ACR Meeting Abstracts

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Abstracts tagged "Bone Resorption"

  • Abstract Number: 1784 • ACR Convergence 2025

    Multimodal Preclinical Screening Of Glucocorticoid-Induced Disruption Of Bone Remodeling In Rat

    Anik Tuladhar, Caitlyn Carter, Erin Vaughan, martin j.voorbach, Sabyasachi Biswas, Timothy Brayman, Pankaj Kumar, anastasia marinopoulos, Xin Huang, Sjoerd J. Finnema, Romy Christmann, Terry vanVleet, Brian Enright, Magali Guffroy and Stacey Fossey, AbbVie, North Chicago, IL

    Background/Purpose: Bone toxicity during drug development can arise from intended pharmacologic mechanisms or off-target effects. Standard histopathological evaluation often fails to detect early skeletal alterations,…
  • Abstract Number: 0086 • ACR Convergence 2025

    Androgen Upregulates Interferon Signaling in Osteoclast Differentiation During Inflammatory State

    Kiana Chen1, Chia-Lung Wu2, Gulzada Kulzhanova2 and Homaira Rahimi3, 1University of Rochester School of Medicine and Dentistry, Bronx, NY, 2University of Rochester Medical Center, Rochester, 3University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic inflammatory erosions and female predominant disease. Androgen, the dominant sex hormone in males, is protective against bone…
  • Abstract Number: 2592 • ACR Convergence 2025

    Romosozumab and Denosumab Combination Therapy in Postmenopausal Osteoporosis

    Giovanni Adami1, Francesco Pollastri2, Angelo Fassio2, Camilla Benini2, Davide Gatti2, Ombretta Viapiana2 and Maurizio Rossini2, 1University of Verona, Italy, Verona, Italy, 2University of Verona, Verona, Italy

    Background/Purpose: Transition from long-term denosumab to PTH-analogs or romosozumab might expose patients to the risk of the so-called rebound phenomenon. Adding romosozumab to denosumab might…
  • Abstract Number: 2120 • ACR Convergence 2025

    Analyzing Gender and Racial Disparities in Paget’s Disease of Bone: A Large-Scale Observational Study

    Kinga Grzybowski1, Ahmer Khan2 and Arthur Lau3, 1Jefferson Einstein Montgomery Hospital, Maspeth, NY, 2Jefferson Einstein Philadelphia Hospital, Philadelphia, 3Jefferson Einstein Hospital, Maple Glen, PA

    Background/Purpose: Osteitis deformans, commonly referred to as Paget’s Disease of the Bone (PDB), affects adults over the age of 55, mainly of European descent and…
  • Abstract Number: 2117 • ACR Convergence 2025

    Denosumab Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis: A Multi-site Randomized Clinical Trial

    Giovanni Adami1, Kenneth Saag2, Gary Cutter3, Rahima Begum3, Elizabeth Dye4, Phillip Foster5, Camilla Benini6, Carmela Dartizio6, Davide Gatti6 and Maria I. ("Maio") Danila7, 1University of Verona, Italy, Verona, Italy, 2The University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, 4UAB, Birmingham, AL, 5University of Alabama at Birmingham, Birmingham, AL, 6University of Verona, Verona, Italy, 7University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL

    Background/Purpose: Prompt anti-resorptive treatment with bisphosphonates after denosumab discontinuation is generally recommended. Glucocorticoid users may not require longer term denosumab and are at greater fracture…
  • Abstract Number: 1815 • ACR Convergence 2025

    New-Onset Juvenile Spondyloarthritis is Characterized by Bone Metabolism Disturbances with Biomarker Potential

    Brittney Newby1, Timothy Brandon1, Pamela Weiss2 and E. John Wherry3, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2Childrens Hospital of Philadelphia, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Juvenile spondyloarthritis (JSpA) management is hindered by the lack of reliable biomarkers to predict which patients will develop progressive structural changes, such as erosions…
  • Abstract Number: 0058 • ACR Convergence 2024

    Bradykinin Receptor B1 Blockade Suppresses Soluble CD13-Induced Differentiation of Osteoclasts from Monocytes

    Sei Muraoka1, Qi Wu2, Mikel Gurrea-Rubio3, Camila Amarista2, William Brodie2, Megan Mattichak2, Yuzo Ikari4, Caroline Foster2, Phillip Campbell2, David Fox5 and Pei-Suen Tsou2, 1University of Michigan, Toyko, Japan, 2University of Michigan, Ann Arbor, MI, 3University of Michigan - Ann Arbor, Ann Arbor, MI, 4Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 5University of Michigan, Dexter, MI

    Background/Purpose: CD13 is an ectopeptidase expressed on myeloid cells, endothelial cells, and rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). Soluble (s) CD13 is generated by matrix…
  • Abstract Number: 0267 • ACR Convergence 2024

    IL-17 Participates in the Pathogenesis of Chronic Gouty Arthritis

    Hong Di1, Xinxin Han1, Yun Zhang2 and Xuejun Zeng1, 1Peking Union Medical College Hospital, Beijing, China, 2Peking Union Medical College Hospital (CAMS), Beijing, China

