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Abstract Number: 1274

Patients with Osteoarthritis Do NOT Have Increased Risk of Cardiovascular Disease in Ullensaker Community in Norway

Silvia Rollefstad1, Ingvild Eeg2, Ida K. Haugen2, Inge C. Olsen3, Nina Østerås4, Barbara Christensen2, Hilde Berner Hammer5, Lars Nordsletten6, Bård Natvig7, Tore K. Kvien8 and Anne Grete Semb1, 1Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Department of rheumatology, National Advisory Unit for rehabilitation in rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Postboks 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, 6Dept of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway, 7General Practice, Oslo University, Oslo, Norway, 8Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Cardiovascular disease, Lipids, osteoarthritis and risk assessment

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Session Information

Session Title: Osteoarthritis - Clinical Aspects: Epidemiology and Pathogenesis

Session Type: Abstract Submissions (ACR)

Background/Purpose

Controversies exist regarding whether patients with osteoarthritis (OA) have an increased risk of cardiovascular (CV) disease. Our aim was to evaluate the CV risk in a population-based OA cohort.

Methods

The Musculoskeletal pain in Ullensaker STudy (MUST) is a cross-sectional investigation comprising a thorough clinical examination, recording of CV risk factors in addition to radiographic evaluation of hands, hips and knees of persons with self-reported OA (The MUST-Heart study). Of the 604 persons examined, 438 fulfilled the ACR classification criteria for OA in the hand, knee and/or hip joints. The study population was divided into: 1) generalized OA, defined as bilateral hand OA or involvement of > 3 out of 6 sites (bilateral hand/hip/knee); 2) focal OA; or 3) non-OA. CV risk was calculated by the SCORE algorithm for persons without CV disease, not using lipid lowering and/or antihypertensive medication (OA n=200 and non-OA n=87). An estimated CV risk < 5% for a fatal myocardial infarction coming 10 years is defined as low to medium risk, while > 5% is the cut off for initiation of CV preventive pharmacotherapy. Comparisons between groups were done by using independent samples T-test, Mann Whitney-U and χ2.

Results

The median CV risk for patients with OA [1.40 (IQR 0.65, 2.92)] was significantly higher compared to non-OA [0.99 (IQR 0.52, 1.92)] (p=0.02). The difference in the CV risk was related to higher age (p <0.001), but not to total cholesterol (p=0.07), systolic blood pressure (p=0.13) or to the OA diagnosis. Only 17/200 (8.5%) of the OA patients and 3/87 (3.4%) of the non-OA persons had a CV risk > 5% (p=0.12) (Table). The presence of established CV disease was comparable for those with (n=72/438, 16.8%) and without OA (n=34/166, 21.1%) (p=0.23). Dividing the OA group into focal and generalized OA, did not reveal any further differences regarding estimated CV risk or CV disease compared with non-OA. Inflammatory biomarkers (erythrocyte sedimentation rate and C-reactive protein) were in the normal range for the whole study population, with no difference between OA and non-OA (p=0.30 and 0.10, respectively)(Fig 1a&b).

Conclusion

Inhabitants with OA in a Norwegian municipality had an overall low risk of CV disease and did not have higher prevalence of established CV disease compared to non-OA.


Disclosure:

S. Rollefstad,
None;

I. Eeg,
None;

I. K. Haugen,
None;

I. C. Olsen,
None;

N. Østerås,
None;

B. Christensen,
None;

H. B. Hammer,
None;

L. Nordsletten,
None;

B. Natvig,
None;

T. K. Kvien,
None;

A. G. Semb,
None.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/patients-with-osteoarthritis-do-not-have-increased-risk-of-cardiovascular-disease-in-ullensaker-community-in-norway/

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