ACR Meeting Abstracts

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Abstracts tagged "chondrocyte"

  • Abstract Number: 0020 • ACR Convergence 2022

    Redoxosomes Mediate a Feed-forward Loop of Cartilage Matrix Destruction Through α5β1 Integrin Signaling in Response to a Fibronectin Matrikine

    Michael Miao1, Peter Su2, Yang Cui1, John Collins3, Edward Bahnson1, Susan Chubinskaya4 and Richard Loeser1, 1University of North Carolina, Chapel Hill, NC, 2University of Technology, Ultimo, Australia, 3Thomas Jefferson University, Philadelphia, PA, 4Rush University, Chicago, IL

    Background/Purpose: Degradation of pericellular matrix proteins creates bioactive fragments called "matrikines" that include fibronectin fragments (FN-f). FN-f found in OA cartilage and synovial fluid exhibit…
  • Abstract Number: 0024 • ACR Convergence 2022

    Exposure to Pollutants with Endocrine Disrupting Properties Is Associated with Early Cartilage Defects and Chondrocyte Inflammatory and Oxidative Activation

    Sabryne Berkani1, Inés Kouki2, Sylvie Babajko3, Audrey Pigenet4, padmaja Natarajan5, Philip Ordoukhanian6, Xavier Houard4, Martin Lotz7, Barbara Demeneix8, Jean-Baptiste Fini8, Francis Berenbaum9, Jérémie SELLAM10 and Alice Courties11, 1Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Department of Rheumatology, Assistance Publique , Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, 2Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Department of Rheumatology, Assistance Publique , Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, 3Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France, Paris, 4Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, 5Center for Computational Biology & Bioinformatics and Genomics Core, Scripps Research, La Jolla, California, USA, La Jolla, 6Center for Computational Biology & Bioinformatics and Genomics Core, Scripps Research, La Jolla, CA, 7Scripps Research, La Jolla, 8UMR 7221, Phyma, CNRS-Muséum National d'Histoire Naturelle, Sorbonne Université, 75005 Paris, France., Paris, 9Sorbonne University - Saint-Antoine hospital, Paris, France, 10Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France, 11Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France

    Background/Purpose: Humans are exposed to pollutants with endocrine disruptors (ED) properties from their in utero life. Among them, a mix of 15 pollutants (perfluorinated compounds,…
  • Abstract Number: 0026 • ACR Convergence 2022

    Silencing of WISP-2 Induces Inflammatory Mediators and Catabolic Factors in Cartilage

    Clara Ruiz-Fernández1, María González-Rodríguez2, Vera Francisco3, Djedjiga Ait Eldjoudi2, Alfonso Cordero-Barreal2, Yousof Farrag2, Jesús Pino4, Miguel Ángel González-Gay5, Antonio Mera6, Francisca Lago2 and Oreste Gualillo7, 1Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain, 2Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain, 3Institute of Health Research-INCLIVA, València, Spain, 4Santiago Clinic Hospital CHUS-Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain, 5Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 6Santiago University Clinical Hospital CHUS, Santiago de Compostela, Spain, 7Hospital Clínico Universitario de Santiago, SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago de Compostela, Spain

    Background/Purpose: Wnt-1 inducible signaling pathway protein 2 (WISP-2/CCN5) is an adipokine that has been described as an important mediator of canonical Wnt activation in adipogenic…
  • Abstract Number: 0032 • ACR Convergence 2022

    Defective Chaperone-mediated Autophagy Is a Hallmark of Joint Disease in Patients with Knee Osteoarthritis

    Irene Lorenzo-Gomez1, uxia Nogueira-recalde1, Christian garcía-Domínguez1, Natividad Oreiro2, Martin Lotz3, JA Pinto-Tasende2, FJ Blanco2 and beatriz caranes1, 1Instituto de Investigación Biomédica de A Coruña (INIBIC), Unidad de Biología del Cartílago, A Coruña, Spain, 2Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 3Scripps Research, La Jolla

    Background/Purpose: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA.Methods: A…
  • Abstract Number: 1455 • ACR Convergence 2021

    IL1β mRNA Expressions in Peripheral Blood Mononuclear Cells Increase and May Associate with Cartilage Damage of the Respiratory Tract Probably Through Matrix metalloproteinase-3 Production in Patients with Relapsing Polychondritis

    Jun Shimizu1, Sueshige Wakisaka1, Tomoko Suzuki1 and Noboru Suzuki2, 1St. Marianna University School of Medicine, Kawasaki, Japan, 2St. Marianna University School of Medicine, Kawasaki Kanagawa, Japan

