ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Clinical"

  • Abstract Number: 2805 • 2017 ACR/ARHP Annual Meeting

    Juvenile-Onset Ankylosing Spondylitis Has a Lower Rate of Radiographic Progression Than Adult-Onset Ankylosing Spondylitis

    Anthony So1, Ammepa Anton2, Florence Tsui3, Ismail Sari4, Renise Ayearst5, Robert D Inman6 and Nigil Haroon4, 1University of British Columbia, Vancouver, BC, Canada, 2University Health Network, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada, 4Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, 5Medicine, University Health Network, Toronto, ON, Canada, 6Department of Immunology, University of Toronto, Toronto, ON, Canada

    Background/Purpose: There are no large radiographic follow up studies assessing progression in juvenile-onset Ankylosing Spondylitis (JoAS) as compared to adult-onset Ankylosing Spondylitis (AoAS). The purpose…
  • Abstract Number: 247 • 2017 ACR/ARHP Annual Meeting

    Near Infrared Indocyanine Green Imaging Reveals Diminished Flow in Basilic Associated Lymphatic Vessels in the Hands of Rheumatoid Arthritis Patients during Flare

    Richard Bell1, Alicia Lieberman2, Ronald Wood3, Cristy Bell4, Homaira Rahimi5, Edward Schwarz6 and Christopher T. Ritchlin7, 1Orthopedics, University of Rochaester, Rochester, NY, 2Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 3University of Rochester, Rochester, NY, 4Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY, 5Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, 6Orthopedeatrics, University of Rochester, Rochester, NY, 7Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY

    Background/Purpose: Near infrared (NIR) imaging studies of subdermal indocyanine green (ICG) in murine models of inflammatory arthritis established the important contribution of lymphatic vessel (LV)…
  • Abstract Number: 306 • 2017 ACR/ARHP Annual Meeting

    Relationship between Inflammatory Anterior or Posterior Arch MRI Abnormalities and Clinical Data in Low Back Pain Patients

    Helene Braun1, Clement Geniez1, Yannick Degboe2, Arnaud Constantin3, Alain Cantagrel4, Delphine Nigon5, Marie Faruch-Bilfeld1 and Adeline Ruyssen-Witrand4, 1Purpan Hospital, Toulouse, France, 2Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France, 3Purpan Hospital, toulouse, France, 4Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, 5CHU Purpan, Toulouse, France

    Background/Purpose: To compare demographic characteristics, characteristics of pain and functional status according to the presence of inflammatory anterior or posterior arch MRI abnormalities in low…
  • Abstract Number: 159 • 2016 ACR/ARHP Annual Meeting

    Assessing Agreement Among Measures of Inflammation Detected on Magnetic Resonance Imaging, Ultrasound and Clinical Findings in the Feet of Patients with Early Rheumatoid Arthritis

    Karen A. Beattie1, George Ioannidis2, Sydney Scheffler3, Saara Totterman4, Edward Schreyer5 and Maggie Larche1, 1Medicine, McMaster University, Hamilton, ON, Canada, 2St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 3McMaster University, Hamilton, ON, Canada, 4Radiology, VirtualScopics Inc., Rochester, NY, 5QMetrics Technologies, Rochester, NY

    Background/Purpose: In metatarsalphalangeal (MTP) joints 2-5 of patients with early rheumatoid arthritis (RA), we aimed to assess the agreement between i) Magnetic Resonance Imaging (MRI)…
  • Abstract Number: 517 • 2016 ACR/ARHP Annual Meeting

    Association of Rheumatoid Arthritis Disease Activity and Clinical Profile with Chronic Periodontitis

    BEATRIZ RODRIGUEZ-LOZANO1, Jorge Luis Garnier Rodríguez2, Jerián González Febles3, Shashi Dadlani4, Ivan Ferraz-Amaro1, Esmeralda Delgado Frías1, Federico Díaz-González1 and Mariano Sanz Alonso3, 1Rheumatology, Hospital Universitario de Canarias, S/C Tenerife, Spain, 2Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, 3Periodontology, Universidad Complutense de Madrid, Madrid, Spain, 4Periodontology, Dental Clinic Garnier, S/C Tenerife, Spain

    Background/Purpose: Recent clinical data show a clear association between periodontitis (P) and RA. However, there is controversy over whether severity of P is associated with…
  • Abstract Number: 687 • 2016 ACR/ARHP Annual Meeting

    Safety and Efficacy of Certolizumab Pegol over 204 Weeks in Patients with Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis

    Atul A. Deodhar1, Maxime Dougados2, Robert Landewé3, Joachim Sieper4, Walter Maksymowych5, Martin Rudwaleit6, Filip van Den Bosch7, Jürgen Braun8, Philip J Mease9, Alan Kivitz10, Jessica Walsh11, Owen Davies12, Bengt Hoepken13, Luke Peterson14 and Désirée van der Heijde15, 1Divison of Arthritis and Rheumatic Diseases, Oregon Health and Science University, Portland, OR, 2Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, 3Academic Medical Center, Amsterdam and Zuyderland Medical Center, Heerlen, Netherlands, 4Rheumatology Department, Charité – University Medicine Berlin, Berlin, Germany, 5Department of Medicine, University of Alberta, Edmonton, AB, Canada, 6Klinikum Bielefeld and Charité – University Medicine Berlin, Berlin, Germany, 7University Hospital Ghent, Ghent, Belgium, 8Rheumazentrum Ruhrgebiet, Herne, Germany, 9Swedish Medical Center and University of Washington, Seattle, WA, 10Altoona Center for Clinical Research, Duncansville, PA, 11Division of Rheumatology, University of Utah School of Medicine, Salt Lake City, UT, 12UCB Pharma, Slough, United Kingdom, 13UCB Pharma, Monheim, Germany, 14UCB Pharma, Raleigh, NC, 15Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: RAPID-axSpA (NCT01087762) investigated the efficacy and safety of certolizumab pegol (CZP) in patients (pts) with axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic…
  • Abstract Number: 1357 • 2016 ACR/ARHP Annual Meeting

    Clinical Description of Patients with Cytoplasmic Discrete Speckles on Indirect Immunofluorescence on HEp-2 Cells in a Universitary Hospital

    Martin Brom1, Carolina Eva Carrizo2, Roberto Arana3 and Cecilia N. Pisoni3, 1Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2CEMIC, Buenos Aires, Argentina, 3Rheumatology and Immunology, CEMIC, Buenos Aires, Argentina

    Background/Purpose: Indirect Immunofluorescence (IIF) shows different nuclear and cytoplasmic fluorescence patterns depending on the antibodies present in the cell. Cytoplasmic patterns are an unusual finding.…
  • Abstract Number: 1805 • 2016 ACR/ARHP Annual Meeting

    Factors Associated with Complete Remission in Patients with Systemic Lupus Erythematosus: A Retrospective Cohort Study in One Center

    Jorge Romo-Tena1, Diana Gómez-Martín1, Roberto Reyna2, Isaac Bartnicki-Navarrete3 and Jorge Alcocer-Varela1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose:  Systemic lupus erythematosus (SLE) is characterized by disease flares, alternated with periods of clinical remission. In the past years, the “treat-to-target” strategy in SLE…
  • Abstract Number: 2665 • 2016 ACR/ARHP Annual Meeting

    Epratuzumab Treatment of Patients with Systemic Lupus Erythematosus and Secondary Sjogren’s Syndrome: An Exploratory Analysis of Phase 3 Studies

    Jacques-Eric Gottenberg1, Thomas Dörner2, Hendrika Bootsma3, Valerie Devauchelle-Pensec4, Simon Bowman5, Gordana Kosutic6, Holger Bartz7, Marga Oortgiesen6, Anthony Shock8, Willem Koetse6, Catrinel Galateanu9, Sabine Bongardt7, Xavier Mariette10 and Caroline Gordon11,12, 1Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2Department of Medicine/Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, 3Department of Rheumatology and Clinical Immunology, University of Groningen, Groningen, Netherlands, 4Department of Rheumatology and Unit of Immunology, Brest University Medical School, Brest, France, 5Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 6UCB Pharma, Raleigh, NC, 7UCB Pharma, Monheim, Germany, 8UCB Pharma, Slough, United Kingdom, 9UCB Pharma, Brussels, Belgium, 10INSERM U1184, Université Paris-Sud, Paris, France, Le Kremlin Bicetre, France, 11NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 12Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: The EMBODY 1 (SL0009; NCT01262365) and EMBODY 2 (SL0010; NCT01261793) phase 3 studies investigated the efficacy and safety of epratuzumab (Emab; Immunomedics Inc), a…
  • Abstract Number: 2801 • 2016 ACR/ARHP Annual Meeting

    Predictors of Incident Episodes of Proteinuria Among Patients with Systemic Lupus Erythematosus

    Laurence S Magder1, Ali Duarte-Garcia2, Erik Barr3 and Michelle Petri4, 1Epidemiology and Public Health, Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD, 2Medicine, Tufts Medical Center, Boston, MA, 3Epidemiology, University of Maryland, Baltimore, MD, 4Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Lupus nephritis remains one of the most devastating SLE complications, occurring in over 50% of the patients.  It is important to identify clinical conditions…
  • Abstract Number: 2902 • 2016 ACR/ARHP Annual Meeting

    Preliminary Evaluation of Gastroesophageal Reflex Disease Outcome Measures in Scleroderma– Scleroderma Clinical Trials Consortium Gastrointestinal Working Group

    Zsuzsanna McMahan1, Tracy M. Frech2, Guya Piemonte3, Marco Matucci-Cerinic4, Susanna Proudman5,6, Veronica J. Berrocal7, Ron Hays8 and Dinesh Khanna9, 1Department of Internal Medicine, Johns Hopkins University, Baltimore, MD, 2Division of Rheumatology, University of Utah, Salt Lake City, UT, 3University of Florence, Florence, Italy, 4Department of Medicine, Division of Rheumatology, University of Florence, Florence, Italy, 5Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 6Discipline of Medicine, University of Adelaide, Adelaide, Australia, 7Div of Rheumatology, University of Michigan, Ann Arbor, MI, 8UCLA, Los Angeles, CA, 9University of Michigan, Ann Arbor, MI

