Abstracts tagged "Cognitive dysfunction"

Abstract Number: 2430 • ACR Convergence 2025
Disease Activity Independently Correlates with Cognitive Impairment in Systemic Lupus Erythematosus
Steven Beiser¹, Asma Qureshi¹, Komel Safdar², Zachary Orban¹, Mary Carns², Vanessa Manada De Lobos¹, Cecilia Stumpf³, Mohammad Daud Khan¹, Tyler Therron⁴, Anh Chung¹, Katherine Puev¹, Neil Pillai¹, Kathleen Aren⁵, John F Seagrist², Jing Song⁶, Jason Ross¹, Harris R Perlman², Yvonne Lee², Deborah Rachelle Winter⁷, Borna Bonakdarpour¹, Mariam Siddiqui⁸, Laura Arneson², Rosalind Ramsey-Goldman⁹, Lutfiyya muhammad⁹, Mary Mahieu⁹, Irene Blanco¹⁰, Eric Larson¹, Elena Grebenciucova¹ and Carla Marie Cuda², ¹Northwestern University, Chicago, ²Northwestern University, Chicago, IL, ³Northwestern University, Elmhurst, IL, ⁴Northwestern Feinberg School of Medicine, Chicago, IL, ⁵Northwestern University Division of Rheumatology, Chicago, IL, ⁶Northwestern University Feinberg School of Medicine, Worthington, MN, ⁷Northwestern University, Skokie, IL, ⁸Northwestern, Chicago, IL, ⁹Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁰Northwestern University, Oak Park, IL
Background/Purpose: Mechanisms driving cognitive impairment (CI) in systemic lupus erythematosus (SLE) remain poorly understood; conflicting results exist regarding the relationship between CI and disease activity.…
Abstract Number: 2002 • ACR Convergence 2025
Methods to Address Survival Bias and Competing Risks in Estimating the Causal Risks of Gout on Dementia Risk
Joshua Baker¹, Harlan Sayles², Chung-Chou Chang³, Brian Coburn⁴, Bryant England² and Ted Mikuls², ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³University of Pittsburgh, Pittsburgh, PA, ⁴Hospital of the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Informative censoring in epidemiologic research studies (the loss of data from the risk set that is related to the exposure and/or outcome) can cause…
Abstract Number: 1742 • ACR Convergence 2025
S100B in Childhood-onset Systemic Lupus Erythematosus: Associations with Disease Features, Interferon Levels, and Cognitive Functioning
Ganesh Ramanathan¹, Justine Ledochowski², Oscar Mwizerwa³, Tala El Tal⁴, Lawrence Ng⁵, Asha Jeyanathan⁶, Adrienne Davis⁶, Ann Yeh⁶, Linda Hiraki², Deborah Levy², Zahi Touma⁷, Joan Wither⁸, Busisiwe Zapparoli⁹, Ashley Danguecan¹⁰ and Andrea Knight¹⁰, ¹The Hospital for Sick Children, Brampton, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada, ³University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada, ⁵The Hospital for Sick Children, Toronto, Canada, Toronto, ON, Canada, ⁶The Hospital for Sick Children, Toronto, Canada, ⁷University of Toronto, Toronto, ON, Canada, ⁸University Health Network, Toronto, ON, Canada, ⁹The Hospital for Sick Children, Etobicoke, ON, Canada, ¹⁰Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Cognitive impairment is common in childhood-onset systemic lupus erythematosus (cSLE), particularly in domains like executive function and attention. However, attributing cognitive difficulties to brain…
Abstract Number: 1482 • ACR Convergence 2025
Evaluation of T Cell Subpopulations, CD4/CD8 Ratio and p16INK4a in Patients with Systemic Lupus Erythematosus and Cognitive Impairment
