Abstracts tagged "Cardiovascular disease"

Abstract Number: 1437 • 2014 ACR/ARHP Annual Meeting
Cholesterol Efflux Capacity of HDL and Coronary Atherosclerosis in Rheumatoid Arthritis
Michelle J. Ormseth¹, Patricia Yancey², Suguru Yamamoto², Annette M. Oeser¹, Tebeb Gebretsadik³, Ayumi Shintani¹, MacRae F. Linton¹, Sergio Fazio¹, Sean Davies¹, L Jackson Roberts II¹, Kasey C. Vickers¹, Paolo Raggi⁴, Valentina Kon¹ and C Michael Stein¹, ¹Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Biostatistics, Vanderbilt University, Nashville, TN, ⁴Emory University, Atlanta, GA
Background/Purpose: Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL…
Abstract Number: 1064 • 2014 ACR/ARHP Annual Meeting
Unique Profile of Cardiovascular Risk Factors in Rheumatoid Arthritis High-Risk Populations with Insufficient Risk Control
Ulf Müller-Ladner¹, Stefan Kleinert², Klaus Krüger³, Bianca Wittig⁴ and Rolf Hecker⁴, ¹Rheumatologie und klinische Immunologie, Kerckhoff-Klinik GmbH, Abt. Rheumatologie und klinische Immunologie, Bad Nauheim, Germany, ²Rheumatologie, Praxisgemeinschaft Rheumatologie-Nephrologie, Rheumatologische Schwerpunktpraxis, Erlangen, Germany, ³Praxiszentrum St. Bonifatius, München, Germany, ⁴Abbvie Deutschland GmbH & Co. KG, Wiesbaden, Germany
Background/Purpose More than 50% of premature deaths in patients with rheumatoid arthritis (RA) are due to cardiovascular disease (CVD). Both the cumulative burden of inflammation…
Abstract Number: 392 • 2014 ACR/ARHP Annual Meeting
Neuroendocrine Hormone and Metabolic Peptide Levels in the Earliest Phases of Rheumatoid Arthritis – Do Free Fatty Acids Play a Role?
Man Wai Tang¹, Frieda A. Koopman², Jan P.M. Visscher², Marjolein J.H. de Hair², Danielle M. Gerlag^2,3 and Paul P. Tak^2,4, ¹Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³GlaxoSmithKline, Cambridge, United Kingdom, ⁴University of Cambridge, Cambridge and GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with several neuroendocrine hormones and metabolic peptides. The crosstalk between the hormones and the immune…
Abstract Number: 2936 • 2014 ACR/ARHP Annual Meeting
Is Ankylosing Spondylitis a Risk Factor for Cardiovascular Diseases, and How Does These Risks Compare to Those in Rheumatoid Arthritis?
Johan Askling¹, Lennart Jacobsson² and Jonas Eriksson¹, ¹Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²sahlrenska academy, gothenburg, Sweden
Background/Purpose Patients with RA are at increased risk of cardiovascular (CV) diseases, including acute coronary syndromes (ACS), deep venous thromboembolism (DVT) and pulmonary embolism (PE),…
Abstract Number: 2103 • 2014 ACR/ARHP Annual Meeting
Benefits of Early Onset of DAS28 (CRP) <2.6 on Physical Functioning, Quality of Life and Resource Use Among RA Patients in a Clinical Practice Setting
E Alemao¹, S Joo², H Kawabata¹, S Banerjee¹, M Frits³, C Iannaccone³, N Shadick³ and M Weinblatt³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Hopewell, NJ, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Guidelines in RA recommend that treatment should be aimed at reaching a target of remission or low disease activity (LDA) as soon as possible,…
Abstract Number: 1413 • 2014 ACR/ARHP Annual Meeting
The Prevalence of Renal Impairment in Patients with Rheumatoid Arthritis
