ACR Meeting Abstracts

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Abstracts tagged "Cartilage Degradation"

  • Abstract Number: 0507 • ACR Convergence 2022

    Gut Microbe Metabolite Short-Chain Fatty Acids May Associate with Development of Respiratory Involvement in Patients with Relapsing Polychondritis

    Jun Shimizu1, Masanori Murayama2, Yoshishige Miyabe1 and Noboru Suzuki3, 1St. Marianna University School of Medicine, Kawasaki, Japan, 2Kansai Medical University, Hirakata, Japan, 3St. Marianna University School of Medicine, Kawasaki Kanagawa, Japan

    Background/Purpose: Relapsing polychondritis (RP) is an inflammatory disease that affects cartilaginous tissues of the body and the clinical manifestations and disease courses vary considerably among…
  • Abstract Number: 1152 • ACR Convergence 2022

    A Novel Serological Biomarker Measuring a Fragment of Cartilage Intermediate Layer Protein 1 Is Highly Upregulated in Rheumatic Diseases

    Helena Port1, Walter P Maksymowych2, Morten Karsdal3, Anne-Christine Bay-Jensen3 and Signe Holm Nielsen3, 1University of Copenhagen, Copenhagen, Denmark, 2Department of Medicine, University of Alberta, Edmonton, AB, Canada, 3Nordic Bioscience, Herlev, Denmark

    Background/Purpose: A hallmark of rheumatic joint diseases is altered cartilage protein turnover and protein composition. During cartilage erosions, the cartilage intermediate layer protein-1 (CILP-1), is…
  • Abstract Number: 1909 • ACR Convergence 2022

    Corticosteroids with or Without Hyaluronic Acid Injections in the Treatment of Trapeziometacarpal (TMC) Osteoarthritis : The Randomised Multicentre RHIZ’ART Trial Study Protocol

    Grégoire Cormier1, Amelie Denis2, CHARLES LESKE3, Stephane Varin1, Jerome Dimet4, Lucie Planche1 and Benoit Le Goff5, 1CHD Vendee, La Roche Sur Yon, France, 2CH Le Mans, Le Mans, France, 3Hospital, Cholet, France, 4CH Mont de Marsan, Mont de Marsan, France, 5CHU Nantes, Nantes, France

    Background/Purpose: Trapeziometacarpal osteoarthritis is highly prevalent (affects 10 to 25% of people). Treatment modalities consist of non-pharmacological and pharmacological measures, including either corticosteroid or hyaluronic…
  • Abstract Number: 1911 • ACR Convergence 2022

    Baseline Bone Curvature a Biomarker for the Prediction of Knee Osteoarthritis Cartilage Volume Loss at One-Year. Use of Machine Learning

    Johanne Martel-Pelletier1, Hossein Bonakdari1, Jean-Pierre Pelletier1 and François Abram2, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montréal, QC, Canada, 2ArthroLab Inc., Montréal, QC, Canada

    Background/Purpose: The hallmark of osteoarthritis is the loss of cartilage. At present, we cannot discriminate, early during the osteoarthritis process, patients for whom cartilage will…
  • Abstract Number: 2262 • ACR Convergence 2022

    Albumin-hitchhiking MMP13 siRNA Conjugate (siMMP13< (EG18L)2) for the Treatment of Rheumatic Disease

    Juan Colazo1, Ella Hoogenboezem1, Fang Yu1, Veeraj Shah1, Justin Lo1, Hongsik Cho2, Karen Hasty2, Leslie Crofford3 and Craig Duvall1, 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Nashville, TN, 2Department of Orthopaedic Surgery and Biomedical Engineering, Memphis VA Medical Center, Memphis, TN, 3Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) decrease quality of life due to joint destruction, pain, and decreased function. Multiple joint osteoarthritis (MJOA) can occur…
  • Abstract Number: 0020 • ACR Convergence 2022

    Redoxosomes Mediate a Feed-forward Loop of Cartilage Matrix Destruction Through α5β1 Integrin Signaling in Response to a Fibronectin Matrikine

    Michael Miao1, Peter Su2, Yang Cui1, John Collins3, Edward Bahnson1, Susan Chubinskaya4 and Richard Loeser1, 1University of North Carolina, Chapel Hill, NC, 2University of Technology, Ultimo, Australia, 3Thomas Jefferson University, Philadelphia, PA, 4Rush University, Chicago, IL

    Background/Purpose: Degradation of pericellular matrix proteins creates bioactive fragments called "matrikines" that include fibronectin fragments (FN-f). FN-f found in OA cartilage and synovial fluid exhibit…
  • Abstract Number: 0030 • ACR Convergence 2022

    Fluidic Shear Stress Reduces TNFα-mediated Cartilage Damage in a 3D Model of Degenerative Joint Disease

    Alexandra Damerau1, Duc Ha Do Nguyen1, Christina Lubahn1, Thomas Leeuw2, Timo Gaber3 and Frank Buttgereit3, 1Charité-Universitätsmedizin Berlin, Berlin, Germany, 2Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany, 3Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany

    Background/Purpose: Degenerative joint diseases such as osteoarthritis (OA) ultimately result in the breakdown of cartilage. The exact underlying mechanisms of cause and progression of OA…
  • Abstract Number: 0210 • ACR Convergence 2021