Erik Cimé-Aké¹, Guadalupe Lima¹, Emilio Godinez-Lazarini¹, Sandra Juárez¹, Hilda Marín-López¹, Amairani Gómez-Rodríguez¹, Daniela Flores-Hernández¹, Ileana Flores-Hernández¹, Diego F. Hernández-Ramírez¹, Luis Llorente¹ and Hilda Fragoso-Loyo², ¹Instituto Nacional de Ciencias Médicas y Nutrición. Salvador Zubirán. Immunology and Rheumatology Department, Mexico City, Mexico, ²Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico City, Mexico
Background/Purpose: Cognitive impairment (CI) in systemic lupus erythematosus (SLE) may be associated with different T cell subpopulations distribution and chronic pro-inflammatory state in which immunosenescence…
Abstract Number: 1478 • ACR Convergence 2025
Construction and Validation of a Prediction Model of Cognitive Dysfunction in Patients with Systemic Lupus Erythematosus
Bin Zhou¹, QIn Huang², Pan Wang³ and Qiguo Cui⁴, ¹Nanfang Hospital, Guangzhou, Guangdong, China (People's Republic), ²Nanfang Hospital, Guangzhou, China (People's Republic), ³southern medical university Nanfang Hospital, Guangzhou, China (People's Republic), ⁴Southern Medical Univercity Nanfang Hospital, guang zhou, China (People's Republic)
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Cognitive dysfunction (CD) is a common but often underestimated complication in…
Abstract Number: 1421 • ACR Convergence 2025
Impact of Psoriatic Arthritis Disease Activity and Fatigue on Subjective Cognitive Decline (“Brainfog”)
Lily Mikolajczak¹, Helena Kuhn¹, Leslie Harrold² and George Reed³, ¹Kuchnir Dermatology and Dermatologic Surgery, Milford, MA, ²CorEvitas, Northborough, MA, ³University of Massachusetts Chan Medical School, Worcester, MA
Background/Purpose: Patients with psoriatic arthritis often report having brain fog, describing symptoms such as forgetfulness, difficulty thinking and memory issues. It has been hypothesized that…
Abstract Number: 0947 • ACR Convergence 2025
Mechanisms of anti-NMDAR antibody-mediated neuronal pathology and mitigation by angiotensin II signaling inhibition
Kaitlin Carroll¹, Mark Mizrachi¹, Sean Simmons², Bahtiyar Toz¹, Czeslawa Kowal³, Nazila Tehrani¹, Aida Zarfeshani¹, Nina Kello¹, Lara El Khoury⁴, Jeffrey Wingard¹, Rachel Weissman-Tsukamoto³, Joshua Levin², Bruce Volpe³ and Betty Diamond⁵, ¹Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, ²Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, ³Feinstein Institute of Molecular Medicine, Manhasset, NY, ⁴Zucker School of Medicine at Hofstra/Northwell Health, Great Neck, NY, ⁵The Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus erythematosus, present in up to 80% of patients and leading to a diminished quality…
Abstract Number: 0616 • ACR Convergence 2025
Neurofilament Light Chain Serum Levels is Associated with Neuropsychiatric Manifestations and Cognitive Dysfunction in Systemic Lupus Erythematosus Patients: A Longitudinal Study
Juliana Silvatti¹, Livia Almeida Dutra², Larissa Araujo Duarte³, Andreza Salvio Lemos³, Helena Alessi⁴, Shaila Amorim Vieira², Gabriel D'Angelo Lacerda², LILIA ALVES MARIA ALVES MARIA⁴, Soniza Leon Alves³ and Cristiane Kayser⁴, ¹Universidade Federal de São Paulo, SAO PAULO, Sao Paulo, Brazil, ²Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Sao Paulo, Brazil, ³Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil, ⁴Universidade Federal de São Paulo, São Paulo, Sao Paulo, Brazil
Background/Purpose: Neuropsychiatric manifestations of systemic lupus erythematosus (SLE) are common and frequently represent a diagnostic challenge due to its heterogeneous manifestations. Neurofilament light chain (NfL)…
Abstract Number: 0226 • ACR Convergence 2025