    Background/Purpose: Gastrointestinal tract (GIT) involvement occurs in approximately 95% of patients with systemic sclerosis (SSc). There is consensus in the Scleroderma Clinical Trials Consortium (SCTC)…
  • Abstract Number: 943 • 2015 ACR/ARHP Annual Meeting

    Development of an Internationally Agreed Minimal Dataset for Juvenile Dermatomyositis (JDM) for Clinical and Research Use

    Liza J. McCann1, Lucy R Wedderburn2, Clarissa Pilkington3, Adam M. Huber4, Angelo Ravelli5, Jamie Kirkham6, Paula Williamson6 and Michael W. Beresford7, 1Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, 2Infection, Inflammation and Rheumatology Section, UCL Institute for Child Health, London, United Kingdom, 3Department of Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, 4Pediatric rheumatology, IWK Health Centre, Halifax, NS, Canada, 5Pediatria-II, IRCCS G. Gaslini and University of Genova, Genova, Italy, 6Department of Biostatistics, University of Liverpool, MRC North West Hub for Trials Methodology Research, Liverpool, United Kingdom, 7Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Juvenile dermatomyositis (JDM) is a rare disease. International collaboration is essential for scrutiny of sufficient patient numbers. We aim to develop a core set…
  • Abstract Number: 950 • 2015 ACR/ARHP Annual Meeting

    In a Two-Year Double-Blind Randomized Controlled Multicenter Study, Chondroitin Sulfate Was Significantly Superior to Celecoxib at Reducing Cartilage Loss with Similar Efficacy at Reducing Disease Symptoms in Knee Osteoarthritis Patients

    Jean-Pierre Pelletier1, Jean Pierre Raynauld2, André Beaulieu3, Louis Bessette4, Frédéric Morin5, Artur J Fernandes6, François Abram7, Marc Dorais8 and Johanne Martel-Pelletier9, 1Rheumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Osteoarthritis Research Unit, CRCHUM, Montreal, Montreal, QC, Canada, 3Centre de rhumatologie St-Louis, St. Louis, QC, Canada, 4Groupe de Recherche en Rhumatologie et Maladies Osseuses, Quebec, Quebec, QC, Canada, 5Centre de Recherche Musculo-squelettique, Trois-Rivières, Trois-Rivières, QC, Canada, 6Centre de Recherche Musculo-squelettique, Trois-Rivières, 6Rheumatology Division, Sherbrooke, Sherbrooke, QC, Canada, 7Medical Imaging Research & Development, ArthroLab Inc, Montreal, QC, Canada, 8StatSciences Inc., Montreal, Canada, Montreal, QC, Canada, 9Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM),, Montreal, QC, Canada

    Background/Purpose: In osteoarthritis (OA) treatment, although chondroitin sulfate (CS) was found in a number of studies using radiography to have a structure modifying effect, to…
  • Abstract Number: 1642 • 2015 ACR/ARHP Annual Meeting

    A Systematic Review and Network Meta-Analysis on the Efficacy of Tumor Necrosis Factor Inhibitor-Methotrexate Combination Therapy Versus Triple Therapy in Methotrexate Inadequate Responders with Rheumatoid Arthritis

    Roy Fleischmann1, Janet E. Pope2, Vanita Tongbram3, Derek Tang4, James Chung5, David Collier5, Shilpa Urs3, Kerigo Ndirangu3, George A. Wells6 and Ronald F. van Vollenhoven7, 1Rheumatology, Metroplex Clinical Research Center, Dallas, TX, 2University of Western Ontario, London, ON, Canada, 3ICON Plc., Morristown, NJ, 4Amgen, Inc., Thousand Oaks, CA, 5Amgen Inc., Thousand Oaks, CA, 6Cardiovascular Research Reference Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada, 7Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Previously published rheumatoid arthritis (RA) trials in which TNFi-MTX and triple therapy (MTX + hydroxychloroquine + sulfasalazine) were included as treatment arms in MTX…
  • Abstract Number: 1654 • 2015 ACR/ARHP Annual Meeting

    A Systematic Review and Network Meta-Analysis on the Efficacy of Tumor Necrosis Factor Inhibitor-Methotrexate Combination Therapy Versus Triple Therapy in Methotrexate-Naïve Patients with Rheumatoid Arthritis

    Roy Fleischmann1, Janet E. Pope2, Vanita Tongbram3, Derek Tang4, James Chung5, David Collier5, Shilpa Urs3, Kerigo Ndirangu3, George A. Wells6 and Ronald F. van Vollenhoven7, 1University of Texas Southwestern Medical Center, Dallas, TX, 2University of Western Ontario, London, ON, Canada, 3ICON Plc., Morristown, NJ, 4Amgen, Inc., Thousand Oaks, CA, 5Amgen Inc., Thousand Oaks, CA, 6Cardiovascular Research Reference Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada, 7Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Several published randomized head-to-head trials in rheumatoid arthritis (RA) have compared TNFi-MTX with triple therapy (MTX + hydroxychloroquine + sulfasalazine) in MTX-naive patients (MTX-Ns)…
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