Abstracts tagged "chondrocyte"

Abstract Number: 0021 • ACR Convergence 2024
A Novel Small Molecule Screening Assay Using Normal Human Chondrocytes Toward Osteoarthritis Drug Discovery
Philip Coryell¹, Kenneth Pearce², Paul Hardy², Susan Chubinskaya³ and Richard Loeser⁴, ¹University of North Carolina-Chapel Hill, Chapel, NC, ²University of North Carolina-Chapel Hill, Chapel Hill, NC, ³University of Texas Medical Branch, Galveston, TX, ⁴University of North Carolina, Chapel Hill, NC
Background/Purpose: A central feature of osteoarthritis (OA) is progressive cartilage degradation driven by increased production of matrix degrading enzymes including MMP-13. There is a critical…
Abstract Number: 0023 • ACR Convergence 2024
Adenosine and Guanosine-based Oligonucleotide Attenuates Catabolic Phenotypes in Chondrocytes and Slows Progression of Surgically Induced Osteoarthritis
Yoonhee Kim¹, Jin Han² and Seungwoo Han³, ¹Kyungpook National University School of Medicine, Buk-gu, Daegu, Republic of Korea, ²Kyungpook National University, Buk-gu, Daegu, Republic of Korea, ³Kyungpook national university hospital, Daegu, South Korea
Background/Purpose: Adenosine is a potent endogenous modulator of inflammation; however, its clinical application is limited due to its extremely short half-life in blood. In this…
Abstract Number: 0024 • ACR Convergence 2024
Trans-Signaling by Soluble CD14 Sensitizes Chondrocytes to Lipopolysaccharide Stimuli, Increasing Chondrocyte Inflammatory Responses
Anna E. Rapp, Baofeng Hu and Carla Scanzello, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The understanding of osteoarthritis (OA) has evolved significantly over the past decade. Recently attention is being drawn to the role of pattern-recognition receptor (PRR)…
Abstract Number: 1658 • ACR Convergence 2024
IGF1 Drives Wnt-induced Joint Damage and Is a Therapeutic Target for Osteoarthritis
Ana Escribano-Nunez¹, Frederique Cornelis², Astrid Deroover¹, An Sermon¹, Frederic Cailotto³, Rik Lories² and Silvia Monteagudo⁴, ¹KU Leuven, Leuven, Vlaams-Brabant, Belgium, ²Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, ³Université Lorraine, Nancy, Lorraine, France, ⁴KU Leuven, Leuven, Belgium
Background/Purpose: Osteoarthritis is the most common joint disease and a global leading cause of pain and disability. Its multifactorial etiology includes excessive activation of Wnt…
Abstract Number: 1710 • ACR Convergence 2024
Extl3 Involved in the Regulation of Endochondral Ossification in Axial SpA
Stéphane Hilliquin¹, OLIVIER FOGEL², Mathilde Tissier³, Chahrazad Cherifi⁴, Karim Ibrahim⁵, Judith Melki⁶, Robert Olaso⁷, Brigitte Baroukh⁵, Philippe Dieudé⁸, Lars Rogge³, Elisabetta Bianchi³, Marcio Do Cruzeiro⁹, Frederique Cornelis¹⁰, Rik Lories¹⁰, Patricia Albanese⁴, Xavier Houard¹¹, Claire Bardet⁵ and Corinne MICELI¹², ¹Département de Rhumatologie, Hôpital Cochin, Assistance publique des Hôpitaux de Paris, Université Paris-Cité, Paris, France, PARIS, France, ²AP-HP, Paris, France, ³Institut Pasteur, Université Paris Cité, Immunoregulation Unit, F-75015 Paris, France, PARIS, France, ⁴Laboratoire Gly-CREET, Université Paris-Est Créteil Val de Marne (UPEC) Faculté des sciences et technologies, Créteil, France, ⁵Université Paris Cité, Institut des maladies musculo-squelettiques, Laboratory Orofacial Pathologies, Imaging and Biotherapies URP2496 and FHU-DDS-Net, Dental School, and Plateforme d’Imagerie du Vivant (PIV), Montrouge, France,, Montrouge, France, ⁶Université Paris-Saclay, Laboratory Diseases and Hormones of the Nervous Systems, Inserm U1195, Le Kremlin Bicêtre, France, Le Kremlin Bicêtre, France, ⁷Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, Evry, France, ⁸Departement of Rheumatology, AP-HP, Bichat Hospital, Paris, France, ⁹Plateformes PDA et MouseT'IC, Institut Cochin, Université Paris Cité, Paris, France, PARIS, France, ¹⁰Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, ¹¹Centre de Recherche Saint-Antoine, UMR_S938 INSERM /Sorbonne Université, Paris, France, Paris, France, ¹²Université de Paris Cité, APHP, Paris, France
