Abstracts tagged "Clinical"

Abstract Number: 1274 • 2017 ACR/ARHP Annual Meeting
Anti-MDA5 Autoantibodies Associated with Juvenile Dermatomyositis Constitute a Distinct Phenotype in North America
Gulnara Mamyrova¹, Takayuki Kishi², Ira N Targoff³, Rodolfo V Curiel⁴, Frederick W Miller² and Lisa G Rider², ¹Rheumatology, George Washington University School of Medicine and Health Sciences, Washington, DC, ²Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ³VA Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴George Washington University School of Medicine and Health Sciences, Washington, DC
Background/Purpose: Anti-MDA5 autoantibodies (Abs) have been associated with clinically amyopathic and classic dermatomyositis (DM), with rapidly progressive interstitial lung disease (ILD) and poor prognosis in…
Abstract Number: 2633 • 2017 ACR/ARHP Annual Meeting
Patients with Secondary Sjögren’s Syndrome to SLE Are Characterized By Typical Autoantibodies and a Pro-Inflammatory State
Marika Kvarnstrom¹, Guillermo Ruacho², Johanna Gustafsson³, Agneta Zickert⁴, Vilija Oke⁵, Johan Rönnelid⁶, Kerstin Elvin⁷, Iva Gunnarsson⁸ and Elisabet Svenungsson⁸, ¹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Department of Medicine, Unit of Rheumatology,, Stockholm, Sweden, ³Dep. of Medicine, Karolinska Institutet, Karolinska University Hospital, Unit of rheumatology,, Stockholm, Sweden, ⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁵Department of Medicine, Rheumatology Unit, Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁶Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁷Department of Clinical Immunology and Transfusion Medicine,, 4Unit of Clinical Immunology, Stockholm, Sweden, ⁸Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose :Sjögren´s syndrome occurs in isolation (primary Sjögren´s syndrome, pSS), but it is also often secondary (sSS) to, and sometimes difficult to delineate from, other…
Abstract Number: 2805 • 2017 ACR/ARHP Annual Meeting
Juvenile-Onset Ankylosing Spondylitis Has a Lower Rate of Radiographic Progression Than Adult-Onset Ankylosing Spondylitis
Anthony So¹, Ammepa Anton², Florence Tsui³, Ismail Sari⁴, Renise Ayearst⁵, Robert D Inman⁶ and Nigil Haroon⁴, ¹University of British Columbia, Vancouver, BC, Canada, ²University Health Network, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ⁵Medicine, University Health Network, Toronto, ON, Canada, ⁶Department of Immunology, University of Toronto, Toronto, ON, Canada
Background/Purpose: There are no large radiographic follow up studies assessing progression in juvenile-onset Ankylosing Spondylitis (JoAS) as compared to adult-onset Ankylosing Spondylitis (AoAS). The purpose…
Abstract Number: 2801 • 2016 ACR/ARHP Annual Meeting
Predictors of Incident Episodes of Proteinuria Among Patients with Systemic Lupus Erythematosus
Laurence S Magder¹, Ali Duarte-Garcia², Erik Barr³ and Michelle Petri⁴, ¹Epidemiology and Public Health, Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD, ²Medicine, Tufts Medical Center, Boston, MA, ³Epidemiology, University of Maryland, Baltimore, MD, ⁴Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Lupus nephritis remains one of the most devastating SLE complications, occurring in over 50% of the patients. It is important to identify clinical conditions…
Abstract Number: 2902 • 2016 ACR/ARHP Annual Meeting
Preliminary Evaluation of Gastroesophageal Reflex Disease Outcome Measures in Scleroderma– Scleroderma Clinical Trials Consortium Gastrointestinal Working Group
Zsuzsanna McMahan¹, Tracy M. Frech², Guya Piemonte³, Marco Matucci-Cerinic⁴, Susanna Proudman^5,6, Veronica J. Berrocal⁷, Ron Hays⁸ and Dinesh Khanna⁹, ¹Department of Internal Medicine, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, University of Utah, Salt Lake City, UT, ³University of Florence, Florence, Italy, ⁴Department of Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ⁵Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ⁶Discipline of Medicine, University of Adelaide, Adelaide, Australia, ⁷Div of Rheumatology, University of Michigan, Ann Arbor, MI, ⁸UCLA, Los Angeles, CA, ⁹University of Michigan, Ann Arbor, MI
