ACR Meeting Abstracts

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Abstracts tagged "Cardiovascular"

  • Abstract Number: 0069 • ACR Convergence 2024

    Activation of Cardiovascular Inflammation and Wnt Signaling in Spondyloarthritis: Insights from the HLA-B27 Transgenic Rat Model

    Su-Ah Yoon, Chorong Kim, Hansun Song, Mie Jin Lim and Seong-Ryul Kwon, College of Medicine, Inha University, Incheon, Republic of Korea

    Background/Purpose: Despite the well-documented link between cardiovascular (CV) disease and spondyloarthritis (SpA), no animal studies have empirically validated this connection or integrated SpA, vascular inflammation,…
  • Abstract Number: 0463 • ACR Convergence 2024

    Evaluation of Inflammatory Indices as Predictive Biomarkers of Carotid Plaque in Patients with Rheumatoid Arthritis

    Jose Antonio Davila Jimenez1, Dionicio Galarza-Delgado2, Iris Jazmín Colunga Pedraza3, jose Ramon Azpiri-Lopez4, Rosa Icela Arvizu-Rivera3, Jesus Cardenas-de la Garza5, Aleydis Gonzalez Melendez3, Andrea Guajardo Aldaco3, Maria F. Elizondo-Benitez6, Rebeca L. Polina-Lugo3 and Diego Salcedo-Almanza7, 1Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 2UANL Hospital Universitario, Monterrey, Nuevo León, Mexico, 3Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 4Division of Cardiology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 5Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 6Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 7Division of Radiology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico

    Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased cardiovascular (CV) risk compared to the general population. All stages of the atherogenic process appear to…
  • Abstract Number: 0705 • ACR Convergence 2024

    Identification of Risk Factors for Incident Cardiomyopathy in Patients with Systemic Sclerosis

    Ji Soo Kim1, Rachel Wallwork1, Carrie Richardson2, Adrianne Woods3, Monica Mukherjee4, Steven Hsu4, Julie Paik1, Christopher Mecoli1, Laura Hummers5, Fredrick Wigley6, Scott Zeger1 and Ami Shah7, 1Johns Hopkins University, Baltimore, MD, 2Northwestern University, Chicago, 3Johns Hopkins University Division of Rheumatology, Baltimore, MD, 4Johns Hopkins University Division of Cardiology, Baltimore, MD, 5Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Ellicott City, MD, 6Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, 7Division of Rheumatology, Johns Hopkins University, Ellicott City, MD

    Background/Purpose: Cardiac involvement in systemic sclerosis (SSc) is one of the leading causes of scleroderma-associated death. There are limited data examining risk factors for incident…
  • Abstract Number: 1097 • ACR Convergence 2024

    CERT Score as a Potential Tool to Predict Cardiovascular Risk in Gout and Hyperuricemia

    Blanka Stiburkova1, Aleš Kvasnička2, Barbora Pisklakova2, Jakub Rozhon2, Karel Pavelka3 and David Friedecky2, 1Institute of Rheumatology, Prague, Czech Republic and Department of Paediatrics and Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic, Prague, Czech Republic, 2Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic, Olomouc, Czech Republic, 3Institute of Rheumatology and Charles University, Praha, Czech Republic

    Background/Purpose: Asymptomatic hyperuricemia and gout are two clinical conditions associated with a high risk of cardiovascular events and mortality. Recent data suggest that the number…
  • Abstract Number: 1486 • ACR Convergence 2024

    Cardiovascular Risk in Systemic Lupus Erythematosus: Carotid Ultrasonography Is Useful for the Re-stratification of Cardiovascular Risk Determined by Score2

