ACR Meeting Abstracts

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Abstracts tagged "Cholesterol and rheumatoid arthritis (RA)"

  • Abstract Number: 86 • 2018 ACR/ARHP Annual Meeting

    Age Dependent Effects of Cholesterol and Smoking on the Risk of Rheumatoid Arthritis in Women – Results from a Nested Case Control Study

    Carl Turesson1,2, Ulf Bergström1, Jan-Åke Nilsson1,2 and Lennart Jacobsson3, 1Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, 3Dept of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden, Gothenburg, Sweden

    Background/Purpose: Smoking is an established risk factor for rheumatoid arthritis (RA). A positive association between body mass index (BMI) and the risk of RA in…
  • Abstract Number: 2354 • 2018 ACR/ARHP Annual Meeting

    Perspectives of Patients with Inflammatory Arthritis Regarding Cardiovascular Risk: A Qualitative Study

    Iris Navarro-Millán1,2, Sarah Young3, Sally Shurbaji4, Chastity McDavid4, Anna Cornelius-Schecter2, Bernadette Johnson4, Andrea Cherrington4, Liana Fraenkel5, Jeffrey R. Curtis4 and Monika M. Safford2, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medicine, New York, NY, 3Binghamton University, Binghamton, NY, 4University of Alabama at Birmingham, Birmingham, AL, 5Yale University, New Haven, CT

    Background/Purpose: Cardiovascular disease (CVD) is the most common cause of death among patients with inflammatory arthritis (IA) such as rheumatoid arthritis (RA), psoriatic arthritis (PsA)…
  • Abstract Number: 1460 • 2016 ACR/ARHP Annual Meeting

    Suppression of Cholesterol Levels and Impairment in Cholesterol Efflux By HDL in K/BxN Mice Is Associated with a Specific Cytokine/Chemokine Profile

    Christina Charles-Schoeman1, Ani Shahbazian2, Yuen Yin Lee3, Buzand Oganesian4, Victor Grijalva5, Anabel Garcia Heredia1 and Srinivasa T. Reddy5, 1University of California, Los Angeles, Los Angeles, CA, 2Medicine-Rheumatology, University of California, Los Angeles, Los Angeles, CA, 3Medicine- Rheumatology, University of California Los Angeles, Los Angeles, CA, 4Medicine-Rheumatology, University of California, Los Angeles, Los ANgeles, CA, 5Medicine-Cardiology, University of California, Los Angeles, Los Angeles, CA

    Background/Purpose:  Better understanding of lipid metabolism in active rheumatoid arthritis (RA) is needed to understand the cholesterol changes associated with active disease, as well as…
  • Abstract Number: 1558 • 2015 ACR/ARHP Annual Meeting

    Serum Cathepsin S and Cystatin C Relation with Carotid Subclinical Atheromatosis in Rheumatoid Arthritis Patients

    Beatriz Tejera Segura1, De Vera-González AM2, Raquel López-Mejías3, Miguel A. Gonzalez-Gay4 and Ivan Ferraz-Amaro1, 1Division of Rheumatology, University Hospital of Canary Islands, Tenerife, Spain, 2Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 4Reumatologia, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular risks. Cathepsin S, a cysteine protease implicated in intracellular and extracellular proteolysis,…
  • Abstract Number: 1681 • 2015 ACR/ARHP Annual Meeting

    4-Week Treatment of Rheumatoid Arthritis Patients with the JAK1-Selective Inhibitor Filgotinib (GLPG0634) Changes Lipid Profile with a Preferential Increase in HDL

    René Galien1, Pille Harrison2, Reginald Brys2, Annegret Van der Aa2, Gerben van 't Klooster2 and Chantal Tasset2, 1Galapagos SASU, Romainville, France, 2Galapagos NV, Mechelen, Belgium

    Background/Purpose: Patients with active rheumatoid arthritis (RA) present low levels of lipids - total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c), high density lipoprotein-cholesterol (HDL-c) and…
  • Abstract Number: 1437 • 2014 ACR/ARHP Annual Meeting

    Cholesterol Efflux Capacity of HDL and Coronary Atherosclerosis in Rheumatoid Arthritis