Background/Purpose: Spondyloarthritis (SpA) is an inflammatory rheumatic disease characterized, in its axial form, by lesions affecting the spine and/or sacroiliac joints (SIJ). Severe forms of…
Abstract Number: 0863 • ACR Convergence 2023
Phenotype and Energy Metabolism Differ Between Osteoarthritic Chondrocytes from Male Compared to Female Patients
Lekha Jain, Caitlin Jardim, Richard Yulo, Scott Bolam, A Paul Monk, Jacob Munro, Rocco Pitto, Jade Tamatea, Nicola Dalbeth and Raewyn Poulsen, University of Auckland, Auckland, New Zealand
Background/Purpose: Changes in chondrocyte phenotype and energy metabolism occur in osteoarthritis (OA). The prevalence of OA is higher in females compared to males however whether…
Abstract Number: 0868 • ACR Convergence 2023
Enhancing Oxidative Phosphorylation Through PDK2 Depletion Alleviates Cartilage Degradation in Surgically Induced Osteoarthritis
Seungwoo Han¹, Jin Han², Yujung kim², Yoonhee Kim² and Donghwi Park³, ¹Kyungpook national university hospital, Daegu, South Korea, ²Kyungpook National University, Daegu, South Korea, ³Daegu Fatima hospital, Daegu, South Korea
Background/Purpose: Although chondrocytes rely primarily on glycolysis to meet their cellular energy needs, they have the metabolic flexibility to shift toward oxidative phosphorylation (OxPhos) in…
Abstract Number: 0871 • ACR Convergence 2023
Mitochondrial Transfer Functionally Restores the Human Osteoarthritis (OA) Chondrocyte, Is Protective Against Oxidative Stress and Improves OA in a Clinical Model of Disease
Fernando Figueroa¹, Angela Court², Patricia Luz Crawford², Ana Maria Vega Letter², Francesca Velarde², Cynthia Garcia² and Maroun Khoury², ¹IMPACT, Santiago de Chile, Chile, ²IMPACT, Santiago, Chile
Background/Purpose: Osteoarthrosis (OA) is a leading cause of pain, disability and early mortality, with no disease modifying treatments. Mitochondrial dysfunction is a known driver of…
Abstract Number: 0877 • ACR Convergence 2023
Loss of Transient Receptor Potential Channel 1 (TRPC1) Links Regulation of Intracellular Calcium to Cellular Senescence and Leads to Development of Osteoarthritis
Meike Sambale¹, starlee lively², Osvaldo Espin-Garcia², Pratibha Potla², Chiara Pastrello³, Alexandra Schaefer¹, Jessica Bertrand⁴, Mohit Kapoor⁵, Thomas Pap¹ and Joanna Sherwood¹, ¹University Hospital Münster, Münster, Germany, ²University Health Network, Toronto, ON, Canada, ³Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, ⁴Department of Orthopaedic Surgery, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, ⁵Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane. It is crucial for the…
Abstract Number: 0882 • ACR Convergence 2023
Activation of Ovarian Cancer G-Protein Coupled Receptor (OGR1) Attenuates Chondrocytes Inflammation via ERK1/2 Signaling Pathways in an in Vitro Model of Osteoarthritis
Omar Syed, Bhakti Patel, William Martin, Martha Diaz-Hernandez, Hicham Drissi and Mohd Nazir Khan, Emory University, Atlanta, GA
Background/Purpose: Osteoarthritis (OA) is the most prevalent joint disease, accounting for 50% of the musculoskeletal burden. Inflammation plays a crucial role in the development of…
Abstract Number: 1199 • ACR Convergence 2023
Association of Dipeptidyl Peptidase-4 Inhibitor Use for Type 2 Diabetes and Incidence of OA in Taiwan
Hsiang-Yen Lee¹, Ching-Kuei Chang¹, Tzu-Min Lin¹, Tzu-Tung Ku², Jin-Hua Chen², Yu-Hsiu Chen³, Shu-Chuan Chen⁴ and Chi-Ching Chang², ¹Taipei Medical University Hospital, Taipei, Taiwan, ²Taipei Medical University, Taipei, Taiwan, ³Tri-Service General Hospital, Taipei, Taiwan, ⁴Idaho State University, Idaho State Pocatello, ID
Background/Purpose: Cellular senescence is involved in osteoarthritis (OA) development. Dipeptidyl Peptidase-4 (DPP4) is associated with senescence in OA chondrocytes. It is uncertain whether DPP4 inhibitor…
Abstract Number: 1592 • ACR Convergence 2023
Memantine Attenuates the Development of Osteoarthritis by Blocking NMDA Receptor Mediated Calcium Overload and Chondrocyte Senescence
