Abstracts tagged "Comorbidity"

Abstract Number: 1646 • ACR Convergence 2022
Major Adverse Cardiovascular Events and Mortality with Opioids versus NSAIDs Initiation in Patients with Rheumatoid Arthritis
Gulsen Ozen¹, Sofia Pedro² and Kaleb Michaud³, ¹University of Nebraska Medical Center, Bellevue, NE, ²Forward, The National Databank for Rheumatic Diseases, Wichita, KS, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Pain management is challenging in RA where ~60% of patients with well-controlled disease activity still experience bothersome pain. The opioid epidemic in the US…
Abstract Number: 0922 • ACR Convergence 2022
Alteration of the Cardiometabolic and Cardiovascular Proteome in Rheumatoid Arthritis. Modulation by Methotrexate and Tofacitinib
Nuria Barbarroja¹, Carlos Pérez-Sánchez¹, Laura Cuesta-Lopez¹, Miriam Ruiz-Ponce¹, Ivan Arias-de la Rosa¹, Antonio Gonzalez², Eva Perez Pampin³, Chamaida Plasencia-Rodriguez⁴, Ana Martinez-Feito⁴, Rafaela Ortega-Castro¹, Jerusalem Calvo-Gutierrez⁵, Alejandro Balsa⁶, Alejandro Escudero-Contreras¹, Eduardo Collantes¹ and Chary López-Pedrera⁷, ¹IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, ²Experimental and Observational Rheumatology and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, ³Experimental and Observational Rheumatology and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clínico Universitario de Santiago, Cordoba, Spain, ⁴Rheumatology Department, La Paz University Hospital, Madrid, Spain, ⁵IMIBIC/University of Cordoba/Reina Sofia Hospital, Córdoba, Spain, ⁶Hospital La Paz Institute for Health Research, Madrid, Spain, ⁷Maimonides Institute for Biomedical Research of Córdoba, Cordoba, Spain
Background/Purpose: Patients with rheumatoid arthritis (RA) have a high risk of suffering cardiovascular disease. The analysis of the cardiovascular and cardiometabolic proteome in RA patients…
Abstract Number: 1767 • ACR Convergence 2022
Epidemiology of Eosinophilic Granulomatosis with Polyangiitis (EGPA) and Hypereosinophilic Syndrome (HES) in Germany: A Claims Database Study
Bernhard Hellmich¹, Konstantin Neukirch², Marco Lukas², Martin Wernitz², Dominik Beier³ and Dennis Häckl⁴, ¹Department of Internal Medicine, Rheumatology and Immunology, Medius Kliniken, University of Tübingen, Kirchheim Teck, Germany, ²GlaxoSmithKline GmbH & Co. KG, Munich, Germany, ³InGef - Institute for Applied Health Research Berlin GmbH, Berlin, Germany, ⁴WIG2 GmbH, Leipzig, Germany
Background/Purpose: EGPA and HES are rare multisystemic diseases associated with eosinophilia. Robust data on the epidemiology and treatment of HES and EGPA are scarce. The…
Abstract Number: 1034 • ACR Convergence 2022
Characterization of Non-radiographic Axial Spondyloarthritis Patients and the Burden of Disease in Routine Clinical Practice
Kathryn Starzyk, Pam Kumparatana and roger Meng, OM¹, Inc., Boston, MA
Background/Purpose: Axial spondyloarthritis [AxSpA and particularly non-radiographic (nr)AxSpA] has one of the longest diagnostic delays in rheumatology. Although improving, lack of radiographic evidence of disease…
Abstract Number: 1806 • ACR Convergence 2022
Characteristics and Comorbidity Burden of Phase 3 Clinical Trial Participants Who Did and Did Not Experience Acute Gout Flares During Biweekly Pegloticase Dosing
Naomi Schlesinger¹, Lissa Padnick-Silver², Katie Obermeyer² and Brian LaMoreaux², ¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Horizon Therapeutics plc, Deerfield, IL
Background/Purpose: Acute gout flare often accompanies urate-lowering therapy initiation and is the most common adverse event associated with pegloticase, a recombinant pegylated uricase that rapidly…
Abstract Number: 1128 • ACR Convergence 2022
The Causal Association Between Osteoarthritis and Common Comorbidities: A Mendelian Randomisation Study
William Thompson¹, Subhashisa Swain², Sizheng Zhao³, Anne Kamps⁴, Carol Coupland⁵, Chang-Fu Kuo⁶, Michael Doherty⁵ and Weiya Zhang⁵, ¹University of Nottingham, Exeter, United Kingdom, ²University of Oxford, Oxford, United Kingdom, ³The University of Manchester, Manchester, United Kingdom, ⁴Erasmus University Medical Centre, Rotterdam, Netherlands, ⁵University of Nottingham, Nottingham, United Kingdom, ⁶Chang Gung Memorial Hospital, Taoyuan, Taiwan
Background/Purpose: Osteoarthritis (OA) is the most common cause of joint pain and a major cause of disability. OA commonly associates with other conditions, such as…
Abstract Number: 1818 • ACR Convergence 2022
Hepatic Steatosis and Fibrosis in Patients with Gout Detected by Elastography
