ACR Meeting Abstracts

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Abstracts tagged "chemokines"

  • Abstract Number: 1990 • ACR Convergence 2024

    Human Umbilical Cord Mesenchymal Stem Cell-derived Microvesicles Alleviate Pulmonary Fibrosis by Inhibiting Monocyte-macrophage Migration Through ERK1/2 Signaling-mediated Suppression of CCL2 Expression

    Xiuping Liang, West China Hospital, Sichuan University, Cheng Du Shi, Sichuan, China

    Background/Purpose: Pulmonary fibrosis (PF) is a disease with high morbidity and mortality rates, but effective treatment options extremely limited. Mesenchymal stem cells (MSCs) and their…
  • Abstract Number: 0012 • ACR Convergence 2024

    Dichotomous Expression of CXCR3 and CCR9 and Relationship to Intestinal Permeability in B Cells in Rheumatoid Arthritis

    Ken Yasaka, Ruoqiao Wang, Nida Pellett, Daria Krenitsky, Juilee Thakar and Jennifer Anolik, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: The gut is a key mucosal tissue that can impact the immune system and contribute to systemic inflammation in the setting of increased intestinal…
  • Abstract Number: 0017 • ACR Convergence 2024

    Syndecan-1 Plays a Role in the Pathogenesis of Sjögren’s Syndrome by Inducing B-cell Chemotaxis Through CXCL13-heparan Sulfate Interaction

    Sang Jin Lee1, Nan Young Lee2, Eun Joo Lee3, Ji Ae Jang3, Gun Woo Kim3 and Eon Jeong Nam2, 1Kyungpook National University Hospital, Daegu, Republic of Korea, 2Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea, 3Daegu Fatima Hospital, Daegu, Republic of Korea

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a prototypical autoimmune disorder with lymphocytic infiltration of exocrine and non-exocrine epithelia, where complex interactions between innate and adaptive…
  • Abstract Number: 0048 • ACR Convergence 2024

    Role of the Chemokine CCL22 in Rheumatoid Arthritis Development

    Marcelo Afonso1, Masa Filipovic1, Alexandra Argyriou2, Alexandra Circiumaru3, Mikael Ringh1, Konstantin Carlberg1, Vijay Joshua1, Szu-Jing Chen1, Marianne Engström1, Heidi Wähämaa1, Tomas Ekström1, Marc H Wadsworth II4, Ravi Kumar1, Aaron Winkler5, Vivianne Malmström1, Anca Catrina1, Karine Chemin1, Aase Hensvold1 and Bence Réthi1, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Solna, Sweden, 3Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden, 4Pfizer, Cambridge, 5Pfizer Inc., Cambridge, MA

    Background/Purpose: Understanding alterations of the immune homeostasis in individuals at risk of rheumatoid arthritis (RA) can be a key to achieve earlier diagnosis and prevention.…
  • Abstract Number: 0605 • ACR Convergence 2024

    Guselkumab Binding to CD64+ IL-23–Producing Myeloid Cells Enhances Potency for Neutralizing IL-23 Signaling

    Dennis McGonagle1, Raja Atreya2, Maria Abreu3, James Krueger4, Kilian Eyerich5, Robert Bissonnette6, Carrie Greving7, He Li8, Tom C. Freeman9, Amy Hart8, Brice Keyes7, Brian Stoveken8, John Hartman8, Kristin Leppard8, Jenna Parrett10, Joshua Wertheimer8, Indra Sarabia7, Janise Deming7, Kristen Kohler7, Christopher Ritchlin11, Iain McInnes12, Matthieu Allez13, Anne Fourie7 and Kacey Sachen7, 1National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds Teaching Hospitals, Leeds, UK, Leeds, England, United Kingdom, 2Department of Medicine I, Gastroenterology, Endocrinology and Pneumology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 3Leonard M. Miller School of Medicine, University of Miami, Miami, FL, 4The Rockefeller University, Laboratory for Investigative Dermatology, New York, NY, 5Karolinska Institute, Department of Medicine – Division of Dermatology and Venereology, Stockholm, Sweden; Medical Center, University of Freiburg, Freiburg, Germany, 6Innovaderm Research Inc., Montréal, QC, Canada, 7Janssen Research & Development, LLC, Immunology, San Diego, CA, 8Janssen Research & Development, LLC, Therapeutics Discovery, Spring House, PA, 9Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 10Janssen Scientific Affairs, LLC, Horsham, PA, 11Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, 12University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 13Hôpital Saint-Louis, Université Paris Cité, Paris, France

    Background/Purpose: IL-23 is implicated in the pathogenesis of psoriasis (PsO), and myeloid cells that express FcγRI (CD64) have been identified as a primary source of…
  • Abstract Number: 0860 • ACR Convergence 2024

    Integrated Metabolic and Immunologic Analyses Reveal Distinctive Features of Comorbid Cancer in Patients with Autoimmune Diseases

