ACR Meeting Abstracts

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Abstracts tagged "Cartilage Degradation"

  • Abstract Number: 0021 • ACR Convergence 2024

    A Novel Small Molecule Screening Assay Using Normal Human Chondrocytes Toward Osteoarthritis Drug Discovery

    Philip Coryell1, Kenneth Pearce2, Paul Hardy2, Susan Chubinskaya3 and Richard Loeser4, 1University of North Carolina-Chapel Hill, Chapel, NC, 2University of North Carolina-Chapel Hill, Chapel Hill, NC, 3University of Texas Medical Branch, Galveston, TX, 4University of North Carolina, Chapel Hill, NC

    Background/Purpose: A central feature of osteoarthritis (OA) is progressive cartilage degradation driven by increased production of matrix degrading enzymes including MMP-13. There is a critical…
  • Abstract Number: 1656 • ACR Convergence 2024

    Loss of Nr4a1 Expression Protects Cartilage During Post-traumatic Osteoarthritis

    Katherine Escalera-Rivera, Jennifer Jonason and Jennifer Anolik, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Osteoarthritis (OA) is a complex disease involving pathological processes in joint tissues such as the cartilage and synovium. Cartilage is degraded by matrix metalloproteinases…
  • Abstract Number: 1658 • ACR Convergence 2024

    IGF1 Drives Wnt-induced Joint Damage and Is a Therapeutic Target for Osteoarthritis

    Ana Escribano-Nunez1, Frederique Cornelis2, Astrid Deroover1, An Sermon1, Frederic Cailotto3, Rik Lories2 and Silvia Monteagudo4, 1KU Leuven, Leuven, Vlaams-Brabant, Belgium, 2Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, 3Université Lorraine, Nancy, Lorraine, France, 4KU Leuven, Leuven, Belgium

    Background/Purpose: Osteoarthritis is the most common joint disease and a global leading cause of pain and disability. Its multifactorial etiology includes excessive activation of Wnt…
  • Abstract Number: 0262 • ACR Convergence 2023

    Destructive Arthritis in Whipple Disease. a Single-center Case Series of 14 Patients

    Xavier Puéchal1, Philippe Blanche2, Olivier Fogel3, Omar Al Tabaa4, Roba Ghossan4, Xavier Ayral4, Jerome AVOUAC5, Maxime Breban6 and Yannick ALLANORE7, 1National Referral Center for Rare Systemic Autoimmune Diseases, Paris, France, 2Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 3HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 4Department of Rheumatology, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 5Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France, 6Department of Rheumatology, Boulogne-Billancourt, France, 7Université Paris Cité, Paris, France

    Background/Purpose: Whipple disease is a chronic, curable, systemic bacterial infection caused by Tropheryma whipplei. The classic form usually begins with recurrent arthritis, followed years later…
  • Abstract Number: 0862 • ACR Convergence 2023

    Role of CRTAC1 as a Biomarker of Osteoarthritis

    Aneta Pekacova1, Jiri Baloun2, Adela Navratilova3, Lucia Ondrejcakova4, Jana Zborovjanova4, Petr Fulin5, Rastislav Ballay6, Michal Tomcik7 and Ladislav Senolt8, 1First faculty of medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Hlavní město Praha, Czech Republic, 4Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 5First Department of Orthopaedics, First Faculty of Medicine of Charles University and Motol University Hospital, Prague, Czech Republic, 6First Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 7Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 8Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Praha, Czech Republic

    Background/Purpose: Cartilage acidic protein-1 (CRTAC1) has been recently considered a promising biomarker of osteoarthritis (OA) progression (1,2). The aim of this study is to compare…
  • Abstract Number: 0873 • ACR Convergence 2023

    FOXO Activators as Drugs for Osteoarthritis

    Ichiro Kurakazu, Merissa Olmer, Kevin Myers and Martin K Lotz, Scripps Research Institute, La Jolla, CA

    Background/Purpose: Forkhead box O (FOXO) proteins are a family of transcription factors involved in lifespan, aging, and autophagy. FOXO are essential for maintaining cartilage homeostasis…
  • Abstract Number: 0883 • ACR Convergence 2023

    The Role of Plasmin and Fibrinolysis Pathways in Osteoarthritis

    Qian Wang, heidi Wong, Audrey Bai, Zelda Love, Constance Chu and William Robinson, Stanford School of Medicine, Stanford, CA

    Background/Purpose: Osteoarthritis (OA) is the major cause of joint failure. Increasing evidence suggests that activation of fibrinolysis is involved in the pathogenesis of OA. Here…
  • Abstract Number: 1593 • ACR Convergence 2023

    Combining Single-cell RNA Sequencing and Population-based Studies Reveals Hand Osteoarthritis-associated Chondrocyte Subpopulations and Pathways

    Hui Li1, Xiaofeng Jiang1, Yongbing Xiao1, Yuqing Zhang2, Weiya Zhang3, Michael Doherty3, Jacquelyn Nestor4, Changjun Li5, Jing Ye1, Tingting Sha6, Houchen Lyu1, Jie Wei7, Chao Zeng1 and Guanghua Lei1, 1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, 2Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 3Academic Rheumatology, Clinical Sciences Building, University of Nottingham, City Hospital, Nottingham, United Kingdom, 4Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China, 6Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China, 7Health Management Center, Xiangya Hospital Central South University, Changsha, China