    Background/Purpose: Relapsing polychondritis (RP) is an inflammatory disorder that affects cartilage of ears, nose, joints, and respiratory tract. The inflammation often spreads to eyes, cardiovascular…
  • Abstract Number: 1471 • ACR Convergence 2021

    Oral Administration of Berberine Limits Post-traumatic Osteoarthritis Development and Associated Pain via AMP-activated Protein Kinase (AMPK) in Mice

    Jun Li1, Yun Wang2, Di Chen3 and Ru Liu Bryan4, 1Rush University Medical Center, Chicago, IL, 2Valo Health, Lexington, MA, 3Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (People's Republic), 4University of California San Diego and VASDHS, San Diego, CA

    Background/Purpose: AMP-activated protein kinase (AMPK), a master regulator of energy balance and metabolism, is implicated to play an important role in cartilage homeostasis. Berberine is…
  • Abstract Number: 1473 • ACR Convergence 2021

    Chaperone-mediated Autophagy Is a Hallmark of Joint Damage in Osteoarthritic Patients

    Irene Lorenzo-Gómez1, Uxía Nogueira-Recalde1, Natividad Oreiro2, José A. pinto3, Francisco Blanco-García4 and Beatriz Caramés1, 1Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, 2Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 3Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain, 4Unidad de Proteómica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). C/ As Xubias de Arriba 84, 15006, A Coruña, España.Universidade da Coruña (UDC), Grupo de Investigación de Reumatología y Salud (GIR-S). Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, Campus de Oza, 15008, A Coruña, España., A Coruña, Spain

    Background/Purpose: In osteoarthritis (OA), defects in Autophagy are evident and precede joint damage. Therefore, identifying hallmarks associated with specific autophagy subtypes could shed light to…
  • Abstract Number: 1927 • ACR Convergence 2021

    Heterogeneity of Juvenile Idiopathic Arthritis Synovial Fibroblasts Correlates to Disease Progression and Provides Compelling Diagnostic Data

    Megan Simonds1, Kathleen Sullivan2, Carlos Rose3 and AnneMarie Brescia4, 1Nemours, Wilmington, DE, 2The Children's Hospital of Philadelphia, Philadelphia, PA, 3Thomas Jefferson University/duPont Hospital for Children, Wilmington, DE, 4Nemours/A.I.duPont Hospital for Children, Wilmington, DE

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by…
  • Abstract Number: 0706 • ACR Convergence 2020

    Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis

    Benjamin Friedman1 and Bruce Cronstein2, 1NYU Rheumatology, New York, NY, 2NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…
  • Abstract Number: 1485 • ACR Convergence 2020

    LNA043, a Novel Cartilage Regenerative Treatment for Osteoarthritis: Results from a First-In-Human Trial in Patients with Knee Osteoarthritis

    Celeste Scotti1, Joseph Gimbel2, Didier Laurent1, Aviv Madar3, Thomas Peters1, Yunyu Zhang3, Florine Polus1, Michael Beste3, Igor Vostiar1, Subhajit Choudhury4, Nicole Gerwin1, Jörg Goldhahn5, Matthias Schieker1 and Ronenn Roubenoff1, 1Novartis Institutes for BioMedical Research, Basel, Switzerland, 2Arizona Research Center, Phoenix, 3Novartis Institutes for BioMedical Research, Cambridge, 4Biostatistics & Pharmacometrics, Novartis Healthcare Pvt. Ltd., Hyderabad, India, 5Department of Health Sciences and Technology, ETH Zürich, Zurich, Switzerland

    Background/Purpose:LNA043 is a modified human angiopoietin-like 3 (ANGPTL3) protein identified in a phenotypic screen for inducers of chondrogenesis and cartilage repair. The primary objective of…
  • Abstract Number: 1980 • 2019 ACR/ARP Annual Meeting

    Disorganization of Chondrocyte Columns in the Growth Plate During Experimental Osteoarthritis in Mice

    Ana Lamuedra1, Víctor Luis Ruiz-Perez 2, Paula Gratal 1, Raquel Largo 3 and Gabriel Herrero-Beaumont 3, 1IIS - Fundacion Jimenez Diaz, Madrid, Madrid, Spain, 2Instituto de Investigaciones Biomédicas 'Alberto Sols', Madrid, Madrid, Spain, 3IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain

    Background/Purpose: Osteoarthritis (OA) is a biomechanical joint disease mainly affecting articular cartilage and subchondral bone. A great variety of animal models, especially mice, are used…
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ACR Pediatric Rheumatology Symposium 2020

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