Background/Purpose: Gastrointestinal tract (GIT) involvement occurs in approximately 95% of patients with systemic sclerosis (SSc). There is consensus in the Scleroderma Clinical Trials Consortium (SCTC)…
Abstract Number: 159 • 2016 ACR/ARHP Annual Meeting
Assessing Agreement Among Measures of Inflammation Detected on Magnetic Resonance Imaging, Ultrasound and Clinical Findings in the Feet of Patients with Early Rheumatoid Arthritis
Karen A. Beattie¹, George Ioannidis², Sydney Scheffler³, Saara Totterman⁴, Edward Schreyer⁵ and Maggie Larche¹, ¹Medicine, McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Radiology, VirtualScopics Inc., Rochester, NY, ⁵QMetrics Technologies, Rochester, NY
Background/Purpose: In metatarsalphalangeal (MTP) joints 2-5 of patients with early rheumatoid arthritis (RA), we aimed to assess the agreement between i) Magnetic Resonance Imaging (MRI)…
Abstract Number: 517 • 2016 ACR/ARHP Annual Meeting
Association of Rheumatoid Arthritis Disease Activity and Clinical Profile with Chronic Periodontitis
BEATRIZ RODRIGUEZ-LOZANO¹, Jorge Luis Garnier Rodríguez², Jerián González Febles³, Shashi Dadlani⁴, Ivan Ferraz-Amaro¹, Esmeralda Delgado Frías¹, Federico Díaz-González¹ and Mariano Sanz Alonso³, ¹Rheumatology, Hospital Universitario de Canarias, S/C Tenerife, Spain, ²Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, ³Periodontology, Universidad Complutense de Madrid, Madrid, Spain, ⁴Periodontology, Dental Clinic Garnier, S/C Tenerife, Spain
Background/Purpose: Recent clinical data show a clear association between periodontitis (P) and RA. However, there is controversy over whether severity of P is associated with…
Abstract Number: 687 • 2016 ACR/ARHP Annual Meeting
Safety and Efficacy of Certolizumab Pegol over 204 Weeks in Patients with Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis
Atul A. Deodhar¹, Maxime Dougados², Robert Landewé³, Joachim Sieper⁴, Walter Maksymowych⁵, Martin Rudwaleit⁶, Filip van Den Bosch⁷, Jürgen Braun⁸, Philip J Mease⁹, Alan Kivitz¹⁰, Jessica Walsh¹¹, Owen Davies¹², Bengt Hoepken¹³, Luke Peterson¹⁴ and Désirée van der Heijde¹⁵, ¹Divison of Arthritis and Rheumatic Diseases, Oregon Health and Science University, Portland, OR, ²Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, ³Academic Medical Center, Amsterdam and Zuyderland Medical Center, Heerlen, Netherlands, ⁴Rheumatology Department, Charité – University Medicine Berlin, Berlin, Germany, ⁵Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁶Klinikum Bielefeld and Charité – University Medicine Berlin, Berlin, Germany, ⁷University Hospital Ghent, Ghent, Belgium, ⁸Rheumazentrum Ruhrgebiet, Herne, Germany, ⁹Swedish Medical Center and University of Washington, Seattle, WA, ¹⁰Altoona Center for Clinical Research, Duncansville, PA, ¹¹Division of Rheumatology, University of Utah School of Medicine, Salt Lake City, UT, ¹²UCB Pharma, Slough, United Kingdom, ¹³UCB Pharma, Monheim, Germany, ¹⁴UCB Pharma, Raleigh, NC, ¹⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: RAPID-axSpA (NCT01087762) investigated the efficacy and safety of certolizumab pegol (CZP) in patients (pts) with axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic…
Abstract Number: 1357 • 2016 ACR/ARHP Annual Meeting
Clinical Description of Patients with Cytoplasmic Discrete Speckles on Indirect Immunofluorescence on HEp-2 Cells in a Universitary Hospital
Martin Brom¹, Carolina Eva Carrizo², Roberto Arana³ and Cecilia N. Pisoni³, ¹Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²CEMIC, Buenos Aires, Argentina, ³Rheumatology and Immunology, CEMIC, Buenos Aires, Argentina
Background/Purpose: Indirect Immunofluorescence (IIF) shows different nuclear and cytoplasmic fluorescence patterns depending on the antibodies present in the cell. Cytoplasmic patterns are an unusual finding.…
Abstract Number: 1805 • 2016 ACR/ARHP Annual Meeting
Factors Associated with Complete Remission in Patients with Systemic Lupus Erythematosus: A Retrospective Cohort Study in One Center
Jorge Romo-Tena¹, Diana Gómez-Martín¹, Roberto Reyna², Isaac Bartnicki-Navarrete³ and Jorge Alcocer-Varela¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by disease flares, alternated with periods of clinical remission. In the past years, the “treat-to-target” strategy in SLE…
