Abstracts tagged "Cardiovascular disease and rheumatoid arthritis (RA)"

Abstract Number: 116 • 2013 ACR/ARHP Annual Meeting
Lack Of Association Between Preclinical Markers For Cardiovascular Disease and Rheumatoid Arthritis-Related Autoimmunity In First-Degree Relatives Without Rheumatoid Arthritis
Jill M. Norris¹, Ryan W. Gan¹, Jan M. Hughes-Austin², Kevin D. Deane³, M. Kristen Demoruelle³, Elaine M. Urbina⁴, Kerrie Moreau⁵, Peter K. Gregersen⁶, Michael H. Weisman⁷ and V. Michael Holers⁸, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Preventive Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Medicine, University of Colorado School of Medicine, Aurora, CO, ⁶Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁷Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Rheumatoid arthritis (RA) is characterized by systemic inflammation and immune dysregulation, including the presence of autoantibodies and elevated inflammatory biomarkers in subjects with classifiable…
Abstract Number: L5 • 2013 ACR/ARHP Annual Meeting
Improvement in High Density Lipoprotein Function in Early Rheumatoid Arthritis Patients Treated with Methotrexate Monotherapy or Combination Therapy in the Treatment of Early Rheumatoid Arthritis Trial
C. Charles-Schoeman¹, Yuen Yin Lee¹, Ani Shahbazian¹, David Elashoff², Xiaoyan Wong³, Jeffrey R. Curtis⁴, Iris Navarro-Millan⁵, Shuo Yang⁶, Lang Chen⁴, Stacey Cofield⁷, Larry W. Moreland⁸, Harold E. Paulus¹, James O' Dell⁹, Joan M. Bathon¹⁰, S. Louis Bridges Jr.¹¹ and Srinivasa T. Reddy¹², ¹Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Medicine- Statistic Core, UCLA Department of Medicine Statistics Core, Los Angeles, CA, ³Medicine-Statistic Core, UCLA Department of Medicine Statistics Core, Los Angeles, CA, ⁴Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹⁰Columbia University, New York, NY, ¹¹Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹²Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Abnormal function of high density lipoprotein (HDL) has been implicated as a potential mechanism for the increased cardiovascular disease (CVD) in patients with rheumatoid…
Abstract Number: 1381 • 2013 ACR/ARHP Annual Meeting
The ZC3HC1 rs11556924 Polymorphism Is Associated With Increased Carotid Intima-Media Thickness In Patients With Rheumatoid Arthritis
Raquel lopez Mejias¹, Fernanda Genre², Mercedes García-Bermúdez³, Alfonso Corrales⁴, Carlos González-Juanatey⁵, J. Llorca⁶, Encarnación Amigo⁷, Jose A. Miranda-Filloy⁸, Javier Rueda-Gotor¹, Ricardo Blanco¹, Santos Castañeda⁹, Javier Martin¹⁰ and Miguel A. Gonzalez-Gay¹¹, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ³Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁴Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁹Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ¹⁰Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ¹¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described…
Abstract Number: 1382 • 2013 ACR/ARHP Annual Meeting
The 11q23.3 Genomic Region – rs964184- Is Associated With Cardiovascular Disease In Patients With Rheumatoid Arthritis
Raquel lopez Mejias¹, Fernanda Genre², Mercedes García-Bermúdez³, Santos Castañeda⁴, Carlos González-Juanatey⁵, J. Llorca⁶, Encarnación Amigo⁷, Alfonso Corrales⁸, Jose A. Miranda-Filloy⁹, Javier Rueda-Gotor¹, Carmen Gomez vaquero¹⁰, Luis Rodriguez Rodriguez¹¹, Benjamin Fernandez Gutierrez¹¹, Alejandro Balsa¹², Dora Pascual-Salcedo¹³, Francisco Javier López-Longo¹⁴, Patricia Carreira¹⁵, Ricardo Blanco¹, Isidoro González-Alvaro¹⁶, Javier Martin¹⁷ and Miguel A. Gonzalez-Gay¹⁸, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ³Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁴Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁹Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ¹⁰Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain, ¹¹Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹²Rheumatology unit, La Paz University Hospital, Rheumatology, Madrid, Spain, ¹³La Paz University Hospital, Rheumatology, Madrid, Spain, ¹⁴Hospital General Universitario Gregorio Marañón, Department of Rheumatology, Madrid, Spain, ¹⁵Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁶Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ¹⁷Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ¹⁸Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular (CV) disease. A recent meta-analysis has…
Abstract Number: 422 • 2013 ACR/ARHP Annual Meeting
Disease Activity In Rheumatoid Arthritis Is Associated With Abnormal Left Ventricular Geometry
