ACR Meeting Abstracts

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Abstracts tagged "Brain"

  • Abstract Number: 0643 • ACR Convergence 2024

    Using FDG PET Brain Scans and Deep Learning Analyses to Identify a Specific Network Correlated with Cognitive Impairment in SLE

    Nha Nguyen1, An Vo1, Chris Tang1, Erik Anderson2, Cynthia Aranow2, Betty Diamond3, David Eidelberg1 and Meggan Mackay4, 1Feinstein Institutes, Manhasset, NY, 2Feinstein Institutes for Medical Research, New York, NY, 3The Feinstein Institutes for Medical Research, Manhasset, NY, 4Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Cognitive impairment (CI) is a debilitating, untreatable problem for up to 80% of individuals with SLE and human and mouse data suggest multiple SLE-related…
  • Abstract Number: 1279 • ACR Convergence 2024

    Cerebrovascular Accidents in Pediatric and Adult Systemic Lupus Erythematosus: A Comparison of Epidemiology and Outcomes

    Ekemini Ogbu1, Jareen Meinzen-Derr2, Michael Wagner2, Rashmi Sahay2, Dhriti Sharma2, J Michael Taylor2, Sudhakar Vadivelu3, Mekibib Altaye2 and hermine brunner1, 1Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3University of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: Cerebrovascular accidents (CVA) are one of the most devastating neurologic manifestations of childhood-onset systemic lupus erythematosus (cSLE).  The spectrum of CVA in cSLE (CVAcSLE)…
  • Abstract Number: 1560 • ACR Convergence 2024

    Changes of Cerebral Structure and Perfusion Vary in Different Subtypes of Systemic Sclerosis: A Brain Magnetic Resonance Imaging Study

    Xinyu Tong1, Huilin He2, Shihan Xu2, Zihan Ning1, Rui Shen1, Xiaofeng Zeng3, qian wang4, Dong Xu5, Xihai zhao1 and Zuoxiang He1, 1Tsinghua University, Beijing, China, 2Peking Union Medical College Hospital, Beijing, China, 3Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China, 4Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, 5Peking Union Medical College Hospital, Dong Cheng District, Beijing, China

    Background/Purpose: The characteristics of brain impairment in different subtypes of systemic sclerosis (SSc) (dcSSc, diffuse cutaneous SSc; lcSSc, limited cutaneous SSc) remain unclear. This study aimed to characterize cerebral structure and perfusion…
  • Abstract Number: 1776 • ACR Convergence 2024

    Animal Models of Pediatric MOGAD

    Yike Jiang1, Elliot Lin2, Estefany Reyes2, Devon DiPalma2, Sundar Khadka2, Heather Van Mater2 and Mari Shinohara2, 1Duke Univerisity, Durham, NC, 2Duke University, Durham, NC

    Background/Purpose: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a devastating demyelinating disease that disproportionally affects children. Discovered in 2018, MOGAD is now internationally recognized as…
  • Abstract Number: 2251 • ACR Convergence 2024

    Stress-Related Neural Activity Measured with FDG-PET/CT Is Associated with Articular Disease Activity, Systemic Inflammation, and Treatment-associated Change in Arterial Inflammation in Rheumatoid Arthritis

    Jon Giles1, Joan Bathon2, Katherine Liao3, Pamela Rist4, Shady Abohashem5, Michael Osborne5, Giovani Civieri5, Zahi Fayad6, Daniel Solomon3 and Ahmed Tawakol7, 1Cedars Sinai Medical Center, Los Angeles, CA, 2Columbia University, New York, NY, 3Brigham and Women's Hospital, Boston, MA, 4Brigham & Women's Hospital/Harvard University, Boston, MA, 5Massachusetts General Hospital/Harvard University, Boston, MA, 6Mount Sinai Medical Center, New York, NY, 7Massachusetts General Hospital/Harvard Medical School, Boston, MA

    Background/Purpose: The amygdala, a limbic structure of the brain’s salience network, links chronic external stressors with downstream effects on the HPA axis and hematopoietic tissues…
  • Abstract Number: 1430 • ACR Convergence 2023