Abstract Number: 2665 • 2016 ACR/ARHP Annual Meeting
Epratuzumab Treatment of Patients with Systemic Lupus Erythematosus and Secondary Sjogren’s Syndrome: An Exploratory Analysis of Phase 3 Studies
Jacques-Eric Gottenberg¹, Thomas Dörner², Hendrika Bootsma³, Valerie Devauchelle-Pensec⁴, Simon Bowman⁵, Gordana Kosutic⁶, Holger Bartz⁷, Marga Oortgiesen⁶, Anthony Shock⁸, Willem Koetse⁶, Catrinel Galateanu⁹, Sabine Bongardt⁷, Xavier Mariette¹⁰ and Caroline Gordon^11,12, ¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Department of Medicine/Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, University of Groningen, Groningen, Netherlands, ⁴Department of Rheumatology and Unit of Immunology, Brest University Medical School, Brest, France, ⁵Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁶UCB Pharma, Raleigh, NC, ⁷UCB Pharma, Monheim, Germany, ⁸UCB Pharma, Slough, United Kingdom, ⁹UCB Pharma, Brussels, Belgium, ¹⁰INSERM U1184, Université Paris-Sud, Paris, France, Le Kremlin Bicetre, France, ¹¹NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ¹²Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: The EMBODY 1 (SL0009; NCT01262365) and EMBODY 2 (SL0010; NCT01261793) phase 3 studies investigated the efficacy and safety of epratuzumab (Emab; Immunomedics Inc), a…
Abstract Number: 398 • 2015 ACR/ARHP Annual Meeting
Clinical and Serological Profile of Children with Positive SSA-Ro/SSB-La Antibodies
Juan G. Ovalles-Bonilla¹, Juan C. Nieto¹, Francisco Javier López Longo¹, Julia Martínez-Barrio², Iustina Janta¹, Esperanza Naredo¹, Carlos M. Gonzalez¹, Michelle Hinojosa¹, Natalia Bello¹, Belen Serrano¹, Carmen Mata¹, Claudia Sáenz Tenorio¹, Diana C. Hernández¹, Lara Valor¹, Indalecio Monteagudo¹ and Luis Carreño¹, ¹Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ²Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Background/Purpose: Several studies have shown the relationship between anti-SSA-Ro/SSB-La antibodies and Systemic Lupus Erythematosus (SLE), Sjögren Syndrome (SS) and other autoimmune diseases in adult population.…
Abstract Number: 451 • 2015 ACR/ARHP Annual Meeting
Efficacy of Tofacitinib in a Real World Setting Using the Database Jointman
Sergio Schwartzman¹, Keith Knapp², Gary Craig³, Karen Ferguson⁴ and Howard Kenney⁵, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Arthritis Northwest, Spokane, WA, ³Discus Analytics, Inc., Spokane, WA, ⁴Arthritis Northwest PLLC., Spokane, WA, ⁵Rheumatology, Arthritis Northwest, Spokane, WA
Background/Purpose: Tofacitinib (TFA) was approved for the treatment of rheumatoid arthritis (RA) in November of 2012. It is well accepted that patients studied in pharmaceutically…
Abstract Number: 734 • 2015 ACR/ARHP Annual Meeting
Disease Patterns, Flare Incidence and Organ Damage Among Filipino Patients with Systemic Lupus Erythematosus: a One-Year Observational Study
Mary Flor Joy Edar, Leonid Zamora, Catherine Macapagal and Sandra V. Navarra, Rheumatology, University of Santo Tomas Hospital, Manila, Philippines
Background/Purpose: This study describes the disease patterns, flare incidence, hospitalizations and causes of mortality in a cohort of Filipino patients with systemic lupus erythematosus (SLE),…
Abstract Number: 744 • 2015 ACR/ARHP Annual Meeting
Longitudinal Assessment of Th1 and Th2 Cytokines: A Comparison Between Adult-Onset and Childhood-Onset Systemic Lupus Erythematous
Karina Pelicari¹, Mariana Postal¹, Nailu A. Sinicato², Fernando A. Peres¹, Roberto Marini Sr.³, Lilian Tereza Costallat⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Pediatrics, State University of Campinas, Campinas, Brazil, ³Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, ⁴RUA EZEQUIEL MAGALHAES,26, Unicamp, Campinas, Brazil, ⁵Division of Rheumatology, Faculty of Medical Science, State University of Campinas, São Paulo, Brazil
Background/Purpose: The clinical presentation may be different between adult-onset SLE (aSLE) and childhood-onset SLE (cSLE). The profile of cytokine may the clarify of SLE pathophysiology. The…

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