Abstracts tagged "Cardiovascular disease"

Abstract Number: 1474 • 2016 ACR/ARHP Annual Meeting
Increased Levels of Lipoprotein(a) in RA Patients with Cardiovascular Disease
Sverre Holm^1,2, Ingvild Oma³, Tor-Arne Hagve⁴, Kjell Saatvedt⁵, Knut Mikkelsen⁶, Hans Rydningen⁷, Sven Martin Almdahl⁸, Pål Aukrust^9,10, Bente Halvorsen^9,11 and Ivana Hollan^6,12,13,14, ¹Hospital For Rheumatic Diseases, Lillehammer, Norway, ²Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ³Innlandet Hospital Trust, Lillehammer, Norway, ⁴Oslo University Hospital, Rikshospitalet, Oslo, Norway, ⁵Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway, ⁶Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁷Feiring Heart Clinic, Feiring, Norway, ⁸Department of Cardiothoracic Surgery, University Hospital of North Norway, Tromsø, Norway, ⁹Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ¹⁰Research Intitute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ¹¹Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ¹²Department of Medicine, Brigham and Women’s Hospital, Boston, MA, ¹³Harvard Medical School, Boston, MA, ¹⁴Department of Medicine, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Patients with various inflammatory rheumatic diseases (IRD) have increased cardiovascular morbidity caused by atherosclerosis. The aetiology of the accelerated atherosclerosis in IRD is still…
Abstract Number: 1653 • 2016 ACR/ARHP Annual Meeting
Delineating the Effects of Rheumatoid Arthritis Pharmacotherapies on Vascular Inflammation: Rationale and Design of a Clinical Trial
Jon T. Giles¹, Katherine Liao², Nina Paynter³, Alyssa Wohlfahrt⁴, Afshin Zartoshti⁵, Rachel Broderick⁶, Daniel H. Solomon⁷ and Joan Bathon⁶, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ³Medicine, Harvard University, Boston, MA, ⁴Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY, ⁶Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁷Division of Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis is associated with an excess cardiovascular disease (CVD) burden. Fewer CVD events associated with specific DMARD therapies have been reported; however, causal…
Abstract Number: 2291 • 2016 ACR/ARHP Annual Meeting
Impact of Plasma Urate and Tophaceous Burden on Inflammatory Biomarkers of Cardiovascular Disease
John FitzGerald¹, Benjamin D. Levine², Jennifer Raymond³ and Maureen A. McMahon¹, ¹Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
Background/Purpose: Gout and hyperuricemia have been associated with cardiovascular disease. Studies have documented the impact of serum urate levels on hypertension and that increased urate…
Abstract Number: 69 • 2016 ACR/ARHP Annual Meeting
IL-32 Promoter SNP rs4786370 Predisposed to Modified Lipoprotein Profiles in Patients with Rheumatoid Arthritis
Michelle S.M.A. Damen¹, Rabia Agca², Suzanne Holewijn³, Jacqueline de Graaf¹, Jéssica C. Dos Santos^1,4, Piet L van Riel⁵, J Fransen⁶, Marieke J.H. Coenen⁷, Mike T. Nurmohamed⁸, M.G. Netea¹, Charles Dinarello⁹, L.A.B. Joosten¹, Bas Heinhuis¹ and Calin Popa¹⁰, ¹Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Rheumatology, Amsterdam Rheumatology and immunology Center, Location Reade, Amsterdam, Netherlands, ³Rijnstate Ziekenhuis, Arnhem, Netherlands, ⁴Instituto de Patologia Tropical e Saúde Pública, Goiás, Brazil, ⁵Scientific Institute for Quality of Healthcare, Radboud University Medical Center, Nijmegen, Netherlands, ⁶Department of Rheumatolgy, Radboud UMC, Nijmegen, Netherlands, ⁷Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁸Rheumatology, Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁹Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, ¹⁰Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease such as rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously…
Abstract Number: 881 • 2016 ACR/ARHP Annual Meeting
Cardiopulmonary Involvement in Takayasu Arteritis