    A Proof-of-concept Study Evaluating the Use of Functional Brain Magnetic Resonance Imaging in Assessing Treatment Response in Psoriatic Arthritis Patients

    Esther Espartal López1, Xabier Michelena Vegas2, Sara Marsal Barril1, Alex Rovira3, Deborah Pareto3 and Alba Erra Duran1, 1Vall Hebron University Hospital, Rheumatology Department, Barcelona, Spain, 2Hospital Universitari Vall Hebron, Barcelona, Spain, 3Vall Hebron University Hospital, Section of Neuroradiology (Department of Radiology, IDI), Barcelona, Spain

    Background/Purpose: Inflammatory cytokines can alter the way the central nervous system processes pain as shown in patients with rheumatoid arthritis. However, the relationship between TNFα…
  • Abstract Number: 1456 • ACR Convergence 2023

    Systematic Review of Effects of Systemic Lupus Erythematosus on Brain Structure and Structural Connectivity and Its Relationship with Cognitive Dysfunction Through an Advanced Neuroimaging Lens

    Ibrahim Mohamed1, Tala El Tal2, santiago arciniegas3, Stephanie Fevrier4, justine ledochowski5 and Andrea Knight4, 1The Hospital for Sick Children, Brampton, ON, Canada, 2Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada, 3University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, ON, Canada, 5Department of Psychology, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Cognitive dysfunction (CD) is highly prevalent in systemic lupus erythematosus (SLE), and advanced structural magnetic resonance imaging (MRI) has revealed brain abnormalities in patients…
  • Abstract Number: 1730 • ACR Convergence 2023

    Gut Microbiota Dysbiosis Impact Autonomic Function in Rheumatoid Arthritis Patients

    Rachel AUDO1, Jérome Thireau2, Louis Rauzier3, Marie Barozet1, JACQUES MOREL4, Patrice Bideaux3, alain Lacampagne2 and Claire Daien5, 1CHU Montpellier, Montpellier, France, 2PhyMedExp INSERM U1046, Montpellier, France, 3PhyMedExp U1046, Montpellier, France, 4Protocole thérapeutique immuno-rhumatologie, Montpellier, France, 5University Hospital, Montpellier, France

    Background/Purpose: Rheumatoid arthritis (RA) is associated with a high risk of cardiovascular (CV) risks, including accelerated atherosclerosis, left ventricular hypertrophy and decreased heart rate variability…
  • Abstract Number: 1913 • ACR Convergence 2023

    Neurosarcoidosis Disease Epidemiology. University Hospital in Northern Spain 1999-2019

    Ana Serrano-Combarro1, Alba Herrero-Morant2, Lara Sanchez-Bilbao3, Inigo Gonzalez-Mazon3, David Martinez-Lopez4, Jose Luis Martin-Varillas5, Raul Fernandez-Ramon6 and Ricardo Blanco7, 1Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, Ontinyent, Spain, 3Hospital Universitario Marques de Valdecilla, Santander, Spain, 4Hospital de Sierrallana, Santander, Spain, 5Hospital de Laredo, Laredo, Spain, 6Hospital Universitario Marqués de Valdecilla, Santander, Spain, 7Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Neurosarcoidosis (NS) is a serious and relative uncommon complication of sarcoidosis. Data on incidence is scarce and varies worldwide. Our objective is toestimate NS…
  • Abstract Number: 2258 • ACR Convergence 2023

    Brain Activity Patterns and Behavioural Performance in SLE Patients During a Spatial Working Memory and Sustained Attention Task

