Abstracts tagged "Chemokine Receptors"

Abstract Number: 40 • 2017 ACR/ARHP Annual Meeting
B-Cell Attracting Chemokine-1 (BCA-1) and Macrophage Inflammatory Protein-3 Alpha (MIP-3α) Act Synergistically in the Recruitment of B Cells in the Rheumatoid Synovium
Estefanía Armas-González¹, María Jesús Domínguez-Luis², María Teresa Arce-Franco³, Javier Castro-Hernández³, Vanesa Hernandez⁴, Sagrario Bustabad⁵, Alberto Cantabrana-Alutiz⁶ and Federico Díaz-González⁷, ¹Universidad de La Laguna, Departamento de Medicina Física y Farmacología, Facultad de Medicina, La Laguna, Tenerife, Spain, ²Laboratorio de Reumatología. Hospital Universitario de Canarias, La Laguna, Spain, ³Laboratorio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ⁴Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, S/C Tenerife, Spain, ⁵Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ⁶Servicio de Reumatología. Hospital Universitario Nuestra Señora de Candelaria, La Laguna, Tenerife, Spain, ⁷Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Background/Purpose: B cells are recognized as key players in the pathogenesis of rheumatoid arthritis (AR) through the production of autoantibodies, the local production of proinflammatory…
Abstract Number: 397 • 2017 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Ameliorates Joint Destruction in Collagen-Induced Arthritis Model through Suppression of Osteoclast Precursor Cell Survival and Migration
Yoshikazu Kuboi¹, Kana Hoshino-Negishi¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai³, ¹KAN Research Institute, Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³KAN Research Institute, Inc., Kobe, Japan
Background/Purpose: In the Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN) mAb demonstrated a promising efficacy in active RA patients who were inadequately…
Abstract Number: 553 • 2017 ACR/ARHP Annual Meeting
Decreased Circulating CXCR3+CCR9+ Th Cells Coincides with Elevated Levels of Their Ligands CXCL10 and CCL25 in the Salivary Gland of Sjögren’s Syndrome Patients Which Synergistically Facilitate Th Cell Migration
Sofie L.M. Blokland^1,2, Maarten R. Hillen^3,4, Stephan Meller⁵, Bernhard Homey⁵, Glennda Smithson⁶, Aike A. Kruize², Timothy R.D.J. Radstake^2,7 and Joel A.G. van Roon^2,3, ¹Rheumatology & Clinical Immunology/ Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Department of Dermatology, University of Düsseldorf, Düsseldorf, Germany, ⁶Takeda Global Research & Development Center, Inc, Chicago, IL, ⁷Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Primary Sjögren’s syndrome (pSS) is characterized by dryness and lymphocytic infiltration in the salivary glands. CXCR3+ T cells and ligands CXCL9/10/11 are known to…
Abstract Number: 925 • 2016 ACR/ARHP Annual Meeting
Complement C5a Receptor Is the Key Initiator of Neutrophil Adhesion and Inflammation in Immune Complex-Induced Arthritis
Yoshishige Miyabe¹, Chie Miyabe¹, Thomas Murooka², Edward Kim³, Nancy Kim³, Thorsten R. Mempel⁴ and Andrew D. Luster¹, ¹Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²University of Manitoba, Winnipeg, MB, Canada, ³Massachusetts General Hospital, Boston, MA, ⁴Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Inflammatory arthritis, including rheumatoid arthritis, is characterized by neutrophil (PMN) recruitment into the joint in a highly regulated process controlled by chemoattractants (CAs). Four…
Abstract Number: 1082 • 2016 ACR/ARHP Annual Meeting
Type I/II Interferon Commits to Abnormal Expression of Chemokine Receptor on B Cells in Patients with Systemic Lupus Erythematosus