    Xiangyi Shen1, Xu Jiang2, Yangzhige He2 and Huaxia Yang3, 1Tsinghua University, Beijing, China, 2National Infrastructure for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 3Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases, the Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Background/Purpose: Autoimmune diseases (AIDs) increase the risk of cancer and impose a substantial socioeconomic burden worldwide. However, the biological characteristics of cancer as a comorbidity…
  • Abstract Number: 0940 • ACR Convergence 2024

    Trans-endothelial Migration of Synovial Fibroblasts Promotes Arthritis Severity Through a PKD1-mediated Feedback Loop

    Jaeyeon Kim, Richard Ainsworth and Nunzio Bottini, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: The application of single cell genomic approaches to the study of rheumatoid synovium has recently enabled scientists to study the complex relationship between different…
  • Abstract Number: 1594 • ACR Convergence 2024

    Response to Mepolizumab Therapy in a Single-center Cohort of Eosinophilic Granulomatosis with Polyangiitis Patients: Characterization of Cytokine/Chemokine Pattern and Phenotypic Stratification

    Michele Moretti1, Francesco Ferro2, Irene Martelli3, Francesca Pistone3, Giulia Greco3, Federica Di Cianni4, Nazzareno Italiano5, ROSARIA TALARICO4, Veronica Seccia6, Chiara Baldini7, Ilaria Puxeddu3 and Marta Mosca7, 1University of Pisa, Pisa, Pisa, Italy, 2Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, 3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 4University of Pisa, Pisa, Italy, 5University of Pisa, Rovigo, Italy, 6Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy, 7University of Pisa, Department of Clinical and Experimental Medicine - Rheumatology Unit, Pisa, Italy

    Background/Purpose: The introduction of Mepolizumab treatment has revolutionized the therapy of EGPA and has promoted the search for biomarkers predictive of response to treatment. However,…
  • Abstract Number: 1703 • ACR Convergence 2024

    Single Cell and Spatial Transcriptomics Implicate Vascular Cell Orchestration of Inflammatory Changes After Ultraviolet Light Exposure

    Rachael Wasikowski1, Erin Theisen2, Jie An3, Lam C. Tsoi1, Ksenia Anufrieva4, Kevin Wei5, Johann Gudjonsson6 and Keith Elkon3, 1Michigan, Dept. of Dermatology, Ann Arbor, MI, 2Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 3University of Washington, Seattle, WA, 4BWH, Cambridge, MA, 5Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 6University of Michigan, Ann Arbor, MI

    Background/Purpose: Skin sensitivity to sunlight affects ~70% of systemic lupus erythematosus (SLE). In addition, ultraviolet radiation (UVR) can stimulate systemic disease flares, but how this…
  • Abstract Number: 1798 • ACR Convergence 2024

    CXCL6 Synthesized by Proximal Tubule Cells May Promote Fibrosis in Lupus Nephritis

    Philip Carlucci1, Nalani Sachan2, Andrea Fava3, Brooke Cohen2, Jasmine Shwetar4, Siddarth Gurajala5, Qian Xiao5, Joseph Mears6, Katie Preisinger2, Devyn Zaminski7, Kristina Deonaraine8, Peter Izmirly9, Judith James10, Joel Guthridge10, Wade DeJager11, David Wofsy12, Cynthia Loomis2, Gyles Ward2, Ming Wu13, Chaim Putterman14, Deepak Rao15, Betty Diamond16, Derek Fine17, Jose Monroy-Trujillo17, H Michael Belmont7, William Apruzzese18, Anne Davidson19, Richard Furie20, Paul Hoover21, Celine Berthier22, Maria Dall'Era23, Diane Kamen24, Kenneth Kalunian25, Jennifer Anolik26, Jennifer Barnas27, Arnon Arazi28, Soumya Raychaudhuri29, Nir Hacohen30, Robert Clancy31, Kelly Ruggles32, Michelle Petri33 and Jill Buyon2, and the Accelerating Medicines Partnership in RA/SLE, 1New York University School of Medicine, New York, NY, 2NYU Grossman School of Medicine, New York, NY, 3Johns Hopkins University, Baltimore, MD, 4New York School of Medicine, Ann Arbor, MI, 5Harvard Medical School, Boston, MA, 6Michigan University, Ann Arbor, MI, 7NYU School of Medicine, New York, NY, 8Jacobs School of Medicine, University at Buffalo, Buffalo, NY, 9New York University Grossman School of Medicine, New York, NY, 10Oklahoma Medical Research Foundation, Oklahoma City, OK, 11Oklahoma Medical Research Foundation, Oklahoma City, 12University of California San Francisco, SF, CA, 13Northwell, New York, NY, 14Albert Einstein College of Medicine, Safed, Israel, 15Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 16The Feinstein Institutes for Medical Research, Manhasset, NY, 17Johns Hopkins School of Medicine, Baltimore, MD, 18Brigham and Women's Hospital, Everett, MA, 19Feinstein Institutes for Medical Research, Manhasset, NY, 20Northwell Health, Manhasset, NY, 21Brigham and Women's Hospital, SWAMPSCOTT, MA, 22University of Michigan, Ann Arbor, MI, 23UCSF, Corte Madera, CA, 24Medical University of South Carolina, Charleston, SC, 25University of California San Diego, La Jolla, CA, 26University of Rochester Medical Center, Rochester, NY, 27University of Rochester, Rochester, NY, 28Feinstein Institutes for Medical Research, Melrose, MA, 29Brigham and Women's Hospital, Boston, MA, 30Broad Institute of MIT and Harvard, Boston, MA, 31Columbia University Medical Center, New York, NY, 32NYU Grossman School of Medicine, Brooklyn, NY, 33Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Detection of urinary CXCL6, a member of the IL-8 chemokine family, has been linked to CKD and is a proposed marker of chronic damage…
  • Abstract Number: 1843 • ACR Convergence 2024