David Brennan¹, Kenneth J. Warrington², Jean Schmidt³, Cynthia S. Crowson⁴ and Matthew J. Koster⁵, ¹Internal Medicine, Mayo Clinic, Rochester, MN, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Department of Internal Medicine and RECIF, Amiens University Hospital, Amiens, France, ⁴Health Sciences Research, Mayo Clinic, Rochester, MN, ⁵Rheumatology, University of California Los Angeles, CA, USA Mayo Clinic, Rochester, MN
Background/Purpose: Takayasu arteritis (TAK) is an inflammatory large-vessel vasculitis of unknown etiology affecting the proximal aorta and its primary branches. Heart disease is a major…
Abstract Number: 1475 • 2016 ACR/ARHP Annual Meeting
Comparative Risk of Cardiovascular Outcomes Between Topical and Oral Non-Selective Nsaids in Taiwanese Rheumatoid Arthritis Patients
Tzu-Chieh Lin¹, Daniel H. Solomon², Sara K. Tedeschi¹, Kazuki Yoshida³ and Yea-Huei Kao Yang⁴, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, Boston, MA, ³Department of Epidemiology, Harvard School of Public Health, Boston, MA, ⁴College of Medicine, National Cheng Kung University, Institute of Clinical Pharmacy and Pharmaceutical Science, Taian, Taiwan
Background/Purpose: Topical NSAIDs (tNSAIDs) have less systemic absorption than oral NSAIDs (oNSAIDs). Thus, tNSAIDs may be associated with a reduced cardiovascular disease (CVD) risk compared…
Abstract Number: 1714 • 2016 ACR/ARHP Annual Meeting
Risk of 10-Year Cardiovascular Disease Assessed By Framingham Risk Score Is Similar in Patients with Psoriatic Arthritis and Psoriasis As Assessed By Atherosclerotic Cardiovascular Disease and Framingham Risk Scores
Natsumi Ikumi¹, Agnes Szentpetery¹, Brian Kirby² and Oliver FitzGerald¹, ¹St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland, ²St. Vincent's University Hospital, Department of Dermatology, Dublin, Ireland
Background/Purpose: Patients with psoriatic arthritis (PsA) and psoriasis (PsO) are at increased risk of cardiovascular diseases (CVD) and the risk is higher in patients with…
Abstract Number: 2293 • 2016 ACR/ARHP Annual Meeting
Cardiometabolic Risk and Subclinical Urate Deposits in Patients with Symptomatic Hyperuricemia and Metabolic Syndrome
Seoyoung C. Kim¹, Rajesh Garg², Stacy Smith³, Alyssa Wohlfahrt⁴, Anarosa Campos⁵, Kathleen Vanni⁴, Lauren K Lee⁶, Penny Wang⁶, Zhi Yu⁷, Marcelo Di Carli⁸ and Daniel H. Solomon⁹, ¹Rheumatology, Immunology and Allergy; Pharmacoepidemiologyand Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ²Endocrinology, Brigham & Women's Hospital, Boston, MA, ³Radiology/Division of Musculoskeletal Imaging & Intervention, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁴Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital, Boston, MA, ⁷Rheumatology Immunology & Allergy, Brigham and Women's Hospital, Boston, MA, ⁸Div. of Nuclear Medicine, Brigham and Women's Hospital, Boston, MA, ⁹Division of Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Elevated serum uric acid (sUA) levels, with and without gout, are associated with systemic inflammation, coronary artery disease (CAD), chronic kidney disease, and diabetes.…
Abstract Number: 128 • 2016 ACR/ARHP Annual Meeting
Call to Action: Cardiovascular Comorbidities in Medicare Rheumatology Beneficiaries
Gurjit S. Kaeley¹ and Sunita Dodani², ¹University of Florida, Ponte Vedra Beach, FL, ²Cardiology and Epidemiology, University of Florida College of Medicine, Jacksonville, Jacksonville, FL
Background/Purpose: Cardiovascular (CV) manifestations of Rheumatological inflammatory diseases have become increasingly recognized, and, in some patients, might even constitute the initial presentation of a Rheumatological…
Abstract Number: 888 • 2016 ACR/ARHP Annual Meeting
Prevalence of Takayasu Arteritis in Young Women Presenting with Acute Ischemic Heart Disease
Giulio Cavalli, Alessandro Tomelleri, Elena Baldissera and Lorenzo Dagna, Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy
Background/Purpose: Ischemic heart disease (IHD) is classically considered a disease of older men. However, 10% of myocardial infarctions occur in patients aged <45; also, in…
Abstract Number: 1477 • 2016 ACR/ARHP Annual Meeting
Exploring the Inadequate Cardiovascular Disease Prevention in Inflammatory Joint Diseases: Results from a Nationwide Norwegian Project