Naomi Schlesinger¹, ankoor patel¹, Vinod Rustgi¹, Anthony Yeo² and Peter Lipsky³, ¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Horizontherapeutics, New York, NY, ³AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: Gout is associated with non-alcoholic fatty liver disease (NAFLD), but neither the frequency nor severity of NAFLD in gout is well described. Elastography is…
Abstract Number: 1190 • ACR Convergence 2022
Multimorbidity in Systemic Sclerosis: Burden and Trends in Prevalence from an Incident Population-based Cohort (1980-2018)
Ashima Makol¹, Sara Achenbach¹, Alicia Hinze², Tina Gunderson³ and Cynthia Crowson⁴, ¹Mayo Clinic, Rochester, MN, Rochester, MN, ²Mayo Clinic - Rochester, MN, Rochester, MN, ³Mayo Clinic, Rochester, MN, ⁴Mayo Clinic, Eyota, MN
Background/Purpose: To estimate the prevalence and trends of multimorbidity (MM; the presence of ≥2 morbidities) in a population-based cohort of patients with Systemic sclerosis (SSc)…
Abstract Number: 1873 • ACR Convergence 2022
Relationship Between Baseline Characteristics of Rheumatoid Arthritis and Types of Mortality: Study of Cohort Followed Prospectively
Cristina Corrales¹, Fabricio Benavides Villanueva¹, Ivan Ferraz Amaro², Nuria Vegas Revenga³, Virgi Portilla⁴, Ricardo Blanco⁵, Miguel Ángel González-Gay⁶ and Alfonso Corrales⁴, ¹Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, ³Hospital Galdakao- Usansolo, Galdakao, Spain, ⁴Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁵Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁶Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased risk of mortality mainly due to cardiovascular (CV) events, infections and malignancies. The relationship between the…
Abstract Number: 1233 • ACR Convergence 2022
Ultrasound Is Reliable in the Assessment of Muscle Echogenicity in Patients with Rheumatic Diseases: Results of a Multicenter International Web-based Study
Andrea Di Matteo¹, Erica Moscioni², Maria Giovanna Lommano¹, Edoardo Cipolletta¹, Gianluca Smerilli¹, Sonia Farah¹, Carla Airoldi³, Sibel Aydin⁴, Becciolini Andrea⁵, Karina Bonfiglioli⁶, Marina Carotti⁷, Greta Carrara⁸, Tomas Cazenave⁹, Davide Corradini¹⁰, Micaela Ana Cosatti¹¹, Juan Josè de Agustin¹², Giulia Maria Destro Castaniti¹³, Marco Di Carlo¹, Eleonora Di Donato⁵, Luca Di geso¹⁴, Ashley Elliott¹⁵, Daniela Fodor¹⁶, Francesca Francioso¹, Alessandra Gabba¹⁷, Cristina Hernández-Díaz¹⁸, Rudolf Horvath¹⁹, Jana Hurnakova¹⁹, Diogo Jesus²⁰, Josefina Marin²¹, Maria Victoria Martire²², Riccardo Mashadi-Mirza²³, Marco Massarotti²⁴, Alice Andreea Musca²⁵, Jagdish Nair²⁶, Tadashi Okano²⁷, Ioannis Papalopoulos²⁸, Javier Eduardo Rosa²¹, Marcos Rosemffet²⁹, João Rovisco³⁰, Davide Rozza⁸, Fausto Salaffi¹, Crescenzio Scioscia³¹, Carlo Alberto Scirè⁸, Maria-Magdalena Tamas³², Shun Tanimura³³, Lucio Ventura-Rios¹⁸, Catalina Villota-Eraso³⁴, Orlando Villota³⁵, Paraksevi V Voulgari³⁶, Florentin Ananu Vreju³⁷, Gentiana Vukatana³⁷, Johana Zacariaz Hereter²¹, Anna Zanetti⁸, Walter Grassi¹ and Emilio Filippucci¹, ¹Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Italy, ²Polytechnic University of Marche, Jesi, Italy, ³Hospital Provincial, Rosario, Argentina, ⁴University of Ottawa, Rheumatology, Ottawa, Canada, Ottawa, ON, Canada, ⁵Department of Medicine, Internal Medicine and Rheumatology Unit, Azienda Ospedaliero Universitaria di Parma, Parma, Italy, ⁶Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁷Department of Radiology, Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy, ⁸Epidemiology Unit, Italian Society of Rheumatology, Milano, Italy, ⁹Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ¹⁰Rheumatology Unit, University Clinic AOU Cagliari, Cagliari, Italy, ¹¹CEMIC, Centro de educación médica e investigaciones médicas "Norberto Quirno", Buenos Aires, Argentina, ¹²Vall D'hebron University Hospital, Barcelona, Spain, ¹³Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology section, University of Palermo, Palermo, Italy, ¹⁴Ospedale Madonna del Soccorso, Department of Internal Medicine, San Benedetto del Tronto, Italy, ¹⁵Centre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom, ¹⁶2nd Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania, ¹⁷Local Health Unit (ASL), Oristano, Italy, ¹⁸Division de Reumatologia. Instituto Nacional de Rehabilitacion "Luis Guillermo Ibarra Ibarra", Ciudad de México, Mexico, ¹⁹Department of Paediatric and Adult Rheumatology, University Hospital Motol, Prague, Czech Republic, ²⁰Rheumatology Department, Centro Hospitalar de Leiria, Leira, Portugal, ²¹Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²²San