Integration of the 5Ms of Geriatrics in a Novel Geri-Rheumatology Clinic
Justin Levinson¹ and Christie Bartels², ¹University of Wisconsin- Madison, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI
Background/Purpose: Geriatric integrative care models, such as the Perioperative Optimization of Senior Health (POSH) initiative, have shown improved outcomes (PMID: 29299599), yet there remains limited…
Abstract Number: 0184 • ACR Convergence 2025
Neurocognitive Complications of Lupus: A Multidisciplinary Program Model for Advanced Diagnostics, Management, and Clinical Research
Douglas Wilcox¹, Matthew Baum², Sophie Lebiedz², John Sullivan², Margaret Naclerio², Jonathan Zurawski², Bonnie Glanz², Rohit Bakshi², Tanuja Chitnis², Shamik Bhattacharyya³ and Karen H. Costenbader⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital, Malden, MA, ⁴Harvard Medical School and Brigham and Women's Hospital, Boston, MA
Background/Purpose: Neurological symptoms in lupus are common and occur in the majority of patients with SLE. Although neuropsychiatric lupus (NPSLE) can involve the entire nervous…
Abstract Number: 1506 • ACR Convergence 2024
Cognitive Impairment Prevalence and Most Affected Domains in Patients with SLE by the ACR Comprehensive Neuropsychological Battery
Chrisanna Dobrowolski¹, Juan Pablo Diaz Martinez², Kathleen Bingham², Michelle Barraclough³, Roberta Kretzmann², Maria Carmela Tartaglia⁴, Lesley Ruttan⁵, May Choi⁶, Simone Appenzeller⁷, Sherief Marzouk², Dennisse Bonilla², Patti Katz⁸, Dorcas Beaton⁹, Robin Green², Joan Wither², Laura Patricia Whittall Garcia², Dafna Gladman¹⁰ and Zahi Touma¹¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY, ²University Health Network, Toronto, ON, Canada, ³The University of Manchester, Manchester, United Kingdom, ⁴University Health Network, University of Toronto, Toronto, ON, Canada, ⁵Toronto Rehab/University Health Network - University Centre, Toronto, Canada, ⁶University of Calgary, Calgary, AB, Canada, ⁷Unicamp, Campinas, SP, Brazil, ⁸UCSF, San Rafael, CA, ⁹Institute for Work & Health, Toronto, ON, Canada, ¹⁰University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ¹¹University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic lupus (SLE) has a well-established association with cognitive impairment (CI) and confers worse quality of life. We previously presented descriptive data regarding the…
Abstract Number: 1513 • ACR Convergence 2024
Assessing Subjective Cognitive Impairment in a Cohort of Canadian Systemic Lupus Erythematosus Patients: Construct Validity of PDQ-20
Omar Marzouk¹, J. Antonio Avina-Zubieta², Mary Fox³, William Shaw⁴, Maggie Ho⁵, Qixuan Li⁵, Catherine Ivory⁶, Paul Fortin⁷, Kathleen Bingham⁵, Stephanie Keeling⁸, Jennifer Reynolds⁹, Derek Haaland¹⁰, Janet Pope¹¹, Lily Lim¹², Patti Katz¹³, Murray Urowitz¹⁴, Laura Patricia Whittall Garcia⁵, Dafna Gladman¹⁵, Behdin Nowrouzi-Kia¹⁶ and Zahi Touma¹⁶, ¹Toronto Western Hospital, Toronto, ²Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada, ³York University, Toronto, ON, Canada, ⁴University of Connecticut, School of Medicine, Farmington, CT, ⁵University Health Network, Toronto, ON, Canada, ⁶The Ottawa Hospital, Ottawa, ON, Canada, ⁷Centre ARThrite - CHU de Québec - Université Laval, Quebec, QC, Canada, ⁸University of Alberta, Edmonton, AB, Canada, ⁹UBC, North Vancouver, BC, Canada, ¹⁰The Waterside Clinic, Oro Medonte, ON, Canada, ¹¹University of Western Ontario, London, ON, Canada, ¹²University of Manitoba, Winnipeg, MB, Canada, ¹³UCSF, San Rafael, CA, ¹⁴Self employed, Toronto, ON, Canada, ¹⁵University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ¹⁶University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) has many symptoms, including cognitive impairment (CI), which negatively impacts social role participation and quality of life. CI is highly…
