Abstracts tagged "Cardiovascular"

Abstract Number: 1641 • ACR Convergence 2021
Long-term Cardiovascular Disease and Mortality Following Kawasaki Disease in Childhood: A Systematic Review
Francis Lao¹, Cal Robinson², Megan Schlorff¹, Jocelyne Ewusie³, Karen Beattie¹ and Michelle Batthish¹, ¹McMaster University, Hamilton, ON, Canada, ²The Hospital for Sick Children, Hamilton, ON, Canada, ³St Joseph's Healthcare, Hamilton, ON, Canada
Background/Purpose: Kawasaki Disease (KD) is a common vasculitis of childhood, with an annual North American incidence of 20-26 per 100,000 children (< 5 years of…
Abstract Number: 0270 • ACR Convergence 2021
Impact of Macrophage Cholesterol Loading Capacity and Interactions with Treatments on Cardiovascular Risk and Coronary Atherosclerosis Burden in Rheumatoid Arthritis
George Karpouzas¹, Bianca Papotti², sarah ormseth³, Marcella Palumbo⁴, Elizabeth Hernandez³, Cinzia Marchi⁴, Francesca Zimetti⁴, Matthew Budoff⁵, Franco Bernini⁴ and Nicoletta Ronda⁴, ¹Harbor-UCLA Medical Center, Torrance, CA, ²2. Department of Food and Drug, University of Parma, Italy, Parma, Italy, ³The Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA, ⁴Department of Food and Drug, University of Parma, Parma, Italy, ⁵Division of Cardiology, and the Lundquist Institute ay Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: Statins and bDMARDs may decrease cardiovascular risk in RA by lowering coronary plaque formation, promoting regression and altering the composition of atherosclerotic lesions. Macrophage…
Abstract Number: 0407 • ACR Convergence 2021
The Clinical Role of T1 Mapping Cardiac Magnetic Resonance Imaging for Detecting Cardiac Involvement in the Early Stage of Systemic Sclerosis
Munkhtuul Purevsuren¹, Masae Uehara¹, Masato Ishizuka¹, Toru Hara¹, Nobutaka Kakuda¹, Taeko Tsuji¹, Tadashi Yamazaki¹, Miyazaki Miki², Hayakazu Sumida², Ayumi Yoshizaki², Yoshihide Asano², Shinichi Sato³, Masaru Hatano¹ and Komuro Issei¹, ¹1. Department of Cardiovascular Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan., Tokyo, Japan, ²2. Department of Dermatology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan., Tokyo, Japan, ³Department of Dermatology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is characterized by skin and internal organs tissue fibrosis including the myocardium. Cardiovascular magnetic resonance (CMR) parametric mapping is a promising…
Abstract Number: 0958 • ACR Convergence 2021
Risk Factors for Major Adverse Cardiovascular Events in Patients Aged ≥ 50 Years with RA and ≥ 1 Additional Cardiovascular Risk Factor: Results from a Phase 3b/4 Randomized Safety Study of Tofacitinib vs TNF Inhibitors
Christina Charles-Schoeman¹, Maya Buch², Maxime Dougados³, Deepak L Bhatt⁴, Jon Giles⁵, Ivana Vranic⁶, Joseph Wu⁷, Cunshan Wang⁷, Sujatha Menon⁷, Jose L Rivas⁸, Arne Yndestad⁹, Carol A Connell⁷ and Zoltan Szekanecz¹⁰, ¹Department of Medicine, University of California, Los Angeles, Los Angeles, CA, ²University of Leeds, Leeds, United Kingdom, ³Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France, ⁴Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ⁵Columbia University, New York, NY, ⁶Pfizer Inc, Tadworth, Surrey, United Kingdom, ⁷Pfizer Inc, Groton, CT, ⁸Pfizer SLU, Madrid, Spain, ⁹Pfizer Inc, Oslo, Norway, ¹⁰Division of Rheumatology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary
Background/Purpose: To identify independent risk factors for major adverse cardiovascular (CV) events (MACE) in ORAL Surveillance (NCT02092467), a long-term, randomized, open-label, non-inferiority, Phase 3b/4 safety…
Abstract Number: 1653 • ACR Convergence 2021
Positron Emission Tomography-Detected Uptake of 18F-Fluorodeoxyglucose in Visceral and Subcutaneous Adipose Tissue Is Associated with Articular Disease Activity and Arterial Inflammation in Rheumatoid Arthritis
Jon Giles¹, Joan Bathon², Hadil Zureigat³ and Ahmed Tawakol⁴, ¹Columbia University Irving Medical Center, Division of Rheumatology, New York, NY, ²Columbia University, New York, NY, ³Harvard University, Boston, MA, ⁴Harvard University/Massachusetts General Hospital, Boston, MA
Background/Purpose: Subcutaneous adipose tissue (SAT) from people with RA contains more macrophages and expresses higher levels of cytokines, chemokines, and other inflammatory mediators compared with…
Abstract Number: L08 • ACR Convergence 2020
Long Term Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Chronic Gout: The Febuxostat versus Allopurinol Streamlined Trial (on Behalf of the FAST Investigators)
Thomas MacDonald¹, Isla Mackenzie¹, George Nuki² and Ian Ford³, ¹University of Dundee, Dundee, Scotland, United Kingdom, ²University of Edinburgh, Edinburgh, Scotland, United Kingdom, ³University of Glasgow, Glasgow, Scotland, United Kingdom
Background/Purpose: Febuxostat and allopurinol are uric acid lowering agents. Following concerns about the cardiovascular safety of febuxostat, the European Medicines Agency (EMA) recommended a post-authorization…
Abstract Number: 0558 • ACR Convergence 2020
Statin Use Pattern in Patients with Inflammatory Joint Disease in a Single Site VA Medical Center
Lenche Kostadinova¹, Sofi Damjanovska², Angela Gupta³, Ibtissam Gad⁴, Sameena Syed⁴, Alyssa Lange⁵, Corinne Kowal⁶, Carey Shive⁷, Christopher Burant⁴, Brigid Wilson⁴, David Canaday⁴, David Zidar⁸, Donald Anthony⁹ and Maya Mattar¹⁰, ¹(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Highland Heights, OH, ²(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH, ³(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, ⁴(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, ohio, ⁵Case Western Reserve University, Cleveland, ⁶Case western reserve university/Cleveland VA Medical Center, ohio, ⁷(2) Department of Pathology, Case Western Reserve University, ohio, ⁸Case Western Reserve University/Cleveland VA Medical Center, Cleveland, ⁹Case Western Reserve University/Cleveland VA Medical Center/MetroHealth Medical Center, Cleveland, OH, ¹⁰Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH
Background/Purpose: Patients with inflammatory joint disease, including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) carry increased risk of cardiovascular disease (CVD). Mechanisms…
Abstract Number: 1184 • ACR Convergence 2020
In a Prospective RA Cohort, Higher Baseline Disease Activity Is an Independent Predictor of Decline in Left Ventricular Diastolic Function
Elizabeth Park¹, Kazato Ito², Christopher Depender¹, Jon Giles¹ and Joan Bathon¹, ¹Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, ²Division of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY
Background/Purpose: Rheumatoid Arthritis (RA) patients are at nearly 50% increased risk of heart failure (HF) compared to non-RA patients, despite adjusting for the presence of…
Abstract Number: 1333 • ACR Convergence 2020
Ankylosing Spondylitis Patients at Risk of Developing Aortic Valve Regurgitation, Need for Mandatory Echocardiography?
