Session Title: Rheumatoid Arthritis - Human Etiology and Pathogenesis
Session Type: Abstract Submissions (ACR)
Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals. In the present study we evaluated the potential association of this gene polymorphism with subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in RA patients.
For this purpose 502 RA patients from Northern Spain were recruited in this study. The ZC3HC1 rs11556924 polymorphism was genotyped with TaqMan single-nucleotide polymorphism (SNP) genotyping assays (C__31283062_10) in a 7900 HT real-time polymerase chain reaction (PCR) system. cIMT was also assessed in these patients by carotid ultrasonography (US) technology.
RA patients carrying the TT genotype had significantly higher cIMT values than those homozygous for the CC genotype (mean ± standard deviation (SD): 0.76 ± 0.18 mm and mean ± SD: 0.71 ± 0.16 mm respectively; p=0.02). Moreover, RA patients carrying the mutant allele T exhibited significantly higher cIMT values than those carrying the wild allele C (mean ± SD: 0.74 ± 0.17 mm and mean ± SD: 0.71 ± 0.17 mm respectively; p=0.02) even after adjusting the results for sex, age at the time of US study, follow-up time and traditional CV risk factors (p=0.019) evidencing that the effect conferred by ZC3HC1 rs11556924 polymorphism is independent of the traditional CV risk factors.
Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA.
R. lopez Mejias,
J. A. Miranda-Filloy,
M. A. Gonzalez-Gay,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-zc3hc1-rs11556924-polymorphism-is-associated-with-increased-carotid-intima-media-thickness-in-patients-with-rheumatoid-arthritis/