    Background/Purpose: Chronic gouty arthritis (CGA) is different from acute gouty arthritis  (AGA), its main characteristics include repeated or even persistent joint symptoms, tophus and bone destruction.…
  • Abstract Number: 0415 • ACR Convergence 2024

    Prevalence and Risk Factors of Low Bone Mineral Density in Children with Juvenile Idiopathic Arthritis

    narendra bagri, Sushain Kalsotra, vandana jain, Manisha Jana, Maroof Ahmed Khan, Yashdeep Gupta and Sumit Kumar Das, All India Institute of Medical Sciences, New Delhi, Delhi, India

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatological disease in children less than 16 years of age. Various factors have been suggested…
  • Abstract Number: 0817 • ACR Convergence 2024

    2024 Clinical Practice Guideline for the Diagnosis and Treatment of Chronic Nonbacterial Osteitis (CNO) in Adults

    Elizabeth Winter, Olaf Dekkers and Anne Leerling, and the Expert Consensus Panel for Chronic Nonbacterial Osteitis (CNO) in Adults, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Adults with sterile bone inflammation are variably labelled as Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO)-syndrome, chronic nonbacterial osteomyelitis, chronic recurrent multifocal osteomyelitis (CRMO), pustulotic…
  • Abstract Number: 2102 • ACR Convergence 2024

    Unraveling Knee Osteoarthritis Subtypes: Differential Effect of Oral Salmon Calcitonin Treatment

    Monica Hannani1, Peder Frederiksen2, Morten Karsdal2, Asger Reinstrup Bihlet3, Jaume Bacardit4, Anne-Christine Bay-Jensen2 and Christian Thudium2, 1Nordic Bioscience & University of Copenhagen, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3NBCD A/S, Soeborg, Denmark, 4School of Computing, Newcastle University, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Osteoarthritis (OA) patients are to this day left without effective treatment options. Despite different etiologies, trials designs do not account for the substantial heterogeneity…
  • Abstract Number: 1300 • ACR Convergence 2023

    Bone Marrow Edema in MRI Is More Associated with Rapid Radiographic Progression Than Clinically Relevant Radiographic Progression

    Kou Katayama1, Takanobu Okubo2, Toshikazu Sato1, Kitaru Tanaka3, Tomoki Kawahata3, Yuichi Makino4 and Hiroshi Ito5, 1Department of Orthopedic Surgery, Katayama Orthopedic Rheumatology Clinic, Asahikawa, Japan, 2Department of Radiology, Katayama Orthopedic Rheumatology Clinic, Asahikawa, Japan, 3Division of Metabolism and Biosystemic Science, Gastroenterology, and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan, 4Department of Medicine, Division of Rheumatology, Asahikawa Medical University Hospital, Asahikawa, Japan, 5Department of orthpedic surgery, Asahikawa Medical University, Asahikawa, Japan

    Background/Purpose: Rapid radiographic progression (RRP) is selected as one of the risk factors for difficult- to- treat RA, which needs to be resolved as soon…
  • Abstract Number: 1670 • ACR Convergence 2023

    Exacerbation of Immune-mediated Inflammatory Diseases in COVID19 Sequelae

    CAMILA CAETANO1, Tamiris Azamor1, Nikki M. Meyer1, Cassandra Calabrese2, Leonard Calabrese2, Nicolas Piuzzi3, M. Elaine Husni2, Suan-Sin Foo1 and Weiqiang Chen1, 1Cleveland Clinic / Infection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland, OH, 2Cleveland Clinic / Department of Rheumatic and Immunologic Diseases, Cleveland, OH, 3Cleveland Clinic / Department of Orthopedic Surgery, Cleveland, OH

    Background/Purpose: Patients with underlying immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), have a higher susceptibility to severe COVID19…
  • Abstract Number: 1715 • ACR Convergence 2023

    Androgen Treatment Exhibits a Protective Role Against Focal Erosions in TNF-Induced Inflammatory Arthritis in Mice

    Kiana Chen1, Adelaide Weidner2, Olga Astapova2, Edward Schwarz2 and Homaira Rahimi2, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and bone erosion and is female predominant. The TNF-transgenic (TNF-Tg) murine model of RA develops…
  • Abstract Number: 1725 • ACR Convergence 2023

    Distinct Perivascular and Intravascular Lymphatic Mast Cells and Their Role in Lymphatic Clearance, Joint Inflammation, and Bone Erosion in the TNF-Transgenic Murine Arthritis Model

    Yue Peng1, H. Mark Kenney2, Karen Bentley3, Lianping Xing4, Christopher T Ritchlin5 and Edward Schwarz3, 1University of Rochester Medical Center, Rochester, NY, 2University of Rochester School of Medicine and Dentistry, Henrietta, NY, 3University of Rochester, Rochester, NY, 4University of Rochester Medical Center, Webster, NY, 5University of Rochester Medical School, Allergy, Immunology & Rheumatology Division, Canandaigua, NY

    Background/Purpose: Inflammatory-erosive arthritis is exacerbated by lymphatic dysfunction (1), and mast cells (MCs) regulate lymphatic vessel contractions via release of inflammatory and vasoactive mediators (2).…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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