ACR Meeting Abstracts

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Abstracts tagged "Cholesterol"

  • Abstract Number: 766 • 2013 ACR/ARHP Annual Meeting

    Cholesterol Accumulation By Synovial Lining Macrophages Results In Ectopic Bone Formation During Experimental Osteoarthritis

    Wouter de Munter1, Arjen B. Blom1, Monique M. Helsen1, Birgitte Walgreen1, Peter M. van Der Kraan1, Leo A. Joosten2, Wim B. van den Berg3 and Peter L. van Lent4, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, 3Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, 4Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Synovial macrophages have previously shown to play a significant role in the etiopathology of experimental collagenase-induced osteoarthritis (OA). In addition to production of pro-inflammatory…
  • Abstract Number: 470 • 2013 ACR/ARHP Annual Meeting

    Sarilumab, a Subcutaneously Administered, Fully Human Monoclonal Antibody Inhibitor Of The IL-6 Receptor Alpha: Relationship Between Inflammation Suppression and Changes In Cholesterol Levels

    Christina Charles-Schoeman1, Steven P. Weinstein2, Janet van Adelsberg3, Tanya Momtahen4, Richard Wu5, Neil Graham6 and Stefano Fiore7, 1Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Clinical Development, Regeneron Pharmaceuticals Inc, Tarrytown, NY, 3Clinical Science, Regeneron Pharmaceutials, Inc., Tarrytown, NY, 4Program Direction, Sanofi, Bridgewater, NJ, 5BioStatistics, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 6Program Direction, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 7Clinical Science, Sanofi, Bridgewater, NJ

    Background/Purpose: Sarilumab (SAR) is a fully human monoclonal antibody directed against the alpha subunit of the IL-6 receptor (IL-6Rα) which is currently being evaluated for…
  • Abstract Number: 342 • 2013 ACR/ARHP Annual Meeting

    TNF Blockage In Psoriatic Arthritis: Long-Term Effect On Lipid Profile

    Julio C. B. Moraes1, Carla G.S. Saad1, Ana Cristina Ribeiro2, Claudia G Schainberg3, Celio R. Gonçalves2, Percival D Sampaio-Barros1 and Eloisa Bonfá2, 1Reumatologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Psoriatic arthritis (PsA) patients have increased cardiovascular morbidity and mortality. Altered lipid profile is an important risk factor for the development of these complications.…
  • Abstract Number: 52 • 2013 ACR/ARHP Annual Meeting

    Altered Lipid Metabolism In Osteoarthritis With Subsequent Proinflammatory Properties Of Apolipoprotein A-I

    Dominique de Seny1, Gaël Cobraiville2, Edith Charlier3, Sophie Neuville2, Laurence Lutteri4, Denis Malaise5, Olivier Malaise3, Jean-Paul Chapelle4, Biserka Relic1 and Michel G. Malaise1, 1Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 2GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 3Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, 4Medical Chemistry - CHU Liège, Liège, Belgium, 5University of Liège, Liège, Belgium

    Background/Purpose: Osteoarthritis (OA) is associated with a local inflammatory process. It is now considered as a metabolic syndrome rather than due to aging or mechanical…
  • Abstract Number: 1290 • 2012 ACR/ARHP Annual Meeting

    Effects of Tofacitinib On Lipid Profiles and Cholesterol and Lipoprotein Kinetics in Patients with Rheumatoid Arthritis

    Christina Charles-Schoeman1, Roy Fleischmann2, Jean Davignon3, Howard Schwartz4, Scott Turner5, Carine Beysen5, Mark Milad6, Zheng Luo7, John Bradley8, Irina Kaplan8, Richard Riese7, Andrea Zuckerman7 and Iain B. McInnes9, 1University of California, Los Angeles, CA, 2Metroplex Clinical Research Center, Dallas, TX, 3University of Montreal, Montreal, Canada, 4Miami Research Associates, Miami, FL, 5KineMed Inc., Emeryville, CA, 6Milad Pharmaceutical Consulting LLC, Plymouth, MI, 7Pfizer Inc., Groton, CT, 8Pfizer Inc, Groton, CT, 9Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Tofacitinib is a novel oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. In RA patients (pts), suppression…
  • Abstract Number: 2157 • 2012 ACR/ARHP Annual Meeting

    Resveratrol Counters Pro-Atherogenic Effects of Systemic Lupus Erythematosus and Rheumatoid Arthritis Plasma On Cholesterol Efflux in Human Macrophages

    Allison B. Reiss1, Iryna Voloshyna1, Ofek Hai1, Michael J. Littlefield1, Elise Belilos2, Kristina B. Belostocki2, Lois A. Bonetti3, Gary C. Rosenblum2 and Steven E. Carsons4, 1Medicine, Winthrop University Hospital, Mineola, NY, 2Rheumatology, Winthrop University Hospital, Mineola, NY, 3Rheum & Immun, Winthrop University Hospital, Mineola, NY, 4Div of Rheumatology, Winthrop University Hospital, Mineola, NY

    Background/Purpose: Our group has demonstrated that resveratrol, a plant polyphenol, possesses atheroprotective properties, enhancing expression of reverse cholesterol transport (RCT) proteins. We have reported that Systemic…
  • Abstract Number: 2515 • 2012 ACR/ARHP Annual Meeting

    Low Density Lipoprotein Receptor Deficiency Results in Osteophyte Formation During Experimental Osteoarthritis Which Is Enhanced Under High Cholesterol Conditions

    Wouter de Munter, Birgitte Walgreen, Monique M. Helsen, Annet W. Sloëtjes, Wim B. van den Berg and Peter L.E.M. van Lent, Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose:  Synovial macrophages are involved in osteophyte formation during experimental collagenase-induced osteoarthritis (OA). Accumulated LDL can be oxidized in an inflammatory environment such as OA…
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