ACR Meeting Abstracts

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Abstracts tagged "Crystal-induced arthritis"

  • Abstract Number: 1103 • ACR Convergence 2024

    The Role of Renal Dual-Energy CT in Exploring the Gouty Kidney: The RENODECT Study

    Tristan Pascart1, Elie Dauphin1, Chio Yokose2, Charlotte Jauffret3, Hyon K. Choi4 and Jean-François Budzik5, 1Université Catholique de Lille, Lille, Nord-Pas-de-Calais, France, 2Massachusetts General Hospital, Boston, MA, 3Lille Catholic University, Lille, Nord-Pas-de-Calais, France, 4Massachusetts General Hospital, Lexington, MA, 5Lille Catholic University, Lille, France

    Background/Purpose: Chronic kidney disease (CKD) is a common feature in gout, and can have multiple causes, some of which are gout specific, such as gout…
  • Abstract Number: 0267 • ACR Convergence 2024

    IL-17 Participates in the Pathogenesis of Chronic Gouty Arthritis

    Hong Di1, Xinxin Han1, Yun Zhang2 and Xuejun Zeng1, 1Peking Union Medical College Hospital, Beijing, China, 2Peking Union Medical College Hospital (CAMS), Beijing, China

    Background/Purpose: Chronic gouty arthritis (CGA) is different from acute gouty arthritis  (AGA), its main characteristics include repeated or even persistent joint symptoms, tophus and bone destruction.…
  • Abstract Number: 1653 • ACR Convergence 2024

    Osteoarthritis Drives Inflammatory Imprinting of Synovial Fibroblasts, Exacerbating Gouty Arthritis Through m6A Modification of S100A4

    ZIYI CHEN1, Yinghui Hua2 and Wenjuan Wang1, 1Department of Sports Medicine, Huashan Hospital,Fudan University, Shanghai, Shanghai, China (People's Republic), 2Department of Sports Medicine, Huashan Hospital,Fudan University, Shanghai, China (People's Republic)

    Background/Purpose: Patients with osteoarthritis (OA) face an elevated risk of future gouty arthritis (GA). To delineate the underlying cellular and molecular mechanisms of OA-driven gout…
  • Abstract Number: 0270 • ACR Convergence 2024

    Longitudinal Patterns of C-Reactive Protein Values in Calcium Pyrophosphate Deposition (CPPD) Disease

    Muneet Gill, Hongshu Guan, Jamie Collins and Sara Tedeschi, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Calcium pyrophosphate deposition (CPPD) disease is a crystalline arthritis affecting older adults. Systemic inflammation occurs during flares of acute calcium pyrophosphate (CPP) crystal arthritis…
  • Abstract Number: 2013 • ACR Convergence 2024

    Elevated Serum Allantoin and Allantoin/uric Acid Ratio as Indicators of Oxidative Stress in Severe Gout and Cardiovascular Comorbidities

    Lenka Hasikova1, Petr Kozlik2, Kveta Kalikova3, Petr Dusek4, Marketa Pavlikova1, Blanka Stiburkova5 and Jakub Závada6, 1Institute of Rheumatology, Prague, Czech Republic; Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Department of Analytical Chemistry, Faculty of Science, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Department of Neurology and Centre of Clinical Neuroscience and Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, Prague, Czech Republic, 5Institute of Rheumatology, Prague, Czech Republic and Department of Paediatrics and Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology and Charles University, Praha, Czech Republic

    Background/Purpose: Uric acid (UA) can be non-enzymatically oxidized into allantoin and other products by reactive oxygen species under conditions of increased oxidative stress. Consequently, allantoin…
  • Abstract Number: 0272 • ACR Convergence 2024

    Calcifications of the Transverse Ligament of the Atlas in Patients Diagnosed with Calciumpyrophosphate Crystal Arthritis – a Retrospective Observational Study

    Shay Brikman1, Noga Shabshin2 and Amir Bieber3, 1Emek Medical Center, Afula, Israel, 2Emek Medical Center, Clalit Health Services, Afula, Israel, 3Emek Medical Center, Clalit Health Services, Raanana, Israel

    Background/Purpose: Chondrocalcinosis (CC) is commonly detected on X-ray films of the knee, wrist, and symphysis pubis. Calcium pyrophosphate (CPP) deposition disease is sometimes associated with…
  • Abstract Number: 2016 • ACR Convergence 2024

    Treat to Target in Gout Yields Superior Outcomes Compared to Treat to Avoid Symptoms Approach (results from the Gout TrEatment Strategy Overture Trial)

    Anusha Moses1, Martijn Oude Voshaar1, Tim L.Th. Jansen2 and Mart Van De Laar1, 1University of Twente, Enschede, The Netherlands, Enschede, Overijssel, Netherlands, 21VieCuri Medisch Centrum, Venlo, Netherlands

    Background/Purpose: Both the European League Against Rheumatism (EULAR) and the American College for Rheumatology (ACR) state that gout can be effectively managed by reducing sUA…
  • Abstract Number: 0276 • ACR Convergence 2024

