Abstracts tagged "Comorbidity"

Abstract Number: 0329 • ACR Convergence 2023
Factors Associated with Suicidal Ideation Among Patients with Inflammatory Rheumatic Musculoskeletal Disease: A Case-Control Study
Eike von Schlichting¹, Jan Dieris-Hirche², Imke Redeker³, Xenofon Baraliakos⁴ and Uta Kiltz⁵, ¹Ruhr-Universität Bochum and Rheumazentrum Ruhrgebiet, Herne, Germany, ²LWL-University Hospital, Department of Psychosomatic Medicine and Psychotherapy, Ruhr Universität Bochum, Bochum, Germany, ³Ruhr Universität Bochum, Bochum, Germany, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵Rheumazentrum Ruhrgebiet, Herne, Germany
Background/Purpose: Mental health contributes to the morbidity of patients with inflammatory rheumatic musculoskeletal disease (iRMD). Despite extensive research conducted on the prevalence of depressive disorders,…
Abstract Number: 1480 • ACR Convergence 2023
Demographic and Clinical Characteristics of Patients with LN: A Multicenter Study from the Gulf Region
Jamal Al-Saleh¹, Faisal Elbadawi¹, Rajaie Namas², Samar Al-Emadi³, Khalid A. Alnaqbi⁴, Humaid A. Al-Wahshi⁵, Amjad Alkadi⁶, Suad Hannawi⁷, Mohamed Hamouda⁸, Averyan Vasylyev⁸, Arwa Al-Shujairi⁸, Reem Al-Jayyousi⁹ and Munther Khamashta⁸, ¹Dubai Hospital, Department of Rheumatology, Dubai, United Arab Emirates, ²Cleveland Clinic Abu Dhabi, Department of Rheumatology, Abu Dhabi, United Arab Emirates, ³Hamad Medical Corporation, Department of Rheumatology, Doha, Qatar, ⁴Tawam Hospital, Department of Rheumatology, Al Ain, United Arab Emirates, ⁵The Royal Hospital, Department of Rheumatology, Muscat, Oman, ⁶Ministry of Health, Kuwait, Kuwait, ⁷Kuwait Hospital, Department of Rheumatology, Dubai, United Arab Emirates, ⁸GSK Gulf, Medical Affairs Department, Dubai, United Arab Emirates, ⁹Mohamed Bin Rashid University of Medicine and Health Sciences, College of Medicine, Dubai, United Arab Emirates, and Mediclinic Parkview, Dubai, United Arab Emirates
Background/Purpose: Data from limited studies of LN in the Gulf region suggest that LN manifests more severely in this region than in Caucasian populations, yet…
Abstract Number: 2420 • ACR Convergence 2023
Sex Differences in Giant Cell Arteritis: Data from the ARTESER Registry
Delia Fernández-Lozano¹, Marta Domínguez², Javier Narvaez³, Noemi Garrido-Puñal⁴, Eugenio De Miguel⁵, Paula V. Estrada-Alarcón⁶, Iñigo Hernández-Rodríguez⁷, Maria. T Silva-Diaz⁸, Joaquín M. Belzunegui⁹, Clara Moriano Morales¹⁰, Julio Sanchez Martin¹¹, Itziar Calvo-Zorrilla¹², Vicente Aldasoro¹³, lydia Abasolo¹⁴, Javier Loricera¹¹, Patricia Moya¹⁵, Maria J. García-Villanueva¹⁶, Carles Galisteo¹⁷, Anne Riveros-Frutos¹⁸, Francisco Ortiz-Sanjuán¹⁹, Selene Labrada-Arrabal²⁰, Margarida Rocha²¹, Carlos García-Porrúa²², Maria García-González²³, Clara Molina Almela²⁴, María Alcalde²⁵, Antonio Juan Mas²⁶, Fernando Alonso²⁷, Santos Castañeda²⁸, Ricardo Blanco²⁹ and on behalf of the Collaborative Group members³⁰, ¹Hospital de Mérida, Merida, Spain, ²Sociedad Española de Reumatología, Madrid, Spain, ³Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Hospital Universitario Virgen del Rocío, Sevilla, Spain, ⁵Hospital Universitario La Paz, Madrid, Spain, ⁶Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, ⁷Hospital do Meixoeiro. Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ⁸Complexo Hospitalario Universitario A Coruña, A Coruña, Spain, ⁹Hospital Universitario Donostia, Donostia, Spain, ¹⁰Rheumatology, Hospital Universitario de León, León, Spain, ¹¹Hospital Universitario Marqués de Valdecilla, Santander, Spain, ¹²Basurto University Hospital, Bilbao, Spain, ¹³Hospital Universitario de Navarra, Pamplona, Spain, ¹⁴Hospital Clínico San Carlos, Madrid, Spain, ¹⁵Hospital de Santa Creu i Sant Pau, Barcelona, Spain, ¹⁶Hospital Ramón y Cajal, Madrid, Spain, ¹⁷Hospital Universitario Parc Taulí, Sabadell, Spain, ¹⁸Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, ¹⁹Hospital Universitario y Politécnico La Fe, Valencia, Spain, ²⁰Hospital del Mar, Barcelona, Spain, ²¹Osakidetza, Bilbo, Spain, ²²Hospital Universitario Lucus Augusti, Lugo, Spain, ²³Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ²⁴Hospital General de Valencia, Valencia, Spain, ²⁵Hospital Severo Ochoa, Madrid, Spain, ²⁶Hospital Universitario Son Llàtzer, Mallorca, Spain, ²⁷Spanish Society of Rheumatology, Madrid, Spain, ²⁸Hospital Universitario de la Princesa, Madrid, Spain, ²⁹Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ³⁰ARTESER group, Madrid, Spain
