increased cardiovascular (CV) risk in gout relates to crystal-driven inflammation. In a preliminary, cross-sectional study we found that silent deposits of monosodium urate (MSU)…
Abstract Number: 225 • 2015 ACR/ARHP Annual Meeting
Gout Patients Present Carotid Plaques at Presentation in Spite of Low-Risk Cardiovascular Score
Mariano Andrés¹, Francisca Sivera², José Antonio Bernal¹, Neus Quilis¹, Loreto Carmona³, Paloma Vela^1,4 and Eliseo Pascual^1,4, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ³Instituto de Salud Musculoesquelética, Madrid, Spain, ⁴Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain
Gout patients present carotid plaques at presentation in spite of low-risk cardiovascular score.Background/Purpose: Gout is associated with an increased cardiovascular (CV) risk related to high…
Abstract Number: 245 • 2015 ACR/ARHP Annual Meeting
Seasonal Variation in Acute Gouty Arthritis: Data from Nationwide Inpatient Sample
Paras Karmacharya¹, Ranjan Pathak², Madan Aryal², Smith Giri³ and Anthony Donato⁴, ¹Internal Medicine, Reading Health System, WEST READING, PA, ²Internal medicine, Reading Health System, West Reading, PA, ³Internal medicine, University of Tennessee Health Science Center, Memphis, TN, ⁴Internal, Reading Health System, Salt Lake, UT
Background/Purpose: Studies describing seasonal variations in acute gouty arthritis note a seasonal trend, but disagree on timing, with most showing a peak in spring months…
Abstract Number: 215 • 2015 ACR/ARHP Annual Meeting
Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ –Induced Anti-Osteoclastogenic Signaling in Human Osteoclast Precursors
Geraldine M. McCarthy¹, Clare C. Cunningham², Emma M. Corr³ and Aisling Dunne³, ¹University College Dublin, Dublin, Ireland, ²School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular calcium hydroxyapatite (HA) crystals are present in the majority of osteoarthritic (OA) joints. They activate macrophages, synovial fibroblasts and articular chondrocytes, resulting in…
Abstract Number: 2148 • 2014 ACR/ARHP Annual Meeting
Dual Energy CT Scanning: Variable Sensitivity for Gout in Non-Tophaceous and Tophaceous Disease and in Individual Erosions
Tracie Kurano¹, Uma Thakur², Gaurav Thawait³, Elliot Fishman⁴, Mara McAdams-DeMarco⁵, Janet W. Maynard⁶, Matthew Fuld⁷, John A. Carrino⁸ and Alan N. Baer⁹, ¹Medicine-Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Musculoskeletal Radiology Section, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ³Musculoskeletal Radiology Section, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Research Collaborations - Computed Tomography R&D, Siemens Medical Solutions USA, Inc., Baltimore, MD, ⁸Radiology, Hospital for Special Surgery, New York, NY, ⁹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Dual energy computed tomography (DECT) is emerging as a diagnostic tool for gout, but its sensitivity has not been established. We assessed the sensitivity…
Abstract Number: 183 • 2014 ACR/ARHP Annual Meeting
Musculoskeletal Ultrasound Reveals Calcific Deposition Arthropathy in Seronegative Inflammatory Arthritis Patients
Sheila L. Arvikar¹, Janice Lin² and Minna J. Kohler³, ¹Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ²Dermatology, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Background/Purpose Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) have vastly improved the diagnosis of rheumatoid arthritis (RA), but the diagnosis and management of seronegative…
Abstract Number: 2000 • 2013 ACR/ARHP Annual Meeting
Changes In The Prevalence Of Gout In The United States General Population Between 1960 and 2010: The National Health and Nutrition Examination Surveys
Eswar Krishnan and Linjun Chen, Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Despite the widely shared impression that the prevalence of gouty arthritis (gout) has increased over time in the US few population data are available.…
Abstract Number: 1722 • 2013 ACR/ARHP Annual Meeting
Does Starting Allopurinol Prolong Acute Treated Gout?
Erica Hill¹, Jay B. Higgs², Karen Sky³, Michelle Sit⁴ and Angelique N. Collamer⁵, ¹Rheumatology, San Antonio Military Medical Center, Fort Sam Houston, TX, ²Rheumatology, San Antonio Military Medical Center, JBSA - Fort Sam Houston, TX, ³Rheumatology, US Department of Veterans Affairs, Alaska VA Healthcare System, Anchorage, AK, ⁴Subspecialty Clinic - Rheumatology, David Grant Medical Center, Travis AFB, CA, ⁵Internal Medicine, Langley AFB Hospital, Langley AFB, VA
Background/Purpose: Gout is a common cause of morbidity in the US population. Traditionally, allopurinol is not initiated during an acute episode to avoid prolonging…
Abstract Number: 1901 • 2012 ACR/ARHP Annual Meeting
Chronic Gout. Improvement According to Outcome Meaures in Rheumatology Domains in Daily Clinical Practice
Janitzia Vazquez-Mellado¹, Betsabé Serrano¹, Jaime Mendoza², Sergio Garcia-Mendez¹, V.Chantal Hernández¹, Virginia Pascual Ramos³, Ruben Burgos-Vargas¹ and Marina Rull-Gabayet², ¹Rheumatology, Hospital General de Mexico, Mexico city, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Dept de Immunología y Reumato, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: OMERACT has proposed domains to evaluate the effect of treatment in patients with acute and chronic gout. Their frequency, time to improve and percentage…
Abstract Number: 1661 • 2012 ACR/ARHP Annual Meeting
CCR1 Potentiates Gouty Inflammation Following Initial CXCR2-Dependent Neutrophil Recruitment to Sites of Monosodium Urate Crystal Deposition in Mice
Robert P. Friday¹, Terry K. Means², Melissa Tai², Christian D. Sadik² and Andrew D. Luster³, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, ³Massachusetts General Hospital, Charlestown, MA
Background/Purpose: During attacks of acute gouty arthritis, monosodium urate (MSU) crystals elicit a potent neutrophilic inflammatory response in the affected joint, causing exquisite pain and…
Abstract Number: 1629 • 2012 ACR/ARHP Annual Meeting
Microarray Analysis of Acute and Intercritical Gout
Alicia Rodriguez-Pla¹, Lynda Bennett¹, Kathryn H. Dao², Edwardo Delgado³, Typhanie Maurouard¹, M. Virginia Pascual⁴ and John J. Cush⁵, ¹Baylor Healthcare System, Baylor Institute for Immunology Research, Dallas, TX, ²Rheumatology, Baylor Research Institute, Dallas, TX, ³Arthritis Care and Research Center, Dallas, TX, ⁴Baylor Institute for Immunology Research, Dallas, TX, ⁵Baylor Research Institute, Dallas, TX
Background/Purpose: We aimed to identify the immune mechanism underlying gouty inflammation using microarrays analysis and modular gene expression signatures. Methods: Whole blood along with clinical…

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