    Using Machine Learning to Predict Medial Knee Cartilage Worsening over 2 Years Using Gait and Physical Activity: The MOST Study

    Kerry Costello1, David Felson1, S. Reza Jafarzadeh2, Neil Segal3, Cora Lewis4, Michael Nevitt5, Cara Lewis6, Vijay Kolachalama2 and Deepak Kumar1, 1Boston University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3University of Kansas Medical Center, Iowa City, IA, 4University of Alabama Birmingham, Birmingham, AL, 5University of California San Francisco, Orinda, CA, 6Boston University, Brookline, MA

    Background/Purpose: Identifying knees at risk of worsening osteoarthritis (OA) could help to identify individuals in need of interventions. While gait and physical activity are considered…
  • Abstract Number: 0216 • ACR Convergence 2021

    Distribution of Medial Femur and Tibia Cartilage Volume Change over 48 Months on MRI: Comparison Among Kellgren-Lawrence Grades

    Rebecca Amesbury1, Hedieh Ragati Haghi1, Todd Laffaye1, Rebekah Stein1, Erin Ashbeck2, C. Kent Kwoh3, Alexander Mathiessen1 and Jeffrey Duryea1, 1Brigham and Women's Hospital, Boston, MA, 2University of Arizona Arthritis Center, Tucson, AZ, 3University of Arizona College of Medicine, Tuscon, AZ

    Background/Purpose: Semi-automated Local Area Cartilage Segmentation (LACS) software uses two robust coordinate systems to measure cartilage change in focused regions in the femur and tibia.…
  • Abstract Number: 0940 • ACR Convergence 2021

    Overactivation of the Kinase IKK2 Causes a Hand Osteoarthritis-Like Phenotype in Mice

    Sergio Ramirez-Perez, kyle Jones, Umesh Gangishetti and Pallavi Bhattaram, Emory University School of Medicine, Atlanta, GA

    Background/Purpose: Hand osteoarthritis (OA) presents the highest prevalence among rheumatic diseases. Synovitis is a defining feature in hand OA that has been associated with radiographic…
  • Abstract Number: 1469 • ACR Convergence 2021

    Lorecivivint (SM04690), an Intra-articular, Small-Molecule CLK/DYRK Inhibitor That Modulates the Wnt Pathway, as a Potential Treatment for Meniscal Injuries

    Timothy Seo1, Vishal Deshmukh1 and Yusuf Yazici2, 1Biosplice Therapeutics, Inc., San Diego, CA, 2New York University School of Medicine, La Jolla, CA

    Background/Purpose: Meniscal injuries are the most common pathology of the knee and are associated with pain, stiffness, and localized swelling. Meniscal damage is a frequent…
  • Abstract Number: 1471 • ACR Convergence 2021

    Oral Administration of Berberine Limits Post-traumatic Osteoarthritis Development and Associated Pain via AMP-activated Protein Kinase (AMPK) in Mice

    Jun Li1, Yun Wang2, Di Chen3 and Ru Liu Bryan4, 1Rush University Medical Center, Chicago, IL, 2Valo Health, Lexington, MA, 3Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (People's Republic), 4University of California San Diego and VASDHS, San Diego, CA

    Background/Purpose: AMP-activated protein kinase (AMPK), a master regulator of energy balance and metabolism, is implicated to play an important role in cartilage homeostasis. Berberine is…
  • Abstract Number: PP05 • ACR Convergence 2021

    Fighting Health-Related Misinformation Using Social Media / How Creating an Online Group for Patients with Relapsing Polychondritis — and Moderating It with Health Professionals — Helps Spread Reliable and Empowering Information

    Michael Linn1, Spenser Mestel2 and Susie Ratledge3, 1Relapsing Polychondritis Foundation, New York, NY, 2New York, NY, 3Relapsing Polychondritis: Secular Science and Support group, Chattanooga, TN

    Background/Purpose: Before I became ill in 2017, I was a registered nurse with a degree in health science who'd often educate patients about how they…
  • Abstract Number: PP06 • ACR Convergence 2021

    Collaborative Advocacy Helps Me and Other Patients With Relapsing Polychondritis (“RP”’) /  My life improved by helping the RP Foundation and Race for RP facilitate awareness, education, and research to improve the quality of life for patients with RP and advance a cure for this disease.

    Michael Linn1 and Dan Smith2, 1Relapsing Polychondritis Foundation, New York, NY, 2Relapsing Polychondritis Foundation, Canton, MI

    Background/Purpose: In March 2020, I was diagnosed as having relapsing polychondritis ("RP"), an understudied, underdiagnosed, and undertreated debilitating autoimmune disease that can be fatal if…
  • Abstract Number: 1652 • ACR Convergence 2020

    Progression of Knee OA with Use of Intra-articular Corticosteroids (CS) vs Hyaluronic Acid (HA)

    Justin Bucci1, Xiaoyang Chen1, James Torner2, Michael Nevitt3, Cora Lewis4 and David Felson5, 1Boston University, Boston, MA, 2University of Iowa, Iowa City, IA, 3University of California, San Francisco, Orinda, CA, 4University of Alabama Birmingham, Birmingham, AL, 5Boston University School of Medicine, Boston, MA

    Background/Purpose: Recent studies have questioned whether CS injections (CSI), a popular treatment recommended by guidelines, hasten progression of knee OA.  A recent cohort study suggested…
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