ACR Meeting Abstracts

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Abstracts tagged "Cardiovascular"

  • Abstract Number: 0462 • ACR Convergence 2024

    Circulating Mediators of Endothelial Dysfunction as Predictors of Incident Heart Failure in Rheumatoid Arthritis

    Tate Johnson1, Michael Duryee1, Carlos Hunter1, Punyasha Roul2, Joshua Baker3, grant Cannon4, Beth Wallace5, Paul Monach6, Andreas Reimold7, Gail Kerr8, Isaac Smith9, John Richards10, Katherine Wysham11, Gary Kunkel12, Iris Lee13, Daniel Anderson14, Geoffrey Thiele1, Ted Mikuls1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC, Omaha, NE, 3University of Pennsylvania, Philadelphia, PA, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 6VA Boston Healthcare System, Boston, MA, 7Dallas VA Medical Center, Dallas, TX, 8Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 9Duke University Hospital, Durham, NC, 10Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 11VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 12University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 13Washington University in St Louis, Saint Louis, MO, 14University of Nebraska Medical Center, Durham, NC

    Background/Purpose: Endothelial dysfunction, leading to myocardial inflammation and dysfunction, may drive a heightened risk of heart failure (HF) in people with rheumatoid arthritis (RA). Circulating…
  • Abstract Number: 0704 • ACR Convergence 2024

    Progression of Global Longitudinal Strain and Identification of Left Ventricular Dysfunction in Systemic Sclerosis Patients

    Jennifer Abdalla1, Yuichiro Okushi2, Chao Zhang3, Zoran Popovic2, Heba Wassif1 and Soumya Chatterjee4, 1Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Cleveland, 3Cleveland Clinic, Cleveland Heights, OH, 4Cleveland Clinic, Richmond Heights, OH

    Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease known for its fibrotic and vascular complications impacting various organs, including the heart. Myocardial involvement causes…
  • Abstract Number: 1089 • ACR Convergence 2024

    Endothelial Activation in Gout

    Michael Toprover1, Binita Shah2, Kamelia Drenkova2, Michael Pillinger3 and Michael Garshick4, 1New York University Langone Health, New York, NY, 2NYU Langone Health, New York, NY, 3New York University Grossman School of Medicine, New York,, NY, 4NYU Langone Health, Tenafly, NJ

    Background/Purpose: Gout is the most common inflammatory arthritis and is associated with increased cardiovascular (CV) disease and cardiovascular mortality. Our prior studies have suggested that…
  • Abstract Number: 1484 • ACR Convergence 2024

    A Retrospective Evaluation of Glucagon-like Peptide-1 Receptor Agonists in SLE Patients

    Philip Carlucci1, Brooke Cohen2, Amit Saxena3, H Michael Belmont3, Mala Masson4, Heather Gold5, Jill Buyon2 and Peter Izmirly6, 1New York University School of Medicine, New York, NY, 2NYU Grossman School of Medicine, New York, NY, 3NYU School of Medicine, New York, NY, 4NYU Langone Health, New York, NY, 5NYU Langone Health, NYC, 6New York University Grossman School of Medicine, New York, NY

    Background/Purpose: Glucagon-like peptide-1 receptor agonists (GLP1-RA) are an emerging class of medications that significantly improve cardiometabolic outcomes. Whether these drugs may be useful in mitigating…
  • Abstract Number: 1898 • ACR Convergence 2024

    Hyperuricemia Is Associated with Higher Levels of Fasting Plasma Glucose and Insulin Resistance in Non-diabetic Subjects

    Janis Timsans1, Jenni Kauppi1, Anne Kerola2, Vappu Rantalaiho3, Hannu Kautiainen4 and Markku Kauppi2, 1Päijät-Häme Central Hospital, Lahti, Finland, 2Päijät-Häme Central Hospital, University of Helsinki, Lahti, Finland, 3Tampere University Hospital, Tampere University and Kanta-Häme Central Hospital, Tampere, Finland, 4Folkhälsan Research Center, Helsinki, Finland

    Background/Purpose: Disorders of glucose metabolism are well-known major contributors to morbidity and mortality. Elevated serum uric acid (SUA), a key precursor of gout attacks, is…
  • Abstract Number: 2275 • ACR Convergence 2024

    Cardiovascular and Cancer Safety of JAKi Compared to TNFi in Patients with Rheumatoid Arthritis: Results from a National Registry of Advanced Therapies