Maiko Yoshikawa¹, Shingo Nakayamada², Satoshi Kubo³, Shigeru Iwata⁴, Kei Sakata⁵, Yusuke Miyazaki³, Kazuhisa Nakano², Kazuyoshi Saito⁶ and Yoshiya Tanaka⁷, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyusyu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁴First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan, ⁶University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁷University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an expanded population of peripheral memory B cells. However, little is known about the qualitative abnormality of…
Abstract Number: 1920 • 2016 ACR/ARHP Annual Meeting
Vitamin D Induces a Type 1 Regulatory T Cell (Tr1)-like Phenotype in Human C-C Chemokine Receptor Type 6 (Ccr6)+ th Cells and Promotes Their Migration to an Inflammatory Environment
Wendy Dankers¹, Jan Piet van Hamburg¹, Nadine Davelaar¹, Patrick Asmawidjaja¹, Hoyan Wen¹, Johannes van Leeuwen², Edgar Colin³ and Erik Lubberts¹, ¹Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, ZGT, Almelo, Netherlands
Background/Purpose: The active vitamin D metabolite 1,25(OH)2D3 suppresses various experimental autoimmune diseases. In addition, serum vitamin D levels, vitamin D intake and polymorphisms in the…
Abstract Number: 2144 • 2016 ACR/ARHP Annual Meeting
Functional Analysis of Macrophages in BehçEt’s Disease: C-C Chemokine Receptor Type 1 (CCR1) and IL-10 Are Implicated in Pathogenesis of the Disease
Hiroto Nakano¹, Yohei Kirino¹, Momoko Ohno¹, Kana Higashitani¹, Mitsuhiro Takeno², Ryusuke Yoshimi¹ and Hideaki Nakajima³, ¹Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
Background/Purpose: The recent GWAS and subsequent studies have identified susceptible genes such as CCR1 and IL10 genes, suggesting pathological roles of macrophages in Behçet's disease…
Abstract Number: 3040 • 2016 ACR/ARHP Annual Meeting
Th17 Migration into the Synovial Fluid of Patients with Active Psoriatic Arthritis Is Enhanced By Regulatory T Cells
Helen Baldwin¹, Amara Ezeonyeji², Mohammed Rohan Butt² and Michael R. Ehrenstein³, ¹Rheumatology, University College London, London, United Kingdom, ²Rheumatology, Medicine, University College London, London, United Kingdom, ³Medicine, University College London, London, United Kingdom
Background/Purpose: Uncontrolled migration of Th17 cells into the skin and joints is a major driver in the pathogenesis of psoriatic arthritis (PsA). Modulation of T…
Abstract Number: 1118 • 2015 ACR/ARHP Annual Meeting
Role of the Chemokine Receptor CXCR3 in the Function of Regulatory B Cells in Patients with SLE
Shun-ichiro Ota^1,2, Hiroaki Niiro³, Naoko Ueki^2,4, Yuri Hirosaki², Hirofumi Tsuzuki², Siamak Jabbarzadeh-Tabrizi², Tsuyoshi Nakayama², Koji Mishima², Ayako Takaki², Hiroki Mitoma², Mitsuteru Akahoshi², Yojiro Arinobu², Hiroshi Tsukamoto² and Koichi Akashi², ¹Department of Rheumatology, Internal medicine and connective tissue disorders, Shimonoseki City Hospital, Shimonoseki, Japan, ²Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ³Clinical Education Center, Kyushu University Hospital, Fukuoka, Japan, ⁴Division of Nephrology and Rheumatology, Fukuoka University, Fukuoka, Japan
Background/Purpose: The emerging application of B-cell directed therapies in autoimmune diseases has led to the discovery of a novel B cell population, referred to as…
Abstract Number: 1173 • 2015 ACR/ARHP Annual Meeting
G Protein Coupled Receptor Kinase 3 Regulation of Inflammatory Arthritis