Marion Couderc Sr.¹, Martin Soubrier², Bruno Pereira³, Aurelien Tiple⁴, Melanie Gilson⁵, Bruno Fautrel⁶, Sophie Pouplin⁷, Emmanuelle Dernis Labous⁸, Laure Gossec⁹, Cécile Gaujoux-Viala¹⁰ and Maxime Dougados¹¹, ¹Chu G.Montpied, Clermont Ferrand, France, ²Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France, ³Clinical research department, Clermont-Ferrand, France, ⁴Nephrology, CHU, Clermont-Ferrand, France, ⁵Rheumatology, CHu Grenoble, Grenoble, France, ⁶Rheumatology, Pitie Salpetriere Hospital, Paris, France, ⁷Rheumatology, Rouen University Hospital, Rouen, France, ⁸Rhumatologie, Ch Du Mans, Le Mans, France, ⁹Rheumatology, UPMC GRC08, Paris 06 University, Pitié Salpétrière Hospital, Paris, France, ¹⁰EA 2415, Montpellier I University, Nîmes University Hospital, Rheumatology Department, Nîmes, France, ¹¹Université Paris René Descartes and Hôpital Cochin, Paris, France
Background/Purpose: To assess the prevalence and associations of renal dysfunction in patients with rheumatoid arthritis (RA). Methods: COMEDRA is a French nationwide cross-sectional multicentre study…
Abstract Number: 1063 • 2014 ACR/ARHP Annual Meeting
Management of Hyperlipidemia Among Patients with Rheumatoid Arthritis in the Primary Care Setting
Kashif Jafri¹, Lynne Taylor², Nehal N. Mehta³, Melissa Nezamzadeh⁴, Joshua Baker⁵ and Alexis Ogdie⁶, ¹Department of Medicine, University of Pennsylvania, Philadelphia, PA, ²Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ³Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Medicine/Rheumatology, University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, ⁶Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Rheumatoid arthritis has been associated with an increased risk of cardiovascular morbidity and mortality. It is unclear, however, whether this knowledge has translated into…
Abstract Number: 385 • 2014 ACR/ARHP Annual Meeting
Validation of a Prognostic Model to Predict Structural Damage Assessed By X-Ray in Patients with RA Using MRI Data from a Clinical Trial
EA Alemao¹, S Joo², S Banerjee¹, P Allison³, P Emery⁴, M Weinblatt⁵ and Katherine Liao⁶, ¹Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Hopewell, NJ, ³University of Pennsylvania, Philadelphia, PA, ⁴University of Leeds, Leeds, United Kingdom, ⁵Brigham and Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: We developed and validated a prognostic model for rapid radiographic progression (RRP) using X-ray data to identify RA patients (pts) at risk of structural…
Abstract Number: 2932 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Deep Vein Thrombosis and Pulmonary Embolism in Sjögren’s Syndrome: A General Population-Based Cohort Study
Marko Yurkovich¹, Hyon K. Choi², Eric C. Sayre³, Kamran Shojania⁴ and J. Antonio Avina-Zubieta⁵, ¹Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ²Boston University School of Medicine, Boston, MA, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: There is limited data available on the risk of deep venous thrombosis (DVT) and pulmonary embolism (PE) in Sjögren's Syndrome (SjS). We estimated the…
Abstract Number: 2098 • 2014 ACR/ARHP Annual Meeting
Genetic Variants of the NLRP3 Inflammasome Are Associated with Stroke in Patients with Rheumatoid Arthritis
Alf Kastbom¹, Lisbeth Ärlestig² and Solbritt M. Rantapää-Dahlqvist³, ¹Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, ²Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ³Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden
Background/Purpose Inflammasomes are intra-cellular protein complexes important for the production of pro-inflammatory cytokines such as interleukin-(IL-)1β and IL-18. Cardiovascular disease is over-represented in patients with…
Abstract Number: 1410 • 2014 ACR/ARHP Annual Meeting
Low Rates of Cardiovascular Risk Factor Modification Among High-Risk Rheumatoid Arthritis Patients: Barrier to Cardiovascular Prevention Strategies?
Kimberly P. Liang¹, Rohit Aggarwal², Juan (June) Feng³, Jason Lyons³, Heather Eng³, Stephen R. Wisniewski³, Melissa Saul⁴, Douglas P. Landsittel⁵, Douglas W. Chew¹, Aryan Aiyer⁶ and Larry W. Moreland⁷, ¹Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, University of Pittsburgh, Pittsburgh, PA, ³Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁴Biomedical Informatics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, ⁵Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, ⁶Department of Medicine, Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁷Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Despite higher risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA), systematic cardiovascular (CV) prevention strategies are lacking. Recent guidelines for CV risk…
Abstract Number: 945 • 2014 ACR/ARHP Annual Meeting
Disease Remission Reduces Risk of Heart Failure in Rheumatoid Arthritis Patients Independent of Treatment Strategy
Thomas Schau¹, Michael Gottwald², Christian Butter¹ and Michael Zaenker³, ¹Cardiology Dept., Immanuel Klinikum Bernau Heart Center Brandenburg, Bernau, Germany, ²Internal Med. Dept., Immanuel Klinikum Bernau, Rheumatology Center Northern Brandenburg, Bernau, Germany, ³Immanuel Klinikum Bernau, Rheumatology Center Northern Brandenburg, Bernau, Germany
Background/Purpose Risk of heart failure (HF) is increased in patients with RA, however there is great variance in reported prevalence rates due to different diagnostic…
Abstract Number: 355 • 2014 ACR/ARHP Annual Meeting
Increased Left Ventricular Mass Index and Decreased Ejection Fraction Are Associated with Disease Activity in Rheumatoid Arthritis Patients without Cardiac Symptoms; Comparison Between Non-Biologic and Biologic Dmards Treatment Groups, Using a Cardiac Magnetic Resonance Imaging
Hitomi Kobayashi¹, Yasuyuki Kobayashi², Atsuma Nishiwaki³, Hirotake Inomata¹, Noboru Kitamura¹, Hidetake Shiraiwa³, Takamasa Nozaki³, Natsumi Ikumi⁴ and Masami Takei⁵, ¹Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ²Radiology, St.Marianna University School of Medicine, Kawasaki, Japan, ³Nihon University School of Medicine, Tokyo, Japan, ⁴Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ⁵Dept of Med Rheumatology, Nihon University School of Medicine, Itabashi Tokyo, Japan
Background/Purpose Patients with rheumatoid arthritis (RA) experience an excess risk of congestive heart failure (CHF), but effects of disease-modifying anti-rheumatic drugs (DMARDs) on cardiac structure…
Abstract Number: 2889 • 2014 ACR/ARHP Annual Meeting
The Association Between Changes in Inflammation and High Density Lipoprotein Cholesterol Efflux Capacity in Rheumatoid Arthritis
K P Liao¹, Martin Playford², Michelle A. Frits³, Christine K. Iannaccone⁴, Jonathan S. Coblyn¹, Michael E. Weinblatt⁵, Nancy A. Shadick⁶ and Nehal N. Mehta⁷, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²National Heart, Blood, and Lung Institute, Bethesda, MD, ³Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁴Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology & Immunology, Brigham and Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital/Harvard University, Cambridge, MA, ⁷Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA
Background/Purpose: High density lipoprotein (HDL) cholesterol efflux capacity measures the functional ability of HDL to remove cholesterol from atherosclerotic plaque. Low HDL efflux capacity is…
Abstract Number: 2084 • 2014 ACR/ARHP Annual Meeting
Are Genetic Markers Associated with Myocardial Infarction in Patients with Early Rheumatoid Arthritis?
Lisbeth Ärlestig¹, Petros Zamout², Lena Innala³, Eva Freyhult⁴, Solveig Wållberg Jonsson² and Solbritt Rantapää-Dahlqvist², ¹Public Health & Clinical Medicine/Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umea, Sweden, ²Public Health & Clinical Medicine/Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden, ³Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden, ⁴Bioinformatics Infrastructure for Life Sciences, Uppsala, Sweden
Background/Purpose Cardiovascular disease (CVD) are increased in patients with rheumatoid arthritis (RA). Traditional as well as disease related risk factors seem to contribute to the…

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