ACR Meeting Abstracts

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Abstracts tagged "Clinical research"

  • Abstract Number: 471 • 2018 ACR/ARHP Annual Meeting

    Early Signs of Diastolic Impairment in Children with Incident Systemic Lupus Erythematosus

    Joyce C. Chang1,2, Brian R. White3, Matthew D. Elias3, Rui Xiao4, Andrea M. Knight5,6,7, Pamela F. Weiss8,9,10 and Laura M. Mercer-Rosa3,7, 1Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, 4Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Center for Pediatric Clinical Effectiveness & PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, 6Division of Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 7Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 8Center for Clinical Epidemiology and Biostastistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 9Division of Rheumatology, Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, 10Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The timing and etiology of diastolic impairment in pediatric-onset systemic lupus erythematosus (pSLE) are poorly understood, and the role of screening echocardiography remains unclear.…
  • Abstract Number: 13L • 2017 ACR/ARHP Annual Meeting

    Significant, Sustained Improvement in Knee Function after Intra-Articular TPX-100: A Double-Blind, Randomized, Multi-Center, Placebo-Controlled Phase 2 Trial

    Dawn McGuire1, Nancy E Lane2, Neil Segal3, Samy Metyas4, Hans Richard Barthel5, Meghan Miller1, David Rosen1 and Yoshi Kumagai1, 1OrthoTrophix, Inc, Oakland, CA, 2UC Davis Medical Center, Sacramento, CA, 3University of Kansas, Shawnee, KS, 4Medvin Clinical Research, Covina, CA, 5Barthel Clinic, Santa Barbara, CA

    Background/Purpose: The current Phase 2 study was designed to evaluate safety, tolerability and preliminary efficacy of TPX-100 by IA administration in subjects with mild to…
  • Abstract Number: 15L • 2017 ACR/ARHP Annual Meeting

    A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Titration-to-Effect Study of Orally Administered CR845 in Patients with Osteoarthritis of the Hip or Knee

    Sukirti Bagal, Catherine Munera, Patricia Brady and Joseph Stauffer, Cara Therapeutics, Stamford, CT

    Background/Purpose: CR845 is a selective kappa opioid receptor agonist with a peripheral mechanism of action. Here we report preliminary results from a Phase 2b study…
  • Abstract Number: 544 • 2017 ACR/ARHP Annual Meeting

    Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF-06650833, a Novel, Potentially First-in-Class Inhibitor of Interleukin-1 Receptor Associated Kinase-4 (IRAK-4) in Healthy Subjects

    Spencer Danto1, Negin Shojaee1, Cheryl Li1, Steven A. Gilbert2, Ravi Shankar Singh1, Zorayr Manukyan1 and Iain Kilty1, 1Worldwide Research and Development, Pfizer, Inc., Cambridge, MA, 2Pfizer, Inc., Cambridge, MA

    Background/Purpose: IRAK‑4 is a key node in innate immune signaling and is activated by the interleukin (IL)‑1 family receptors (IL‑1R, IL‑18R, and IL‑33R), in addition…
  • Abstract Number: 583 • 2017 ACR/ARHP Annual Meeting

    Associations of Changes of Radiographic Disease and Spinal Mobility Measures in Ankylosing Spondylitis

    Mark Hwang1,2,3, Michael Weisman4, MinJae Lee5, Lianne S. Gensler6, Matt Brown7, Amirali Tahanan5, Laura A. Diekman8, Thomas Learch9, Seth Eisen10, Mohammad H. Rahbar5, Michael Ward11 and John D. Reveille12, 1Medicine, University of Texas-McGovern Medical School, Houston, TX, 2Internal Medicine-Rheumatology, University of Texas-McGovern Medical School, Saint Louis, MO, 3Washington University at Saint Louis School of Medicine, Saint Louis, MO, 4Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, 5Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, 6Medicine/Rheumatology, UCSF, San Francisco, CA, 7Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, 8Rheumatology, University of Texas-McGovern Medical School, Houston, TX, 9Radiology, Cedars Sinai Medical Center, Los Angeles, CA, 10Division of Rheumatology, Washington University at Saint Louis School of Medicine, St Louis, MO, 11NIH/NIAMS, Bethesda, MD, 12University of Texas McGovern Medical School, Houston, TX

    Background/Purpose: Metrology indices aimed as assessing spinal mobility in ankylosing spondylitis (AS) patients are used in clinical trials and clinical practice to assess disease severity…
  • Abstract Number: 771 • 2017 ACR/ARHP Annual Meeting

