Abstracts tagged "Cognitive dysfunction"

Abstract Number: 770 • 2018 ACR/ARHP Annual Meeting
Cognitive Function Trajectories Are Associated with the Depressive Symptoms Trajectories in SLE over Time
Zahi Touma¹, Jiandong Su¹ and Patricia Katz², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of California San Francisco, San Francisco, CA
Background/Purpose: We have shown that cognitive function followed particular trajectories over time in SLE, with some patients having persistently low scores and others normal scores.…
Abstract Number: 782 • 2018 ACR/ARHP Annual Meeting
Cognitive Impairment and Health-Related Quality of Life in a Lupus Cohort
Chrisanna Dobrowolski¹, Lisa Engel², Robin Green³, Lesley Ruttan⁴, Sabrina Lombardi⁴, Carmela Tartaglia⁵, Nicole Anderson², Kenneth Colosimo², Michelle Vitti², Dennisse Bonilla², Joan E. Wither⁶, Marvin J. Fritzler⁷, Dorcas Beaton⁸ and Zahi Touma², ¹University of Ottawa, Ottawa, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Brain and Therapeutics, Toronto Rehabilitation Institute, Toronto, ON, Canada, ⁴Toronto Rehabilitation Institute, Toronto, ON, Canada, ⁵University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, ⁶Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁷Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁸Mobility Program Clinical Research Unit, St Michael's Hospital, Toronto, ON, Canada
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are commonly affected by cognitive impairment (CI), with a meta-analysis finding a prevalence of 38%. Despite this high…
Abstract Number: 1623 • 2017 ACR/ARHP Annual Meeting
Prevalence of Cognitive Impairment in Systemic Lupus Erythematosus Assessed By a Comprehensive Neuropsychological Battery
Zahi Touma¹, Robin Green², Carmela Tartaglia³, Lesley Ruttan⁴, Sabrina Lombardi⁴, Nicole Anderson⁵, Jiandong Su⁶, Kenneth Colosimo⁶, Michelle Vitti⁶, Dennisse Bonilla⁶, Joan E. Wither⁵, Marvin J. Fritzler⁷ and Dorcas Beaton⁸, ¹Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, ²Brain and Therapeutics, Toronto Rehabilitation Institute, Toronto, ON, Canada, ³University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, ⁴Toronto Rehabilitation Institute, Toronto, ON, Canada, ⁵Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁷Medicine, University of Calgary, Calgary, AB, Canada, ⁸Mobility Program Clinical Research Unit, St Michael's Hospital, Toronto, ON, Canada
Background/Purpose: Cognitive impairment (CI) is a common neurobehavioural manifestation of SLE. In our recent systematic review, the prevalence of CI was 38% (95% CI: 33-43%)…
Abstract Number: 2824 • 2017 ACR/ARHP Annual Meeting
Sleep and Depression Mediate the Relationship between Pain and Cognitive Dysfunction in Lupus Patients
Teresa A. Lillis¹, Vanessa Tirone¹, Stacy Weinberg², Nisarg Gandhi³, Ailda Nika⁴, Winston Sequeira⁴, Stevan E. Hobfoll¹, Joel A. Block² and Meenakshi Jolly⁴, ¹Behavioral Sciences, Rush University Medical Center, Chicago, IL, ²Division of Rheumatology, Rush University Medical Center, Chicago, IL, ³Rush University Medical Center, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Cognitive Dysfunction (CD) is seen among 20-80% of patients with Systemic Lupus Erythematosus (SLE) and adversely affects their quality of life and productivity. Pain,…
Abstract Number: 563 • 2016 ACR/ARHP Annual Meeting
Factors Associated with Cognitive Impairment in Korean Adults with Rheumatoid Arthritis
So Young Shin¹, Joo Hyun Lee² and Bo Young Yoon³, ¹Department of Nursing, Inje University, College of Medicine, Department of Nursing, Busan, Korea, The Republic of, ²Rheumatology/Internal medicine, Inje University Ilsan Paik Hospital, Goyang, Korea, The Republic of, ³Rheumatology/Internal medicine, Inje Iniversity Ilsan Paik Hospital, Goyang, Korea, The Republic of
Background/Purpose: For persons with chronic diseases such as rheumatoid arthritis (RA), intact cognitive function is crucial for performing main daily activities and adhering to self-management…