Ning Wang¹, Qingmei Cheng¹, Xiaoxiao Li², ke he¹, Junyu Zhu¹, Hui Li³ and Jie Wei⁴, ¹中南大学湘雅医院, Changsha, China, ²Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, ³Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ⁴Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Memantine is an FDA proved drug utilized for the treatment of dementia and exerts its function by blocking the NMDA (N-methyl-D-aspartate) receptor, a calcium…
Abstract Number: 1593 • ACR Convergence 2023
Combining Single-cell RNA Sequencing and Population-based Studies Reveals Hand Osteoarthritis-associated Chondrocyte Subpopulations and Pathways
Hui Li¹, Xiaofeng Jiang¹, Yongbing Xiao¹, Yuqing Zhang², Weiya Zhang³, Michael Doherty³, Jacquelyn Nestor⁴, Changjun Li⁵, Jing Ye¹, Tingting Sha⁶, Houchen Lyu¹, Jie Wei⁷, Chao Zeng¹ and Guanghua Lei¹, ¹Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ²Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, ³Academic Rheumatology, Clinical Sciences Building, University of Nottingham, City Hospital, Nottingham, United Kingdom, ⁴Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China, ⁶Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China, ⁷Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Hand osteoarthritis (OA) is a common heterogeneous joint disorder with differences in etiology and pathophysiology from the large weight-bearing knee or hip OA. Its…
Abstract Number: 0024 • ACR Convergence 2022
Exposure to Pollutants with Endocrine Disrupting Properties Is Associated with Early Cartilage Defects and Chondrocyte Inflammatory and Oxidative Activation
Sabryne Berkani¹, Inés Kouki², Sylvie Babajko³, Audrey Pigenet⁴, padmaja Natarajan⁵, Philip Ordoukhanian⁶, Xavier Houard⁴, Martin Lotz⁷, Barbara Demeneix⁸, Jean-Baptiste Fini⁸, Francis Berenbaum⁹, Jérémie SELLAM¹⁰ and Alice Courties¹¹, ¹Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Department of Rheumatology, Assistance Publique , Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, ²Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Department of Rheumatology, Assistance Publique , Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ³Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France, Paris, ⁴Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, ⁵Center for Computational Biology & Bioinformatics and Genomics Core, Scripps Research, La Jolla, California, USA, La Jolla, ⁶Center for Computational Biology & Bioinformatics and Genomics Core, Scripps Research, La Jolla, CA, ⁷Scripps Research, La Jolla, ⁸UMR 7221, Phyma, CNRS-Muséum National d'Histoire Naturelle, Sorbonne Université, 75005 Paris, France., Paris, ⁹Sorbonne University - Saint-Antoine hospital, Paris, France, ¹⁰Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France, ¹¹Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France
Background/Purpose: Humans are exposed to pollutants with endocrine disruptors (ED) properties from their in utero life. Among them, a mix of 15 pollutants (perfluorinated compounds,…
Abstract Number: 0026 • ACR Convergence 2022
Silencing of WISP-2 Induces Inflammatory Mediators and Catabolic Factors in Cartilage
Clara Ruiz-Fernández¹, María González-Rodríguez², Vera Francisco³, Djedjiga Ait Eldjoudi², Alfonso Cordero-Barreal², Yousof Farrag², Jesús Pino⁴, Miguel Ángel González-Gay⁵, Antonio Mera⁶, Francisca Lago² and Oreste Gualillo⁷, ¹Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain, ²Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain, ³Institute of Health Research-INCLIVA, València, Spain, ⁴Santiago Clinic Hospital CHUS-Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain, ⁵Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ⁶Santiago University Clinical Hospital CHUS, Santiago de Compostela, Spain, ⁷Hospital Clínico Universitario de Santiago, SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago de Compostela, Spain
Background/Purpose: Wnt-1 inducible signaling pathway protein 2 (WISP-2/CCN5) is an adipokine that has been described as an important mediator of canonical Wnt activation in adipogenic…

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