Abstracts tagged "Crystal-induced arthritis"

Abstract Number: 0276 • ACR Convergence 2024
Exploring the Prevalence of Crowned Dens Syndrome in a Polymyalgia Rheumatica Veterans Affairs Patient Cohort
Marlene Marte Furment¹, Binod Kc¹, Bhavya Poudyal¹, Aakritee Sharma Subedi², Mahnoor Sherazi³, Jihad Ben Gabr¹, Shveta Trikha⁴, Brian Cooney⁵ and Fatme Allam⁵, ¹SUNY Upstate Medical University, Syracuse, NY, ²SUNY Upstate University Hospital, Syracuse, ³State University of New York, Syracuse, NY, ⁴Syracuse VA Medical Center, Syracuse, ⁵Syracuse VA Medical Center, Syracuse, NY
Background/Purpose: Crowned Dens (CD) is the radiological finding of calcium pyrophosphate dihydrate (CPPD) crystal deposition in the cruciform and alar ligaments giving the appearance of…
Abstract Number: 2219 • ACR Convergence 2024
Association of Chondrocalcinosis with Disease Activity and Drug Response in Rheumatoid Arthritis: Baseline Characteristics of the Swiss Rheumatoid Arthritis Outcomes Cohort
Tobias Manigold¹, Nicolas Bodmer², Rosoux Elisabeth³, Deborah Markham⁴, Guillaume Fahrni³, Raphael Micheroli⁵, Lucas Bachmann², Jonas Brändli⁶, Fabio Becce⁷ and Thomas Hügle⁸, ¹Department of Rheumatology, Inselspital University Hospital Bern, Bern, Switzerland., Bern, Switzerland, ²Medignition, Zürich, Switzerland, ³3) Department of Radiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland, Lausanne, Switzerland, ⁴Department of Rheumatology, University Hospital Lausanne (CHUV), Switzerland, Lausanne, Switzerland, ⁵University Hospital Zurich, Zurich, Switzerland, ⁶6) Data Science Team, Swiss Clinical Quality Management Foundation, Zurich, Switzerland, Zürich, Switzerland, ⁷Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁸Lausanne University Hospital, Lausanne, Switzerland
Background/Purpose: Calcium pyrophosphate deposition disease (CPPD) disease can mimic or interfere with the course of rheumatoid arthritis (RA). Previous studies suggest higher prevalence of Chondrocalcinosis…
Abstract Number: 0278 • ACR Convergence 2024
Efficacy and Safety of Genakumab versus Compound Betamethasone in Gout: The GUARD-1 Study
Yu Xue¹, Tianshu Chu², Jiankang Hu³, Wei Gou⁴, Ning Zhang⁵, Juan Li⁶, Jing Yu⁷, Songping Li⁸, Songbin Li⁹, Long Qian¹⁰, Xinwang Duan¹¹, Lihua Duan¹² and Hejian Zou¹, ¹Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China (People's Republic), ²Department of Rheumatology, Henan Provincial People's Hospital, Zhengzhou, China, Zhengzhou, China (People's Republic), ³Department of Rheumatology, Pingxiang People's Hospital, Pingxiang, China, Pingxiang, China (People's Republic), ⁴Department of Rheumatology, Hebei Petro China Central Hospital, Langfang, China, Langfang, China (People's Republic), ⁵Department of Rheumatology, Shengjing Hospital of China Medical University, Shenyang, China, Shenyang, China (People's Republic), ⁶Department of Rheumatology, The First Affiliated Hospital of Hainan Medical University, Haikou, China, Haikou, China (People's Republic), ⁷Department of Rheumatology, The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China, Shenyang, China (People's Republic), ⁸Department of Rheumatology, The First Affiliated Hospital of Ganna Medical University, Ganzhou, China, Ganzhou, China (People's Republic), ⁹Department of Rheumatology, The First Hospital of Qiqihar, Qiqihar, China, Qiqihar, China (People's Republic), ¹⁰Department of Rheumatology, The Second Hopital of Anhui Medical University, Hefei, China, Hefei, China (People's Republic), ¹¹Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, Nanchang, China (People's Republic), ¹²Department of Rheumatology, Jiangxi Provincial People's Hospital, Nanchang, China, Nanchang, China (People's Republic)
Background/Purpose: The GUARD (Genakumab in high Uric Acid-induced Arthritis/goutfor Resolution and Delay study) program was designed to investigate the efficacy and safety of Genakumab, a…
Abstract Number: 2562 • ACR Convergence 2024
Efficacy and Safety of Tocilizumab in the Treatment of Chronic Inflammatory Forms of CPPD: Retrospective Study of 55 Cases
