ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstracts tagged "Cell Death"

  • Abstract Number: 0142 • ACR Convergence 2022

    A Systemic Autoinflammatory Syndrome Caused by NEMO Exon 5 Skipping

    Bin Lin1, Adriana Almeida de Jesus2, Eric Karlins1, Dana Kahle1, Sophia Park3, Andre Rastegar1, Jacob Mitchell4, sofia Torregiani1, Farzana Bhuyan5, Sara Alehashemi6, Kader Cetin Gedik7, Kat Uss8, Eric Hanson9, Amer Khojah10, Eveline Wu11, Christiaan Scott12, Timothy Ronan Leahy13, Emma J. MacDermott13, Orla G. Killeen13, Chyi-Chia Richard Lee14, Thaschawee Arkachaisri15, Zoran Gucev16, Kathryn Cook17, Vafa Mammadova18, Gulnara Nasrullayeva18, Mariana Correia Marques19, Abigail Bosk20, Seza Ozen21, Abigail Lang22, Brian Nolan23, Scott Canna24, Maude Tusseau25, Emilie Chopin25, Guilaine Boursier26, Danielle Fink27, Douglas Kuhns27, Clifton Dalgard28, Alexandre Belot29, Timothy Moran30, Andrew Oler3 and Raphaela Goldbach-Mansky31, 1NIH, Bethesda, MD, 2NIAID, NIH, Silver Spring, MD, 3NIAID, Bethesda, MD, 4NIAID NIH, Bethesda, MD, 5National Institutes of Health, Bethesda, MD, 6NIH/NIAID/TADS, Clarksville, MD, 7Translational Autoinflammatory Diseases Section (TADS)/NIAID/NIH, Bethesda, MD, 8National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 9Indiana University School of Medicine, Indianapolis, IN, 10Umm Al-Qura University, Makkah, Saudi Arabia, 11University of North Carolina, Chapel Hill, NC, 12University of Cape Town, Red Cross War Memorial Children's Hospital, Cape Town, South Africa, 13CHI at Crumlin, Dublin, Ireland, 14National Cancer Institute, National Institutes of Health, Bethesda, MD, 15KK Women's and Children's Hospital, SingHealth, Singapore, Singapore, 16University Children's Hospital, Medical Faculty Skopje, Skopje, Macedonia, 17Akron Children's Hospital, Akron, OH, 18Azerbaijan Medical University, Baku, Azerbaijan, 19National Institute of Arthritis and Musculoskeletal and Skin Diseases / Children`s National Hospital, Bethesda, MD, 20Children's National Hospital, Washington, DC, 21Hacettepe University Faculty of Medicine, Ankara, Turkey, 22Lurie Children's Hospital, Chicago, IL, 23Ann & Robert H. Lurie Children's Hospital, Chicago, IL, 24Children's Hospital of Philadelphia, Philadelphia, PA, 25Service de Néphrologie, Rhumatologie, Dermatologie Pédiatriques, Centre de Référence des Rhumatismes Inflammatoires et Maladies Auto-Immunes Rares de l'Enfant (RAISE), Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Bron, France, 26Laboratoire de Génétique des Maladies Rares et Autoinflammatoires, Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, CEREMAIA, CHU de Montpellier, Univ Montpellier, Montpellier, France, 27National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, 28The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, 29Hospices Civils de Lyon, Collonges au mont d'or, France, 30University of North Carolina School of Medicine, Chapel Hill, NC, 31NIH/NIAID, Potomac, MD

    Background/Purpose: NF-kB essential modulator (NEMO, encoded by IKBKG) is an essential gene in immune response, development, and cell death regulation. Mutations in NEMO have been…
  • Abstract Number: 0611 • ACR Convergence 2022

    Proteomics Reveals Dysregulated Molecular Mechanisms of Cell Death in Neutrophils in Rheumatoid Arthritis

    Jennifer Amsler1, Constance Beaudouin2, Morgane LeGall3, Géraldine Falgarone4, François Rannou5, Léa Tourneur3 and Véronique Witko-Sarsat3, 1Institute Cochin, Schoenenwerd, Switzerland, 2Hôpital Privé de Provence, Aix-en-Provence, France, 3Institute Cochin, Paris, France, 4Hôpital Avicenne, Paris, France, 5Hôpital Cochin, Paris, France

    Background/Purpose: Favoring apoptosis of neutrophils infiltrating the joints of patients suffering from rheumatoid arthritis (RA) and perpetuating inflammation has recently been discussed as an alternative…
  • Abstract Number: 0615 • ACR Convergence 2022