Eirik Ikdahl¹, Silvia Rollefstad², Grunde Wibetoe³, Anne Salberg⁴, Dag Magnar Soldal⁵, Inge C Olsen⁶, Tore K Kvien⁷, Anne Grete Semb¹ and Glenn Haugeberg⁸, ¹Preventive Cardio-Rheuma clinic, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁵Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, ⁶Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁷Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁸Martina Hansens Hospital, Bærum, Norway
Background/Purpose: Antihypertensives (antiHT) and lipid lowering therapies (LLT) prevent cardiovascular disease (CVD) effectively. It has been reported that patients with rheumatoid arthritis (RA) receive suboptimal…
Abstract Number: 1727 • 2016 ACR/ARHP Annual Meeting
Association Between Biologic Therapies and Major Adverse Cardiac Events or Cardiac Heart Failure in Psoriatic Arthritis or Psoriasis: A Meta-Analysis
Benedicte Champs, Rheumatology, Medecine Toulouse Purpan Hospital, Lescure d'albigeois, France
Association between biologic therapies and major adverse cardiac events or cardiac heart failure in psoriatic arthritis or psoriasis: a meta-analysis. 1Champs B, 1Degboe Y, 1Ruyssen-Witrand…
Abstract Number: 2359 • 2016 ACR/ARHP Annual Meeting
Dose-Related Risks of Cardiovascular, Gastrointestinal, and Renal Adverse Events Associated with Meloxicam Among Patients with Osteoarthritis: An Observational Study Using US Claims Data
Elaine Hoffman¹, Deirdre M. Mladsi¹, Byron Cryer², William Hopkins³, D. Craig Brater⁴, Rohan Parikh¹, Ravi Goyal¹, Jordi Castellsague⁵, Dana Stafkey-Mailey⁶ and Clarence Young⁷, ¹Health Economics, RTI Health Solutions, Research Triangle Park, NC, ²University of Texas Southwestern Medical School, Dallas, TX, ³Fletcher Allen Health Care, University of Vermont College of Medicine, Burlington, VT, ⁴Indiana University School of Medicine, Bloomington, IN, ⁵Epidemiology, RTI Health Solutions, Barcelona, Spain, ⁶Xcenda, AmerisourceBergen, Palm Harbor, FL, ⁷Iroko Pharmaceuticals, LLC, Philadelphia, PA
Background/Purpose: Safety studies have shown that risks associated with non-steroidal anti-inflammatory drugs (NSAIDs) are related to dose; however, there is little evidence regarding this dose-toxicity…
Abstract Number: 232 • 2016 ACR/ARHP Annual Meeting
Impact of Gout Flare Prophylaxis and Urate-Lowering Therapy on Endothelial Function, Smooth Muscle Responsiveness and Markers of Inflammation: Results of a Prospective Observational Pilot Study
Talia Igel^1,2, Aaron Garza Romero², Virginia Pike³, Stuart Katz⁴, Binita Shah⁵, Irina Dektiarev⁴, Svetlana Krasnokutsky Samuels⁶ and Michael H. Pillinger⁷, ¹Monash University School of Medicine, Melbourne, Australia, ²Medicine/Rheumatology, NYU School of Medicine, New York, NY, ³Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁴Medicine/Cardiology, NYU School of Medicine, New York, NY, ⁵NYU School of Medicine, Division of Cardiology, New York, NY, ⁶Svetlana Krasnokutsky, NYU Hospital for Joint Diseases, New York, NY, ⁷NYU School of Medicine, New York, NY
Background/Purpose: To date, most studies of gout and cardiovascular disease have been cross-sectional or retrospective, and have addressed the outcome of acute coronary syndromes. Less…
Abstract Number: 896 • 2016 ACR/ARHP Annual Meeting
Risk for Cardiovascular Disease in Giant Cell Arteritis and Polymyalgia Rheumatica
Florencia Beatriz Mollerach¹, Emmanuel Bertiller¹, Maria de los Angeles Gallardo², Maximiliano José Martinez¹, Marina Scolnik³, Javier Rosa¹, Luis J. Catoggio⁴ and Enrique R. Soriano¹, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Hospital Italiano de Buenos Aires, CABA, Argentina, ³Rheumatology Section, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ⁴Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Argentina., Buenos Aires, Argentina
Background/Purpose: chronic inflammatory diseases are at a substantially increased risk of cardiovascular events (CVE). Scarce data is available in patients with Giant cell arteritis (GCA)…

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