Abstracts tagged "Bone"

Abstract Number: 2130 • 2014 ACR/ARHP Annual Meeting
Bone Microstructure in Patients with Cutaneous Psoriasis and No History of Psoriatic Arthritis Shows Bone Anabolic Changes at a Greater Extent Than in Healthy Controls
David Simon¹, Francesca Faustini¹, Matthias Englbrecht¹, Arnd Kleyer¹, Roland Kocijan², Judith Haschka³, Stephanie Finzel¹, Sebastian Kraus³, Axel J. Hueber¹, Michael Sticherling⁴, Georg Schett¹ and Jürgen Rech³, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medical Department II, St. Vincent Hospital, Vienna, Austria, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose Psoriasis (PSO) is a frequent disease which affects about 1-2% of the population and can be associated to arthritis (PsA). Skin disease often predates…
Abstract Number: 2143 • 2014 ACR/ARHP Annual Meeting
Cortical Breaks and Bone Erosions in the Hand Joints: A Cadaver Study Comparing Conventional Radiography with High-Resolution and Micro-Computed Tomography
A. Scharmga¹, A. van Tubergen¹, J. van den Bergh¹, J. de Jong¹, M. Peters¹, B. van Rietbergen² and P. Geusens¹, ¹Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ²Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
Background/Purpose . Conventional radiography (CR) is considered the gold standard for diagnosing bone erosions in rheumatic diseases. However, High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) and…
Abstract Number: 1914 • 2014 ACR/ARHP Annual Meeting
IL-17A Deficiency Promotes Periosteal Bone Formation in a Model of Inflammatory Arthritis
Anita T. Shaw¹, Yukiko Maeda¹, Catherine Manning¹ and Ellen M. Gravallese^1,2, ¹Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Enthesial and periosteal bone formation in spondyloarthropathies (SpAs) are important sequelae of disease that contribute to patient morbidity. Anti-TNF therapies do not significantly alter…
Abstract Number: 1892 • 2014 ACR/ARHP Annual Meeting
In Vivo Visualization of Cortical Microchannels in Metacarpal Bones in Patients with Cutaneous Psoriasis By High Resolution Peripheral Computed tomography – Detecting Cortical Pathologies before the Clinical Onset of Psoriatic-Arthritis
David Simon¹, Francesca Faustini¹, Arnd Kleyer¹, Judith Haschka¹, David Werner¹, Axel J. Hueber¹, Michael Sticherling², Georg Schett¹ and Juergen Rech¹, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose Normal bones present cortical micro-channels (CMC), which carry micro-vessels and ensure communication between the bone marrow and the synovial compartment. Only recently these structures…
Abstract Number: 1857 • 2013 ACR/ARHP Annual Meeting
Identification Of SOX5 and SOX6 As Potent Regulators Of RANKL Expression Contributing To Bone Erosion In Rheumatoid Arthritis and Experimental Arthritis Model
Wenfeng Tan¹, Xiaoke Feng², Lingxiao Xu³, Ke Gan⁴, Fang Wang³, Miaojia Zhang⁵, Hui Wu⁶ and Betty P. Tsao⁷, ¹Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, ³Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ⁴Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁵Department of Rheumatology, Jiangsu Provincial People's Hospital, Nanjing, China, ⁶Rheumatology, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ⁷Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA
Background/Purpose: We previously reported a RANKLpromoter SNP confers an elevated promoter activity after stimulation via binding to a SOX family transcription factor SOX5 and is…
Abstract Number: 1828 • 2013 ACR/ARHP Annual Meeting
In Vivo Cartilage-Specific Deletion Of Ephrin-B2 In Mice Results In Developmental Locomotory Defects Associated With Hip Bone Abnormality
Gladys Valverde-Franco¹, Bertrand Lussier², David Hum¹, Jiangping Wu³, Jean-Pierre Pelletier¹, Mohit Kapoor¹ and Johanne Martel-Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada, ³Laboratory of Immunology, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada
Background/Purpose: The ephrins and their related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events. We have…
Abstract Number: 1839 • 2013 ACR/ARHP Annual Meeting
Osteoclastogenesis Is Enhanced By Synovial Fluid Derived Anti-Citrullinated Proteins Antibodies In Rheumatoid Arthritis
Akilan Krishnamurthy¹, Heidi Wähämaa¹, Vijay Joshua¹, Catia Cerqueira¹, Elena Ossipova², Nancy Vivar Pomiano³, Karin Lundberg², Vivianne Malmström⁴, Per-Johan Jakobsson⁵, Lars Klareskog⁵, Georg Schett⁶, Jimmy Ytterberg¹ and Anca I Catrina⁵, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁵Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁶Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Anti citrullinated modified vimentin antibodies isolated from peripheral blood (PB) of RA patients induce osteoclasts (OC) formation from PB derived monocytes of healthy individuals.…
Abstract Number: 1481 • 2013 ACR/ARHP Annual Meeting
Negative Effect Of Glucocorticoids Persistence Therapy On Porosity In Rheumatoid Arthritis Patients Treated With TNFα Blockers
Hubert Marotte¹, Sara Djemouai², Béatrice Pallot-Prades², Hervé Locrelle³ and Thierry Thomas⁴, ¹LBTO INSERM U1059 University Jean Monnet, Saint-Etienne, France, ²University Hospital, Saint-Etienne, France, ³INSERM U1059 and University Hospital, Hôpital Nord, Saint-Etienne, France, ⁴INSERM U1059 and University Hospital, Saint-Etienne, France
