Abstracts tagged "Cardiovascular disease"

Abstract Number: 2445 • 2014 ACR/ARHP Annual Meeting
A Distinct Profile of Circulating Microparticles Is Associated with Disease Features in Rheumatoid Arthritis Patients and Impairs Endothelial Functionality in Vitro
Javier Rodríguez-Carrio¹, Mercedes Alperi-López², Patricia López¹, Sara Alonso-Castro², Santiago Rubén Carro-Esteban¹, Javier Ballina-García² and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Rheumatology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
Background/Purpose Cell-derived microparticles (MPs) could be considered biomarkers of cell damage and activation and they are thought to have a role in cardiovascular (CV) and inflammatory…
Abstract Number: 1846 • 2014 ACR/ARHP Annual Meeting
The Association Between Hydroxychloroquine Treatment and Cardiovascular Morbidity Among Rheumatoid Arthritis Patients
Michael Shapiro¹ and Yair Levy², ¹Haim Lebanon 55, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ²Internal Medicine E, Meir Medical Center, Kfar Saba, Israel
Background/Purpose: Accelerated atherosclerosis and cardiovascular disease are the main causes of mortality in Rheumatoid Arthritis (RA). The anti-malarial drug Hydroxychloroquine (HCQ) has long been used…
Abstract Number: 1362 • 2014 ACR/ARHP Annual Meeting
Impact of Rapid Attainment of Stringent Measures of Efficacy in Rheumatoid Arthritis on Patient-Reported Outcomes
EA Alemao¹, S Joo², S Banerjee¹, P Emery³ and M Weinblatt⁴, ¹Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Hopewell, NJ, ³University of Leeds, Leeds, United Kingdom, ⁴Brigham and Women's Hospital, Boston, MA
Background/Purpose: Treatment guidelines in RA recommend that therapies aim to reach a target of remission or low disease activity (LDA) and that these targets should…
Abstract Number: 836 • 2014 ACR/ARHP Annual Meeting
Categorical Change in 6MWD in Patients with Connective Tissue Disease Associated Pulmonary Arterial Hypertension Receiving Ambrisentan over 3-Years
Aryeh Fischer¹, Virginia D. Steen², Steven Nathan³, Hunter Gillies⁴, James Tislow⁵ and Chris Blair⁶, ¹Rheumatology / ILD Program, National Jewish Health, Denver, CO, ²Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ³Heart Failure/Transplant, Inova Medical Group, Falls Church, VA, ⁴Clinical Research - Cardiovascular, Gilead Sciences, Inc., Foster City, CA, ⁵Medical Affairs, Gilead Sciences, Inc., Foster City, CA, ⁶Biostatistics, Gilead Sciences, Inc., Foster City, CA
Background/Purpose: The 6MWD is a valuable tool for evaluating response to therapy in patients with pulmonary arterial hypertension and may be considered a surrogate measure…
Abstract Number: 154 • 2014 ACR/ARHP Annual Meeting
Cimt in Individuals with Rheumatoid Arthritis Compared to Individuals with Type2 Diabetes
Helen Pahau Sr.^1,2, Leanne Short³, Brian Haluskas⁴, Vibeke Videm⁵ and Ranjeny Thomas⁶, ¹Diamantina Institute, The University of Queensland, Woolloongabba, Australia, ²Diamantina Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ³Cardiovascular Imaging Research Centre, University of Queensland, Woolloongabba, Australia, ⁴Cardiovascular Imaging Research Centre, the University of Queensland, Woolloongabba, Australia, ⁵Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, and Department of Immunology and Transfusion Medicine, Trondheim University Hospital,, Trondheim, Norway, ⁶University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose It is well known that patients with RA or Type 2 diabetes (T2DM) have increased risk of atherosclerosis and CVD. Carotid ultrasound measurement of…
Abstract Number: 2452 • 2014 ACR/ARHP Annual Meeting
Protective Effect of the IL33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
