ACR Meeting Abstracts

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Abstracts tagged "Cell-signalling molecules"

  • Abstract Number: 0879 • ACR Convergence 2024

    A Novel, Oral, Allosteric Inhibitor of Tyrosine Kinase 2 (TYK2) Demonstrates In Vitro Potency, Selectivity, and In Vivo Efficacy in Mouse Models of Psoriasis

    Razika Hussein1, Pamela Tsuruda1, Shahab Mortezaei1, Nicky Ferdyan1, Christopher Wegerski2, Karthik Srinivasan1, Gavin Hirst1 and Neelufar Mozaffarian1, 1Atomwise Inc., San Francisco, 2Atomwise Inc., San Francisco, CA

    Background/Purpose: Tyrosine kinase 2 (TYK2), a member of the Janus kinase (JAK) family, plays a key role in several inflammatory diseases.  Orthosteric, small molecule inhibitors…
  • Abstract Number: 0932 • ACR Convergence 2024

    IRAK4 Degrader GS-6791 Inhibits TLR and IL-1R-Driven Inflammatory Signaling, and Ameliorates Disease in a Preclinical Arthritis Model

    Grace Teng1, Thomas Fung2, Annamaria Mocciaro2, Ceyda Llapashtica1, Angie Hammond3, Jesse Gurgel4, zhiyu Huang1, Maria Mouchess1, Vanessa Gorney5, Wesley Minto1, Sunish Mohanan1, Adam Schrier1, Wylie Palmer2, Alexandra Borodovsky2 and Gundula Min-oo1, 1Gilead Sciences, Foster City, CA, 2Nurix Therapeutics, San Francisco, CA, 3Gilead Sciences, Inc., Seattle, WA, 4Gilead Sciences, Seattle, CA, 5Alterome Therapeutics, San Diego, CA

    Background/Purpose: Despite advances in treatment, chronic inflammatory diseases such as rheumatoid arthritis (RA) represent areas of high unmet medical need. IRAK4 is a proximal mediator…
  • Abstract Number: 2596 • ACR Convergence 2024

    Clock Gene Bmal1 Contributes to Inflammation via Phosphorylation of NF-κB/p65 in RA-FLS

    Hikari Tsukamoto1, Kenta Kaneshiro1, Kohsuke Yoshida1, Koji Tateishi2, Yasuhiro Terashima2, Nao Shibanuma3, Yoshitada Sakai4 and Akira Hashiramoto1, 1Kobe University Graduate School of Health Sciences, Kobe, Hyogo, Japan, 2Hakuhokai Kakogawa Hospital, Kakogawa, Hyogo, Japan, 3Kobe Kaisei Hospital, Kobe, Hyogo, Japan, 4Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

    Background/Purpose: Inflammatory cytokines such as TNF-α, IL-6, and IFN-γ show their peaks at midnight in sera of patients with rheumatoid arthritis (RA), which is thought…
  • Abstract Number: 0942 • ACR Convergence 2023

    G Protein-coupled Receptor Kinase 5 in Fibrotic Tissue Remodeling

    Cuong Tran-Manh1, Thuong Trinh-Minh1, Christoph Liebel1, Chih-Wei Chen2 and Joerg Distler1, 1Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, 23 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany

    Background/Purpose: G-protein coupled receptor kinase 5, GRK5, is a central regulator of G protein-coupled receptors (GPCRs), a vast family of cell surface receptors involved in…
  • Abstract Number: 0964 • ACR Convergence 2023

    Systemic Sclerosis (SSc) Dermal Fibroblasts Show Shortened Primary Cilia Due to Aberrant Aurora a Kinase Activation Independently of Transforming Growth Factor β Signalling

    Rebecca Wells1, Rebecca Ross2, Alex Timmis1, Ioanna Georgiou1, Colin Johnson1, Natalia Riobo-Del Galdo1 and Francesco Del Galdo3, 1University of Leeds, Leeds, United Kingdom, 2Medicine and Health, University of Leeds, Leeds, United Kingdom, 3University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder characterised by abnormal activation of tissue fibroblasts, resulting in tissue and vascular fibrosis of the skin and…
  • Abstract Number: 1602 • ACR Convergence 2023

    NADPH Oxidase Exerts a B Cell-intrinsic Contribution to Lupus Risk by Modulating Endosomal Toll-like Receptor (TLR) Signals

    Shuozhi Liu1, Natali Shumlak1, Andrea Largent1, Sebastien Lewis1, Mridu Acharya1 and Shaun Jackson2, 1Seattle Children's Research Institute, Seattle, WA, 2Seattle Children's Research Institute / University of Washington, Seattle, WA

    Background/Purpose: Genome-wide association studies in systemic lupus erythematosus (SLE) have linked loss-of-function mutations in phagocytic NADPH oxidase complex (NOX2) genes, including NCF1 and NCF2, to…
  • Abstract Number: 1778 • ACR Convergence 2023

    Role of GITR/GITRL Interaction in Modulating T Helper 9, T Helper 17 and T Regulatory Response in Psoriatic Arthritis

    Chiara Rizzo1, Lidia La Barbera1, Marianna Lo Pizzo1, Leila Mohammadnezhad1, federica Camarda1, Francesco Dieli1, Francesco Ciccia2 and Giuliana Guggino1, 1University of Palermo, Palermo, Italy, 2University of Campania - Luigi Vanvitelli, Naples, Italy