    Cristina Corrales Selaya1, Carmen Bejerano2, Carmen Secada Gómez3, Virginia Portilla-González4, Ricardo Blanco-Alonso5, Victor Manuel Martinez Taboada6, Leyre Riancho7 and alfonso Corrales-Martínez8, 1Rheumatology, Marques de Valdecilla University Hospital. IDIVAL, Santander, Cantabria, Spain, 2Hospital Universitario Marques de Valdecilla, Immunopathology group, IDIVAL, Santander, Cantabria, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 4Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 5Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, 6Facultad de Medicina. Universidad de Cantabria, Santander, Cantabria, Spain, 7Hospital Sierrallana, Torrelavega, Cantabria, Spain, 8Hospital Universitario Marques de Valdecilla, Santander, Spain

    Background/Purpose: Systemic lupus erythematosus (SLE) patients have an increased cardiovascular (CV) risk compared to the general population. Although SCORE2 (systematic coronary risk evaluation 2) has…
  • Abstract Number: 1899 • ACR Convergence 2024

    Recurrent Heart Failure Hospitalization in Rheumatoid Arthritis: A National Veterans Affairs Matched Cohort Study

    Tate Johnson1, Yangyuna Yang1, Punyasha Roul2, Joshua Baker3, Gary Kunkel4, Sauer brian5, grant Cannon6, Ted Mikuls1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC, Omaha, NE, 3University of Pennsylvania, Philadelphia, PA, 4University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 5Salt Lake City VA/University of Utah, Salt Lake City, UT, 6University of Utah and Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: People with rheumatoid arthritis (RA) are at an increased risk of heart failure (HF), which is among the most burdensome chronic conditions and a…
  • Abstract Number: 2357 • ACR Convergence 2024

    Longitudinal Evaluation of Neutrophil-to-Lymphocyte Ratio in Guselkumab-Treated Patients with Psoriatic Disease and Levels of Systemic Inflammation Associated with Elevated Cardiovascular Risk: Post-hoc Analysis of 4 Phase 3, Randomized, Controlled Studies

    Joseph Merola1, Alexis Ogdie2, Arthur Kavanaugh3, Evan Leibowitz4, Emmanouil Rampakakis5, Ryan Funk6, Francois Nantel7, Frederic Lavie8, Katelyn Rowland9 and Enrique R. Soriano10, 1UT Southwestern Medical Center, Newton, MA, 2Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3University of California San Diego, La Jolla, CA, 4Janssen Scientific Affairs, LLC, Fair Lawn, NJ, 5McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 6Johnson & Johnson Innovative Medicine, Long Grove, IL, 7Nantel MedSci Consult, Montreal, QC, Canada, 8Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 9Janssen Pharmaceuticals, Horsham, PA, 10Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Psoriatic disease (PsD) is associated with an increased risk of cardiovascular (CV) disease. Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of systemic inflammation; NLR ≥2.5…
  • Abstract Number: 0098 • ACR Convergence 2024

    Anti-HSP90α as a Protective Natural Antibody Against Secondary Antiphospholipid Syndrome in Systemic Lupus Erythematosus

    Marina Barguil Macedo1, Jorge Armando Gonzalez-Chapa1, Anders Bengtsson2, Iva Gunnarsson3, Elisabet Svenungsson4 and Christian Lood1, 1University of Washington, Seattle, WA, 2Lund University, Lund, Sweden, 3Karolinska Institute, Stockholm, Sweden, 4Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Heat shock protein 90 alpha (HSP90α) is an epichaperone present ubiquitously inside the cell, whose dimers function as a foldase that helps the correct…
  • Abstract Number: 0469 • ACR Convergence 2024

    SCORE2 Is Superior to SCORE in Predicting the Presence of Carotid Plaques and Intima-media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study with Carotid Ultrasound

