Abstracts tagged "bone marrow lesions"

Abstract Number: 0217 • ACR Convergence 2021
The OMERACT Knee Inflammation MRI Scoring System: Validation of Quantitative Methodologies and Tri-compartmental Overlays by Comparison with the MRI Osteoarthritis Knee Score
Walter Maksymowych¹, Jacob Jaremko², Susanne Pedersen³, Iris Eshed⁴, Ulrich Weber⁵, Paul Bird⁶, Andrew McReynolds², Stephanie Wichuk², Joel Paschke⁷ and Robert Lambert², ¹Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³Rigshospitalet, Center for Arthritis Research, Glostrup, Denmark, ⁴Sheba Medical Center, Ramat Gan, Israel, ⁵Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, ⁶University of New South Wales, Sydney, Australia, ⁷CARE Arthritis, Edmonton, AB, Canada
Background/Purpose: Bone marrow lesions (BML) and synovitis on MRI are independently associated with the severity and progression of osteoarthritis (OA) and randomized controlled trials have…
Abstract Number: 1474 • ACR Convergence 2021
Automatic Detection of Bone Marrow Lesions from Knee MRI Data from the OAI Study
Shen Liu¹, Xiaoxiao Sun¹, Frank Roemer², Erin Ashbeck³, Edward Bedrick¹, Zong-Ming Li¹, Ali Guermazi⁴ and Kent Kwoh¹, ¹University of Arizona, Tucson, AZ, ²Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany, ³University of Arizona Arthritis Center, Tucson, AZ, ⁴Boston University, Boston, MA
Background/Purpose: Subchondral bone marrow lesions (BMLs) are associated with symptoms and structural progression of knee OA. BMLs are characterized by diffuse hyperintensity on fat suppressed…
Abstract Number: 851 • 2019 ACR/ARP Annual Meeting
Association Between Bone Marrow Edema and Structural Progression in the Same Quadrant in Axial Spondyloarthritis – 5-year Data from the DESIR Cohort
Santiago Rodrigues-Manica¹, Alexandre Sepriano ², Sofia Ramiro ³, Robert B.M. Landewé ⁴, Pascal Claudepierre ⁵, Anna Molto ⁶, Maxime Dougados ⁷, Miranda van Lunteren ² and Désirée van der Heijde ², ¹CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, ²Leiden University Medical Center, Leiden, Netherlands, ³Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, ⁴Amsterdam University Medical Center, Amsterdam, Netherlands, ⁵Rheumatology, CHU Henri Mondor Créteil, Paris, France, ⁶Paris Descartes University, Medicine Faculty; APHP, Rheumatology, Hôpital Cochin, Hôpitaux de Paris, Paris, Paris, France, ⁷Cochin Hospital, Paris, France
Background/Purpose: The overall presence of inflammation in the MRI-SIJ is associated with overall 5-year radiographic damage in patients with axSpA. But we do not know…
Abstract Number: 1162 • 2019 ACR/ARP Annual Meeting
Changes in Novel Composite Scores of Disease Activity and Cumulative Damage Are Prognostic of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Matthew Harkey¹, Julie Davis ², Bing Lu ³, Lori Lyn Price ⁴, Robert Ward ⁵, James MacKay ⁶, Charles Eaton ⁷, Grace Lo ⁸, Mary Barbe ⁹, Ming Zhang ⁵, Jincheng Pang ¹⁰, Alina Stout ¹¹, Lavalley Michael ¹², Timothy McAlindon ¹³ and Jeffrey Driban ¹³, ¹University of Massachusetts Medical School, Worcester, ²George Washington University, Washington DC, ³Brigham and Women's Hospital, Boston, MA, ⁴Tufts Medical Center, Tufts University, Boston, MA, ⁵Tufts Medical Center, Boston, ⁶University of Cambridge, Cambridge, United Kingdom, ⁷Brown University Center for Primary Care and Prevention, Pawtucket, ⁸Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, ⁹Temple University, Philadelphia, ¹⁰Pfizer, Inc., Cambridge, MA, ¹¹Northeastern University, Boston, ¹²Boston University, Boston, ¹³Tufts Medical Center, Boston, MA
Background/Purpose: Composite imaging scores that reflect cartilage damage, bone marrow lesions (BMLs), and effusion-synovitis may enable us to conceptualize knee osteoarthritis (KOA) disease progression as…
Abstract Number: 420 • 2018 ACR/ARHP Annual Meeting
Accelerated Knee Osteoarthritis Is Characterized By Destabilizing Meniscal Tears and Pre-Radiographic Structural Disease Burden