    Semaphorin 5A Suppresses Ferroptosis Through Activation of PI3K-AKT-mTOR Signaling in Rheumatoid Arthritis

    Qi Cheng, Mo chen, Mengdan Liu, Xin chen, Huaxiang Wu and Yan Du, The Second Affiliated Hospital Of Zhejiang University School Of Medicine, Hangzhou, China

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease with synovial inflammation as the main pathological feature, and can eventually lead to irreversible joint or…
  • Abstract Number: 0630 • ACR Convergence 2022

    Ferroptosis of CD163+ Tissue Infiltrating Macrophages in Lupus Nephritis

    Qi Cheng, Huaxiang Wu and Yan Du, The Second Affiliated Hospital Of Zhejiang University School Of Medicine, Hangzhou, China

    Background/Purpose: Lupus nephritis (LN) is one of the most common complications of systemic lupus erythematosus (SLE), with high morbidity and mortality. Despite a better understanding…
  • Abstract Number: 0653 • ACR Convergence 2022

    JAK Inhibitors Counteract Cellular Toxicity of Hydroxychloroquine in Vitro

    Hiroshi Kajiyama1, Yoshimi Aizaki2, Hiroaki Yazawa3, Kazuhiro Yokota3, Yasuto Araki2, Yuji Akiyama2 and Toshihide Mimura4, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Yokohama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma Saitama, Japan, 3Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma Saitama, 4Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: Hydroxychloroquine (HCQ) is an anti-malarial medicine and an immunomodulator to treat autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Clinical…
  • Abstract Number: 0694 • ACR Convergence 2021

    Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Fiber Necroptosis and Muscle Inflammation and Ameliorates Muscle Weakness in Experimental Polymyositis

    Mari Kamiya1, Fumitaka Mizoguchi1, Hirokazu Sasaki2, Natsuka Umezawa1 and Shinsuke Yasuda3, 1Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 3Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: While glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM), GC-induced myopathy is inevitable, which deteriorates muscle weakness. Therefore, novel therapeutic strategy…
  • Abstract Number: 0975 • ACR Convergence 2020

    Gasdermin D Modulates Murine Lupus and Its Associated Organ Damage

    Xinghao Wang1, Luz Blanco2, Carmelo Carmona-Rivera3, Shuichiro Nakabo3, Hege Pedersen4, Zu-Xi Yu5 and Mariana Kaplan3, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, Canton, MI, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases, Centreville, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, 5National Heart, Lung, and Blood Institute Pathology Core, Bethesda

    Background/Purpose: Gasdermin D (GSDMD) is the key executioner of the inflammatory cell death mechanism pyroptosis. Recent reports have also implicated GSDMD in other mechanisms of…
  • Abstract Number: 1077 • ACR Convergence 2020

    Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Inflammation and Muscle Fiber Death, and Ameliorates Muscle Weakness in Experimental Polymyositis

    Mari Kamiya1, Seon Uk Kim2, Jeong Yeon Kim3, Shinsuke Yasuda4, Eun Young Lee5 and Fumitaka Mizoguchi1, 1Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Jongno-gu, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 4Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Tokyo, Japan, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Background/Purpose: Glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM). However, the treatment with GC causes GC-induced myopathy, which further deteriorates the muscle…
  • Abstract Number: 1532 • ACR Convergence 2020

    The Non-psychotropic Phytocannabinoids Cannabigerol and Tetrahydrocannabinolic Acid Inhibit Rheumatoid Arthritis Synovial Fibroblast Function by Targeting the Wasabi Receptor TRPA1

    Torsten Lowin1, Matthias Schneider2 and Georg Pongratz3, 1Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, Düsseldorf, Germany, 2Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, Duesseldorf, Germany, 3Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, D�sseldorf, Germany

    Background/Purpose: While medical cannabis is available for german patients since 2017, its use to alleviate symptoms of rheumatic diseases is not recommended due to a…
  • Abstract Number: 1950 • ACR Convergence 2020

    Elevated Serum Gasdermin D N-terminal Implicates Macrophage Pyroptosis in Adult-onset Still’s Disease and Systemic Juvenile Idiopathic Arthritis

    Hideto Nagai1, Yohei Kirino2, Hiroto Nakano3, Yosuke Kunishita1 and Michael Ombrello4, 1Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan, 2Yokohama City University Graduate School of Medicine, Yokohama, Japan, 3NIAMS, NIH, Bethesda, 4Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD

    Background/Purpose: Elevation of serum IL-18 in adult-onset Still's disease (AOSD) and systemic juvenile idiopathic arthritis (sJIA) suggests involvement of one or more inflammasome in these…
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences