ACR Meeting Abstracts

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Abstracts tagged "Cardiovascular"

  • Abstract Number: 1240 • ACR Convergence 2022

    A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy for the Diagnosis of Cardiac Sarcoidosis

    Omar Abialmouna1, Mohamad Kalot2, Mohamad Hamade3, Ronak Bahuva2, Ariba Hasmi2, Aamir Ahmed2, Zachary Brumberger2, Jordan Troy2, Ali Choaib4, Ronak Bharucha2, Ross Moyer2, Karin Provost2, Brian Page2 and Umesh Sharma2, 1University at Buffalo, North Tonawanda, NY, 2University at Buffalo, Buffalo, NY, 3University of Miami, Miami, FL, 4Lebanese American University, Beirut, Lebanon

    Background/Purpose: Autopsy reports for patients with sarcoidosis have suggested that up to 25% have cardiac involvement, mostly undiagnosed. Given the limited diagnostic accuracy of endomyocardial…
  • Abstract Number: 1535 • ACR Convergence 2022

    Frequency of Arrhythmias, Abnormal Electrocardiography and Sudden Cardiac Death in Systemic Sclerosis: A Systematic Review and Meta-analysis

    Jessica Fairley1, Laura Ross2, Alannah Quinlivan3, Dylan Hansen4, Elizabeth Paratz5, Wendy Stevens4, Peter M Kistler6, Andre La Gerche7 and Mandana Nikpour8, 1The University of Melbourne, Melbourne, Australia, 2The University of Melbourne at St. Vincent's Hospital, Brunswick, Australia, 3St Vincent's Hospital Melbourne and the University of Melbourne, Melbourne, Australia, 4St Vincent's Hospital Melbourne, Melbourne, Australia, 5The Baker Institute; St Vincent's Hospital Melbourne, Melbourne, Australia, 6The Baker Heart and Diabetes Institute; The University of Melbourne; Monash University, Melbourne, Australia, 7The Baker Heart and Diabetes Institute; The University of Melbourne, Melbourne, Australia, 8The University of Melbourne at St. Vincent's Hospital Melbourne, Melbourne, Australia

    Background/Purpose: Scleroderma (SSc) Heart Involvement (SHI) is an under recognised complication of SSc and may manifest as arrhythmias or sudden cardiac death(SCD). The incidence of…
  • Abstract Number: 1816 • ACR Convergence 2022

    Assessing Urate Deposition and Inflammation in the Vasculature of Gout Patients Using Dual Energy Computed Tomography and Positron Emission Tomography Pre and Post Pegloticase- a Pilot Study

    Ira Khanna, Venkatesh Mani, Renata Pyzik, Audrey Kaufman, Wei Wei Chi, Emilia Bagiella, Philip Robson and Yousaf Ali, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Gout is the most common inflammatory arthritis, caused by hyperuricemia and subsequent deposition of aggregated monosodium urate (MSU) crystals in both articular and extra-articular…
  • Abstract Number: 2217 • ACR Convergence 2022

    Disease Response in Rheumatoid Arthritis Across 4 Biologic Therapies Associates with Improvement in Paraoxonase-1 Activity

    Amir Razmjou1, Jennifer Wang1, Ani Shahbazian1, Jeffrey Curtis2, Dimitrios Pappas3, Joel Kremer4 and Christina Charles-Schoeman5, 1UCLA Medical Center, Los Angeles, CA, 2University of Alabama at Birmingham, Hoover, AL, 3CorEvitas, LLC, Waltham, MA, 4The Corrona Research Foundation, Delray Beach, FL, 5Division of Rheumatology, University of California, Los Angeles, Santa Monica, CA

    Background/Purpose: Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme with paraoxonase, lactonase, and arylesterase activities (1). PON1 is integral to the anti-inflammatory, anti-atherogenic functions of…
  • Abstract Number: 0244 • ACR Convergence 2022

    Identification of Novel Response Predictors via Cardiovascular Biomarker Proteomic Analysis of Serum Samples from Patients with Early, Seropositive RA Treated with Abatacept or Adalimumab

    Yicong Li1, Chun Wu2, Michael Maldonado2, Peter Schafer2, S. Louis Bridges, Jr.3, William Rigby4, Vivian Bykerk3, Jane Buckner5 and Jinqi Liu2, 1Parexel International, Durham, NC, 2Bristol Myers Squibb, Princeton, NJ, 3Hospital for Special Surgery, New York, NY, 4Dartmouth Hitchcock Medical Center, Lebanon, PA, 5Benaroya Research Institute at Virginia Mason, Seattle, WA

    Background/Purpose: Effective RA therapies should not only improve joint signs and symptoms, but also mitigate additional disease-related consequences, such as the increased risk of cardiovascular…
  • Abstract Number: 0539 • ACR Convergence 2022

