ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "chondrocyte"

  • Abstract Number: 0706 • ACR Convergence 2020

    Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis

    Benjamin Friedman1 and Bruce Cronstein2, 1NYU Rheumatology, New York, NY, 2NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…
  • Abstract Number: 1485 • ACR Convergence 2020

    LNA043, a Novel Cartilage Regenerative Treatment for Osteoarthritis: Results from a First-In-Human Trial in Patients with Knee Osteoarthritis

    Celeste Scotti1, Joseph Gimbel2, Didier Laurent1, Aviv Madar3, Thomas Peters1, Yunyu Zhang3, Florine Polus1, Michael Beste3, Igor Vostiar1, Subhajit Choudhury4, Nicole Gerwin1, Jörg Goldhahn5, Matthias Schieker1 and Ronenn Roubenoff1, 1Novartis Institutes for BioMedical Research, Basel, Switzerland, 2Arizona Research Center, Phoenix, 3Novartis Institutes for BioMedical Research, Cambridge, 4Biostatistics & Pharmacometrics, Novartis Healthcare Pvt. Ltd., Hyderabad, India, 5Department of Health Sciences and Technology, ETH Zürich, Zurich, Switzerland

    Background/Purpose:LNA043 is a modified human angiopoietin-like 3 (ANGPTL3) protein identified in a phenotypic screen for inducers of chondrogenesis and cartilage repair. The primary objective of…
  • Abstract Number: 1980 • 2019 ACR/ARP Annual Meeting

    Disorganization of Chondrocyte Columns in the Growth Plate During Experimental Osteoarthritis in Mice

    Ana Lamuedra1, Víctor Luis Ruiz-Perez 2, Paula Gratal 1, Raquel Largo 3 and Gabriel Herrero-Beaumont 3, 1IIS - Fundacion Jimenez Diaz, Madrid, Madrid, Spain, 2Instituto de Investigaciones Biomédicas 'Alberto Sols', Madrid, Madrid, Spain, 3IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain

    Background/Purpose: Osteoarthritis (OA) is a biomechanical joint disease mainly affecting articular cartilage and subchondral bone. A great variety of animal models, especially mice, are used…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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