Abstracts tagged "Chemokine Receptors"

Abstract Number: 1914 • 2017 ACR/ARHP Annual Meeting
Discovery of a Novel CD8+ T Cell Population in Ankylosing Spondylitis Implicates Gut-Joint Trafficking in the Disease
Zoya Qaiyum^1,2, Eric Gracey^3,4, Yuchen Yao^3,4 and Robert D Inman⁵, ¹Genetics and Development, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Immunology, University of Toronto, Toronto, ON, Canada, ³Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Immunology and Institute of Medical Science, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Ankylosing spondylitis (AS) has a strong connection with gut inflammation: 10% of AS patients have inflammatory bowel disease (IBD) and 60% have subclinical ileal…
Abstract Number: 2231 • 2017 ACR/ARHP Annual Meeting
MCC22, a Novel Compound That Targets Both CCR5 and Mu Opioid Receptors, Is Highly Effective in Treating Inflammatory Arthritis Pain
Raini Dutta¹, Mary Lunzer², Jennifer L. Auger³, Eyup Akgün², Philip Porthoghese² and Bryce A. Binstadt³, ¹Pediatrics, University of Minnesota, Minneapolis, MN, ²Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, ³Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN
Background/Purpose: The pain that accompanies rheumatoid arthritis and other chronic inflammatory conditions is difficult to manage. Although opioids provide potent analgesia, chronic opioid use is…
Abstract Number: 2232 • 2017 ACR/ARHP Annual Meeting
A Role for CCR2 in Chronic Behavioral and Neuroimmune Changes in the DMM Model of Osteoarthritis
Phuong Tran¹, Shingo Ishihara², Rachel E. Miller³, Richard J. Miller⁴ and Anne-Marie Malfait¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Biochemistry, Rush University Medical Center, Chicago, IL, ⁴Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL
Background/Purpose: The aim of this study was to explore pain-related behaviors and associated cellular changes in the pain pathway in experimental osteoarthritis (OA) induced by…
Abstract Number: 925 • 2016 ACR/ARHP Annual Meeting
Complement C5a Receptor Is the Key Initiator of Neutrophil Adhesion and Inflammation in Immune Complex-Induced Arthritis
Yoshishige Miyabe¹, Chie Miyabe¹, Thomas Murooka², Edward Kim³, Nancy Kim³, Thorsten R. Mempel⁴ and Andrew D. Luster¹, ¹Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²University of Manitoba, Winnipeg, MB, Canada, ³Massachusetts General Hospital, Boston, MA, ⁴Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Inflammatory arthritis, including rheumatoid arthritis, is characterized by neutrophil (PMN) recruitment into the joint in a highly regulated process controlled by chemoattractants (CAs). Four…
Abstract Number: 1082 • 2016 ACR/ARHP Annual Meeting
Type I/II Interferon Commits to Abnormal Expression of Chemokine Receptor on B Cells in Patients with Systemic Lupus Erythematosus
Maiko Yoshikawa¹, Shingo Nakayamada², Satoshi Kubo³, Shigeru Iwata⁴, Kei Sakata⁵, Yusuke Miyazaki³, Kazuhisa Nakano², Kazuyoshi Saito⁶ and Yoshiya Tanaka⁷, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyusyu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁴First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan, ⁶University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁷University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an expanded population of peripheral memory B cells. However, little is known about the qualitative abnormality of…
Abstract Number: 1920 • 2016 ACR/ARHP Annual Meeting
Vitamin D Induces a Type 1 Regulatory T Cell (Tr1)-like Phenotype in Human C-C Chemokine Receptor Type 6 (Ccr6)+ th Cells and Promotes Their Migration to an Inflammatory Environment
Wendy Dankers¹, Jan Piet van Hamburg¹, Nadine Davelaar¹, Patrick Asmawidjaja¹, Hoyan Wen¹, Johannes van Leeuwen², Edgar Colin³ and Erik Lubberts¹, ¹Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, ZGT, Almelo, Netherlands
Background/Purpose: The active vitamin D metabolite 1,25(OH)2D3 suppresses various experimental autoimmune diseases. In addition, serum vitamin D levels, vitamin D intake and polymorphisms in the…
Abstract Number: 2144 • 2016 ACR/ARHP Annual Meeting
Functional Analysis of Macrophages in BehçEt’s Disease: C-C Chemokine Receptor Type 1 (CCR1) and IL-10 Are Implicated in Pathogenesis of the Disease
Hiroto Nakano¹, Yohei Kirino¹, Momoko Ohno¹, Kana Higashitani¹, Mitsuhiro Takeno², Ryusuke Yoshimi¹ and Hideaki Nakajima³, ¹Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
Background/Purpose: The recent GWAS and subsequent studies have identified susceptible genes such as CCR1 and IL10 genes, suggesting pathological roles of macrophages in Behçet's disease…
Abstract Number: 3040 • 2016 ACR/ARHP Annual Meeting
Th17 Migration into the Synovial Fluid of Patients with Active Psoriatic Arthritis Is Enhanced By Regulatory T Cells
Helen Baldwin¹, Amara Ezeonyeji², Mohammed Rohan Butt² and Michael R. Ehrenstein³, ¹Rheumatology, University College London, London, United Kingdom, ²Rheumatology, Medicine, University College London, London, United Kingdom, ³Medicine, University College London, London, United Kingdom