Abstract Number: 785 • 2016 ACR/ARHP Annual Meeting
What Is the Prevalence of Cognitive Impairment in Lupus and Which Instruments Are Used to Measure It? a Systematic Review and Meta-Analysis
Hanan Al Rayes¹, Chiara Tani², Marta Mosca², Jorge Medina-Rosas³, Ahmed Moustafa⁴, Panayiotis Lambiris⁵ and Zahi Touma¹, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Clinical and Experimental Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy, ³Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Medicine, Western University, London, ON, Canada, ⁵University Health Network, Toronto, ON, Canada
Background/Purpose: To systematically review literature on: 1) the prevalence of Cognitive Impairment (CI) in SLE patients in the presence or absence of neuropsychiatric involvement (NPSLE),…
Abstract Number: 1396 • 2016 ACR/ARHP Annual Meeting
Cognitive Function in Children with SLE Nephritis: A Cross-Sectional Comparison to Children with Other Glomerular Chronic Kidney Diseases
Andrea Knight^1,2,3, Matthew Matheson⁴, Susan Furth⁵, Brad Warady⁶, Stephen Hooper⁷ and Amy Kogon⁸, ¹Division of Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ³Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁵Division of Nephrology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁶Division of Nephrology, Children's Mercy Hospital, Kansas City, MO, ⁷Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC, ⁸Division of Nephrology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH
Background/Purpose: Children with lupus nephritis (LN) are at risk for cognitive impairment due to effects on the brain from systemic inflammation and from potential effects…
Abstract Number: 2205 • 2016 ACR/ARHP Annual Meeting
Cognitive Functioning in Fibromyalgia: The Central Role of Effort
Jacob Ablin¹, Tamar Bar On –Kalfon², Gilad Gal³ and Ran Shorer², ¹Rheumatology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, ²Rheumatology, Tel Aviv Sourasky medical center, Tel Aviv, Israel, ³School of Behavioral Sciences, Tel Aviv-Jaffa Academic College, Tel Aviv, Israel
Background/Purpose: Fibromyalgia syndrome (FMS) patients demonstrate deficits in tests of attention, executive functioning and verbal memory. We assessed the role of effort in the cognitive…
Abstract Number: 2951 • 2015 ACR/ARHP Annual Meeting
Anti-NR2 Antibody and Blood-Brain Barrier Disruption in Systemic Lupus Erythematosus Patients with Cognitive Dysfunction
Gaurav Gulati¹, Philip Iffland², Damir Janigro², Bin Zhang³ and Michael Luggen⁴, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ³Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁴Division of Immunology, University of Cincinnati Medical Center, Cincinnati, OH
Background/Purpose: Cognitive Dysfunction (CD) is one of the most common manifestations of neuropsychiatric SLE (NPSLE) and one of the most devastating. The pathogenesis of CD…
Abstract Number: 2958 • 2015 ACR/ARHP Annual Meeting
Vitamin D, Cognition and Cerebral Structural Abnormalities in Childhood- Onset Systemic Lupus Erythematosus
Nailu A. Sinicato¹, Mariana Postal², Aline Tamires Lapa², Bruna B Siqueira³, Karina Pelicari², Paula T Fernades³, Roberto Marini Sr.⁴ and Simone Appenzeller⁵, ¹Pediatrics, State University of Campinas, Campinas, Brazil, ²Medicine, State University of Campinas, Campinas, Brazil, ³State University of Campinas, Campinas, Brazil, ⁴Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, ⁵Division of Rheumatology, Faculty of Medical Science, State University of Campinas, São Paulo, Brazil
Background/Purpose: About 16-95% of SLE patients have vitamin D insufficiency. Vitamin D levels, especially vitamin D deficiency, are associated with cognitive performance in adults. We…
Abstract Number: 2959 • 2015 ACR/ARHP Annual Meeting
Patterns of Vascular Brain Injury in Systemic Lupus Erythematosus Patients with Ischemic Stroke: Impact on Neuropsychological, Neurobehavioral and Physical Function Outcome