Raquel López-Mejías¹, Fernanda Genre¹, Mercedes García-Bermúdez², Alfonso Corrales¹, Carlos González-Juanatey³, Begoña Ubilla¹, J. Llorca⁴, Encarnación Amigo⁵, Jose A. Miranda-Filloy⁶, Trinitario Pina Murcia¹, Ricardo Blanco⁷, Santos Castañeda⁸, Javier Martin⁹ and Miguel A González-Gay¹, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ³Hospital Universitario Lucus Augusti. Cardiology Division, Lugo, Spain, ⁴Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁵Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁶Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁷Hospital Marques de Valdecilla, Santander, Spain, ⁸Rheumatology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ⁹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex inflammatory disease characterized by chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. Interleukin 33 (IL-33) is a…
Abstract Number: 1769 • 2014 ACR/ARHP Annual Meeting
Abdominal Visceral Adipose Tissue Measured By DXA As a Novel Surrogate Marker of Cardiovascular Risk in Primary Necrotizing Vasculitides
Bertrand Dunogué¹, Karine Briot², Sami Kolta³, Alexis Regent⁴, Pascal Cohen⁵, Alice Berezne⁶, Xavier Puéchal⁵, Claire Le Jeunne⁵, Luc Mouthon⁵, Christian Roux⁷, Loïc Guillevin for the French Vasculitis Study Group⁵ and Benjamin Terrier⁸, ¹Internal Medicine, Hôpital Cochin, Paris, France, ²Cochin Hospital, Paris Descartes University, Paris, France, ³Rheumatology B, Paris Descartes University, Cochin hospital, Paris, France, ⁴Internal Medicine, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ⁵National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁶Paris Descartes University, Internal Medicine department, Cochin Hospital, Paris, France, ⁷Paris Descartes University, Cochin Hospital, Paris, France, ⁸National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France
Background/Purpose Studies have shown a strong prevalence of cardiovascular events among patients with primary necrotizing vasculitides. Recent studies indicate that visceral adipose tissue (VAT) is…
Abstract Number: 1361 • 2014 ACR/ARHP Annual Meeting
Rheumatologists’ Attitudes on Cardiovascular Risk and Lipid Screening in Patients with Rheumatoid Arthritis at an Academic Medical Center
Ashwini Komarla¹ and Alexis Ogdie², ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Cardiovascular (CV) disease is a major cause of morbidity and mortality in the rheumatoid arthritis (RA) population. Thus, the recognition and management of cardiovascular…
Abstract Number: 818 • 2014 ACR/ARHP Annual Meeting
Incident Rheumatoid Arthritis and Risk of Mortality Among Women Followed Prospectively from 1976 to 2010 in the Nurses’ Health Study
Jeffrey A. Sparks¹, Shun-Chiao Chang^1,2, Katherine P. Liao¹, Bing Lu¹, Daniel H. Solomon¹, Karen H. Costenbader¹ and Elizabeth W. Karlson¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose RA has been associated with increased mortality compared to general population estimates. Previous studies were limited due to the inability to directly compare RA…
Abstract Number: 96 • 2014 ACR/ARHP Annual Meeting
Comparison of Cardiovascular Risk Factor Management in Patients with RA and Matched Non-RA Patients
H Cawston¹, E Alemao², F Bourhis¹, T Le³, M Al⁴, M Rutten-van Molken⁴, Katherine Liao⁵ and DH Solomon⁶, ¹OptumInsight, Nanterre, France, ²Bristol-Myers Squibb, Princeton, NJ, ³Bristol-Myers Squibb, Hopewell, NJ, ⁴Erasmus University, Rotterdam, Netherlands, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital, Boston, MA
Background/Purpose : The relative risk of acute myocardial infarction in RA patients (pts) has been shown to range from 1.5 to 2.0, with a 1.4–2.7-fold…
Abstract Number: 2388 • 2014 ACR/ARHP Annual Meeting
DMARD Use after an Initial Acute MI Is Associated with Reduced Risk of a Recurrent Event and Mortality