Sophie Carrabin¹, Margaux Houze², Charlotte Jauffret³, Thomas Bardin⁴, Hang Korng Ea⁴, Frédéric Lioté⁴, Pascal Richette⁵, Tristan Pascart² and Augustin Latourte⁶, ¹Hôpital Lariboisière APHP.Nord, Paris, Paris, France, ²Lille Catholic University, Lille, France, ³Lille Catholic University, Lille, Nord-Pas-de-Calais, France, ⁴Hôpital Lariboisière APHP.Nord, Paris, France, ⁵Lariboisière Hospital, Paris, France, ⁶AP-HP, Paris, France
Background/Purpose: Calcium pyrophosphate deposition disease (CPPD) is a heterogeneous disease that can manifest as acute or chronic arthritis. Treatment options for chronic forms of the…
Abstract Number: 0279 • ACR Convergence 2024
Macrophage Intracellular Fates of Monosodium Urate and Calcium Pyrophosphate Crystals: Phagocytosis, Exchanged/expulsion and Dissolution of Crystals
Charles Leroy¹, Nghia Pham², François Brial³, Brenda Kischkel⁴, gwénaêlle Jayat⁵, Elena Ishow⁶, Christèle Combes⁷, Leo Joosten⁴, Augustin Latourte⁸, Pascal Richette⁹ and Hang-Korng Ea¹⁰, ¹Inserm 1132 / Université Paris Cité, levallois-perret, France, ²INSERM 1132, BIOSCAR, Lariboisière hospital, Paris, France, ³Inserm 1132/ Université Paris Cité, Paris, France, ⁴Radboudumc, Nijmegen, Netherlands, ⁵Université Paris cité / Inserm 1132, paris, France, ⁶Université de Nantes / Ceisam, Nantes, France, ⁷INP-ENSIACET, Toulouse, France, ⁸AP-HP, Paris, France, ⁹Lariboisière Hospital, Paris, France, ¹⁰Université Paris Cité, INSERM UMR 1132 BIOSCAR, Paris, France
Background/Purpose: Gout, due to the presence of monosodium urate crystals (MSU) and calcium pyrophosphate (CPP) crystal deposition disease are both responsible for recurrent inflammation flares.…
Abstract Number: 0280 • ACR Convergence 2024
Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform
Mark Russell¹, Jon Massey², Edward Roddy³, Brian MacKenna⁴, Seb Bacon⁴, Ben Goldacre⁴, Colm Andrews⁴, George Hickman⁴, Amir Mehrkar², Arti Mahto⁵, Andrew Rutherford⁶, Samir Patel¹, Maryam Adas⁷, Edward Alveyn⁷, deepak Nagra¹, Katie Bechman⁷, Joanna Ledingham⁸, Joanna Hudson⁹, Sam Norton¹, Andrew Cope⁷ and James Galloway¹⁰, ¹King's College London, London, England, United Kingdom, ²University of Oxford, Oxford, England, United Kingdom, ³Keele University, Keele, England, United Kingdom, ⁴University of Oxford, Oxford, United Kingdom, ⁵King's College Hospital NHS Foundation Trust, London, United Kingdom, ⁶King's College Hospital NHS Foundation Trust, London, England, United Kingdom, ⁷King's College London, London, United Kingdom, ⁸Portsmouth Hospitals University NHS Trust, Portsmouth, United Kingdom, ⁹King's College London, King's College London, United Kingdom, ¹⁰Centre for Rheumatic Diseases, King's College London, London, United Kingdom
Background/Purpose: Data from before the COVID-19 pandemic had shown persistently poor care for people with gout in many countries worldwide. Whether this was further exacerbated…
Abstract Number: 0315 • ACR Convergence 2023
Identification of Calcium Crystals in End-Stage Osteoarthritis with Raman Spectroscopy
Tom Niessink¹, Tim Welting², Matthijs Janssen³, Cees Otto⁴ and Tim Jansen⁵, ¹University of Twente, Utrecht, Netherlands, ²MUMC+, Maastricht, Netherlands, ³Viecuri MC / Venlo, Wijgmaal, Belgium, ⁴University of Twente, Enschede, Netherlands, ⁵VieCuri MC, Venlo, Netherlands
Background/Purpose: Calcium containing crystals in osteoarthritis (OA) are of interest as they potentially stimulate the NRLP-3 inflammasome and may become treatable with novel therapeutics. Previous…
Abstract Number: 0812 • ACR Convergence 2023
Length of Synovial Fluid Monosodium Urate Crystals According to Sonographic Articular Deposits: Advancing in the Crystallization Process
Elena Sansano¹, Mª Carmen López-González², Cristina Rodríguez-Alvear³, Irene Calabuig-Sais³, Agustín Martínez-Sanchís³, Eliseo Pascual³ and Mariano Andrés³, ¹Miguel Hernandez University, Alicante, Spain, ²General University Hospital Dr. Balmis, Alacante, Spain, ³Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain
Background/Purpose: We described bands of fibers having deposited orderly arrayed monosodium urate (MSU) crystals suggesting the need for protein templates to start crystallization [PMID 9709185].…