Background/Purpose: Giant cell arteritis (GCA) is the most common vasculitis in North America and Western Europe. GCA is more likely to occur in women (1).…
Abstract Number: 0448 • ACR Convergence 2023
Cardioprotective Impact of JAKi, Tofacitinib, on CV Risk in Rheumatoid Arthritis: JAKi CV Risk Impact Study
Ashit Syngle¹, Inderjeet verma², Nidhi Garg³, Kanchan Chauhan¹, Sapna Patyal¹ and Devaansh Syngle⁴, ¹Healing Touch City Clinic, Chandigarh, India, ²Maharishi Markandeshwar University, Mulana, India, ³Chitkara, Rajpura, India, ⁴Healing Touch Foundation, Chandigarh, India
Background/Purpose: RA patients have at least twice the risk of CVD. In fact, CVD is the leading cause of morbidity and premature mortality in RA.…
Abstract Number: 1539 • ACR Convergence 2023
Digital Ischemia, a Rare Manifestation in Anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV)
Adil Vural¹, Chao Zhang² and Kinanah Yaseen¹, ¹Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Digital ischemia is a rare, yet severe manifestation observed in AAV. Despite gangrene being a major criterion in the Birmingham Vasculitis Activity Score, this…
Abstract Number: 2471 • ACR Convergence 2023
Higher Pain and Functional Impairment in Erosive Hand Osteoarthritis Than in Treated Rheumatoid Arthritis: A Comparative Study Between DIGICOD and ESPOIR Cohorts
Sabryne Berkani¹, Ainhoa Aparicio Monforte², Sophie tuffet², alexandra rousseau², nathalie rincheval³, emmanuel maheu⁴, bernard combe³, Alain SARAUX⁵, Bruno Fautrel⁶, Laure Gossec⁷, Francis Berenbaum⁴, Jeremie SELLAM⁶ and alice courties⁴, ¹Sorbonne Université, Rheumatology department, (AP-HP) Saint-Antoine Hospital, Paris, France, ²Department of Clinical Pharmacology and Clinical Research Platform Paris-East (URCEST-CRC-CRB), APHP, Hôpital St Antoine, Paris, France, ³Department of Rheumatology, University of Montpellier, Montpellier, France, ⁴Sorbonne Université Assistance Publique – Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital, Department of Rheumatology, Paris, France, ⁵CHU Brest, Brest, France, ⁶Sorbonne Université APHP, Paris, France, ⁷Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France
Background/Purpose: Hand osteoarthritis (HOA) is considered as a less severe disease with a better functional prognosis and a lower global burden than rheumatoid arthritis (RA).…
Abstract Number: 0559 • ACR Convergence 2023
Development of Charlson Comorbidity Index (CCI) Comorbidities and CCI Score in Danish Nationwide Cohort of 3,178 Patients with Newly Diagnosed Systemic Lupus Erythematosus
Renata Baronaite Hansen, Copenhagen Research Center for Autoimmune Connective Tissue Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Background/Purpose: Comorbidity risk is remarkably increased in patients with Systemic Lupus Erythematosus (SLE) compared with the general population. A better understanding of comorbidity development in…
Abstract Number: 1542 • ACR Convergence 2023
The Burden of Multimorbidity in ANCA-Associated Vasculitis: A Cohort Study
Zachary Wallace¹, Xiaoqing Fu², Shruthi Srivatsan², Zachary Williams², Claire Cook², Jennifer Hanberg², John Stone³, Hyon K. Choi⁴ and Yuqing Zhang⁵, ¹Massachusetts General Hospital, Newton, MA, ²Massachusetts General Hospital, Boston, MA, ³Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Concord, MA, ⁴Massachusetts General Hospital and Harvard Medical School, Lexington, MA, ⁵Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA
Background/Purpose: With improvements in the risks of relapse and mortality in ANCA-associated vasculitis (AAV), a better understanding of disease- and treatment-related complications is necessary to…
Abstract Number: 0723 • ACR Convergence 2023
Investigating the Effects and Molecular Mechanisms of TRAF5 on the Pathogenesis of SLE Associated Pulmonary Arterial Hypertension
Xiaoyue Deng¹, Junyan Qian¹, Ranran Wang², JIULIANG ZHAO³, Qian Wang⁴, Tianyi Yuan², MENGTAO LI¹ and Xiaofeng Zeng⁵, ¹Peking Union Medical College Hospital, Beijing, China, ²Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ³Beijing Union Medical College Hospital, Beijing, China, ⁴Peking Union Medical College, Beijing, China, ⁵Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Background/Purpose: Pulmonary arterial hypertension (PAH) is a serious complication in SLE patients, with rapid progression and poor prognosis. In China, approximately 3% of the over…