Background/Purpose: Uncontrolled migration of Th17 cells into the skin and joints is a major driver in the pathogenesis of psoriatic arthritis (PsA). Modulation of T…
Abstract Number: 991 • 2015 ACR/ARHP Annual Meeting
CaMK4 Facilitates Recruitment of IL-17 Producing Cells to Target Organs through the CCR6/CCL20 Axis in Th17-Driven Inflammatory Diseases
Tomohiro Koga^1,2, Kotaro Otomo³, Masayuki Mizui², Nobuya Yoshida⁴, José C. Crispin², Atsushi Kawakami⁵ and George C. Tsokos⁴, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan
Background/Purpose: The recruitment of IL-17 producing T helper (Th17) cells to the inflammatory sites has been implicated in the development of organ damage in inflammatory…
Abstract Number: 1118 • 2015 ACR/ARHP Annual Meeting
Role of the Chemokine Receptor CXCR3 in the Function of Regulatory B Cells in Patients with SLE
Shun-ichiro Ota^1,2, Hiroaki Niiro³, Naoko Ueki^2,4, Yuri Hirosaki², Hirofumi Tsuzuki², Siamak Jabbarzadeh-Tabrizi², Tsuyoshi Nakayama², Koji Mishima², Ayako Takaki², Hiroki Mitoma², Mitsuteru Akahoshi², Yojiro Arinobu², Hiroshi Tsukamoto² and Koichi Akashi², ¹Department of Rheumatology, Internal medicine and connective tissue disorders, Shimonoseki City Hospital, Shimonoseki, Japan, ²Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ³Clinical Education Center, Kyushu University Hospital, Fukuoka, Japan, ⁴Division of Nephrology and Rheumatology, Fukuoka University, Fukuoka, Japan
Background/Purpose: The emerging application of B-cell directed therapies in autoimmune diseases has led to the discovery of a novel B cell population, referred to as…
Abstract Number: 1173 • 2015 ACR/ARHP Annual Meeting
G Protein Coupled Receptor Kinase 3 Regulation of Inflammatory Arthritis
Matthew J. Billard¹, Roman Timoshchenko², D. Stephen Serafin² and Teresa K. Tarrant³, ¹Medicine, University of North Carolina, Chapel Hill, NC, ²Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ³Rheumatology, University of North Carolina, Chapel Hill, NC
Background/Purpose: Chemokine receptors are G Protein Coupled Receptor (GPCR) family members that direct cell migration, differentiation, and survival in inflammatory conditions, but neutralization strategies…
Abstract Number: 1369 • 2015 ACR/ARHP Annual Meeting
Enhanced Myelopoiesis Downstream of Toll-like Receptor 9 Activation Drives a Feed-Forward Inflammatory Response
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Monocytes are myeloid cells important for the initiation of inflammation and have been implicated in the pathogenesis of autoimmunity. Monocytes interact with their environment…
Abstract Number: 1931 • 2015 ACR/ARHP Annual Meeting
PLCe1 Mediates Cellular Adhesion Downstream of SDF-1 in T Cells
Adam Mor¹ and Marianne Strazza², ¹Rheumatology and Pathology, NYU Langone Medical Center, New York, NY, ²NYU, New York, NY
Background/Purpose: The presentation of chemokines by endothelial cells results in chemoattraction of leukocytes that express the correlative chemokine receptors. In this way, chemokines direct leukocyte…
Abstract Number: 2009 • 2015 ACR/ARHP Annual Meeting
CC-Chemokine Receptor 7 (CCR7) Deficiency Reduces Early Structural and Functional Features of Disease in a Murine Model of Osteoarthritis
Nisha Sambamurthy^1,2, Vu Nguyen^1,2, Patrick Diviney³, Justin Gan⁴, Charles Bush-Joseph⁵, Susanna Chubinskaya⁶, Anne-Marie Malfait⁷, George Dodge^2,3 and Carla R. Scanzello^8,9, ¹Medicine / Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Research, Philadelphia VA Medical Center, Philadelphia, PA, ³Orthopedics, University of Pennsylvania, Philadelphia, PA, ⁴Rheumatology, Rush University Medical Center, Chicago, IL, ⁵Orthopedics, Rush University Medical Center, Chicago, IL, ⁶Biochemistry, Rush University Medical Center, Chicago, IL, ⁷Rush University Medeical Center, Chicago, IL, ⁸Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Rheumatology, University of Pennsylvania Perelman School of Medicine & Philadelphia VA Medical Center, Philadelphia, PA
Background/Purpose: Synovial expression of CCR7 has been associated with inflammation and severity of symptoms in patients with meniscal tears and early osteoarthritis (OA). This receptor…
Abstract Number: 2013 • 2015 ACR/ARHP Annual Meeting
TIARP Attenuates Autoantibody-Mediated Arthritis Via the Suppression of Neutrophil Infiltration into the Joint
Asuka Inoue¹, Isao Matsumoto¹, Yuki Tanaka², Naoto Umeda¹, Hoshimi Kawaguchi¹, Hiroshi Ebe¹, Yoshihiro Matsumoto³ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan, ³Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: TIARP (TNFα-induced adipose-related protein) is dominantly expressed in macrophages (Mφ), neutrophils (PMN) and fibroblast-like synoviocytes (FLS). Recently, we found that TIARP functions as a…

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