Milad Baniaamam¹, Sjoerd C. Heslinga², Laura Boekel¹, M. Louis Handoko³, Thelma C. Konings³, Otto Kamp³, Vokko P. van Halm⁴, J. Christiaan van Denderen¹, Irene van der Horst-Bruinsma² and Mike Nurmohamed⁵, ¹Reade, Amsterdam, Netherlands, ²Department of Rheumatology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ³Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ⁴Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, ⁵Amsterdam Rheumatology and immunology Center, location Reade and Amsterdam UMC, VU medical center, Amsterdam, Netherlands
Background/Purpose: The overall mortality rate in ankylosing spondylitis (AS) patients is increased by 60–90% compared with the general population. This higher mortality rate is predominately…
Abstract Number: 1795 • ACR Convergence 2020
Intracellular Homocysteine and Homocysteine Metabolites in Systemic Lupus Erythematosus (SLE)
George Stojan¹, Jessica Li¹, Amrita Raj², Maureen Kane³ and Michelle Petri⁴, ¹Johns Hopkins University, BALTIMORE, MD, ²Johns Hopkins University, Baltimore, ³University of Maryland School of Pharmacy, Baltimore, ⁴Johns Hopkins University School of Medicine, Baltimore
Background/Purpose: In SLE, homocysteine has been shown to be a potentially modifiable, independent risk factor for stroke and thrombotic events. All previous epidemiological studies used…
Abstract Number: 0650 • ACR Convergence 2020
Risk of Vertebral Fractures at Lateral Chest Radiographies in Patients with Gout
Marco Ferrández-Jiménez¹, Irene Calabuig², Maria Luisa Peral², Miguel Gómez-Garberí¹ and Mariano Andrés², ¹Universidad Miguel Hernández de Elche, Alicante, Spain, ²Hospital General Universitario de Alicante-ISABIAL and Universidad Miguel Hernández de Elche, Alicante, Spain
Background/Purpose: Osteoporosis causes significant morbidity and mortality through the development of fragility fractures, including vertebral fractures (VF). Patients with gout may show an increased risk…
Abstract Number: 1185 • ACR Convergence 2020
Performance of the MBDA-based CVD Risk Score in RA Patient Groups of Clinical Interest
Jeffrey R Curtis¹, Fenglong Xie², Cynthia Crowson³, Eric Sasso⁴, Elena Hitraya⁴, Cheryl Chin⁵, Richard Bamford⁵, Rotem Ben-Shachar⁵, Alexander Gutin⁵, Darl Flake⁵, Brent Mabey⁵ and Jerry Lanchbury⁵, ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Mayo Clinic, Rochester, Minnesota, USA, Rochester, MN, ⁴Myriad Autoimmune, South San Francisco, CA, ⁵Myriad Genetics, Inc., Salt Lake City, UT
Background/Purpose: A novel risk prediction score combines serum biomarkers from the multi-biomarker disease activity (MBDA) test with clinical information to predict 3-year risk for a…
Abstract Number: 1393 • ACR Convergence 2020
Systemic Sclerosis: Subclinical Aterosclerosis and Morbimortality
Miriam Retuerto¹, Jose Luis Rosales², Maria Martin¹, Beatriz Joven¹ and Patricia E Carreira¹, ¹Hospital universitario 12 de octubre, Madrid, Spain, ²Hospiten Rambla, Santa Cruz de Tenerife, Spain
Background/Purpose: Rheumatic diseases are associated with accelerated atherosclerosis, and an increase in cardiovascular morbidity and mortality. This process is mediated by classic cardiovascular risk factors…
Abstract Number: 1821 • ACR Convergence 2020
Early Assessment of Left Ventricular Assessment Using Speckle Tracking Echocardiography and It´s Relationship with Insulin Resistance in Women with Systemic Lupus Erythematosus
Pamela Munguía-Realpozo¹, Claudia Mendoza-Pinto², Socorro Méndez-Martínez², Liliana Pérez-Aquino³, Ivet Etchegaray-Morales¹ and Mario Garcia-Carrasco², ¹Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Puebla, Mexico, ²Instituto Mexicano del Seguro Social, Puebla, Puebla, Mexico, ³Facultad de Medicina, Beneméria Universidad Autónoma de Puebla, Puebla, Puebla, Mexico
Background/Purpose: Systemic lupus erythematosus patients (SLE) have increased cardiovascular risk. Patients with SLE are associated with significant alterations in cardiac structure and function as demonstrated…
Abstract Number: 0654 • ACR Convergence 2020
The Effects of Dietary Macronutrients on Serum Urate: A Secondary Analysis of the OmniHeart Trial
Matthew Belanger¹, Christina Wee¹, Kenneth Mukamal¹, Edgar Miller², Frank Sacks³, Lawrence Appel², Robert Shmerling⁴, Hyon Choi⁵ and Stephen Juraschek¹, ¹Beth Israel Deaconess Medical Center/Harvard Medical School, Division of General Medicine, Boston, MA, ²Johns Hopkins University, School of Medicine, Department of Medicine, Division of General Internal Medicine, Baltimore, MD, ³Harvard T. H. Chan School of Public Health, Department of Nutrition, Boston, MA, ⁴Beth Israel Deaconess Medical Center/Harvard Medical School, Division of Rheumatology, Mashpee, MA, ⁵Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA
Background/Purpose: Diet is a significant determinant of hyperuricemia and risk for gout. Dietary recommendations to prevent gout emphasize reducing purine intake; however, low-purine diets are…

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