    Cristina Campos Fernández1, Jorge Juan Fragío Gil2, Roxana González Mazario3, Pablo Martínez Calabuig4, Laura Salvador Maicas5, Mireia Lucía Sanmartín Martínez6, Iván Jesús Lorente Betanzos6, Clara Molina Almela6, juan José Lerma Garrido7, Amalia Rueda3 and Jose A Román-Ivorra8, 1Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain, 2Hospital General Universitario, Valencia, Comunidad Valenciana, Spain, 3Hospital General de Valencia, Valencia, Comunidad Valenciana, Spain, 4HOSPITAL GENERAL UNIVERSITARIO VALENCIA SPAIN, Ontinyent, Comunidad Valenciana, Spain, 5Consorcio Hospital General Universitario de Valencia, Castellón de la Plana, Comunidad Valenciana, Spain, 6Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain, 7Hospital General Universitario Valencia, Valencia, Comunidad Valenciana, Spain, 8Hospital Universitari i Politècnic la Fe, Valencia, Comunidad Valenciana, Spain

    Background/Purpose: Rheumatoid arthritis (RA) escalates the risk of premature mortality, predominantly through cardiovascular diseases. Although SCORE and its updated version, SCORE2, are employed to assess…
  • Abstract Number: 0735 • ACR Convergence 2024

    ANCA-associated Vasculitis (AAV) and Long-term Risk of Cardiovascular Disease: Large-scale Propensity-matched Global Retrospective Cohort Study

    Sebastian Klapa1, Henry Nording2, Marlene Ludwig3, Sabrina Arnold4, Khalaf Kridin5, Anja Staehle6, Ralf Ludwig7 and Peter Lamprecht4, 1University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, 2University of Lübeck, Cardioimmunology Research Group, Lübeck, Germany, 3Independent Researcher, Groß Grönau, Germany, 4University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, 55. Bar-Ilan University, Azrieli Faculty of Medicine, Safed, Israel, 6University of Lübeck, Department of Rheumatology and Immunology, Lübeck, Germany, 7University of Lübeck, Lübeck Institute of Experimental Dermatology, Lübeck, Germany

    Background/Purpose: In spite of significantly improved therapy during the last years, long-term morbidity and mortality has remained high in ANCA-associated vasculitis (AAV). The main causes…
  • Abstract Number: 1098 • ACR Convergence 2024

    Prognostic Value of Hyperuricemia in Developing Cardiovascular Events in Patients with Chronic Inflammatory Arthritis: A 10-Year Prospective Study

    Antonio Avilés1, Zulema Plaza2, Fernando Sánchez-Alonso3, Santos Castañeda4, Benjamin fernandez-Gutierrez5, César Díaz6, Pilar Font7, Olga Martinez8, Emilio Giner9, José Miguel Senabre10, Amalia Rueda11, Ana Perez12, Gines Sanchez13, Carlos Gonzalez14, Javier García15, Javier Llorca16, Miguel Angel Gonzalez-Gay17 and Mariano Andres18, and CARMA project, reserch group., 1Rheumatology section, Dr. Balmis General University Hospital-ISABIAL, Alicante, Spain, Alicante, Spain, 2Fundacion Española de Reumatología, Madrid, Spain, 3Sociedad Española de Reumatología, Madrid, Spain, 4Hospital Universitario de la Princesa, Madrid, Spain, 5HOSPITAL CLINICO SAN CARLOS, Madrid, Spain, 6Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 7IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 8Hospital Universitario de Salamanca, Zamora, Spain, 9Hospital Royo Villanova, Teruel, Spain, 10Hospital Marina Baixa Alicante, Alicante, Spain, 11Hospital General de Valencia, VALENCIA, Comunidad Valenciana, Spain, 12Hospital Universitario Principe de Asturias, Alcala de Henares, Madrid, Spain, 13Hospital General de Albacete, Albacete, Spain, 14Hospital Universitario Lucus Augusti; Biodiscovery HULA-USC Group, Instituto de Investigación Sanitaria de Santiago de Compostela IDIS., Lugo, Spain, 15Hospital Universitario 12 de Octubre, Madrid, Spain, 16CIBER Epidemiología y Salud Pública (CIBERESP) and Department of Medical and Surgical Sciences, University of Cantabria, Santander, Spain, 17University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, 18Hospital General Universitario de Alicante, Alicante, Spain

    Background/Purpose: The role of concurrent hyperuricemia as a cardiovascular risk factor in patients with chronic inflammatory arthritis (CIA) has yet to be studied. We aim…
  • Abstract Number: 1505 • ACR Convergence 2024

    Incidence of Cardiovascular and Venous Thromboembolic Events in Four Autoantibody-defined Systemic Lupus Erythematosus Clusters

    Sara Ferrigno1, Elizabeth Arkema2, Lina Marcela Diaz-Gallo3, Iva Gunnarsson4, Agneta Zickert4 and Elisabet Svenungsson5, 1Department of Systems' Medicine, University of Rome Tor Vergata, Rome, Italy, 2Department of Medicine Solna, Clinical Epidemiology Division, Stockholm, Sweden, 3Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 4Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 5Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Systemic lupus erythematosus (SLE) patients have higher cardiovascular (CV) risk compared to the general population, with a standardized CV mortality rate of 2-3 and…
  • Abstract Number: 1957 • ACR Convergence 2024

    Assessing Left Ventricular Hemodynamic Forces in Systemic Sclerosis Patients: Pilot Study

    Aïcha Kante1, Andreea Afana2, Damien Sène3, Valérie Bousson4, Trecy Goncalves5, Edouard Ballout5, Solenn Toupin5, Jean-Guillaume Dillinger6, William Bigot3, Valentin Pagis7, Karine Champion3, Ruxandra burlacu7, stephane mouly3, Patrick Henry6, Theo Pezel6 and Cloé Comarmond3, 1Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Université Paris Cité, Paris, Ile-de-France, France, 2Department of Cardiology, University of Medicine and Pharmacy Craiova, Craiova, Romania, 3Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Lariboisière Hospital, Université Paris Cité, Paris, Ile-de-France, France, 4Department of Radiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, Ile-de-France, France, 5Department of Cardiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, France, 6Department of Cardiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, Ile-de-France, France, 7Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Lariboisière Hospital, Université Paris Cité, Paris, France

    Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease marked by inflammation, microvascular changes and fibrosis. Cardiac comorbidities are the leading cause of mortality. Early…
  • Abstract Number: 2414 • ACR Convergence 2024

    A Retrospective Comparative Analysis of Cardiovascular Risk Factors, Atherosclerotic Cardiovascular Disease and Statin Use as Secondary Prevention in a Cohort of Patients with Systemic Lupus Erythematosus versus Without Rheumatological Disease from a Single-Center Patient Registry

    Alma Aveytia Camacho1, Rakesh Gullapelli2, Vineetha Philip3, Soudabeh Daliri1, Ruba Memon4, Helene DiGregorio2, Lily Romero Karam2, Kanika Monga3, Eleonora Avenatti2, Khurram Nasir2 and Myriam Guevara1, 1Houston Methodist, Houston, TX, 2Houston Methodist Hospital, Houston, TX, 3Houston Methodist Hospital, Sugar Land, TX, 4Houston Methodist, Missouri City, TX

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased prevalence of cardiovascular risk factors (RFs), which predispose to higher risk of premature atherosclerotic cardiovascular disease…
  • Abstract Number: 0130 • ACR Convergence 2024

    Depression Genetic Risk, Diagnoses, and Treatments in Association with Cardiovascular Disease Events Among Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis in the All of Us Research Program

    Jing Cui1, Jeong Yee1, Emily Oakes1, Elizabeth Karlson1, Leah Santacroce1, Hongshu Guan1, Laura D. Kubzansky2, Karestan C. Koenen2, Candace Feldman1 and Karen Costenbader3, 1Brigham and Women's Hospital, Boston, MA, 2Harvard School of Public Health, Boston, MA, 3Brigham and Women's Hospital/ Harvard Medical School, Boston, MA

    Background/Purpose: Diagnoses of depression, highly prevalent in SLE and RA populations, were associated with increased cardiovascular disease (CVD) risk in the All of Us Research…
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