Background/Purpose: Rheumatoid arthritis is the most common joint inflammatory disease associated with an increased risk of bone fractures. The standard of therapeutic strategy is to…
Abstract Number: 1236 • 2013 ACR/ARHP Annual Meeting
Outcomes and Costs Of Sacral Insufficiency Fractures
Shahryar Hadavi¹, Sanam Kia¹, Christian Dejaco², Bhaskar Dasgupta² and Frances Borg³, ¹Rheumatology Department, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ²Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ³Rheumatology, Southend University Hospital, Westcliff-on-sea, United Kingdom
Background/Purpose: Sacral insufficiency fracture (SIF) is a poorly recognised cause of lower back pain in the elderly with significant potential morbidity. Diagnosis is often slow…
Abstract Number: 1131 • 2013 ACR/ARHP Annual Meeting
Peri-Articular Fractal Signature Analysis and Bone Mineral Density Measure Different Aspects Of Bone: Cross-Sectional Data From The Osteoarthritis Initiative
Jeffrey B. Driban¹, Felix Liu², Alina O'Brien³, Lori Lyn Price⁴, Grace H. Lo⁵, Michael C. Nevitt⁶, Charles Eaton⁷, Timothy E. McAlindon⁸ and John A. Lynch⁹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²University of California at San Francisco, San Francisco, CA, ³Tufts Medical Center, Boston, MA, ⁴Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ⁶Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁷Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁹Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA
Background/Purpose: Peri-articular fractal signature analysis (FSA) and bone mineral density (paBMD) are potentially cost-effective prognostic imaging markers for osteoarthritis (OA) progression. While we know that…
Abstract Number: 526 • 2013 ACR/ARHP Annual Meeting
Endochondral Bone Formation and Advanced Enthesitis Are Key Features Of Proteoglycan Induced Spondylitis Mouse Model Of Ankylosing Spondylitis
Gethin P Thomas¹, Hsu-Wen Tseng², Allison Pettit^3,4, Tibor T. Glant⁵, Allan McRae² and Matthew A. Brown⁶, ¹Translational Reserch Institute, University of Queensland Diamantina Institute, Woolloongabba, Australia, ²University of Queensland Diamantina Institute, Woolloongabba, Australia, ³Mater Research, Woolloongabba, Australia, ⁴University of Queensland Centre for Clinical Research, Herston, Australia, ⁵Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ⁶University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Transition from an initial inflammatory phase to the disabling osteoproliferative phase in ankylosing spondylitis (AS) is very poorly understood. Elucidation of the mechanisms underlying…
Abstract Number: 213 • 2013 ACR/ARHP Annual Meeting
Digital Tomosynthesis for Measurement of Bone Erosion in Gout: Comparison With Computed Tomography
Nicola Dalbeth¹, Anthony Doyle², Mark Roger³, Angela Gao⁴ and Fiona M. McQueen⁵, ¹Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ⁴Radiology, Auckland District Health Board, Auckland, New Zealand, ⁵Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Digital tomosynthesis is a recently developed imaging method in which multiple projected images obtained at different angles are collected with a digital detector. These…
Abstract Number: 215 • 2013 ACR/ARHP Annual Meeting
Relationship Between Structural Joint Damage and Urate Deposition In Gout: A Site-By-Site Analysis Using Plain Radiography and Dual Energy Computed Tomography
Nicola Dalbeth¹, Opetaia Aati², Ramanamma Kalluru³, Anne Horne², Anthony Doyle⁴ and Fiona M. McQueen⁵, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, ⁴University of Auckland, Auckland, New Zealand, ⁵Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Structural joint damage, including erosion, joint space narrowing (JSN) and new bone formation (NBF), is frequently observed in patients with tophaceous gout. Although imaging…
Abstract Number: 65 • 2013 ACR/ARHP Annual Meeting
The Frequency Of Bone Marrow Oedema Adjacent To The Cruciate Ligament Peri-Entheseal Vascular Channels In Inflammatory and Degenerative Arthritis
Daniel Binks^1,2, Melissa Matzelle³, Diane Bergin⁴, Richard J. Hodgson^2,5, Ai Lyn Tan^1,2, Ellen M. Gravallese⁶, Dennis McGonagle^1,2,7 and Aleksandra Radjenovic^1,2, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ³Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁴Radiology, Galway University Hospitals, Galway, Ireland, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁶Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA, ⁷Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: We noted in mouse models of inflammatory arthritis (IA) that an early point of entry of inflammation into the marrow space occurred at sites…
Abstract Number: 71 • 2013 ACR/ARHP Annual Meeting
Subchondral Bone Turnover and Osteophyte Formation Are Key Aspects In The Progression Of Osteoarthritis and May Be Assessed and Predicted By a-CTX
Morten Asser Karsdal¹, Janet L. Huebner², Virginia Byers Kraus², Diana J. Leeming¹, Edward Coleman², Gary E. McDaniel³, Kim M. Huffman³, Kim Henriksen¹ and Anne C. Bay-jensen¹, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Medicine/Rheumatology, Duke University Medical Center, Durham, NC, ³Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritic disease. It is characterized by pathological changes in both bone and cartilage turnover as well…

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