Roque Hospital, La Plata, Buenos Aires, Argentina, ²³Radiology Department, A.O. Ospedali Riuniti Marche Nord, Pesaro, Italy, ²⁴Department of Rheumatology, University Hospitals Dorset NHS Foundation Trust, Christchurch Hospital, Christchurch, United Kingdom, ²⁵Department of Rheumatology - Colentina Clinical Hospital, Bucharest, Romania, ²⁶Rheumatology, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom, ²⁷Department of Orthopedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, ²⁸Department of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece, ²⁹Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Capital Federal, Argentina, ³⁰Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ³¹Department of Emergency and Organ Transplantations-Rheumatology Unit, University of Bari "Aldo Moro", Bari, Italy, ³²Department of Rheumatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania, ³³Rheumatology Department, Hokkaido Medical Center for Rheumatic Diseases, Sapporo, Japan, ³⁴IPS Servicio integral de reumatología e inmunología Dr Orlando Villota, Pasto, Colombia, ³⁵Division of Rheumatology, Fundación Hospital San Pedro, Pasto, Colombia, ³⁶Department of Rheumatology, School of Health Science, Faculty of Medicine, University of Ioannina, Ioannina, Greece, ³⁷Rheumatology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania, ³⁷Rheumatology Unit; IRCCS Policlinico S. Orsola Malpighi, Bologna, Italy
Background/Purpose: Studies have showed that an increased ultrasound (US) muscle echogenicity indicating fatty replacement/fibrosis of muscle tissue may represent an early indicator of muscle involvement associated…
Abstract Number: 1919 • ACR Convergence 2022
Underdiagnosis and Undertreatment of Knee Osteoarthritis in Persons with Type 2 Diabetes: A Cross-sectional Study
Lauren King¹, Esther Waugh¹, Ian Stanaitis², Alanna Weisman¹, Baiju Shah¹, Lorraine Lipscombe¹ and Gillian Hawker¹, ¹University of Toronto, Toronto, ON, Canada, ²Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) and type 2 diabetes commonly co-occur due to shared risk factors. Concomitant knee OA makes type 2 diabetes management, particularly engaging…
Abstract Number: 1290 • ACR Convergence 2022
Inflammation Is More Prominent Than Joint Damage at Initial Visits of Patients with Inflammatory Arthritides, but Organ Damage and Patient Distress Are as Prominent in Overall Rheumatology Care: Data from a Feasible Physician RheuMetric Checklist
Juan Schmukler¹, Tengfei Li², Joel Block¹ and Theodore Pincus¹, ¹Rush University Medical Center, Chicago, IL, ²Georgetown University, Washington, DC
Background/Purpose: Most widely-used rheumatology indices, e.g., DAS28, CDAI, SLEDAI, ASDAS, DAPSA, reflect the mission of rheumatologists to control inflammatory activity (INF) to prevent subsequent organ…
Abstract Number: 1921 • ACR Convergence 2022
Association Between Knee Osteoarthritis and Health-Related Quality of Life in Persons with Type 2 Diabetes
Lauren King¹, Esther Waugh¹, Ian Stanaitis², Alanna Weisman¹, Baiju Shah¹, Lorraine Lipscombe¹ and Gillian Hawker¹, ¹University of Toronto, Toronto, ON, Canada, ²Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) and type 2 diabetes commonly co-occur due to shared risk factors. Both knee OA and type 2 diabetes negatively impact health-related…
Abstract Number: 1388 • ACR Convergence 2022
Updating and Validating the Rheumatic Disease Comorbidity Index to Incorporate ICD-10 Diagnostic Codes
Anthony Dolomisiewicz¹, Hanifah Ali², Punyasha Roul³, Yangyuna Yang¹, Grant Cannon⁴, Joshua Baker⁵, Ted Mikuls⁶, Kaleb Michaud¹ and Bryant England¹, ¹University of Nebraska Medical Center, Omaha, NE, ²UNMC, Omaha, ³UNMC, Omaha, NE, ⁴Salt Lake City VA, Salt Lake city, ⁵University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, ⁶Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: The Rheumatic Disease Comorbidity Index (RDCI) was designed to quantify comorbidity burden for risk stratification of health outcomes in patients with rheumatic disease. Developed…
Abstract Number: 1950 • ACR Convergence 2022
Morbidities Associated with Serious Infections in Patients with Rheumatoid Arthritis
Bradly Kimbrough¹, Cynthia Crowson², Ryan Lennon³, John Davis³ and Elena Myasoedova³, ¹Mayo Clinic Rochester, Rochester, MN, ²Mayo Clinic, Eyota, MN, ³Mayo Clinic, Rochester, MN
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for serious infections. Several infection risk scores have been developed over the last decade for…

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