Abstracts tagged "Bone"

Abstract Number: 1794 • 2014 ACR/ARHP Annual Meeting
The Sting Pathway Regulates Bone Remodeling in a Model of Autoimmune Disease
Rebecca Baum¹, Jason M. Organ², David B. Burr³, Ann Marshak-Rothstein⁴, Katherine A. Fitzgerald⁵ and Ellen M. Gravallese⁶, ¹Cell Biology, University of Massachusetts Medical School, Worcester, MA, ²Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, ³Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, ⁴Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁵Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁶Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Cytosolic DNA sensors detect viral and bacterial DNA, inducing inflammatory cytokines and type I IFNs via the adaptor stimulator of interferon genes (STING) to…
Abstract Number: 1424 • 2014 ACR/ARHP Annual Meeting
Bone Erosions in Patients with RA: Exploring the Impact of the Anatomy of Interest on the Relationship Between MRI and X-Ray Erosion Detection
Michael Tomizza¹, Isabel Rodrigues¹, Matthew Jessome¹, Joshua Barbosa¹, Karen Beattie², William G. Bensen², Raja Bobba², Alfred Cividino², Patrick D. Emond², Karen Finlay³, Chris Gordon², Lawrence Hart², George Ioannidis², Erik Jurriaans³, Melissa Koh¹, Maggie Larche², Arthur Lau², Naveen Parasu³, Ruben Tavares², Stephen Tytus², Hao Wu¹ and Jonathan D. Adachi^1,2, ¹McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³Radiology, Hamilton Health Sciences, Hamilton, ON, Canada
Background/Purpose: Detection of bone erosions in patients with RA is critical in clinical practice, with treatment initiation and effectiveness largely based on limiting erosive progression.…
Abstract Number: 1301 • 2014 ACR/ARHP Annual Meeting
Trabecular Bone Impairment Assessed By HR-pQCT in Juvenile-Onset Systemic Lupus Erythematous with Vertebral Fractures
Juliane Paupitz, Glauce Lima, Valéria Caparbo, Henrique Fuller, Eloisa Bonfa and Rosa M R Pereira, Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose The three-dimensional evaluation of bone by HR-pQCT has the advantage to provide assessment to not only bone density, but also to a noninvasive evaluation…
Abstract Number: 1215 • 2014 ACR/ARHP Annual Meeting
Circulating Mediators of Bone Remodeling in Patients with Tophaceous Gout
Ashika Chhana¹, Opetaia Aati², Gregory Gamble², Karen E. Callon¹, Anthony Doyle³, Mark Roger⁴, Fiona M. McQueen⁵, Anne Horne², Ian R. Reid², Jillian Cornish¹ and Nicola Dalbeth², ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Auckland, Auckland, New Zealand, ⁴Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ⁵Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Disordered bone remodeling has been implicated in the development of bone erosion in tophaceous gout. The function of bone cells in the skeleton is…
Abstract Number: 1236 • 2013 ACR/ARHP Annual Meeting
Outcomes and Costs Of Sacral Insufficiency Fractures
Shahryar Hadavi¹, Sanam Kia¹, Christian Dejaco², Bhaskar Dasgupta² and Frances Borg³, ¹Rheumatology Department, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ²Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ³Rheumatology, Southend University Hospital, Westcliff-on-sea, United Kingdom
Background/Purpose: Sacral insufficiency fracture (SIF) is a poorly recognised cause of lower back pain in the elderly with significant potential morbidity. Diagnosis is often slow…
Abstract Number: 1131 • 2013 ACR/ARHP Annual Meeting
Peri-Articular Fractal Signature Analysis and Bone Mineral Density Measure Different Aspects Of Bone: Cross-Sectional Data From The Osteoarthritis Initiative
Jeffrey B. Driban¹, Felix Liu², Alina O'Brien³, Lori Lyn Price⁴, Grace H. Lo⁵, Michael C. Nevitt⁶, Charles Eaton⁷, Timothy E. McAlindon⁸ and John A. Lynch⁹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²University of California at San Francisco, San Francisco, CA, ³Tufts Medical Center, Boston, MA, ⁴Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ⁶Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁷Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁹Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA
Background/Purpose: Peri-articular fractal signature analysis (FSA) and bone mineral density (paBMD) are potentially cost-effective prognostic imaging markers for osteoarthritis (OA) progression. While we know that…
Abstract Number: 526 • 2013 ACR/ARHP Annual Meeting
Endochondral Bone Formation and Advanced Enthesitis Are Key Features Of Proteoglycan Induced Spondylitis Mouse Model Of Ankylosing Spondylitis
Gethin P Thomas¹, Hsu-Wen Tseng², Allison Pettit^3,4, Tibor T. Glant⁵, Allan McRae² and Matthew A. Brown⁶, ¹Translational Reserch Institute, University of Queensland Diamantina Institute, Woolloongabba, Australia, ²University of Queensland Diamantina Institute, Woolloongabba, Australia, ³Mater Research, Woolloongabba, Australia, ⁴University of Queensland Centre for Clinical Research, Herston, Australia, ⁵Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ⁶University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Transition from an initial inflammatory phase to the disabling osteoproliferative phase in ankylosing spondylitis (AS) is very poorly understood. Elucidation of the mechanisms underlying…
Abstract Number: 213 • 2013 ACR/ARHP Annual Meeting
Digital Tomosynthesis for Measurement of Bone Erosion in Gout: Comparison With Computed Tomography