Helga Midtbø¹, Eva Gerdts^1,2, Inge C. Olsen³, Tore K. Kvien⁴, Einar Davidsen¹ and Anne Grete Semb³, ¹Department of Heart Disease, Haukeland University Hospital, Bergen, Norway, ²Department of Cinical Science, University of Bergen, Bergen, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose :Disease activity is related to risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients1,2. Left ventricular (LV) geometry strongly predicts CV mortality and…
Abstract Number: 404 • 2013 ACR/ARHP Annual Meeting
Arterial Stiffness Is Associated With Abnormal Left Ventricular Geometry In Patients With Rheumatoid Arthritis
Helga Midtbø¹, Eva Gerdts^1,2, Inge C. Olsen³, Tore K. Kvien⁴, Einar Davidsen¹ and Anne Grete Semb³, ¹Department of Heart Disease, Haukeland University Hospital, Bergen, Norway, ²Department of Cinical Science, University of Bergen, Bergen, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Rheumatoid arthritis (RA) predisposes for increased arterial stiffness(1). In hypertension, arterial stiffness is a powerful modulator of left ventricular (LV) geometry(2). Whether this is…
Abstract Number: 406 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Case Fatality In Rheumatoid Arthritis Is Decreasing; Results From a Current Low Disease Activity Rheumatoid Arthritis Cohort and Review Of The Literature
Inger L. Meek¹, Harald E. Vonkeman² and Mart A.F.J. van de Laar³, ¹Rheumatology & Clinical Immunology, Rheumatology Center Twente, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, ²Medisch Spectrum Twente & University of Twente, Enschede, Netherlands, ³Rheumatology, Medisch Spectrum Twente & University of Twente, Enschede, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular (CV) morbidity and mortality. Previous studies, found increased case fatality after myocardial infarction and more frequent…
Abstract Number: 360 • 2013 ACR/ARHP Annual Meeting
Visit-To-Visit Variability In Blood Pressure In Patients With Rheumatoid Arthritis (RA) Vs General Population, and Its Impact On Cardiovascular Events and All-Cause Mortality In RA
Elena Myasoedova¹, Cynthia S. Crowson², Abigail B. Green², Eric L. Matteson³ and Sherine E. Gabriel⁴, ¹Internal Medicine and Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Blood pressure (BP) variability has been associated with increased risk of cardiovascular (CV) disease and death in the general population. The impact of BP…
Abstract Number: 368 • 2013 ACR/ARHP Annual Meeting
Detrimental Impact Of Long-Term Cumulative Burden Of Rheumatoid Arthritis (RA) Disease Severity On Cardiovascular Outcomes In RA
Elena Myasoedova¹, Birkan Ilhan², Helen Khun³, Eric L. Matteson⁴ and Cynthia S. Crowson³, ¹Internal Medicine and Rheumatology, Mayo Clinic, Rochester, MN, ²Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey, ³Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Several studies have shown the associations of various measures of rheumatoid arthritis (RA) disease severity with unfavorable cardiovascular (CV) outcomes in RA. The association…
Abstract Number: 1263 • 2012 ACR/ARHP Annual Meeting
Carotid Arterial Wall Inflammation Is Associated with a Specific Profile of Inflammatory Biomarkers and Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Patients
Caroline Grönwall¹, Gregg J. Silverman¹, Zahi Fayad², Venkatesh Mani², Victoria Furer³, Michael Farkouh², Manish Jain¹, Cheongeun Oh⁴, John Todd⁵, Mukundan Attur⁶, Steven B. Abramson⁷ and Jeffrey D. Greenberg⁸, ¹Rheumatology, NYU School of Medicine, New York, NY, ²Mount Sinai Hospital, New York, NY, ³Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ⁴Biostatistics, NYU School of Medicine, New York, NY, ⁵Singulex, Alameda, California, Alameda, CA, ⁶Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY, ⁷Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ⁸New York Hospital for Joint Disease, New York, NY
Background/Purpose: Patients with RA are at increased risk of cardiovascular (CV) comorbidity and premature mortality. While generally attributed to accelerated atherosclerosis, the pathogenesis remains poorly understood.…
Abstract Number: 1264 • 2012 ACR/ARHP Annual Meeting
Vascular Age in Rheumatoid Arthritis Patients
Jl Rosales-Alexander¹, César Magro Checa¹, Juan Salvatierra¹, Silvia Montes García¹, Jesús Cantero Hinojosa² and Enrique Raya Álvarez¹, ¹Rheumatology, University Hospital San Cecilio, Granada, Spain, ²Internal Medicine, University Hospital San Cecilio, Granada, Spain
Background/Purpose: The European League Against Rheumatism (EULAR) recommends cardiovascular risk (CV) assessment using the systematic coronary risk evaluation (SCORE) chart in rheumatoid arthritis (RA) patients.…
Abstract Number: 1269 • 2012 ACR/ARHP Annual Meeting
Serum Cytokines Associated with Carotid Atherosclerosis in Rheumatoid Arthritis