    Background/Purpose: Hand osteoarthritis (OA) is a common heterogeneous joint disorder with differences in etiology and pathophysiology from the large weight-bearing knee or hip OA. Its…
  • Abstract Number: 1721 • ACR Convergence 2023

    The Therapeutic Effects of Gingival Mesenchymal Stem Cells and Their Exosomes in a Chimeric Model of Rheumatoid Arthritis

    shane Bruckner1, Braden Zeno2, Vittoria Capria1, William Willis3, Latha Prabha Ganesan1 and wael Jarjour1, 1Ohio State University, Columbus, OH, 2Ohio State University, Upper Arlington, OH, 3Ohio State University, Reynoldsburg, OH

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that leads to progressive joint destruction involving multiple joints. There is a large body of…
  • Abstract Number: 1789 • ACR Convergence 2023

    Microtrauma Exacerbates Arthritis and Enthesitis in Curdlan-administered SKG Mice by Inducing FGF16 Expresssion

    Seung Hoon Lee1, Chanhyeok Jeon1, Sungsin Jo1 and Tae-Hwan Kim2, 1Hanyang University Institute for Rheumatology Research, Seoul, South Korea, 2Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea

    Background/Purpose: Microtrauma might be considered a crucial of various environmental factors in AS, but there is still unknown whether microtrauma has a direct/indirect role in…
  • Abstract Number: 1989 • ACR Convergence 2023

    Shared Variation Among Cartilage Thickness Change Maps and Baseline Clinical Features at the Initiation of Structural Knee Osteoarthritis

    Thomas Keefe1, Marc Niethammer1, Boqi Chen1, Zhengyang Shen1, Daniel Nissman1, Mary Catherine Minnig2, Yvonne Golightly3, J.S. Marron1 and Amanda Nelson1, 1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2University of North Carolina at Chapel Hill, Durham, NC, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: To identify features of cartilage thickness change and baseline clinical indicators associated with the transition from normal to mildly reduced joint space as an…
  • Abstract Number: 0507 • ACR Convergence 2022

    Gut Microbe Metabolite Short-Chain Fatty Acids May Associate with Development of Respiratory Involvement in Patients with Relapsing Polychondritis

    Jun Shimizu1, Masanori Murayama2, Yoshishige Miyabe1 and Noboru Suzuki3, 1St. Marianna University School of Medicine, Kawasaki, Japan, 2Kansai Medical University, Hirakata, Japan, 3St. Marianna University School of Medicine, Kawasaki Kanagawa, Japan

    Background/Purpose: Relapsing polychondritis (RP) is an inflammatory disease that affects cartilaginous tissues of the body and the clinical manifestations and disease courses vary considerably among…
  • Abstract Number: 1152 • ACR Convergence 2022

    A Novel Serological Biomarker Measuring a Fragment of Cartilage Intermediate Layer Protein 1 Is Highly Upregulated in Rheumatic Diseases

    Helena Port1, Walter P Maksymowych2, Morten Karsdal3, Anne-Christine Bay-Jensen3 and Signe Holm Nielsen3, 1University of Copenhagen, Copenhagen, Denmark, 2Department of Medicine, University of Alberta, Edmonton, AB, Canada, 3Nordic Bioscience, Herlev, Denmark

    Background/Purpose: A hallmark of rheumatic joint diseases is altered cartilage protein turnover and protein composition. During cartilage erosions, the cartilage intermediate layer protein-1 (CILP-1), is…
  • Abstract Number: 1909 • ACR Convergence 2022

    Corticosteroids with or Without Hyaluronic Acid Injections in the Treatment of Trapeziometacarpal (TMC) Osteoarthritis : The Randomised Multicentre RHIZ’ART Trial Study Protocol

    Grégoire Cormier1, Amelie Denis2, CHARLES LESKE3, Stephane Varin1, Jerome Dimet4, Lucie Planche1 and Benoit Le Goff5, 1CHD Vendee, La Roche Sur Yon, France, 2CH Le Mans, Le Mans, France, 3Hospital, Cholet, France, 4CH Mont de Marsan, Mont de Marsan, France, 5CHU Nantes, Nantes, France

    Background/Purpose: Trapeziometacarpal osteoarthritis is highly prevalent (affects 10 to 25% of people). Treatment modalities consist of non-pharmacological and pharmacological measures, including either corticosteroid or hyaluronic…
  • Abstract Number: 1911 • ACR Convergence 2022

    Baseline Bone Curvature a Biomarker for the Prediction of Knee Osteoarthritis Cartilage Volume Loss at One-Year. Use of Machine Learning

    Johanne Martel-Pelletier1, Hossein Bonakdari1, Jean-Pierre Pelletier1 and François Abram2, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montréal, QC, Canada, 2ArthroLab Inc., Montréal, QC, Canada

    Background/Purpose: The hallmark of osteoarthritis is the loss of cartilage. At present, we cannot discriminate, early during the osteoarthritis process, patients for whom cartilage will…
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