Abstract Number: 1514 • ACR Convergence 2024
Immunosenescent and Exhausted T Cells in Patients with Systemic Lupus Erythematosus and Cognitive Impairment
Erik Cimé-Aké¹, Guadalupe Lima², Emilio G. Lazarini¹, Sandra Juárez³, Luis Llorente² and Hilda Fragoso-Loyo¹, ¹Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department, Mexico City, Mexico, ²Instituto Nacional de Ciencias Médicas y Nutrición. Salvador Zubirán. Immunology and Rheumatology Department, Mexico City, Mexico, ³Instituto Nacional de Ciencias Médicas y Nutrición. Salvador Zubirán. Neurology and Psychiatry Department, Mexico City, Mexico
Background/Purpose: Cognitive impairment (CI) in systemic lupus erythematosus (SLE) may result from a chronic pro-inflammatory state in which immunosenescent and exhausted T-lymphocytes could be involved.…
Abstract Number: 1794 • ACR Convergence 2024
Biobehavioral Basis and Outcomes of Cognitive Dysfunction in Childhood Systemic Lupus Erythematosus
Hanne van der Heijden¹, Andrea Knight², Itamar Ronen³, Gabrielle Alonzi⁴, Kyle McBrearty⁴, Aditi Deokar⁴, Joseph Gonzalez-Heydrich⁴, Joyce Chang⁴ and Jaymin Upadhyay⁵, ¹Boston Children's Hospital Harvard Medical School, Boston, MA, ²Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ³Brighton and Sussex Medical School, University of Sussex, Brighton, UK, Brighton, United Kingdom, ⁴Boston Children's Hospital, Boston, MA, ⁵Boston Children's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Cognitive dysfunction (CD) in childhood-onset SLE (cSLE) is undertreated yet profoundly impacts lifelong health-related quality of life. Investigating CD in cSLE is crucial, given…
Abstract Number: 2625 • ACR Convergence 2024
Brain Injury Markers Correlate with Impaired Executive Function and Disease Activity in Children with Systemic Lupus Erythematosus
Oscar Mwizerwa¹, Justine Ledochowski², Tala El Tal³, Ganesh Ramanathan², Sarah Mossad⁴, Ibrahim Mohamed⁵, Joanna Law⁶, Lawrence Ng², Paris Moaf², Asha Jeyanathan¹, Adrienne Davis⁷, Ann Yeh², Linda Hiraki², Deborah Levy², Zahi Touma⁸, Joan Wither⁹, Busi Zapparoli¹⁰, Ashley Danguecan¹¹ and Andrea Knight¹², ¹The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada, ³The Hospital For Sick Children & Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁴Hospital for Sick Children, Toronto, ON, Canada, ⁵The Hospital for Sick Children, Brampton, ON, Canada, ⁶The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁷Division of Pediatric Emergency Medicine, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁸University of Toronto, Toronto, ON, Canada, ⁹University Health Network, Toronto, ON, Canada, ¹⁰The Hospital for Sick Children, Etobicoke, ON, Canada, ¹¹The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, ¹²Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Background/Purpose: Patients with childhood-onset systemic lupus erythematosus (cSLE) commonly experience impaired executive function (EF), and attribution to neuropsychiatric lupus (NPSLE) is challenging. Serum markers of…

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