Inmaculada del Rincon¹, Roy W. Haas², Daniel H. O'Leary³, Joseph F. Polak³, Daniel F. Battafarano⁴ and Agustin Escalante⁵, ¹Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ²Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, ³Radiology, Tufts University-Boston Campus, Boston, MA, ⁴Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, ⁵Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: The mechanism for the increased cardiovascular morbidity and mortality in rheumatoid arthritis (RA) is incompletely understood. In a previous analysis, we found that both…
Abstract Number: 1247 • 2012 ACR/ARHP Annual Meeting
Delay in Diagnosis of Rheumatoid Arthritis Increases the Cardiovascular Risk
Chan-Bum Choi¹, Yoon-Kyoung Sung², Soo-Kyung Cho², Dae-Hyun Yoo³, Shin-Seok Lee⁴, Jisoo Lee⁵, Jinseok Kim⁶, Hye-Soon Lee⁷, Tae-Hwan Kim³, Bo Young Yoon⁸, Wan-Hee Yoo⁹, Jung-Yoon Choe¹⁰, Sang-Heon Lee¹¹, Seung-Cheol Shim¹², Won-Tae Chung¹³, Seung-Jae Hong¹⁴, Choong Ki Lee¹⁵, Eunmi Koh¹⁶, Jae-Bum Jun³, So-Young Bang⁷, Seong-Kyu Kim¹⁷, Hoon-Suk Cha¹⁶, Jeeseon Shim¹⁸, Sang-Cheol Bae¹⁹ and Korean Observational Study Network for Arthritis (KORONA)²⁰, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁴Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ⁵Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea, ⁶Internal Medicine, Jeju National University Hospital, Jeju, South Korea, ⁷Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ⁸Inje University Ilsan Paik Hospital, Goyang, South Korea, ⁹Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ¹⁰Internal Medicine, Catholic university of Daegu School of mediine, Arthritis and autoimmunty research center, Daegu, ¹¹Division of Rheumatology, Department of Internal Medicine,, Konkuk University School of Medicine, Seoul, South Korea, ¹²Rheumatology, Eulji University Hospital, Daejeon, South Korea, ¹³Rheumatology, Dong-A University Hospital, Busan, South Korea, ¹⁴Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, ¹⁵Internal medicine, school of medicine, Yeungnam University, Daegu, South Korea, ¹⁶Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ¹⁷Catholic University of Daegu School of Medicine, Daegu, South Korea, ¹⁸Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ¹⁹Hanyang University Hospital for Rheumatic Disease, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ²⁰Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul
Background/Purpose: Patients with rheumatoid arthritis (RA) are known to be at increased risk for cardiovascular diseases. Inflammation as well as traditional risk factors contributes to…
Abstract Number: 1248 • 2012 ACR/ARHP Annual Meeting
Accelerated Aging Influences Cardiovascular Disease Risk in Rheumatoid Arthritis
Cynthia S. Crowson¹, Terry M. Therneau¹, John M. Davis III², Veronique L. Roger³, Eric L. Matteson² and Sherine E. Gabriel⁴, ¹Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Health Sciences Research and Cardiology, Mayo Clinic, Rochester, MN, ⁴Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: People with rheumatoid arthritis (RA) suffer an excess burden of cardiovascular disease (CVD), yet standard risk assessments designed for the general population do not…
Abstract Number: 1205 • 2012 ACR/ARHP Annual Meeting
Study of Association of CD40-CD154 Gene Polymorphisms with Disease Susceptibility and Cardiovascular Risk in Spanish Rheumatoid Arthritis Patients
Mercedes García-Bermúdez¹, Carlos González-Juanatey², Alfonso Corrales³, Raquel López-Mejías⁴, Maria Teruel⁵, Jose A. Miranda-Filloy⁶, Santos Castañeda-Sanz⁷, Alejandro Balsa⁸, B. Fernández-Gutierrez⁹, Isidoro González-Álvaro¹⁰, Carmen Gómez-Vaquero¹¹, R. Blanco Alonso¹², Javier Llorca¹³, Javier Martin¹⁴ and Miguel Angel González-Gay⁴, ¹Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ²Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ³Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁴Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁵Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁶Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁷Rheumatology, Hospital Universitario de La Princesa. Madrid. Spain, Madrid, Spain, ⁸Rheumatology, La Paz Hospital. IdiPaz, Madrid, Spain, ⁹Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, ¹⁰Servicio de Reumatología, Reumatología (Hospital Universitario de La Princesa), Madrid, Spain, ¹¹Rheumatology Service, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, ¹²Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, ¹³Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ¹⁴Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Since CD40-CD154 binding has direct consequences on inflammation process initiation,…

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