ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Cell-signalling molecules"

  • Abstract Number: 0282 • ACR Convergence 2020

    Expression of the cGAMP Transporter SLC19A1 Is Altered in Systemic Lupus Erythematosus

    Jeong Min Yu1, Gantsetseg Tumurkhuu2, Erica Montano2, Gabriela de los Santos2, Daniel J Wallace2, Mariko Ishimori3 and Caroline Jefferies1, 1Cedars-Sinai Medical Center, West Hollywood, CA, 2Cedars-Sinai Medical Center, Los Angeles, 3Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Inappropriate sensing of nucleic acids leading to enhanced type I interferon (IFN) induction is a hallmark of SLE, contributing to breakdown of immune tolerance…
  • Abstract Number: 0292 • ACR Convergence 2020

    Exhausted pSTAT5-IFNα Signaling Pathways in SLE Patients Are Correlated with Age-associated B Cells and Disease Activity

    Samantha Slight-Webb1, Miles Smith2, Kevin Thomas1, Susan Macwana1, Holden Maecker3, Paul Utz4, Judith James5 and Joel Guthridge1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, 3Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, 4Stanford University School of Medicine, Stanford, CA, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by periods of elevated and suppressed clinical symptoms. Specific cell subsets, such as CD11c+ age-associated…
  • Abstract Number: 0304 • ACR Convergence 2020

    Type I Interferon Inhibits Glucocorticoid-Induced Leucine Zipper (GILZ) Expression and Upregulation by Glucocorticoids

    Wendy Dankers1, Melissa Northcott2, Taylah Bennett3, Brendan Russ3, Jacqueline Flynn1, Sarah Jones2 and Eric Morand1, 1Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, 2Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia, 3Department of Microbiology, Monash University, Melbourne, Australia

    Background/Purpose: Glucocorticoids (GC) are broadly used in the treatment of inflammatory diseases, including systemic lupus erythematosus (SLE). Despite their widespread use, most SLE patients do…
  • Abstract Number: 0461 • ACR Convergence 2020

    High-Throughput Single-Cell Analysis Reveals Unique Lung Cellular Subsets in a Murine Model of Rheumatoid Arthritis-Inflammatory Lung Disease

    Rohit Gaurav1, Ted Mikuls1, Geoffrey Thiele1, Amy Nelson1, Meng Niu1, Chittibabu Guda1, James Eudy1, Austin Barry1, Debra Romberger1, Michael Duryee1, Bryant England1 and Jill Poole1, 1University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA)-associated inflammatory lung disease is an extra-articular manifestation of RA associated with increased morbidity and mortality, whose precise molecular mechanisms remain undetermined.…
  • Abstract Number: 0861 • ACR Convergence 2020

    Hydroxychloroquine Use Is Associated with Diminished Type I Interferon-related Pathways in Systemic Lupus Erythematosus Patients

    Samantha Slight-Webb1, Kevin Thomas1, Rufei Lu1, Susan Macwana1, Joan Merrill1, Cristina Arriens1, Eliza Chakravarty1, Teresa Aberle1, Holden Maecker2, Paul Utz3, Joel Guthridge1 and Judith James4, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, 3Stanford University School of Medicine, Stanford, CA, 4Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK

    Background/Purpose: Hydroxychloroquine (HCQ) has been used for decades to treat systemic lupus erythematosus (SLE) and is associated with decreased lupus flares and damage. However, despite…
  • Abstract Number: 1402 • ACR Convergence 2020

    Galectin-3 Decreases the Activity of 4-1BB by Facilitating Its Decoy Surface Binding in Rheumatoid Arthritis

    Morten Aagaard Nielsen1, Kristian Juul-Madsen2, John Stegmayr3, Chao Gao4, Tue Wenzel Kragstrup1, Malene Hvid1, Thomas Vorup-Jensen1, Richard Cummings5, Hakon Leffler3 and Bent Deleuran1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University, Aarhus, Midtjylland, Denmark, 3Lund University, Lund, Sweden, 4Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, 5Beth Israel Deaconess Medical Center Harvard Medical School, Boston

    Background/Purpose: Orchestration of immune checkpoints is central for the outcome of immune activation, especially in patients with rheumatoid arthritis (RA). We have previously shown that…
  • Abstract Number: 1526 • ACR Convergence 2020

    Single Cell Analysis of Skin and Blood of Scleroderma Patients Towards Identification of New Disease Mechanisms, Prognostic Biomarkers and Potential Therapeutic Targets

    Chamutal Gur1, Postil 1586262, Hagit Peleg3, Suhail Aamar3, Fadi Kharouf3, Anat Elazary3, Yolanda Braun-Moscovici Braun-Moscovici4, Shuang-Yin Wang5 and Ido Amit5, 1Hadassah Medical Center, Hebrew University, Laboratory for Immuno-Genomics, Weizmann Institute of Science, Jerusalem, Israel, 2Rambam Health Care Campus, Technion-Israeli Institute of Technology, Kiriat Mozkin, HaZafon, Israel, 3Hadassah Medical Center, Jerusalem, Israel, 4Rambam Health Care Campus, Technion-Israeli Institute of Technology, Haifa, Israel, 5Laboratory for Immuno-Genomics, Weizmann Institute of Science, Rehovot, Israel

    Background/Purpose: Systemic sclerosis (SSc) is characterized by fibrosis, microangiopathy and immune dysregulation. Despite many years of research, the pathogenesis of SSc is poorly understood; there…
  • Abstract Number: 1952 • ACR Convergence 2020

    Activated Memory T Cells Produce Ligands That Cause NF-κB-dependent Inflammatory Activation of the Endothelium: Identification of Novel Therapeutic Targets

    Kim Jeucken1, Jan Piet van Hamburg1, Lotte Kocken1 and Sander Tas2, 1Amsterdam Rheumatology and Immunology Center (ARC), Department of Rheumatology and Clinical Immunology, Department of Experimental Immunology and Amsterdam Infection and Immunity Institute, Amsterdam UMC; location AMC, University of Amsterdam, Netherlands, Amsterdam, Netherlands, 2Amsterdam Rheumatology and Immunology Center (ARC), Department of Rheumatology and Clinical Immunology, Department of Experimental Immunology and Amsterdam Infection and Immunity Institute, Amsterdam UMC; location AMC, University of Amsterdam, Netherlands, Utrecht, Netherlands

    Background/Purpose: Endothelial cells (EC) are important contributors to inflammation via expression of inflammatory mediators, including cytokines, chemokines and adhesion molecules. Production of these inflammatory mediators…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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