    Lucia Otero-Varela1, Carlos Sanchez-Piedra2, Elena Rabadán Rubio3, Juan Camilo Sarmiento-Monroy4, Chamaida Plasencia-Rodríguez5, Diana Sueiro6, Olga Martinez7, Noemí Busquets Pérez8, Mercedes Freire González9, Fernando Sánchez-Alonso10, José María Álvaro-Gracia11 and Isabel Castrejon12, and BIOBADASER group, 1Spanish Society of Rheumatology, Madrid, Spain, 2Agencia de Evaluación de Tecnologías Sanitarias, Instituto de Salud Carlos III, Madrid, Spain, 3Hospital Universitario Principe de Asturias, Alcalá de Henares, Madrid, Spain, 4Hospital Clínic Barcelona, Barcelona, Spain, 5Hospital Universitario La Paz, MADRID, Spain, 6Complexo Hospitalario Universitario de Ourense, Ourense, Spain, 7Hospital Universitario de Salamanca, Zamora, Spain, 8HOSP. GENERAL DE GRANOLLERS, GRANOLLERS, Spain, 9Complexo Hospitalario Universitario de A Coruña, La coruna, Galicia, Spain, 10Sociedad Española de Reumatología, Madrid, Spain, 11Hospital Gregorio Marañón, Madrid, Spain, 12Hospital General Universitario Gregorio Marañon, Madrid, Spain

    Background/Purpose: Preliminary results from the ORAL Surveillance clinical trial showed an increase in the risk of major adverse cardiovascular events (MACE) and malignancies in patients…
  • Abstract Number: 0069 • ACR Convergence 2024

    Activation of Cardiovascular Inflammation and Wnt Signaling in Spondyloarthritis: Insights from the HLA-B27 Transgenic Rat Model

    Su-Ah Yoon, Chorong Kim, Hansun Song, Mie Jin Lim and Seong-Ryul Kwon, College of Medicine, Inha University, Incheon, Republic of Korea

    Background/Purpose: Despite the well-documented link between cardiovascular (CV) disease and spondyloarthritis (SpA), no animal studies have empirically validated this connection or integrated SpA, vascular inflammation,…
  • Abstract Number: 0463 • ACR Convergence 2024

    Evaluation of Inflammatory Indices as Predictive Biomarkers of Carotid Plaque in Patients with Rheumatoid Arthritis

    Jose Antonio Davila Jimenez1, Dionicio Galarza-Delgado2, Iris Jazmín Colunga Pedraza3, jose Ramon Azpiri-Lopez4, Rosa Icela Arvizu-Rivera3, Jesus Cardenas-de la Garza5, Aleydis Gonzalez Melendez3, Andrea Guajardo Aldaco3, Maria F. Elizondo-Benitez6, Rebeca L. Polina-Lugo3 and Diego Salcedo-Almanza7, 1Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 2UANL Hospital Universitario, Monterrey, Nuevo León, Mexico, 3Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 4Division of Cardiology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 5Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 6Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 7Division of Radiology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico

    Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased cardiovascular (CV) risk compared to the general population. All stages of the atherogenic process appear to…
  • Abstract Number: 0705 • ACR Convergence 2024

    Identification of Risk Factors for Incident Cardiomyopathy in Patients with Systemic Sclerosis

    Ji Soo Kim1, Rachel Wallwork1, Carrie Richardson2, Adrianne Woods3, Monica Mukherjee4, Steven Hsu4, Julie Paik1, Christopher Mecoli1, Laura Hummers5, Fredrick Wigley6, Scott Zeger1 and Ami Shah7, 1Johns Hopkins University, Baltimore, MD, 2Northwestern University, Chicago, 3Johns Hopkins University Division of Rheumatology, Baltimore, MD, 4Johns Hopkins University Division of Cardiology, Baltimore, MD, 5Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Ellicott City, MD, 6Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, 7Division of Rheumatology, Johns Hopkins University, Ellicott City, MD

    Background/Purpose: Cardiac involvement in systemic sclerosis (SSc) is one of the leading causes of scleroderma-associated death. There are limited data examining risk factors for incident…
  • Abstract Number: 1097 • ACR Convergence 2024

    CERT Score as a Potential Tool to Predict Cardiovascular Risk in Gout and Hyperuricemia

    Blanka Stiburkova1, Aleš Kvasnička2, Barbora Pisklakova2, Jakub Rozhon2, Karel Pavelka3 and David Friedecky2, 1Institute of Rheumatology, Prague, Czech Republic and Department of Paediatrics and Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic, Prague, Czech Republic, 2Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic, Olomouc, Czech Republic, 3Institute of Rheumatology and Charles University, Praha, Czech Republic

    Background/Purpose: Asymptomatic hyperuricemia and gout are two clinical conditions associated with a high risk of cardiovascular events and mortality. Recent data suggest that the number…
  • Abstract Number: 1486 • ACR Convergence 2024

    Cardiovascular Risk in Systemic Lupus Erythematosus: Carotid Ultrasonography Is Useful for the Re-stratification of Cardiovascular Risk Determined by Score2