Abstract Number: 1631 • ACR Convergence 2023
Comparison of Peripheral Biomarker Profiles Across Unique Multimorbidity Patterns in Rheumatoid Arthritis
Chloe Peyton¹, Tate Johnson¹, Joshua Baker², Yangyuna Yang¹, Punyasha Roul¹, Michael Duryee¹, Jill Poole¹, Geoffrey Thiele¹, Ted R Mikuls³ and Bryant England¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Pennsylvania, Philadelphia, PA, ³Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid arthritis (RA) predisposes affected individuals to develop multiple chronic conditions (i.e., multimorbidity). Mechanisms underlying multimorbidity onset in RA are incompletely understood, particularly for…
Abstract Number: 0739 • ACR Convergence 2023
Major Adverse Cardiovascular Event and Venous Thromboembolism Risk Comparing Advanced Therapies Among Individuals with Axial Spondylarthritis and Psoriatic Arthritis
Sali Merjanah¹, Devin Driscoll², Christine Peloquin³, Jean liew³ and Maureen Dubreuil⁴, ¹Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ²Boston University/Boston Medical Center, Boston, MA, ³Boston University, Boston, MA, ⁴Department of Rheumatology, Boston University School of Medicine, Milton, MA
Background/Purpose: Individuals with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) have increased cardiovascular risk compared to the general population, which is partly explained by systemic…
Abstract Number: 1632 • ACR Convergence 2023
Incident Malignancies in Patients with Rheumatoid Arthritis in Daily Rheumatological Care
Martin Schaefer¹, Yvette Meissner¹, Bernhard Manger², Sylvia Berger³, Karin Rockwitz⁴, Anne Regierer⁵ and Anja Strangfeld¹, ¹German Rheumatism Research Center, Berlin, Germany, ²Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, ³Rheumatologist, Naunhof, Germany, ⁴Rheumatologist, Goslar, Germany, ⁵Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany
Background/Purpose: In 2021, the European and US-American regulatory agencies EMA and FDA issued warnings about malignancy risk associated with the Janus kinase inhibitor (JAKi) tofacitinib…
Abstract Number: 0869 • ACR Convergence 2023
Clinical Impact of PTEN as a Marker for Diabetes-Associated Osteoarthritis
Irene Lorenzo Gomez¹, Uxía nogueira Recalde², Christian García Domínguez¹, Natividad Oreiro Villar³, Jose Antonio Pinto Tasende³, Mohit Kapoor⁴, Francisco J. Blanco³ and Beatriz Carames¹, ¹Unidad de Biología del Cartílago, Grupo de Reumatología, Instituto de Investigación Biomédica de A Coruña (iNIBIC), A Coruña, Spain, ²Unidad de Biología del Cartílago, Grupo de Reumatología, Instituto de Investigación Biomedica de A Coruña (iNIBIC), A Coruña, Spain, ³Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, ⁴Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Defects in homeostatic mechanisms, such as autophagy, contribute to joint aging and Osteoarthritis (OA) and precede joint damage (1). OA is a complex and…
Abstract Number: 1855 • ACR Convergence 2023
Using a Whole-population Approach to Help Design More Effective and Efficient Healthcare Services for People with Fibromyalgia
Gary Macfarlane¹, Roxanne Cooksey², Ernest Choy³ and Rosemary Hollick⁴, ¹Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²Cardiff University, Cardiff, United Kingdom, ³Section of Rheumatology, Cardiff University, Cardiff, United Kingdom, ⁴University of Aberdeen, Aberdeen, United Kingdom
Background/Purpose: A large body of evidence has informed, internationally, management recommendations for people with fibromyalgia. However there are very few studies which have examined how…
Abstract Number: 0985 • ACR Convergence 2023
Assessing the Value of Comorbidity Clusters in Predicting Clinical Outcomes in Rheumatoid Arthritis: A Machine Learning Approach Using a Very Large US Registry
Daniel Solomon¹, Fredrik Johansson², Hongshu Guan³, Leah Santacroce⁴, Lin Guo⁵, Wendi Malley⁵ and Heather Litman⁵, ¹Brigham and Women's Hospital, Newton, MA, ²Chalmers University of Technology, Goteborg, Sweden, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵CorEvitas, LLC, Waltham, MA
Background/Purpose: Comorbid conditions are very common in rheumatoid arthritis (RA) and several prior studies have derived comorbidity clusters using machine learning (ML). Clustering using ML…

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