    Background/Purpose: The inflammatory process characterizing Psoriatic Arthritis (PsA) is mainly driven by interleukin (IL)-23/IL-17 axis and IL-9 overexpression, in presence of T helper (Th)17 and…
  • Abstract Number: 1787 • ACR Convergence 2023

    Regulatory Role of JAK-1/TYK2 Signaling on the Pannus Formation: Novel Mechanisms for JAK Inhibitors in Psoriatic Disease

    Siba Raychaudhuri1, Christine Abria2 and Smriti K Raychaudhuri2, 1UC Davis, School of Medicine/ VA Medical Center, Sacramento, Davis, CA, 2VA Sacramento Medical Center, Mather, CA

    Background/Purpose: In psoriatic arthritis (PsA) aberrant activation/migration of specific T cell subpopulations (Th17/Th9/MAIT cells) in the joint synovium induce synovial inflammation and pannus formation. Several…
  • Abstract Number: 2507 • ACR Convergence 2023

    ZCCHC6 Modulates the Global Phosphorylation Landscape in TNF-a-induced Rheumatoid Arthritis Synovial Fibroblasts

    Anil Singh, Farheen Sultan Shaikh and Salahuddin Ahmed, Washington State university, Spokane, WA

    Background/Purpose: ZCCHC6, also known as TUT7 or TENT2, plays a crucial role in RNA processing and metabolism through its uridylyl transferase function. This function involves…
  • Abstract Number: 0011 • ACR Convergence 2023

    Clock Gene Bmal1 Promotes Transcriptional Activity of NF-κB to Regulate Production of Inflammatory Mediators in RA-FLS

    Hikari Tsukamoto1, Kenta Kaneshiro2, Kohsuke Yoshida1, Koji Tateishi3, Yasuhiro Terashima3, Nao Shibanuma4, Yoshitada Sakai5 and Akira Hashiramoto1, 1Kobe University Graduate School of Health Sciences, Kobe, Japan, 2Kobe University Graduate School of Health Sciences, Osaka, Japan, 3Kohnan Kakogawa Hospital, Kakogawa, Japan, 4Kobe Kaisei Hospital, Kobe, Japan, 5Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Rheumatoid arthritis (RA), an autoimmune polyarthritis characterized by 'tumor-like' proliferation of RA fibroblast-like synovial cells (RA-FLS), has characteristic symptoms such as "morning stiffness of…
  • Abstract Number: 0799 • ACR Convergence 2023

    Human Chimeric Antigen Receptor (CAR)-Tregs Targeting OX40L for Treatment of Systemic Lupus Erythematosus

    Holly Wobma1, Xianliang Rui2, Francesca Alvarez-Calderon2, Ulrike Gerdemann2, Connor McGuckin2, Bruce Blazar3, Victor Tkachev4 and Leslie Kean2, 1Division of Immunology, Boston Children's Hospital, Boston, MA, 2Division of Hematology-Oncology, Boston Children's Hospital, Boston, MA, 3Division of Pediatric Blood & Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN, 4Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    Background/Purpose: Chimeric Antigen Receptor Regulatory T cells (CAR-Tregs) are an emerging strategy to restore immune tolerance during auto- or allo-immune conditions. However, most autoimmune diseases…
  • Abstract Number: 0559 • ACR Convergence 2022

    JAK Inhibitor Withdrawal Causes a Transient Proinflammatory Signaling Cascade in Minor Salivary Gland Mesenchymal Stromal Cells

    Ilya Gurevic, jacques Galipeau and Sara McCoy, University of Wisconsin, Madison, WI

    Background/Purpose: Sjögren's Disease (SjD) has high glandular IFNg levels, associated with disease activity and lymphoma risk. We previously showed IFNg-stimulated minor salivary gland (SG)-mesenchymal stromal…
  • Abstract Number: 1691 • ACR Convergence 2022

    Pentagalloyl Glucose Inhibits MSU-Induced Inflammation via Transforming Growth Factor-β-Activated Kinase 1 (TAK1)

    Paul Panipinto, Anil Singh, Farheen Sultan Shaikh and Salahuddin Ahmed, Washington State University, Spokane, WA

    Background/Purpose: Gout disease flares occur when primed macrophages interact with and phagocytose monosodium urate crystals (MSU), activating IL-1β via the NLRP3 inflammasome. Abrogation of inflammasome…
  • Abstract Number: 1700 • ACR Convergence 2022

    IL-21/STAT3 Pathway Mediated Th2-like Vδ2 T Cells Promote Plasmablasts Differentiation in IgG4-Related Disease

    Jieqiong Li1 and Wen Zhang2, 1Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China, 2Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: To explore the phenotype and role of gamma delta (γδ) T cells in the pathogenesis of IgG4-related disease (IgG4-RD), focusing on the effect on…
  • Abstract Number: 1991 • ACR Convergence 2022

    Mice Do Not Develop CIA: Knocking out of Kv1.3 Renders CD4+TEMCells Resistant to Activation

    Siba Raychaudhuri1, Smriti Raychaudhuri2 and Heike Wulff3, 1UC Davis, School of Medicine/ VA Medical Center, Sacramento, CA, 2VA Medical Center, Sacramento, CA, 3UC Davis, Davis, CA

    Background/Purpose: Engagement of the TCR triggers Ca++ influx through Ca++ channels. Ca++ influx is only possible with a counterbalancing K+ efflux through Kv1.3 and/or KCa3.1.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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