Abstract Number: 0814 • ACR Convergence 2023
Treat-to-target Urate-lowering Therapy Reduces Gout Flare Burden: Post-hoc Analysis of a Multicenter, Randomized, Double-blind, Non-inferiority Trial
Joshua Qu¹, Lindsay Helget¹, Maria Androsenko², Hongsheng Wu³, Bridget Kramer¹, Jefferey Newcomb⁴, Mary Brophy³, Anne Davis-Karim⁵, Bryant England¹, Ryan Ferguson³, Michael Pillinger⁶, Tuhina Neogi⁷, Paul Palevsky⁸, James O'Dell¹ and Ted R Mikuls⁹, ¹University of Nebraska Medical Center, Omaha, NE, ²Department of VA, Newton, MA, ³Boston VA, Boston, MA, ⁴University of Nebraska, Omaha, NE, ⁵Albuquerque VA, Albuquerque, NM, ⁶New York University Grossman School of Medicine, New York, NY, ⁷Boston University School of Medicine, Boston, MA, ⁸University of Pittsburgh, Pittsburgh, PA, ⁹Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: To optimally manage gout, the ACR recommends a treat-to-target (T2T) strategy, which entailsthe titration of urate-lowering therapy (ULT) to achieve and maintain a serum…
Abstract Number: 0815 • ACR Convergence 2023
Intermittent Fasting Reduces Crystal-induced Inflammation
Nghia Pham¹, Twinu Wilson Chirayath², Florence Castelli³, François Fenaille³, Anvi-Laetitia Nguyen³, François Brial⁴, Augustin Latourte⁴, Frédéric Lioté⁴, Pascal Richette⁵, Thomas Bardin⁶ and Hang Korng EA⁷, ¹INSERM 1132, BIOSCAR, Lariboisière hospital, Paris, France, ²INSERM, Paris, France, ³Laboratoire d’études du métabolisme des médicaments UMS 28, CEA Saclay, Gif-sur-Yvette, France, ⁴INSERM 1132, BIOSCAR, Paris, France, ⁵Lariboisière Hospital, Paris, France, ⁶Université de Paris Cité, Paris, France, ⁷INSERM-BIOSCAR, Paris, France
Background/Purpose: Inflammation induced by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals depends on interleukin (IL)-1β activated by the NLRP3 inflammasome. The inflammatory response can…
Abstract Number: 1100 • ACR Convergence 2023
A Comparison of Characteristics of Patients with Crystalline and Septic Arthritis Confirmed by Synovial Fluid Analysis: Towards the Development of a Diagnostic Rule
Maria Salgado Guerrero¹, Mariana Urquiaga¹, Nishah Panchani² and Angelo Gaffo³, ¹University of Alabama at Birmingham, Birmingham, AL, ²Tinsley Harrison Internal Medicine Residency Program, University of Alabama at Birmingham, Arlington, TX, ³Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, AL; Birmingham VA Medical Center, Birmingham, AL
Background/Purpose: Distinguishing crystalline from septic arthritis is a common challenge in patients admitted with acute joint inflammation. Arthrocentesis for synovial fluid analysis is considered the…
Abstract Number: 1101 • ACR Convergence 2023
Systemic Inflammation Associated with Silent Deposition of Monosodium Urate Crystals in Asymptomatic Hyperuricemia
Maria-Luisa Peral-Garrido¹, Paula Boix-Navarro², Silvia Gómez-Sabater³, Rocío Caño-Alameda³, Alejandra Bermúdez-García⁴, Teresa Lozano⁴, Ruth Sanchez-Ortiga⁴, Miguel Perdiguero⁴, Elena Caro-Martínez⁵, Carolina Ruiz-García⁶, Eliseo Pascual⁴, Rubén Francés² and Mariano Andrés⁴, ¹Vinalopó University Hospital, Novelda, Spain, ²Miguel Hernandez University, San Juan de Alicante, Spain, ³Rheumatology Department, Dr. Balmis University General Hospital, Alicante. Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain, ⁴Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain, ⁵San Vicente Hospital-HACLE, San Vicente del Raspeig, Spain, ⁶Campoamor Health Centre, Alicante, Spain
Background/Purpose: Whether the presence of subclinical monosodium urate (MSU) crystal deposition leads to a pro-inflammatory state in asymptomatic hyperuricemia (AH) is unknown. We aimed to…
Abstract Number: 1115 • ACR Convergence 2023
EULAR Recommendations for the Use of Imaging in the Diagnosis and Management of Crystal-induced Arthropathies in Clinical Practice
