ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Cell Death"

  • Abstract Number: 0694 • ACR Convergence 2021

    Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Fiber Necroptosis and Muscle Inflammation and Ameliorates Muscle Weakness in Experimental Polymyositis

    Mari Kamiya1, Fumitaka Mizoguchi1, Hirokazu Sasaki2, Natsuka Umezawa1 and Shinsuke Yasuda3, 1Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 3Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: While glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM), GC-induced myopathy is inevitable, which deteriorates muscle weakness. Therefore, novel therapeutic strategy…
  • Abstract Number: 0975 • ACR Convergence 2020

    Gasdermin D Modulates Murine Lupus and Its Associated Organ Damage

    Xinghao Wang1, Luz Blanco2, Carmelo Carmona-Rivera3, Shuichiro Nakabo3, Hege Pedersen4, Zu-Xi Yu5 and Mariana Kaplan3, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, Canton, MI, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases, Centreville, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, 5National Heart, Lung, and Blood Institute Pathology Core, Bethesda

    Background/Purpose: Gasdermin D (GSDMD) is the key executioner of the inflammatory cell death mechanism pyroptosis. Recent reports have also implicated GSDMD in other mechanisms of…
  • Abstract Number: 1077 • ACR Convergence 2020

    Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Inflammation and Muscle Fiber Death, and Ameliorates Muscle Weakness in Experimental Polymyositis

    Mari Kamiya1, Seon Uk Kim2, Jeong Yeon Kim3, Shinsuke Yasuda4, Eun Young Lee5 and Fumitaka Mizoguchi1, 1Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Jongno-gu, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 4Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Tokyo, Japan, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Background/Purpose: Glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM). However, the treatment with GC causes GC-induced myopathy, which further deteriorates the muscle…
  • Abstract Number: 1532 • ACR Convergence 2020

    The Non-psychotropic Phytocannabinoids Cannabigerol and Tetrahydrocannabinolic Acid Inhibit Rheumatoid Arthritis Synovial Fibroblast Function by Targeting the Wasabi Receptor TRPA1

    Torsten Lowin1, Matthias Schneider2 and Georg Pongratz3, 1Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, Düsseldorf, Germany, 2Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, Duesseldorf, Germany, 3Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, D�sseldorf, Germany

    Background/Purpose: While medical cannabis is available for german patients since 2017, its use to alleviate symptoms of rheumatic diseases is not recommended due to a…
  • Abstract Number: 1950 • ACR Convergence 2020

    Elevated Serum Gasdermin D N-terminal Implicates Macrophage Pyroptosis in Adult-onset Still’s Disease and Systemic Juvenile Idiopathic Arthritis

    Hideto Nagai1, Yohei Kirino2, Hiroto Nakano3, Yosuke Kunishita1 and Michael Ombrello4, 1Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan, 2Yokohama City University Graduate School of Medicine, Yokohama, Japan, 3NIAMS, NIH, Bethesda, 4Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD

    Background/Purpose: Elevation of serum IL-18 in adult-onset Still's disease (AOSD) and systemic juvenile idiopathic arthritis (sJIA) suggests involvement of one or more inflammasome in these…
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ACR Pediatric Rheumatology Symposium 2020

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