Jie Zhang¹, Fenglong Xie², Lang Chen³, Huifeng Yun⁴, Paul M. Muntner⁵, Emily Levitan⁵, Monica Safford⁶, Kenneth G. Saag⁷, Jasvinder A. Singh⁶ and Jeffrey R. Curtis⁶, ¹Ryals Soph Bldg., Rm. 517b, Univ. of Alabama at Birmingham, Birmingham, AL, ²Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ³Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, ⁵Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL
Background/Purpose Previous studies have suggested that disease modifying anti-rheumatic drugs (DMARDs) may reduce cardiovascular risk among patients with rheumatoid arthritis (RA). This analysis examined whether…
Abstract Number: 1582 • 2014 ACR/ARHP Annual Meeting
Cumulative Inflammatory Burden Is Independently Associated with Increased Arterial Stiffness in Patients with Psoriatic Arthritis
Jiayun Shen¹, Qing Shang¹, Ying Ying Leung², Edmund Li¹, Tracy Y. Zhu¹ and Lai-Shan Tam¹, ¹Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore
Background/Purpose: Patients with psoriatic arthritis (PsA) are at increased risk of cardiovascular (CV) morbidity compared with the general population, probably as a result of chronic…
Abstract Number: 1322 • 2014 ACR/ARHP Annual Meeting
Cardiopulmonary Involvement in Juvenile Systemic Sclerosis: Development of Recommendations for Screening and Investigation
Ivan Foeldvari¹, Clare Pain², Tamás Constantin³, Eileen Baildam⁴, Christian Beyer⁵, Michael Blakley⁶, Dana Nemkova⁷ and Clarissa A Pilkington⁸, ¹Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, ²Pediatric Rheumatology, University Children´s Hospital, Liverpool, United Kingdom, ³Pediatric Rheumatology, University Childrens Hospital, Budapest, Hungary, ⁴Paediatric Rheumatology, Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, ⁵Pediatric Cardiology, Hamburg, Germany, ⁶Internal Medicine and Pediatrics, Indiana University School of Medicine and Riley Hospital for Children at IU Health, Indianapolis, IN, ⁷Pedaitric Rheumatology, Prague, Czech Republic, ⁸Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Background/Purpose There are currently no agreed recommendations on how to investigate children for cardiopulmonary involvement in Juvenile Systemic Sclerosis (JSSc). The aim of screening is…
Abstract Number: 799 • 2014 ACR/ARHP Annual Meeting
Peripheral Arterial Disease in Patients with Giant Cell Arteritis: A Systematic Review and Meta-Analysis
Patompong Ungprasert¹, Praveen Ratanasrimetha², Charat Thongprayoon³, Wisit Cheungpasitporn³ and Promporn Suksaranjit⁴, ¹Department of Internal medicine, Bassett medical center, Cooperstown, NY, ²Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ³Department of Medicine, Mayo clinic, Rochester, MN, ⁴Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT
Peripheral Arterial Disease in Patients with Giant Cell Arteritis: A Systematic Review and Meta-analysisBackground/Purpose: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus…
Abstract Number: 2360 • 2014 ACR/ARHP Annual Meeting
Glucocorticoids and Vascular Function in Arthritis: Benefic or Deleterious Effects? Study in Rat
Frank Verhoeven¹, Katy Maguin-Gaté², Perle Totoson³, Daniel Wendling⁴ and Céline Demougeot⁵, ¹Rheumatology, CHU jean Minjoz, Besançon, France, ²EA 4267 « Fonctions et Dysfonctions Epithéliales » , Faculté de Médecine-Pharmacie, Besançon, France, ³UFR Sciences Médicales et Pharmaceutiques, EA 4267 "Fonctions et Dysfonctions Epithéliales", besançon, France, ⁴Service de Rhumatologie, CHU J Minjoz, Besancon, France, ⁵UFR Sciences Médicales et Pharmaceutiques, EA 4267 "Fonctions et Dysfonctions Epithéliales", Besançon, France
Background/Purpose: Rheumatoid Arthritis (RA) is associated to an increase of cardiovascular (CV) risk explained in part by an accelerated atherosclerosis as a consequence of endothelial…

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