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Abstracts tagged "citrulline"

  • Abstract Number: 834 • 2017 ACR/ARHP Annual Meeting

    Citrulline-Polyspecific B Cell Antigen Receptors Arising from Somatic Hypermutation within Clades Demonstrate Pathogenicity in Rheumatoid Arthritis

    Philip J. Titcombe1,2, Gustaf Wigerblad3, Natalie Sippl3, Na Zhang1, Anna K. Shmagel4, Peter Sahlström5, Yue Jack Zhang1, Laura Barsness Motschenbacher1, Yogita Ghodke-Puranik6, Monika Hansson7, Lena Israelsson5, Timothy B. Niewold8, Lars Klareskog9, Camilla Svensson10, Khaled Amara7, Vivianne Malmström11 and Daniel L. Mueller1, 1Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, 2Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 4Rheumatic & Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, 5Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 6Colton Center for Autoimmunity, New York University, New York, NY, 7Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 8Rheumatology and Immunology, Mayo Clinic, Rochester, MN, 9Rheumatology unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 10Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, 11Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Citrulline–modified proteins arising from the post-translational modification of arginine residues are recognized as primary rheumatoid arthritis (RA) autoantigen targets based on the strong association…
  • Abstract Number: 2430 • 2017 ACR/ARHP Annual Meeting

    For Each HLA-DRB1 Genotype, the Likelihood to Develop RA Correlates with the Probability of Binding at Least a Peptide from PAD4

    Isabelle Auger1, Nathalie Balandraud2 and Jean Roudier3, 1INSERM UMRs 1097, Marseille, France, 2Rheumatology, APHM, Marseilles, France, 3Arthrites auto-immunes, INSERM UMRs 1097, Marseille, France

    HLA-DRB1 genotypic risk to develop ACPA positive RA correlates with capability of encoded HLA-DRB1 chains to bind Peptidyl Arginyl Deiminase (PAD4) peptides, not citrullinated Fibrinogen…
  • Abstract Number: 2915 • 2017 ACR/ARHP Annual Meeting

    Increased Expression of Malondialdehyde-Acetaldehyde Adducts (MAA) and Anti-Maa Antibody in Rheumatoid Arthritis-Interstitial Lung Disease

    Bryant R. England1, Geoffrey M. Thiele2, Michael J. Duryee3, Dana P. Ascherman4, Liron Caplan5, M. Kristen Demoruelle6, Kevin D. Deane5 and Ted R. Mikuls7, 1Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Omaha, NE, 3Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL, 5Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 61775 Aurora Ct, 1775 Aurora Ct, Aurora, CO, 7Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Generated under oxidative stress, malondialdehyde-acetaldehyde adducts (MAA), and antibody responses to MAA appear to facilitate loss of immune tolerance and generate pro-inflammatory responses in…
  • Abstract Number: 1914 • 2016 ACR/ARHP Annual Meeting

    Immune Recognition of a Novel Citrullinated Epitope of Cartilage Proteoglycan Aggrecan in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis

    Adrienn Markovics1, Timea Ocsko1, Robert S. Katz2, Edit I Buzas3, Tibor T. Glant1 and Katalin Mikecz1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Rush University Medical Center, Chicago, IL, 3Semmelweis University, Budapest, Hungary

    Background/Purpose:  Rheumatoid arthritis (RA) is an autoimmune disease leading to the inflammatory destruction of synovial joints. Anti-citrullinated protein antibodies (ACPA) are frequently detected in the…
  • Abstract Number: 177 • 2013 ACR/ARHP Annual Meeting

    Differences and Overlap Of Immunological Pathways Implicated In The Aetiology Of Anti-Citrullinated Peptide Antibody Positive and Negative Rheumatoid Arthritis

    Sebastien Viatte1, Paul Martin2, Andrew Brass3, Mark Lunt4, Anne Barton5 and Stephen Eyre5, 1Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 2Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 3School of Computer Science, University of Manchester, Manchester, United Kingdom, Manchester, United Kingdom, 4Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, 5Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Genome-wide association studies have been successful in identifying single nucleotide polymorphisms (SNPs) associated with disease. However, previous studies have been under-powered to detect differences…
  • Abstract Number: 2659 • 2012 ACR/ARHP Annual Meeting

    An Expanded Repertoire of Anti-Citrullinated Peptide Antibodies Is Associated with Interstitial Lung Disease in Rheumatoid Arthritis

    Jon T. Giles1, Sonye Danoff2, Jeremy Sokolove3, Robert Winchester4, Dimitrios A. Pappas5, Catriona Cramb6, Geoffrey Connors7, Stanley S. Siegelman8, William H. Robinson9 and Joan M. Bathon5, 1Medicine, Columbia University, New York, NY, 2Medicine/Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD, 3Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 4Dept of Medicine & Pathology, Columbia University, New York, NY, 5Columbia University, New York, NY, 6VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, 7Division of Pulmonary and Critical Care Medicine, Yale University, New Haven, CT, 8Department of Radiology, Johns Hopkins University, Baltimore, MD, 9Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Interstitial lung disease (ILD) is an outcome with high morbidity and mortality in rheumatoid arthritis (RA).  Citrullinated proteins are observed in these lung tissues;…
  • Abstract Number: 2578 • 2012 ACR/ARHP Annual Meeting

    Monoclonal IgG Antibodies (ACPAs) From Synovial Fluid B Cells of Rheumatoid Arthritis Patients – Antigen-Driven Affinity Maturation and Cross Reactivity

    Khaled Amara1, Johanna Steen2, Fiona Murray2, Henner Morbach3, Blanca Fernandez-Rodriguez4, Vijay Balasingh2, Marianne Engström2, Omri Snir2, Lena Israelsson5, Anca Catrina2, Hedda Wardemann6, Davide Corti4, Eric Meffre Sr.3, Lars Klareskog7 and Vivianne Malmström8, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-17176 Solna, Stockholm, Sweden., Stockholm, Sweden, 2Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 4Institute for Research in Biomedicine, Bellinzona, Switzerland, 5Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 6Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, 7Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 8Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Antibodies targeting citrullinated proteins (ACPA) are commonly found in patients with Rheumatoid Arthritis (RA), strongly associate with distinct HLA-DR alleles and predict a more…
  • Abstract Number: 737 • 2012 ACR/ARHP Annual Meeting

    Citrullination of ENA-78/CXCL5 Results in Conversion From a Non-Monocyte Recruiting to a Monocyte Recruiting Chemokine

    Ken Yoshida1, Olex Korchynskyi2, Paul P. Tak3, Takeo Isozaki4, Jeffrey H. Ruth5, Phillip Campbell6, Dominique L. Baeten7, Danielle M. Gerlag7, M. Asif Amin8 and Alisa E. Koch9, 1Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2Department of Cellular Proliferation and Apoptosis, Institute of Cell Biology, Lviv, Ukraine, 3Departments of Experimental Immunology and Internal Medicine, GlaxoSmithKline U.K. and Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 5Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 6Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 7Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 8Department of Medicine, University of Michigan, Ann Arbor, MI, 9Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Citrullination is a post-translational modification that is the conversion of arginine to citrulline in proteins mediated by peptidylarginine deiminase (PAD). Antibodies directed towards the…
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