Matthew J. Billard¹, Roman Timoshchenko², D. Stephen Serafin² and Teresa K. Tarrant³, ¹Medicine, University of North Carolina, Chapel Hill, NC, ²Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ³Rheumatology, University of North Carolina, Chapel Hill, NC
Background/Purpose: Chemokine receptors are G Protein Coupled Receptor (GPCR) family members that direct cell migration, differentiation, and survival in inflammatory conditions, but neutralization strategies…
Abstract Number: 1369 • 2015 ACR/ARHP Annual Meeting
Enhanced Myelopoiesis Downstream of Toll-like Receptor 9 Activation Drives a Feed-Forward Inflammatory Response
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Monocytes are myeloid cells important for the initiation of inflammation and have been implicated in the pathogenesis of autoimmunity. Monocytes interact with their environment…
Abstract Number: 1931 • 2015 ACR/ARHP Annual Meeting
PLCe1 Mediates Cellular Adhesion Downstream of SDF-1 in T Cells
Adam Mor¹ and Marianne Strazza², ¹Rheumatology and Pathology, NYU Langone Medical Center, New York, NY, ²NYU, New York, NY
Background/Purpose: The presentation of chemokines by endothelial cells results in chemoattraction of leukocytes that express the correlative chemokine receptors. In this way, chemokines direct leukocyte…
Abstract Number: 2009 • 2015 ACR/ARHP Annual Meeting
CC-Chemokine Receptor 7 (CCR7) Deficiency Reduces Early Structural and Functional Features of Disease in a Murine Model of Osteoarthritis
Nisha Sambamurthy^1,2, Vu Nguyen^1,2, Patrick Diviney³, Justin Gan⁴, Charles Bush-Joseph⁵, Susanna Chubinskaya⁶, Anne-Marie Malfait⁷, George Dodge^2,3 and Carla R. Scanzello^8,9, ¹Medicine / Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Research, Philadelphia VA Medical Center, Philadelphia, PA, ³Orthopedics, University of Pennsylvania, Philadelphia, PA, ⁴Rheumatology, Rush University Medical Center, Chicago, IL, ⁵Orthopedics, Rush University Medical Center, Chicago, IL, ⁶Biochemistry, Rush University Medical Center, Chicago, IL, ⁷Rush University Medeical Center, Chicago, IL, ⁸Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Rheumatology, University of Pennsylvania Perelman School of Medicine & Philadelphia VA Medical Center, Philadelphia, PA
Background/Purpose: Synovial expression of CCR7 has been associated with inflammation and severity of symptoms in patients with meniscal tears and early osteoarthritis (OA). This receptor…
Abstract Number: 2013 • 2015 ACR/ARHP Annual Meeting
TIARP Attenuates Autoantibody-Mediated Arthritis Via the Suppression of Neutrophil Infiltration into the Joint
Asuka Inoue¹, Isao Matsumoto¹, Yuki Tanaka², Naoto Umeda¹, Hoshimi Kawaguchi¹, Hiroshi Ebe¹, Yoshihiro Matsumoto³ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan, ³Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: TIARP (TNFα-induced adipose-related protein) is dominantly expressed in macrophages (Mφ), neutrophils (PMN) and fibroblast-like synoviocytes (FLS). Recently, we found that TIARP functions as a…
Abstract Number: 2702 • 2015 ACR/ARHP Annual Meeting
Immunophenotyping of Rheumatoid Arthritis Reveals the Linkage Between HLA-DRB1 Genotype, CXCR4 Expressions on Memory CD4+ T Cells, and Disease Activity
Yasuo Nagafuchi¹, Hirofumi Shoda¹, Shuji Sumitomo¹, Shinichiro Nakachi¹, Rika Kato², Yumi Tsuchida², Haruka Tsuchiya², Keiichi Sakurai², Norio Hanata², Shoko Tateishi², Hiroko Kanda², Keishi Fujio¹ and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose: The HLA-DRB1 is the strongest genetic risk factor for rheumatoid arthritis (RA). Although this fact suggests a pivotal role for adaptive immunity in RA,…

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