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Abstracts tagged "complement and innate immunity"

  • Abstract Number: 2895 • 2019 ACR/ARP Annual Meeting

    Complement Protein CL-K1 at High Concentrations Protects Against the Development of Lupus Nephritis

    Anne Troldborg1, Anne Voss 2, Søren Werner Karlsjov Hansen 3, Jens Christian Jensenius 4, Kristian Stengaard-Pedersen 5 and Steffen Thiel 6, 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, Aarhus, Denmark, 2Odense University Hospital, Department of Rheumatology, Odense, Denmark, 3University of Southern Denmark, Odense, Denmark, 4Aarhus University, department of biomedicine, Aarhus, Denmark, 5Department of Rheumatology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark, Aarhus, Denmark, 6Department of Biomedicine, Aarhus University, Aarhus, Denmark, Aarhus, Denmark

    Background/Purpose: Nephritis is a severe manifestation of systemic lupus erythematosus (SLE) that develops in 30 to 50 percent of the patients. At the time of…
  • Abstract Number: 1024 • 2018 ACR/ARHP Annual Meeting

    Unique Pattern of Lectin Pathway Complement Protein Levels in Axial Spondyloarthritis

    Anne Troldborg1,2,3, Steffen Thiel1, Clara Mistegaard Joergensen4, Kristian Stengaard-Pedersen3,5 and Anne Gitte Loft3,6, 1Biomedicine, Aarhus University, Aarhus, Denmark, 2clinical medicine, Aarhus University, Aarhus, Denmark, 3Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 4Emergency Medicine, Regional Hospital Horsens, Horsens, Denmark, 5Clinical medicine, Aarhus University, Aarhus, Denmark, 6Clinical Medicine, Aarhus University, Aarhus, Denmark

    Background/Purpose: Spondyloarthritis (SpA) represents a group of immune-mediated inflammatory diseases that exhibit overlapping clinical features, genetic predisposition and a not fully understood pathogenesis. Inflammation and…
  • Abstract Number: 2730 • 2014 ACR/ARHP Annual Meeting

    FcγRIIIa Ligation in Human Peripheral CD4+ T-Cells Generate TH17 like Population

    Anil K. Chauhan1, Terry Moore2 and Chen Chen3, 1Rheumatology, Saint Louis University, St. Louis, MO, 2Rheumatology/Immunology, St Louis University, Saint Louis, MO, 3Rheumatology/Internal Medicine, Saint Louis University, St. Louis, MO

    Background/Purpose: Cytokines produced during TH17 response, IL-17A and IL17F drive inflammation and autoimmunity. They also act as a bridge between adaptive and innate immunity. Immune…
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