    Serological Biomarkers of Collagen Formation Is Increased in Systemic Sclerosis

    Pernille Juhl1, Mette Mogensen2, Line Iversen2, Tonny Karlsmark2, Morten Karsdal3, Anne-C. Bay-Jensen4 and Anne Sofie Siebuhr5, 1Nordic Bioscience, Herlev, Denmark, 2Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, 3Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, 4Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark, 5Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, Herlev, Denmark

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem, autoimmune disease characterized by immune dysregulation, vasculopathy and excessive fibrosis of the skin and internal organs. Fibrosis is…
  • Abstract Number: 885 • 2017 ACR/ARHP Annual Meeting

    48-Week Complete Remission By Ethnic, Sex and Age Subgroups in Patients with Active Lupus Nephritis Treated with Voclosporin

    David Wofsy1, David A. Isenberg2, Frédéric A. Houssiau3, Mary Anne Dooley4, Neil Solomons5 and Simrat Randhawa6, 1Rheumatology, UCSF, San Francisco, CA, 2Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, 3Rheumatology, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, 4UNC Kidney Centre, Chapel Hill, NC, 5Aurinia Pharmaceuticals Inc., Victoria, BC, Canada, 6Medical Affairs, Aurinia Pharmaceuticals, Victoria, BC, Canada

    Background/Purpose: Voclosporin (VCS) is a novel CNI with a favorable metabolic profile, no observed effect on electrolytes, and a predictable dose response potentially eliminating the…
  • Abstract Number: 1147 • 2017 ACR/ARHP Annual Meeting

    Macrophage Activation Syndrome or Acquired Hemophagocytic Lymphohistiocytosis in Adults: Demographics, Clinical Characteristics, and Survivorship in an American Academic Medical Center

    Seema Malkana1 and Irene Tan2, 1Internal Medicine, Temple University Hospital, Philadelphia, PA, 2Section of Rheumatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA

    Background/Purpose:  Macrophage Activation Syndrome, also known as acquired Hemophagocytic Lymphohistiocytosis in adults, is an immune-mediated systemic inflammatory state. It is associated with multisystem organ failure…
  • Abstract Number: 1661 • 2017 ACR/ARHP Annual Meeting

    STAT4 Regulates Pathogenic IL-21 and IFN-γ in Tfh Cells in Murine and Human Lupus

    Fotios Koumpouras1, XueMei Dong2, Jason Weinstein2 and Joseph E. Craft3, 1Internal Medicine, Rheumatology, Yale University School of Medicine, New Haven, CT, 2Rheumatology, Yale University School of Medicine, New Haven, CT, 3Department of Internal Medicine/Rheumatology, Yale University School of Medicine, New Haven, CT

    Background/Purpose: Follicular helper T cells (Tfh) cells regulate the germinal center (GC) response by delivery of contact-dependent interactions and cytokines including IL-4, IFN-γ and IL-21.…
  • Abstract Number: 1780 • 2017 ACR/ARHP Annual Meeting

    Prognostic Factors in Patients with Granulomatosis with Polyangiitis Requiring Hospitalization- a 10 Year Nationwide Analysis

    Yumeng Wen1, Yiming Luo1 and Changchuan Jiang2, 1Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Medicine, Mount Sinai St. Luke's West Hospitals. Icahn School of Medicine at Mount Sinai., New York, NY

    Background/Purpose: Granulomatosis with Polyangiitis (GPA) is a form of systemic vasculitis with necrotizing granulomatous inflammation commonly involving upper and lower respiratory tracts, necrotizing glomerulonephritis and…
  • Abstract Number: 1854 • 2017 ACR/ARHP Annual Meeting

    Identifying Vulnerable Patient Populations Based on Age and Physical Function on Clinical Outcomes Following Total Knee Arthroplasty

    Jesse Christensen1, Andrew Kittelson2, Brian Loyd3, Jackie Del Giorno4, Brian Burnikel5 and Jennifer Stevens-Lapsley6, 1University of Utah, SLC, UT, 2Rehabilitation Science PhD Program, University of Colorado Anschutz Medical Campus, Aurora, CO, 3University of Colorado Anschutz Medical Campus, Aurora, CO, 4ATI Physical Therapy, Greenville, SC, 5Steadman Hawkins Clinic of the Carolinas, Greenville Health Systems, Greenville, SC, 6Universtiy of Colorado, Anschutz Medical Campus, Aurora, CO

    Background/Purpose:  : Total knee arthroplasty (TKA) has historically been viewed as a surgical procedure of last resort for older adults suffering with chronic arthritis. However,…
  • Abstract Number: 2167 • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety of Rituximab in Anti-Synthetase Positive and Negative Patients with Idiopathic Inflammatory Myopathy– a Registry-Based Study