Nicola Dalbeth¹, Anthony Doyle², Mark Roger³, Angela Gao⁴ and Fiona M. McQueen⁵, ¹Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ⁴Radiology, Auckland District Health Board, Auckland, New Zealand, ⁵Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Digital tomosynthesis is a recently developed imaging method in which multiple projected images obtained at different angles are collected with a digital detector. These…
Abstract Number: 215 • 2013 ACR/ARHP Annual Meeting
Relationship Between Structural Joint Damage and Urate Deposition In Gout: A Site-By-Site Analysis Using Plain Radiography and Dual Energy Computed Tomography
Nicola Dalbeth¹, Opetaia Aati², Ramanamma Kalluru³, Anne Horne², Anthony Doyle⁴ and Fiona M. McQueen⁵, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, ⁴University of Auckland, Auckland, New Zealand, ⁵Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Structural joint damage, including erosion, joint space narrowing (JSN) and new bone formation (NBF), is frequently observed in patients with tophaceous gout. Although imaging…
Abstract Number: 65 • 2013 ACR/ARHP Annual Meeting
The Frequency Of Bone Marrow Oedema Adjacent To The Cruciate Ligament Peri-Entheseal Vascular Channels In Inflammatory and Degenerative Arthritis
Daniel Binks^1,2, Melissa Matzelle³, Diane Bergin⁴, Richard J. Hodgson^2,5, Ai Lyn Tan^1,2, Ellen M. Gravallese⁶, Dennis McGonagle^1,2,7 and Aleksandra Radjenovic^1,2, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ³Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁴Radiology, Galway University Hospitals, Galway, Ireland, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁶Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA, ⁷Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: We noted in mouse models of inflammatory arthritis (IA) that an early point of entry of inflammation into the marrow space occurred at sites…
Abstract Number: 71 • 2013 ACR/ARHP Annual Meeting
Subchondral Bone Turnover and Osteophyte Formation Are Key Aspects In The Progression Of Osteoarthritis and May Be Assessed and Predicted By a-CTX
Morten Asser Karsdal¹, Janet L. Huebner², Virginia Byers Kraus², Diana J. Leeming¹, Edward Coleman², Gary E. McDaniel³, Kim M. Huffman³, Kim Henriksen¹ and Anne C. Bay-jensen¹, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Medicine/Rheumatology, Duke University Medical Center, Durham, NC, ³Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritic disease. It is characterized by pathological changes in both bone and cartilage turnover as well…
Abstract Number: 2801 • 2013 ACR/ARHP Annual Meeting
Comparative Longitudinal Analysis Of Periarticular Bone Structure In Patients Treated With Methotrexate In Combination Of Either TNF Blockers Or Tocilizumab
Sebastian Kraus¹, Matthias Englbrecht¹, Juergen Rech², Roland Kocijan¹, Georg A. Schett¹ and Stephanie Finzel¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Inhibition of tumor necrosis factor alpha (TNFi) and interleukin-6 receptor (IL6Ri, tocilzumab) are among the most potent therapeutic strategies in patients with rheumatoid arthritis…
Abstract Number: 2729 • 2013 ACR/ARHP Annual Meeting
Identification Of Osteoarthritis Patients With Chronic Inflammation Driven Disease Progression
Anne Sofie Siebuhr¹, Kristian Kjaer Petersen², Lars Arendt-Nielsen³, Line Egsgaard², Thomas Navndrup Eskehave⁴, Ole Simonsen⁵, Claus Christiansen^4,6, Hans Christian Hoeck⁴, Morten Asser Karsdal⁷ and Anne C. Bay-Jensen⁸, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ³Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁴Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, ⁵Frederikshavn Hospital, Frederikshavn, Denmark, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁸Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: In osteoarthritis (OA) it is evident that a subset of patients experiences chronic tissue inflammation and may benefit from anti-inflammatory treatment. The systemic inflammation…
Abstract Number: 1953 • 2013 ACR/ARHP Annual Meeting
The Progression of Cartilage Damage in Rheumatoid Arthritis: A Three Year Prospective 3T- Magnetic Resonance Imaging Study Examining Predictive Factors
Fiona M. McQueen¹, Alexandra McHaffie², Andrew Clarke², Arier Lee³, Quentin Reeves², Barbara Curteis¹ and Nicola Dalbeth⁴, ¹Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand, ²Radiology, Auckland District Health Board, Auckland, New Zealand, ³Biostatistics and Epidemiology, University of Auckland, Auckland, New Zealand, ⁴Auckland District Health Board, Auckland, New Zealand
Background/Purpose: Cartilage damage impacts on patient disability in RA. The aims of this MRI study were to investigate cartilage damage over 3 years and determine…
Abstract Number: 1857 • 2013 ACR/ARHP Annual Meeting
Identification Of SOX5 and SOX6 As Potent Regulators Of RANKL Expression Contributing To Bone Erosion In Rheumatoid Arthritis and Experimental Arthritis Model
Wenfeng Tan¹, Xiaoke Feng², Lingxiao Xu³, Ke Gan⁴, Fang Wang³, Miaojia Zhang⁵, Hui Wu⁶ and Betty P. Tsao⁷, ¹Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, ³Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ⁴Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁵Department of Rheumatology, Jiangsu Provincial People's Hospital, Nanjing, China, ⁶Rheumatology, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ⁷Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA
Background/Purpose: We previously reported a RANKLpromoter SNP confers an elevated promoter activity after stimulation via binding to a SOX family transcription factor SOX5 and is…

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