Jeffrey B. Driban¹, Julie Davis², Bing Lu³, Lori Lyn Price^4,5, Robert J. Ward⁶, James MacKay⁷, Charles B. Eaton⁸, Grace H. Lo⁹, Mary Barbe¹⁰, Ming Zhang¹¹, Jincheng Pang¹², Alina Stout¹³, Matthew Harkey¹³ and Timothy E. McAlindon¹⁴, ¹Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, BOSTON, MA, ³Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Radiology, Tufts Medical Center, Boston, MA, ⁷Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁸Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹⁰Temple University School of Medicine, Philadelphia, PA, ¹¹Tufts Medical Center, Boston, MA, ¹²Electrical Engineering, Tufts University, Medford, MA, ¹³Rheumatology, Tufts Medical Center, Boston, MA, ¹⁴Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: A subset of adults who develop knee osteoarthritis (KOA) quickly progress from no radiographic disease to advanced-stage disease often in ≤12 months. Adults with…
Abstract Number: 443 • 2018 ACR/ARHP Annual Meeting
Impact of Intra-Articular Steroid Injection on Bone Marrow Lesions in Osteoarthritis of the Hip: An Assessment Using the Outcome Measures in Rheumatology Hip MRI Inflammation Scoring System
Walter P. Maksymowych^1,2, Robert G. Lambert³, Marcus Pianta⁴, Zeid Al-Ani⁵, Duncan Lindsay⁵, Ulrich Weber⁶, Susanne J Pedersen⁷, Stephanie Wichuk⁸, Kieran Steer⁹, Geoffrey Bostick¹⁰, Joel Paschke¹ and Jacob L. Jaremko¹¹, ¹CaRE Arthritis, Edmonton, AB, Canada, ²Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ³Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ⁴Rheumatology, St. Vincent's Hospital, Melbourne, Australia, ⁵Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ⁶Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, ⁷Rheumatology, Gentofte Hospital, Copenhagen, Denmark, ⁸University of Alberta, Edmonton, AB, Canada, ⁹Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ¹⁰Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ¹¹Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Intra-articular (I/A) steroid injection is an effective treatment for alleviating symptoms in osteoarthritis (OA) of the hip but the impact of this treatment on…
Abstract Number: 954 • 2018 ACR/ARHP Annual Meeting
A New Way to Think about Composite Magnetic Resonance Imaging Scores to Measure Osteoarthritis Severity and Progression
Lori Lyn Price^1,2, Jeffrey B. Driban³, Grace H. Lo⁴, Ming Zhang⁵, Michael P. LaValley⁶ and Timothy E. McAlindon⁷, ¹Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ⁵Tufts Medical Center, Boston, MA, ⁶Biostatistics, Boston University School of Public Health, Boston, MA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: For some rheumatologic diseases (e.g. lupus), separate scores evaluate cumulative damage and disease activity. No such strategy exists for osteoarthritis (OA). The prevailing approach…
Abstract Number: 1646 • 2018 ACR/ARHP Annual Meeting
Prevalence of Spondyloarthritis in Patients with Anterior Uveitis
Kristyna Bubova^1,2, Monika Gregová^1,2, Katerina Zegzulkova^1,2, Karel Pavelka^1,2, Jarmila Heissigerova^3,4 and Ladislav Šenolt^2,5, ¹Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ³Department of Ophthalmology, First Faculty of Medicine, Charles University, Prague Czech Republic, Prague, Czech Republic, ⁴Department of Ophthalmology, General University Hospital in Prague, Prague, Czech Republic, Prague, Czech Republic, ⁵First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Anterior uveitis (AU) is a common extraarticular manifestation in spondyloarthritis (SpA). The disease can precede the typical axial and peripheral features. Additionally, some studies…
Abstract Number: 2923 • 2018 ACR/ARHP Annual Meeting
Is All MRI-SIJ Inflammation the Same? Gradient of Structural Damage with Increasing Cumulative Inflammation at the SIJ Quadrant Level in Axial Spondyloarthritis – 5-Year Data from the DESIR Cohort
Santiago Rodrigues Manica^1,2, Alexandre Sepriano^1,3, Sofia Ramiro^3,4, Robert B.M. Landewé⁵, Pascal Claudepierre⁶, Anna Moltó⁷, Maxime Dougados⁸, Miranda van Lunteren³ and Désirée van der Heijde⁹, ¹CEDOC, NOVA Medical School, Lisbon, Portugal, ²Rheumatology, Hospital de Egas Moniz - Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Zuyderland Medical Center, Heerlen, Netherlands, ⁵Amsterdam Rheumatology & Clinical Immunology Center and Zuyderland Medical Center, Amsterdam; Heerlen, Netherlands, ⁶Hôpital Henri Mondor, Créteil, France, ⁷Paris Descartes University, Cochin Hospital, Paris, France, ⁸Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, ⁹Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Axial inflammation is a key feature in axial spondyloarthritis (axSpA). An (overall) definition of bone marrow oedema (BMO) on the MRI of the SIJ…