    Michelle J. Ormseth1, Patricia Yancey2, Suguru Yamamoto2, Annette M. Oeser1, Tebeb Gebretsadik3, Ayumi Shintani1, MacRae F. Linton1, Sergio Fazio1, Sean Davies1, L Jackson Roberts II1, Kasey C. Vickers1, Paolo Raggi4, Valentina Kon1 and C Michael Stein1, 1Vanderbilt University, Nashville, TN, 2Medicine, Vanderbilt University, Nashville, TN, 3Biostatistics, Vanderbilt University, Nashville, TN, 4Emory University, Atlanta, GA

    Background/Purpose: Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL…
  • Abstract Number: 399 • 2014 ACR/ARHP Annual Meeting

    Lipid Concentrations and Particle Sizes in Drug Naive Patients with Rheumatoid Arthritis

    Aulikki Kononoff1, Hannu Kautiainen2, Pasi Soininen3,4, Antti Kangas3,4, Leena Laasonen5, Leena Arstila1,6, Pia Elfving1, Elina Savolainen7, Helena Niinisalo8,9, Mika Ala-Korpela3,4,10,11 and Oili Kaipiainen-Seppanen1, 1Department of Medicine, Kuopio University Hospital, Kuopio, Finland, 2Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland, 3Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, 4NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 5Helsinki Medical Imaging Center, Helsinki University Hospital, Helsinki, Finland, 6Iisalmi Hospital, Iisalmi, Finland, 7Kuopio Municipal Hospital, Kuopio, Finland, 8Varkaus Hospital, Varkaus, Finland, 9Suonenjoki Health Center, Suonenjoki, Finland, 10Oulu University Hospital, Oulu, Finland, 11Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom

    Background/Purpose Excess mortality attributed to cardiovascular causes has been described among patients with rheumatoid arthritis (RA). Atherosclerotic lipid profile has been reported in patients with…
  • Abstract Number: 334 • 2014 ACR/ARHP Annual Meeting

    Inflammatory Arthritis in K/BxN Mice Is Associated with Abnormal HDL Function

    C. Charles-Schoeman1, Ani Shahbazian1, Yuen Yin Lee1 and Srinivasa T. Reddy2, 1Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality.  Abnormal function of high density lipoprotein (HDL) has been implicated as…
  • Abstract Number: 1256 • 2012 ACR/ARHP Annual Meeting

    High Inflammation May Condition the Antiatherogenic Function of Small, Dense HDL in Patients with Active Rheumatoid Arthritis

    Carla Saucedo1, Leonardo gomez Rosso2, Tomas Meroño2, Fernando Brites2, Anatol Kontush3, Luis J. Catoggio4, Enrique Soriano4, Laurent Camont5, Marie Lhomme5, Veronica Malah6, Patricia Sorroche7, Sandrine Chantepie5, Paul Robillard8 and John Chapman5, 1Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2University of Buenos Aires, Laboratory of Lipids and Lipoproteins, School of Pharmacy and Biochemistry, Buenos Aires, Argentina, 3Université Pierre et Marie Curie-Paris, Paris, France, 4Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Université Pierre et Marie Curie, Paris, France, 6Rheumatology section, Hospital de Clínicas “José de San Martín”, Buenos Aires, Argentina, 7Central Laboratory , Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 8Université Pierre et Marie Curie, Paris, Argentina

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased mortality, mainly due to cardiovascular disease.  High grade inflammation might drive to premature atherosclerosis. High-density lipoprotein (HDL)…
  • Abstract Number: 1252 • 2012 ACR/ARHP Annual Meeting

    Association of Paraoxonase 1 Gene Polymorphisms and Enzyme Activity with Carotid Plaque in Rheumatoid Arthritis

    Christina Charles-Schoeman1, Yuen Yin Lee1, Veena K. Ranganath1, John FitzGerald1, Mihaela B. Taylor2, Maureen A. McMahon1, David Elashoff3 and Srinivasa T. Reddy4, 1University of California, Los Angeles, CA, 2University of California, Los Angeles, Los Angeles, CA, 3Medicine- Statistic Core, UCLA Department of Medicine Statistics Core, Los Angeles, CA, 4Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Paraoxonase 1 (PON1) is a high density lipoprotein (HDL) associated enzyme, which promotes the anti-oxidant and anti-inflammatory properties of HDL.  PON1 polymorphisms and enzyme…
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