    Valérie Leclair, Maryam Dastmalchi, Angeles Shunashy Galindo-Feria and Ingrid E. Lundberg, Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rituximab (RTX) in idiopathic inflammatory myopathies (IIM) failed to show efficacy in the placebo-controlled Rituximab in Myositis (RIM) trial. However, post hoc analyses indicated…
  • Abstract Number: 2855 • 2017 ACR/ARHP Annual Meeting

    Subcutaneous Abatacept in Patients Aged 2–17 Years with Polyarticular Juvenile Idiopathic Arthritis and Inadequate Response to Biologic or Non-Biologic Disease-Modifying Antirheumatic Drugs: Pharmacokinetics, Effectiveness, Safety and Immunogenicity over 2 Years

    Hermine I. Brunner1, N Ruperto2, G Vega-Cornejo3, A Berman4, Inmaculada Calvo5, R Cuttica6, F Ávila-Zapata7, Michael Henrickson1, DJ Kingsbury8, D Viola9, V Keltsev10, K Minden11, John F. Bohnsack12, X Li13, M Nys14, R Wong13, S Banerjee13, Daniel J Lovell1 and Alberto Martini15, 1Cincinnati Children’s Hosp. Medical Center, Cincinnati, OH, 2Istituto G. Gaslini Pediatria II Reumatologia, Genoa, Italy, 3Clinica de Reumatología y Enfermedades Autoinmunes (CREA), Hospital México Americano, Guadalajara Jalisco, Mexico, 4Universidad Nacional de Tucuman and Centro Médico Privado de Reumatología, Tucuman, Argentina, 5Hospital Univ. La Fe, Valencia, Spain, 6Hospital General de Niños Pedro de Elizalde, Buenos Aires, Argentina, 7Star Medica Hospital, Yucatán, Mexico, 8Randall Children’s Hospital at Legacy Emanuel, Portland, OR, 9CAICI Institute, Rosario City, Santa Fe State, Argentina, 10GBUZ Samara region "Togliatti City Clinical Hospital No.5" Rheumatology Department, Togliatti, Russian Federation, 11German Rheumatism Research Center and Charité University Medicine, Berlin, Germany, 12University of Utah School of Medicine, Salt Lake City, UT, 13Bristol-Myers Squibb, Princeton, NJ, 14Bristol-Myers Squibb, Braine-l’Alleud, Belgium, 15Istituto G. Gaslini Pediatria II Reumatologia and University of Genova, Genoa, Italy

    Background/Purpose: IV abatacept (ABA) 10 mg/kg every 4 weeks is well tolerated and effective in reducing the signs and symptoms of polyarticular juvenile idiopathic arthritis…
  • Abstract Number: 3136 • 2016 ACR/ARHP Annual Meeting

    Impact of Novel Smartphone Application on Pain and Mobility in Osteoarthritis Patients Treated with Hylan G-F 20

    Nebojsa Skrepnik1, Andrew Spitzer2, Roy Altman3, John A. Hoekstra4, John Stewart5 and Richard Toselli6, 1Tucson Orthopaedic Institute, Tucson, AZ, 2Cedars-Sinai Orthopedic Center, Los Angeles, CA, 3UCLA Medical Center, Los Angeles, CA, 4National Clinical Research–Richmond, Richmond, VA, 5Sanofi, Laval, QC, Canada, 6Sanofi, Cambridge, MA

    Background/Purpose: Methods: In this study, both groups were treated with hylan G-F 20 and showed significantly increased mobility and reduced pain, however, patients using the…
  • Abstract Number: 242 • 2016 ACR/ARHP Annual Meeting

    Clinical and Laboratory Features of IgG4-Related Retroperitoneal Fibrosis/Periarteritis in Japan: Retrospective Multicenter Study of 99 Cases

    Ichiro Mizushima1, Satomi Kasashima2, Motohisa Yamamoto3, Takako Saeki4, Kazunori Yamada5, Dai Inoue6, Fuminori Kasashima7, Yasushi Matsumoto7, Eisuke Amiya8, Kenji Notohara9, Yasuharu Sato10, Yoh Zen11, Shigeyuki Kawa12, Mitsuhiro Kawano1 and Nobukazu Ishizaka13, 1Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan, 2Department of Clinical Laboratory and Pathology, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan, 3First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, 4Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan, 5Department of Advanced Research in Community Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, 6Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan, 7Department of Cardiovascular Surgery, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan, 8Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 9Department of Pathology, Kurashiki Central Hospital, Kurashiki, Japan, 10Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan, 11Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan, 12Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan, 13Department of Cardiology, Osaka Medical College, Osaka, Japan

    <span">Background/Purpose:  IgG4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disorder that can affect many organs. It frequently causes retroperitoneal/periarterial lesions, which are referred to…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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