Abstract Number: 2181 • 2017 ACR/ARHP Annual Meeting
Is a Decrease in MRI-Defined Inflammation Associated with a Decrease in Pain in Patients with Hand Osteoarthritis? a Two-Year Follow-up Study
S. van Beest¹, W. Damman¹, R. Liu¹ and M. Kloppenburg², ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Joint pain in hand osteoarthritis (OA) is associated with synovitis in cross-sectional studies. Therefore we hypothesized that synovitis could be a target for treatment.…
Abstract Number: 2192 • 2017 ACR/ARHP Annual Meeting
Association between Mitochondrial DNA (mtDNA) Haplogroups and Bone Marrow Lesions at 24 Months in Osteoarthritis Subjects: Subjets from the Osteoarthritis Initiative
Ignacio Rego-Pérez¹, Jean-Pierre Pelletier², François Abram³, Natividad Oreiro⁴, Carlos Fernandez-Lopez¹, Ana Cecilia Raga¹, Francisco J Blanco¹ and Johanne Martel-Pelletier², ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ²Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ³Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ⁴Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruna, Spain
Background/Purpose: Bone marrow lesions (BMLs) have been consistently associated with the development of osteoarthritis (OA); however the extent to which they are genetically driven by…
Abstract Number: 2196 • 2017 ACR/ARHP Annual Meeting
An Exploratory Analysis of Physical Activity Levels and the Presence of Bone Marrow Lesions in Adults with Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Amanda R. Canavatchel¹, Lori Lyn Price², Jeffrey B. Driban³, Ming Zhang¹, Grace H. Lo⁴ and Timothy E. McAlindon⁵, ¹Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Many people with knee OA have bone marrow lesions (BMLs). BMLs are related with structural pathology and pain. Some investigators have found an association…
Abstract Number: 2198 • 2017 ACR/ARHP Annual Meeting
Combinatorial Peripheral Blood Inflammatory and MRI-Based Biomarkers Predict Radiographic Joint Space Narrowing in Knee OA
Svetlana Krasnokutsky Samuels¹, Hua Zhou², Mukundan Attur¹, Jonathan Samuels¹, Gregory Chang³, Jenny Bencardino⁴, Sisi Ma², Leon Rybak³ and Steven B. Abramson⁵, ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Bioinformatics, New York University, New York, NY, ³Department of Radiology, NYU Langone Medical Center, New York, NY, ⁴Radiology, NYU Langone Medical Center, New York, NY, ⁵Dept of Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Inflammation contributes to OA disease pathogenesis. Subsets of knee OA patients with peripheral blood leukocyte (PBL) detected inflammatory gene expression profiles exhibit more rapid…
Abstract Number: 2947 • 2017 ACR/ARHP Annual Meeting
Do Bone Marrow Lesions Reactivate Endochondral Ossification Leading to Osteophyte Genesis? Data from the Osteoarthritis Initiative
Leticia Deveza¹, Laurence Teoh², Elena Ochoa-Albiztegui³, Ali Guermazi⁴, Frank Roemer^4,5 and David Hunter¹, ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ²Department of General Medicine, Middlemore Hospital, Auckland, New Zealand, Auckland, New Zealand, ³Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, New York, NY, ⁴Department of Radiology, Boston University School of Medicine, Boston, MA, USA, Boston, MA, ⁵Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Osteophytes are formed through reactivation of endochondral ossification. In adults, reactivation of endochondral ossification may occur in the context of fracture repair. As yet,…
Abstract Number: 1295 • 2016 ACR/ARHP Annual Meeting
The Prevalence of Inflammatory and Structural Lesions on MRI of the Sacroiliac Joints in Patients with Very Early Peripheral Spondyloarthritis
Gaëlle Varkas¹, Philippe Carron², Heleen Cypers¹, Dirk Elewaut¹, Lennart Jans³ and Filip van Den Bosch⁴, ¹Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³Department of Radiology, Ghent University Hospital, Ghent, Belgium, ⁴Rheumatology, Ghent University Hospital, Ghent, Belgium
Background/Purpose: To assess the prevalence of inflammatory and structural lesions on MRI of the sacroiliac joints (SIJ) in patients with peripheral spondyloarthritis (PSpA) in a…

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