    Immune Responses to Herpes Zoster Vaccine Responses in Rheumatic Patients on JAK Inhibitors: Insights in Humoral and Cellular Response

    cristiana sieiro santos1, Juan Garcia Herrero2, Jose Ordas Martínez3, Alejandra López Robles4, Carolina Álvarez Castro4, Ronald Colindres4, Estefanía Robles Martin4, Ana María Sahagún5 and Jose María Ruiz de Morales4, 1Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 2Complejo Asistencial Universitario de León, León, Castilla y Leon, Spain, 3Complejo Asistencial Universitario de Leon, Leon, 4Complejo Asistencial Universitario de León, León, Spain, 5University of Leon, León, Spain

    Background/Purpose: Patients with immune-mediated rheumatic diseases treated with JAK inhibitors face an elevated risk of herpes zoster (HZ) infection. Shingrix, a recombinant inactive vaccine, offers…
  • Abstract Number: 1856 • ACR Convergence 2024

    Distinct Proliferative and Special Properties of Peripheral Helper T Cells in RA Synovium

    Yuki Masuo1, Akinori Murakami1, Rinko Akamine1, Osamu Iri1, Koichi Murata1, Kohei Nishitani1, Hiromu Ito1, Takayuki Fujii1, Ryu Watanabe2, Takeshi Iwasaki1, Shinichiro Nakamura1, Shinichi Kuriyama1, Yugo Morita1, Yasuhiro Murakawa1, Chikashi Terao3, Yukinori Okada4, Motomu Hashimoto2, Shuichi Matsuda5, Hideki Ueno1 and Hiroyuki Yoshitomi1, 1Kyoto University, Kyoto, Japan, 2Osaka Metropolitan University, Osaka, Japan, 3RIKEN, Tokyo, Japan, 4The University of Tokyo / Osaka University / RIKEN, Tokyo, Japan, 5Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan

    Background/Purpose: Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells that are frequently observed in the target tissues of chronic diseases. In patients with…
  • Abstract Number: 2206 • ACR Convergence 2023

    Increased Frequency of Activated MAIT Cells Expressing the Gut Homing Receptor CCR9 in Patients with Radiographic Axial Spondyloarthritis

    Eric Toussirot1, Caroline Laheurte2, Eléonore Gravelin2, Charline Vauchy3, Marc Puyraveau3 and Philippe Saas4, 1University Hospital of Besancon, Besançon, France, 2INSERM UMR1098, plateforme de biomonitoring, EFS Bourgogne-Franche-Comté, Besançon, France, 3INSERM CIC-1431, Besançon, France, 4INSERM UMR1098, EFS Bourgogne-Franche-Comté, Besançon, France

    Background/Purpose: MAIT (mucosal associated invariant T) cells are involved in mucosa defense against bacteria. This cellular subset is characterized by a semi-invariant αβ TCR and…
  • Abstract Number: 2352 • ACR Convergence 2023

    High Serum C-X-C Motif Chemokine Ligand 10 (CXCL10) Potentially Predicts New Onset of Systemic Sclerosis-Interstitial Lung Disease

    Yehya Al-Adwi, Isabella Atzeni, Berber Doornbos-van der Meer, Marcel J van der Leij, Bart-Jan Kroesen, Alja Stel, Wim Timens, C.Tji Gan, Harry van Goor, Johanna Westra and Douwe J Mulder, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Systemic sclerosis-interstitial lung disease (SSc-ILD) is the leading cause of death in SSc patients. There is an unmet need for predictive biomarkers of ILD…
  • Abstract Number: 2357 • ACR Convergence 2023

    The Involvement of CCR3-CCL24 Axis in Endothelial to Mesenchymal Transition Process and Pulmonary Arterial Hypertension in Systemic Sclerosis Patients

    Itzchak Amoyal1, Tzipi Hornik-Lurie2, Tali Zitman-Gal1, Hilit Levy3, Ilan Vaknin3, Liat Drucker4, Ishai Heusler5, Yair Levy1 and Shelly Tartakover Matalon1, 1Meir Medical Center, Autoimmune Research Laboratory, Kfar-Saba, Israel, 2Meir Medical Center, Data Research Department, Kfar-Saba, Israel, 3Chemomab Ltd, Tel Aviv, Israel, 4Meir Medical Center, Oncogenetics Laboratory, Kfar Saba, Israel, 5Meir Medical Center, Department of Obstetric and Genecology, Kfar-Saba, Israel

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and extensive tissue fibrosis of the skin and internal organs. Endothelial cells (ECs),…
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