    Exploring the Prevalence of Crowned Dens Syndrome in a Polymyalgia Rheumatica Veterans Affairs Patient Cohort

    Marlene Marte Furment1, Binod Kc1, Bhavya Poudyal1, Aakritee Sharma Subedi2, Mahnoor Sherazi3, Jihad Ben Gabr1, Shveta Trikha4, Brian Cooney5 and Fatme Allam5, 1SUNY Upstate Medical University, Syracuse, NY, 2SUNY Upstate University Hospital, Syracuse, 3State University of New York, Syracuse, NY, 4Syracuse VA Medical Center, Syracuse, 5Syracuse VA Medical Center, Syracuse, NY

    Background/Purpose: Crowned Dens (CD) is the radiological finding of calcium pyrophosphate dihydrate (CPPD) crystal deposition in the cruciform and alar ligaments giving the appearance of…
  • Abstract Number: 2219 • ACR Convergence 2024

    Association of Chondrocalcinosis with Disease Activity and Drug Response in Rheumatoid Arthritis: Baseline Characteristics of the Swiss Rheumatoid Arthritis Outcomes Cohort

    Tobias Manigold1, Nicolas Bodmer2, Rosoux Elisabeth3, Deborah Markham4, Guillaume Fahrni3, Raphael Micheroli5, Lucas Bachmann2, Jonas Brändli6, Fabio Becce7 and Thomas Hügle8, 1Department of Rheumatology, Inselspital University Hospital Bern, Bern, Switzerland., Bern, Switzerland, 2Medignition, Zürich, Switzerland, 33) Department of Radiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland, Lausanne, Switzerland, 4Department of Rheumatology, University Hospital Lausanne (CHUV), Switzerland, Lausanne, Switzerland, 5University Hospital Zurich, Zurich, Switzerland, 66) Data Science Team, Swiss Clinical Quality Management Foundation, Zurich, Switzerland, Zürich, Switzerland, 7Lausanne University Hospital (CHUV), Lausanne, Switzerland, 8Lausanne University Hospital, Lausanne, Switzerland

    Background/Purpose: Calcium pyrophosphate deposition disease (CPPD) disease can mimic or interfere with the course of rheumatoid arthritis (RA). Previous studies suggest higher prevalence of Chondrocalcinosis…
  • Abstract Number: 0278 • ACR Convergence 2024

    Efficacy and Safety of Genakumab versus Compound Betamethasone in Gout: The GUARD-1 Study

    Yu Xue1, Tianshu Chu2, Jiankang Hu3, Wei Gou4, Ning Zhang5, Juan Li6, Jing Yu7, Songping Li8, Songbin Li9, Long Qian10, Xinwang Duan11, Lihua Duan12 and Hejian Zou1, 1Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China (People's Republic), 2Department of Rheumatology, Henan Provincial People's Hospital, Zhengzhou, China, Zhengzhou, China (People's Republic), 3Department of Rheumatology, Pingxiang People's Hospital, Pingxiang, China, Pingxiang, China (People's Republic), 4Department of Rheumatology, Hebei Petro China Central Hospital, Langfang, China, Langfang, China (People's Republic), 5Department of Rheumatology, Shengjing Hospital of China Medical University, Shenyang, China, Shenyang, China (People's Republic), 6Department of Rheumatology, The First Affiliated Hospital of Hainan Medical University, Haikou, China, Haikou, China (People's Republic), 7Department of Rheumatology, The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China, Shenyang, China (People's Republic), 8Department of Rheumatology, The First Affiliated Hospital of Ganna Medical University, Ganzhou, China, Ganzhou, China (People's Republic), 9Department of Rheumatology, The First Hospital of Qiqihar, Qiqihar, China, Qiqihar, China (People's Republic), 10Department of Rheumatology, The Second Hopital of Anhui Medical University, Hefei, China, Hefei, China (People's Republic), 11Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, Nanchang, China (People's Republic), 12Department of Rheumatology, Jiangxi Provincial People's Hospital, Nanchang, China, Nanchang, China (People's Republic)

    Background/Purpose: The GUARD (Genakumab in high Uric Acid-induced Arthritis/goutfor Resolution and Delay study) program was designed to investigate the efficacy and safety of Genakumab, a…
  • Abstract Number: 2562 • ACR Convergence 2024

    Efficacy and Safety of Tocilizumab in the Treatment of Chronic Inflammatory Forms of CPPD: Retrospective Study of 55 Cases

    Sophie Carrabin1, Margaux Houze2, Charlotte Jauffret3, Thomas Bardin4, Hang Korng Ea4, Frédéric Lioté4, Pascal Richette5, Tristan Pascart2 and Augustin Latourte6, 1Hôpital Lariboisière APHP.Nord, Paris, Paris, France, 2Lille Catholic University, Lille, France, 3Lille Catholic University, Lille, Nord-Pas-de-Calais, France, 4Hôpital Lariboisière APHP.Nord, Paris, France, 5Lariboisière Hospital, Paris, France, 6AP-HP, Paris, France

