ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1381

The ZC3HC1 rs11556924 Polymorphism Is Associated With Increased Carotid Intima-Media Thickness In Patients With Rheumatoid Arthritis

Raquel lopez Mejias1, Fernanda Genre2, Mercedes García-Bermúdez3, Alfonso Corrales4, Carlos González-Juanatey5, J. Llorca6, Encarnación Amigo7, Jose A. Miranda-Filloy8, Javier Rueda-Gotor1, Ricardo Blanco1, Santos Castañeda9, Javier Martin10 and Miguel A. Gonzalez-Gay11, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, 2Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 3Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 4Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 5Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, 6Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, 7Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, 8Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 9Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, 10Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 11Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Session Title: Rheumatoid Arthritis - Human Etiology and Pathogenesis

Session Type: Abstract Submissions (ACR)

Background/Purpose:

Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals. In the present study we evaluated the potential association of this gene polymorphism with subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in RA patients.

Methods:

For this purpose 502 RA patients from Northern Spain were recruited in this study. The ZC3HC1 rs11556924 polymorphism was genotyped with TaqMan single-nucleotide polymorphism (SNP) genotyping assays (C__31283062_10) in a 7900 HT real-time polymerase chain reaction (PCR) system. cIMT was also assessed in these patients by carotid ultrasonography (US) technology.

Results:

RA patients carrying the TT genotype had significantly higher cIMT values than those homozygous for the CC genotype (mean ± standard deviation (SD): 0.76 ± 0.18 mm and mean ± SD: 0.71 ± 0.16 mm respectively; p=0.02). Moreover, RA patients carrying the mutant allele T exhibited significantly higher cIMT values than those carrying the wild allele C (mean ± SD: 0.74 ± 0.17 mm and mean ± SD: 0.71 ± 0.17 mm respectively; p=0.02) even after adjusting the results for sex, age at the time of US study, follow-up time and traditional CV risk factors (p=0.019) evidencing that the effect conferred by ZC3HC1 rs11556924 polymorphism is independent of the traditional CV risk factors.

Conclusion:

Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA.

Disclosure:

R. lopez Mejias,
None;

F. Genre,
None;

M. García-Bermúdez,
None;

A. Corrales,
None;

C. González-Juanatey,
None;

J. Llorca,
None;

E. Amigo,
None;

J. A. Miranda-Filloy,
None;

J. Rueda-Gotor,
None;

R. Blanco,
None;

S. Castañeda,
None;

J. Martin,
None;

M. A. Gonzalez-Gay,
None.

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