Jamal A. Mikdashi¹, Marcia Wozniak², Umran Ashraf³ and William Regenold⁴, ¹Div of Rheumatology, Univ of Maryland Schl of Med, Baltimore, MD, ²Neurology, University of Maryland School of Medicine, Baltimore, MD, ³Radiology, University fo Maryland, Baltimore, MD, ⁴Psychiatry, Univeristy of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Ischemic strokes in Systemic lupus erythematosus (SLE) patients contribute to increased morbidity and mortality. Little is known however, about the patterns of ischemic brain…
Abstract Number: 3123 • 2015 ACR/ARHP Annual Meeting
Evidence of Altered Blood Brain Barrier Permeability in Systemic Lupus Erythematosus Using Magnetic Resonance Imaging
Gaurav Gulati¹, Jordan T. Jones², Mekibib Altaye³, Jamie Meyers Eaton⁴, Kasha Wiley², Mark DiFrancesco⁵ and Hermine I. Brunner⁶, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Biostatistics and Epidemiology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁴Division of Pediatric Rheumatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁵Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Neurocognitive dysfunction is a common manifestation of childhood-onset Systemic Lupus Erythematosus (cSLE). Murine models suggest that loss of the blood-brain barrier (BBB) integrity allows…
Abstract Number: 63 • 2015 ACR/ARHP Annual Meeting
Association of Smoking and Cognitive Function in Patients with Fibromyalgia
Lin Ge^1,2, Terry H. Oh³, Ann Vincent⁴, Arya Mohabbat⁵, li Jiang⁶, Mary Whipple⁷, Samantha McAllister⁸, Zhen Wang⁹ and WenChun Qu¹⁰, ¹Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, ²Rheumatology, Guang An Men Hospital, China Academy of Chinese Medical Science,, Beijing, China, ³Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN, ⁴General Internal Medicine, Mayo Clinic, Rochester, MN, ⁵Department of Medicine, Mayo Clinic, Rochester, MN, ⁶Rehabilitation, The Third Affiliated Hospital，Sun Yat-sen University,China, Guangzhou, China, ⁷Fibromyalgia and Chronic Fatigue Clinic, Mayo Clinic, Rochester, MN, ⁸Mayo Clinic, Rochester, MN, ⁹Health Sciences Research, Mayo Clinic, Rochester, MN, ¹⁰Department Physical Medicine and Rehabilitation, Department of Anesthesiology Division of Pain Medicine, Mayo Clinic, Rochester, MN
Background/Purpose: To evaluate the association between smoking and cognitive function in patients with fibromyalgia (FM). Methods: We surveyed 668 patients with FM from May 2012…
Abstract Number: 2045 • 2015 ACR/ARHP Annual Meeting
Cross-Validation of the Pediatric Automated Neuropsychological Assessment Metrics-Cognitive Performance Scores in the Screening of Neurocognitive Impairment in Childhood-Onset Systemic Lupus Erythematosus
Jasmine Nguyen¹, Tricia Williams², Earl Silverman³ and Deborah M. Levy⁴, ¹Royal College of Surgeons in Ireland, Dublin, Ireland, ²Psychology, Hospital for Sick Children, Toronto, ON, Canada, ³Division of Rheumatology, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Neurocognitive impairment (NCI) is an important morbidity in childhood-onset systemic lupus erythematosus (cSLE); however, the gold standard formal neuropsychological assessment is difficult to access. Screening for…
Abstract Number: 2476 • 2015 ACR/ARHP Annual Meeting
Patient-Reported Cognitive Impairment, Pain, and Depressive Symptoms in Patients with Systemic Lupus Erythematosus and Comorbid Depression
Kelly Beck¹, Xing Gao², Yu Cheng³ and Carol M. Greco⁴, ¹School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA, ²Biostatistics, University of Pittsburgh, Pittsburgh, PA, ³Biostatistics and Psychiatry, University of Pittsburgh, Pittsburgh, PA, ⁴University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Patients with systemic lupus erythematosus (SLE) frequently report cognitive impairment as well as depressive symptoms and significant pain. However, depression criteria and SLE symptoms…

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