    Cristina Corrales Selaya1, Carmen Bejerano2, Carmen Secada Gómez3, Virginia Portilla-González4, Ricardo Blanco-Alonso5, Victor Manuel Martinez Taboada6, Leyre Riancho7 and alfonso Corrales-Martínez8, 1Rheumatology, Marques de Valdecilla University Hospital. IDIVAL, Santander, Cantabria, Spain, 2Hospital Universitario Marques de Valdecilla, Immunopathology group, IDIVAL, Santander, Cantabria, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 4Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 5Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, 6Facultad de Medicina. Universidad de Cantabria, Santander, Cantabria, Spain, 7Hospital Sierrallana, Torrelavega, Cantabria, Spain, 8Hospital Universitario Marques de Valdecilla, Santander, Spain

    Background/Purpose: Systemic lupus erythematosus (SLE) patients have an increased cardiovascular (CV) risk compared to the general population. Although SCORE2 (systematic coronary risk evaluation 2) has…
  • Abstract Number: 1899 • ACR Convergence 2024

    Recurrent Heart Failure Hospitalization in Rheumatoid Arthritis: A National Veterans Affairs Matched Cohort Study

    Tate Johnson1, Yangyuna Yang1, Punyasha Roul2, Joshua Baker3, Gary Kunkel4, Sauer brian5, grant Cannon6, Ted Mikuls1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC, Omaha, NE, 3University of Pennsylvania, Philadelphia, PA, 4University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 5Salt Lake City VA/University of Utah, Salt Lake City, UT, 6University of Utah and Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: People with rheumatoid arthritis (RA) are at an increased risk of heart failure (HF), which is among the most burdensome chronic conditions and a…
  • Abstract Number: 2357 • ACR Convergence 2024

    Longitudinal Evaluation of Neutrophil-to-Lymphocyte Ratio in Guselkumab-Treated Patients with Psoriatic Disease and Levels of Systemic Inflammation Associated with Elevated Cardiovascular Risk: Post-hoc Analysis of 4 Phase 3, Randomized, Controlled Studies

    Joseph Merola1, Alexis Ogdie2, Arthur Kavanaugh3, Evan Leibowitz4, Emmanouil Rampakakis5, Ryan Funk6, Francois Nantel7, Frederic Lavie8, Katelyn Rowland9 and Enrique R. Soriano10, 1UT Southwestern Medical Center, Newton, MA, 2Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3University of California San Diego, La Jolla, CA, 4Janssen Scientific Affairs, LLC, Fair Lawn, NJ, 5McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 6Johnson & Johnson Innovative Medicine, Long Grove, IL, 7Nantel MedSci Consult, Montreal, QC, Canada, 8Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 9Janssen Pharmaceuticals, Horsham, PA, 10Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Psoriatic disease (PsD) is associated with an increased risk of cardiovascular (CV) disease. Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of systemic inflammation; NLR ≥2.5…
  • Abstract Number: 0098 • ACR Convergence 2024

    Anti-HSP90α as a Protective Natural Antibody Against Secondary Antiphospholipid Syndrome in Systemic Lupus Erythematosus

    Marina Barguil Macedo1, Jorge Armando Gonzalez-Chapa1, Anders Bengtsson2, Iva Gunnarsson3, Elisabet Svenungsson4 and Christian Lood1, 1University of Washington, Seattle, WA, 2Lund University, Lund, Sweden, 3Karolinska Institute, Stockholm, Sweden, 4Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Heat shock protein 90 alpha (HSP90α) is an epichaperone present ubiquitously inside the cell, whose dimers function as a foldase that helps the correct…
  • Abstract Number: 0469 • ACR Convergence 2024

    SCORE2 Is Superior to SCORE in Predicting the Presence of Carotid Plaques and Intima-media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study with Carotid Ultrasound

    Cristina Campos Fernández1, Jorge Juan Fragío Gil2, Roxana González Mazario3, Pablo Martínez Calabuig4, Laura Salvador Maicas5, Mireia Lucía Sanmartín Martínez6, Iván Jesús Lorente Betanzos6, Clara Molina Almela6, juan José Lerma Garrido7, Amalia Rueda3 and Jose A Román-Ivorra8, 1Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain, 2Hospital General Universitario, Valencia, Comunidad Valenciana, Spain, 3Hospital General de Valencia, Valencia, Comunidad Valenciana, Spain, 4HOSPITAL GENERAL UNIVERSITARIO VALENCIA SPAIN, Ontinyent, Comunidad Valenciana, Spain, 5Consorcio Hospital General Universitario de Valencia, Castellón de la Plana, Comunidad Valenciana, Spain, 6Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain, 7Hospital General Universitario Valencia, Valencia, Comunidad Valenciana, Spain, 8Hospital Universitari i Politècnic la Fe, Valencia, Comunidad Valenciana, Spain

    Background/Purpose: Rheumatoid arthritis (RA) escalates the risk of premature mortality, predominantly through cardiovascular diseases. Although SCORE and its updated version, SCORE2, are employed to assess…
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