    Cardiac Complications, Thrombosis, Infections and All-cause Mortality Among Patients with End-Stage Kidney Disease Due to Lupus Nephritis in the USRDS 2006-2013 According to SLE Medication Use

    Anna Broder1, Wenzhu B. Mowrey2, Kazuki Yoshida3 and Karen Costenbader3, 1Hackensack University Medical Center, Hackensack, NJ, 2Albert Einstein College of Medicine, Bronx, NY, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Medication management strategies in patients with lupus-related end stage kidney disease (ESKD) have not been studied. Our prior work has shown that HCQ may…
  • Abstract Number: 0908 • ACR Convergence 2022

    The Association of Cardiovascular Comorbidities with Remission in Rheumatoid Arthritis Patients Undergoing Treatment with Baricitinib and Conventional Synthetic DMARDs: A Post-Hoc Analysis

    Arkady Manning-Bennett1, Ashley Hopkins2, Michael Sorich2, Susanna Proudman3, David Foster1, Ahmad Abuhelwa2 and Michael Wiese1, 1University of South Australia, Adelaide, Australia, 2Flinders University, Adelaide, Australia, 3Rheumatology Unit, Royal Adelaide Hospital, and Discipline of Medicine, University of Adelaide, Adelaide, Australia

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic autoimmune disease that is characterised by inflammation in the synovium of diarthrodial joints and low-level inflammation in multiple…
  • Abstract Number: 1263 • ACR Convergence 2022

    Impact of Cardiovascular Risk on the Diagnostic Accuracy of the Ultrasound Halo Score for Giant Cell Arteritis

    Juan Molina1, KATERINE FABIOLA LOPEZ GLORIA2, Isabel Castrejon3, Juan Carlos Nieto González1, Julia Martinez-Barrio1, Ana M Anzola Alfaro4, Javier Rivera4 and José María Älvaro-Gracia1, 1Hospital General Universitario Gregorio Marañón, Madrid, Spain, 2Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, Madrid, Spain, 3Hospital Universitario Gregorio Marañón, Madrid, Spain, 4Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Background/Purpose: To evaluate the impact of cardiovascular risk (CVR) on the diagnostic accuracy of the ultrasonographic (US) Halo Score in patients with suspected giant cell…
  • Abstract Number: 1540 • ACR Convergence 2022

    Correlations of Soluble Interleukin-2 Receptor Serum Levels with Markers of Inflammation and Pathological High-sensitivity Troponin T and Its Possible Role as a Predictor of Early Clinical Progress in Systemic Sclerosis

    Luise Schumacher1, Sebastian Klapa2, Antje Mueller3 and Gabriela Riemekasten4, 1University of Lübeck, Lübeck, Germany, 2Universityhospital Schleswig-Holstein; University of Lübeck; Clinic of Rheumatology and Clinical Immunology, Luebeck, Germany, 3University Hospital Schleswig-Holstein (UKSH), Lübeck, 4University Clinic Schleswit-Holstein (UKSH), Luebeck, Germany

    Background/Purpose: Systemic sclerosis (SSc) is characterized by chronic inflammation leading to damage of the vascular endothelium and excessive collagen deposition in several target organs. The…
  • Abstract Number: 1825 • ACR Convergence 2022

    Vascular Calcifications Adjacent to the Involved Joint of Patients Diagnosed with Calcium Pyrophosphate Crystal Arthritis – a Retrospective Observational Study

    Shay Brikman1, Amir Bieber2 and Reuven Mader1, 1Rheumatic Diseases Unit, Emek Medical Center, Afula, Israel, 2Emek Medical Center, Raanana, Israel

    Background/Purpose: Prior studies have shown an association between chondrocalcinosis (CC) and vascular calcifications. In this study, we aimed to assess the presence of vascular calcifications…
  • Abstract Number: 2219 • ACR Convergence 2022

    Time-Dependent Evaluation of Glucocorticoid Exposure Duration and Major Adverse Cardiovascular Events in a Cohort of Veterans with Rheumatoid Arthritis

    Beth Wallace1, Yuqing Gao2, H. Myra Kim3, Punyasha Roul4, Ted Mikuls5, Daniel Clauw6, Bryant England7, Joshua Baker8, Brian Sauer9, Grant Cannon10, Shirley Cohen-Mekelberg1, Wyndy Wiitala2, Jeremy Sussman1, Rodney Hayward1 and Akbar Waljee1, 1University of Michigan Department of Internal Medicine; Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, 2Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, 3Center for Statistical Consultation and Research, University of Michigan; Center for Clinical Management Research, VA Ann Arbor Healthcare Center, Ann Arbor, MI, 4UNMC, Omaha, NE, 5Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 6University of Michigan Department of Anesthesia, Ann Arbor, MI, 7University of Nebraska Medical Center, Omaha, NE, 8University of Pennsylvania, Philadelphia, PA, 9Salt Lake City VA/University of Utah, Salt Lake City, UT, 10Retired, Salt Lake City, UT