    Michelle Barraclough1, Shane McKie2, Alex Kafkas2, Ben Parker3, Juan Pablo Diaz Martinez4, Andrea Knight5, Kathleen Bingham1, Jiandong Su1, Mahta Kakvan6, Carolina Munoz-Grajales7, Carmela Tartaglia8, Lesley Ruttan9, Joan Wither1, Dennisse Bonilla1, Daniela Montaldi2, Rebecca Elliott2, Patti Katz10, Dorcas Beaton11, Robin Green9, Ian Bruce2 and Zahi Touma12, 1University Health Network, Toronto, ON, Canada, 2University of Manchester, Manchester, United Kingdom, 3Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 4Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, 5The Hospital for Sick Children, Toronto, ON, Canada, 6University Health Network, University of Toronto, Toronto, ON, Canada, 7UHN/TWH, Toronto, ON, Canada, 8Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 9University Health Network, Toronto Rehabilitation Institute, Toronto, ON, Canada, 10University of California San Francisco, San Rafael, CA, 11Institute for Work & Health, Toronto, ON, Canada, 12University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is a significant problem in SLE but there is a disconnect between objective and subjective CI. This makes it difficult to…
  • Abstract Number: 2591 • ACR Convergence 2023

    Under Assault: Ongoing Brain Dysfunction Identified on Resting State-functional MRI (rs-fMRI) in SLE Patients in Clinical Remission

    Meggan MacKay, an vo, Erik Anderson, Cynthia Aranow, Betty Diamond and David Eidelberg, Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: There is substantial evidence that the brain is targeted early in SLE, likely from disease inception. Data from mouse models and human studies suggest…
  • Abstract Number: 0280 • ACR Convergence 2023

    Immunosuppression in the Treatment of Susac Syndrome: A Retrospective Evaluation of the Largest Cohort of Susac Syndrome

    Adam Brown1, Robert Rennebohm2, Ghulam Abbas Kharal2, Devon Conway2, Sunil Srivastava3, Sumit Sharma2, Careen Lowder2, Leonard Calabrese4 and Rula Hajj-Ali2, 1Cleveland Clinic Department of Rheumatic and Immunologic Diseases, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH, 3Cincinnati Eye Institute, Cincinnati, OH, 4Cleveland Clinic / Department of Rheumatic and Immunologic Diseases, Cleveland, OH

    Background/Purpose: Susac Syndrome is a rare autoimmune condition causing microvascular occlusions in the brain, retina and inner ear leading to the characteristic triad of encephalopathy,…
  • Abstract Number: 0312 • ACR Convergence 2023

    Frontal Lobe Activation and Gait Alterations During Single- and Dual-task Walking in People with Knee Osteoarthritis: A Functional Near-infrared Spectroscopy Study

    Soyoung Lee, Meryem Yücel, Claudio Ferre, Baekdong Cha, Ehyun Kim and Deepak Kumar, Boston University, Boston, MA

    Background/Purpose: Altered gait patterns, including high variability or muscular co-contraction, can increase fall risk and worsen disease progression in people with knee osteoarthritis (OA). However,…
  • Abstract Number: 0653 • ACR Convergence 2023

    Association Between Systemic Sclerosis and Increased Risk of Ischemic Stroke: A Meta-Analysis

    Christina Flourou1, Andreas Liampas1 and Konstantinos Parperis2, 1Nicosia General Hospital, Nicosia, Cyprus, 2University of Cyprus Medical School, Nicosia, Cyprus

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune rheumatic disease characterized by significant vascular abnormalities due to microvascular damage and intimal proliferation in the small arterioles.…
  • Abstract Number: 0837 • ACR Convergence 2023

    A Randomized, Double-Blind, Sham-Controlled, Clinical Trial of Auricular Vagus Nerve Stimulation for the Treatment of Active Rheumatoid Arthritis

    Matthew Baker1, Sarah Kavanagh2, Stanley Cohen3, Alan Matsumoto4, Ara Dikranian5, John Tesser6, Alan Kivitz7, Konstantinos Alataris8 and Mark Genovese9, 1Stanford University, Menlo Park, CA, 2Kavanagh Statistical Consulting, LLC, Apex, NC, 3Metroplex Clinical Research Center, Dallas, TX, 4Arthritis and Rheumatism Associates, Wheaton, MD, 5Cabrillo Center for Rheumatic Disease, San Diego, CA, 6Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, 7Altoona Center for Clinical Research, Duncansville, PA, 8Nēsos, Menlo Park, CA, 9Stanford University, Sunnyvale, CA

    Background/Purpose: Vagus nerve stimulation (VNS) has emerged in recent decades as a potential therapy for RA.We have previously shown that auricular VNS produced an average…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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