    Background/Purpose: Calcium pyrophosphate deposition disease (CPPD) is a heterogeneous disease that can manifest as acute or chronic arthritis. Treatment options for chronic forms of the…
  • Abstract Number: 0279 • ACR Convergence 2024

    Macrophage Intracellular Fates of Monosodium Urate and Calcium Pyrophosphate Crystals: Phagocytosis, Exchanged/expulsion and Dissolution of Crystals

    Charles Leroy1, Nghia Pham2, François Brial3, Brenda Kischkel4, gwénaêlle Jayat5, Elena Ishow6, Christèle Combes7, Leo Joosten4, Augustin Latourte8, Pascal Richette9 and Hang-Korng Ea10, 1Inserm 1132 / Université Paris Cité, levallois-perret, France, 2INSERM 1132, BIOSCAR, Lariboisière hospital, Paris, France, 3Inserm 1132/ Université Paris Cité, Paris, France, 4Radboudumc, Nijmegen, Netherlands, 5Université Paris cité / Inserm 1132, paris, France, 6Université de Nantes / Ceisam, Nantes, France, 7INP-ENSIACET, Toulouse, France, 8AP-HP, Paris, France, 9Lariboisière Hospital, Paris, France, 10Université Paris Cité, INSERM UMR 1132 BIOSCAR, Paris, France

    Background/Purpose: Gout, due to the presence of monosodium urate crystals (MSU) and calcium pyrophosphate (CPP) crystal deposition disease are both responsible for recurrent inflammation flares.…
  • Abstract Number: 0280 • ACR Convergence 2024

    Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform

    Mark Russell1, Jon Massey2, Edward Roddy3, Brian MacKenna4, Seb Bacon4, Ben Goldacre4, Colm Andrews4, George Hickman4, Amir Mehrkar2, Arti Mahto5, Andrew Rutherford6, Samir Patel1, Maryam Adas7, Edward Alveyn7, deepak Nagra1, Katie Bechman7, Joanna Ledingham8, Joanna Hudson9, Sam Norton1, Andrew Cope7 and James Galloway10, 1King's College London, London, England, United Kingdom, 2University of Oxford, Oxford, England, United Kingdom, 3Keele University, Keele, England, United Kingdom, 4University of Oxford, Oxford, United Kingdom, 5King's College Hospital NHS Foundation Trust, London, United Kingdom, 6King's College Hospital NHS Foundation Trust, London, England, United Kingdom, 7King's College London, London, United Kingdom, 8Portsmouth Hospitals University NHS Trust, Portsmouth, United Kingdom, 9King's College London, King's College London, United Kingdom, 10Centre for Rheumatic Diseases, King's College London, London, United Kingdom

    Background/Purpose: Data from before the COVID-19 pandemic had shown persistently poor care for people with gout in many countries worldwide. Whether this was further exacerbated…
  • Abstract Number: 0281 • ACR Convergence 2024

    Intra-articular Treatment Combining Sustained Release Colchicine Encapsulated in Microspheres, and Ropivacaine, Is Effective in Inflammatory Arthritis in Rats

    Julien GRASSOT1, Farah MARZOUKI2, Roxane HERVE3, Magali BECKLER4, Luca SEMERANO5, Natacha BESSIS6, Elodie RIVIERE7, Charles SANSON2, Gauthier POULIQUEN2, Philippe POULETTY8 and Marie-Christophe BOISSIER9, 1PK MED, LYON, Rhone-Alpes, France, 2PK MED, LYON, France, 3INSERM U1125, Bobigny, France, 4INSERM 1125, Bobigny, France, 5Avicenne Teaching Hospital APHP, Bobigny, France, 6INSERM, Université Sorbonne Paris Nord, PARIS, France, 7INSERM, Université Sorbonne Paris Nord, APHP, PARIS, France, 8PK MED, PARIS, France, 9University Sorbonne Paris Nord, Bobigny, France

    Background/Purpose: Gout is a common disease with a prevalence and incidence on the rise worldwide. However, approved treatments to treat acute gout flares have slow…
  • Abstract Number: 0282 • ACR Convergence 2024

    Electronic Health Record-Based Calcium Pyrophosphate Deposition Disease Registry: A Feasibility Study

    Nils Bürgisser1, Denis Mongin2, Samia Mehouachi2, Delphine Sophie Courvoisier3 and Kim Lauper4, 1Division of Rheumatology and internal medicine, Geneva University Hospital, Switzerland, Geneva, Switzerland, 2Division of Rheumatology, Geneva University Hospital, Switzerland, Geneva, Switzerland, 3Division of Rheumatology, Geneva University Hospitals, Geneva, Switzerland, 4Geneva University Hospitals, Geneva, Switzerland

    Background/Purpose: Despite its prevalence, calcium pyrophosphate deposition disease (CPPD) remains insufficiently studied. Leveraging electronic health record (EHR) data, a rich source of patient information, could…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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