    Background/Purpose: Three-quarters of RA patients use glucocorticoids (GC) at some point to manage RA symptoms. Prior work suggests recent GC use is associated with major…
  • Abstract Number: 0251 • ACR Convergence 2022

    Nuclear Factor of Activated T Cells Cytoplasmic 1 as a Potential Biomarker of Increased Cardiovascular Risk in Patients with Early Rheumatoid Arthritis

    Sara Remuzgo-Martinez1, Fernanda Genre1, Veronica Pulito-Cueto2, Alfonso Corrales1, Virgi Portilla1, Leticia Lera-Gómez1, Belén Atienza-Mateo1, María Sebastián Mora-Gil1, J Gonzalo Ocejo-Vinyals3, Oreste Gualillo4, Ricardo Blanco5, Ivan Ferraz Amaro6, Santos Castañeda7, Raquel Lopez Mejias2 and Miguel Ángel González-Gay8, 1Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2IDIVAL, Santander, Spain, 3Department of Immunology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Hospital Clínico Universitario de Santiago, SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago de Compostela, Spain, 5Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 6Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, 7Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 8Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: NFKB1, NKIRAS1, NFATc1, NFATc2 and MTHFR, inflammation and immune response-related genes, predispose to the increased risk of cardiovascular (CV) disease in patients with RA…
  • Abstract Number: 0575 • ACR Convergence 2022

    Myocardial Infarction and Stroke Risks Among Patients Who Initiated Treatment with Denosumab or Zoledronic Acid for Osteoporosis

    Leslie Spangler1, Carrie Nielson1, M Alan Brookhart2, Rohini K Hernandez1, Robert Kees Stad3 and Jay Lin1, 1Amgen, Inc., Thousand Oaks, CA, 2NoviSci, Inc., Durham, NC, 3Amgen Inc., Zug, Switzerland

    Background/Purpose: There has been inconsistent evidence published regarding the cardio- and cerebrovascular benefits and risks of anti-osteoporosis medications. EU regulators requested Amgen to evaluate the…
  • Abstract Number: 0909 • ACR Convergence 2022

    Unsupervised Clustering Analysis of Circulating Molecular Profiles in Rheumatoid Arthritis Patients Defines Precise CV Risk. Effects of TNFi, IL6Ri, and JAKinibs

    Chary Lopez-Pedrera1, Laura Muñoz-Barrera1, Tomás Cerdó2, Maria Luque-Tevar3, Pilar Font1, Montserrat Romero-Gomez2, Desiree Ruiz-Vilchez4, Sara Remuzgo-Martinez5, Raquel Lopez Mejias6, María Carmen Ábalos-Aguilera7, Rafaela Ortega-Castro1, José Perez-Venegas8, Mª Dolores Ruiz-Montesinos8, Carmen Dominguez8, Carlos Rodriguez-Escalera9, Carmen Romero-Barco9, Antonio Fernandez-Nebro10, Natalia Mena Vazquez10, Jose Luis Marenco11, Julia Uceda Montañez11, Charo Santos12, Nuria Barbarroja1, Mª Angeles Aguirre13, Alejandro Escudero-Contreras2, Eduardo Collantes1, Miguel Ángel González-Gay14 and Carlos Pérez-Sánchez1, 1IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, 2IMIBIC/University of Cordoba/Reina Sofia Hospital, Córdoba, Spain, 3IMIBIC, Córdoba, Spain, 4Reina Sofia University Hospital, Cordoba, Cordoba, Spain, 5Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 6IDIVAL, Santander, Spain, 7Imibic/ University of Córdoba/ Reina Sofía Hospital, Córdoba, Spain, 8Virgen Macarena University Hospital, Sevilla, Spain, 9Virgen de la Victoria Hospital, Málaga, Spain, 10Regional University Hospital of Málaga, Málaga, Spain, 11Virgen de Valme University Hospital, Sevilla, Spain, 12Virgen de Valme University Hospital, Málaga, Spain, 13Maimonides Institute for Biomedical Research of Córdoba, Cordoba, Spain, 14Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: This study aimed to 1) Analyze the circulating inflammatory profile of Rheumatoid Arthritis (RA) patients, in order to recognize distinctive clinical phenotypes associated with…
  • Abstract Number: 1391 • ACR Convergence 2022

    Inadequate Cardiovascular Disease Risk Screening and Preventative Treatment in Patients with Rheumatoid Arthritis

    Tooba Munawar1, Farzam Khokhar2 and Andras Perl3, 1SUNY Upstate Medical Unviersity, Jamesville, NY, 2SUNY Upstate Medical University, Syracuse, NY, 3SUNY, Syracuse, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease. Patients with RA are at risk of accelerated cardiovascular disease (CVD). The purpose of this study…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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