Abstracts tagged "CD T cells"

Abstract Number: 492 • 2013 ACR/ARHP Annual Meeting
Distinction Between Glucocorticoid-Responders and Non-Responders In Rheumatoid Arthritis: A New Role For Endoplasmic Reticulum Aminopeptidase 2
Ruth Fritsch-Stork¹, Sandra Cardoso¹, Jasper Broen¹, Marian Groot-Koerkamp², Arno Concepcion¹, Floris Lafeber¹ and Johannes W.J. Bijlsma¹, ¹Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Glucocorticoids (GC) have been a cornerstone of Rheumatoid arthritis (RA)-therapy for the last decades. However, about a third of RA-patients do not respond adequately.…
Abstract Number: 2503 • 2012 ACR/ARHP Annual Meeting
CD8+Foxp3-CD103+ Regulatory T Cells Generated Ex Vivo with TGF-β Suppress Autoimmunity Through IL-10-Dependet Mechanism
Ya Liu¹, An-Ping Xu², David A. Horwitz³ and Song G. Zheng⁴, ¹Medicine, USC Keck School of Medicine, Los Angeles, CA, ²Kidney disease and rheumatology, 2nd Affiliated Hospital of Sun Yat-sen University, ³Medicine-Rheumatology-Immun, Keck School of Medicine of USC, Los Angeles, CA, ⁴Medicine, Keck School of Medicine of USC, Los Angeles, CA
Background/Purpose: TGF-β is crucial for induction of CD4+Foxp3+ Tregs and maintenance of immunologic tolerance. It is, however, unclear if TGF-β also induces the similar CD8+…
Abstract Number: 2310 • 2012 ACR/ARHP Annual Meeting
Enhancement of CRACM1 Expression in Functionally Aberrant Naïve CD4⁺ T Cells in Active Rheumatoid Arthritis
Shuang Liu¹, Shohei Watanabe², Miyuki Kuno³, Hiromasa Miura² and Kazutaka Maeyama¹, ¹Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Toon-shi, Ehime, Japan, ²Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Toon, Japan, ³Department of Molecular and Cellular Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Lymphocytes from rheumatoid arthritis (RA) patients have been reported to exhibit increased basal intracellular Ca2+ concentrations compared with the lymphocytes of healthy controls. A…
Abstract Number: 2313 • 2012 ACR/ARHP Annual Meeting
The Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) Belongs to CCR4⁺CD45RB^lo122^lo CD4 Subpopulation: A Novel ‘Self-Organized Criticality Theory’ Explains the Cause of Systemic Lupus Erythematosus (SLE)
Yumi Miyazaki¹, Ken Tsumiyama² and Shunichi Shiozawa², ¹Kyushu University Beppu Hospital/ Kobe University Graduate School of Health Sciences, Beppu/ Kobe, Japan, ²Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 2269 • 2012 ACR/ARHP Annual Meeting
The Differences of DNA Methylome and Transcriptome Among Diverse Clinical Manifestations of Systemic Lupus Erythematosus
Ming Zhao¹, Shuangyan Luo¹, Honglong Wu², Siyang Liu², Meini Tang¹, Wenjing Cheng¹, Qing Zhang¹, Xinhai Yu¹, Tak Mao Chan³, Yudong Xia², Na Yi², Fei Gao², Li Wang², Ning Li² and Qianjin Lu⁴, ¹Department of Dermatology, Second Xiangya Hospital, Central South University; Hunan Key Laboratory of Medical Epigenomics, Changsha, China, ²Beijing Genomics Institute at Shenzhen, Shenzhen, China, Shenzhen, China, ³Division of Nephrology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China, ⁴Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Aberrant DNA methylation and gene expression have been observed in systemic lupus erythematosus (SLE). However, patterns of DNA methylation and gene expression associated with…
Abstract Number: 1439 • 2012 ACR/ARHP Annual Meeting
CTL-Promoting Effects of IL-21 Results in B Cell Elimination and Disease Improvement in a Murine Model of Lupus
Vinh Nguyen¹, Daniel Veizaga-Udaeta², Horea Rus³ and Violeta Rus⁴, ¹Medicine, University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland at Baltimore County, MD, ³Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ⁴Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD
Background/Purpose: IL-21 is a member of the type I cytokine family with pleiotropic activities. IL-21 enhances CD8 T cells maturation into cytotoxic T lymphocytes (CTL),…
Abstract Number: 429 • 2012 ACR/ARHP Annual Meeting
The Significance of the Apoptosis Level and the Apoptosis Related Signal Proteins of CD4⁺t�ACD4⁺Foxp3⁺t Cell in Patients with Rheumatoid Arthritis
Ning Li¹, Tianrui Ma², Jie Han¹, Jieru Zhou¹ and Songguo Zheng³, ¹Rheumatology, Shanghai East Hospital, Shanghai, China, ²Rheumatology, Ningbo Pediatric Hospital, Ningbo, China, ³Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA
Background/Purpose: To investigate the apoptosis of CD4+T cell and Tregs in the pathogenesis and disease activity of rheumatoid arthritis patients. Methods: Isolated lymphocytes from human…

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