Peter Mandl¹, Maria-Antonietta D'Agostino², Victoria Navarro-Compán³, Irina Gessl¹, Garifallia Sakellariou⁴, Abhishek Abhishek⁵, Fabio Becce⁶, Nicola Dalbeth⁷, Hang-Korng Ea⁸, Emilio Filippucci⁹, Hilde Berner Hammer¹⁰, Annamaria Iagnocco¹¹, Annette De Thurah¹², Esperanza Naredo¹³, Sebastien Ottaviani¹⁴, Tristan Pascart¹⁵, Fernando Perez-Ruiz¹⁶, Irene Pitsillidou¹⁷, Fabian Proft¹⁸, Juergen Rech¹⁹, Wolfgang Schmidt²⁰, Luca Sconfienza²¹, Lene Terslev²², Brigitte Wildner²³, Pascal Zufferey²⁴ and Georgios Filippou²⁵, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Universita Cattolica del Sacro Cuore Rome, Courbevoie, France, ³Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ⁴Department of Internal Medicine and Therapeutics, Università di Pavia, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy, ⁵University of Nottingham, Nottingham, United Kingdom, ⁶Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁷University of Auckland, Auckland, New Zealand, ⁸Hôpital Lariboisière, APHP-Nord, Service de Rhumatologie, Université de Paris Cité, Paris, France, ⁹Polytechnic University of Marche, Jesi, Italy, ¹⁰Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway AND University of Oslo, Faculty of Medicine, Oslo, Norway, ¹¹University of Turin, Roma, Italy, ¹²Aarhus University Hospital, Aarhus, Denmark, ¹³Hospital Fundación, Madrid, Spain, ¹⁴Assistance Publique Hopitaux de Paris, Paris, France, ¹⁵Department of Rheumatology, Saint-Philibert Hospital, Lille Catholic University, Lille, France, ¹⁶Rheumatology Division, Osakidetza, OSI-EE Cruces, Cruces University Hospital, Barakaldo, Spain, ¹⁷EULAR Patient Research Partner, Executive Secretary of Cyprus League Against Rheumatism, Nicosia, Cyprus, ¹⁸Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ¹⁹University Clinic Erlangen, Erlangen, Germany, ²⁰Rheumatology, Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin-Buch, Berlin, Germany, ²¹Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano AND IRCCS Istituto Ortopedico Galeazzi, 20161, Milan, Italy, ²²Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ²³University Library, Medical University of Vienna, Vienna, Austria, ²⁴Rheumatology Department, University of Lausanne, CHUV, Lausenne, Switzerland, ²⁵IRCCS Galeazzi - Sant'Ambrogio Hospital, Milan, Italy
Background/Purpose: The multifaceted clinical presentation in crystal-induced arthropathies (CiA) poses challenges to imaging. Our goal was to formulate evidence-based recommendations on the use of imaging…
Abstract Number: 1118 • ACR Convergence 2023
The Nomenclature of Calcium Pyrophosphate Deposition (CPPD) Disease – Results of a Systematic Literature Review for the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) CPPD Nomenclature Project
Silvia Sirotti¹, Charlotte Jauffret², Edoardo Cipolletta³, Daniele Cirillo⁴, Luca Ingrao⁴, Alessandro Lucia⁴, Antonella Adinolfi⁵, Debora Pireddu⁴, Emilio Filippucci⁶, Tristan Pascart², Sara Tedeschi⁷, Robert Terkeltaub⁸, Nicola Dalbeth⁹ and Georgios Filippou¹, ¹IRCCS Galeazzi - Sant'Ambrogio Hospital, Milan, Italy, ²Saint-Philibert Hospital, Lille Catholic University, Lille, France, ³Polytechnic University of Marche, Ancona, Italy, ⁴Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy, ⁵Rheumatology Unit, Grande Ospedale Metropolitano Niguarda, Milano, Italy, ⁶Polytechnic University of Marche, Jesi, Italy, ⁷Brigham and Women's Hospital, Boston, MA, ⁸University of California San Diego, San Diego, CA, ⁹University of Auckland, Auckland, New Zealand
Background/Purpose: Despite prior attempts at standardising terminology of calcium pyrophosphate deposition (CPPD) disease (including the 2011 EULAR recommendations for CPPD terminology and diagnosis), many different…
Abstract Number: 1121 • ACR Convergence 2023
Cardiovascular Safety of Febuxostat in Patients with Gout or Hyperuricemia: A Systematic Review of Randomized Controlled Trials
Roba Ghossan¹, Ouidade Aitisha Tabesh², Fouad Fayad², Pascal Richette³ and Thomas Bardin⁴, ¹COCHIN HOSPITAL, Paris, France, ²Hotel Dieu de France, Beirut, Lebanon, ³Lariboisière Hospital, Paris, France, ⁴Université de Paris Cité, Paris, France
Background/Purpose: To this date, a causal relationship between febuxostat and cardiovascular disease remains controversial as comparison between trials can be challenging and may lead to…

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