ACR Meeting Abstracts

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Abstracts tagged "bone density and osteoporosis"

  • Abstract Number: 1875 • 2019 ACR/ARP Annual Meeting

    Subject Characteristics and Changes in Bone Mineral Density After Transitioning from Denosumab to Alendronate in the Denosumab Adherence Preference Satisfaction (DAPS) Study

    David Kendler1, Arkadi Chines 2, Patricia Clark 3, Peter R. Ebeling 4, Michael McClung 5, Yumie Rhee 6, Shuang Huang 2, Robert Kees Stad 7 and Nick Freemantle 8, 1University of British Columbia, Vancouver, BC, Canada, 2Amgen Inc., Thousand Oaks, CA, 3Hospital Infantil de Mexico Federico Gómez and National University of Mexico, Mexico City, Mexico, 4Monash University, Melbourne, Victoria, Australia, 5Oregon Osteoporosis Center, Portland, OR, 6Yonsei University College of Medicine, Seoul, Republic of Korea, 7Amgen Inc., Rotkreuz, Zug, Switzerland, 8University College London, London, England, United Kingdom

    Background/Purpose: There are limited data on patients transitioning from denosumab (DMAb) to bisphosphonates (BPs). The Denosumab Adherence Preference Satisfaction (DAPS) study (NCT00518531) reported that alendronate…
  • Abstract Number: 59 • 2017 ACR/ARHP Annual Meeting

    Abaloparatide, a Novel PTHrP Analog, Increased Bone Mass and Density at Cortical and Trabecular Sites in an Orchiectomized Rat Model of Male Osteoporosis

    Heidi Chandler1 and Gary Hattersley2, 1Research, Radius Health Inc, Waltham, MA, 2Radius Health, Inc., Waltham, MA

    Background/Purpose: Male osteoporosis, a disease of reduced bone mass leading to an increased risk of fragility fractures, often results from androgen deficiency caused by hypogonadism…
  • Abstract Number: 2516 • 2017 ACR/ARHP Annual Meeting

    Trabecular Bone Score As an Assessment Tool to Identify the Risk of Osteoporosis in Axial Spondyloarthritis: A Case-Control Study

    Kwi Young Kang, Internal Medicine, Catholic University of Korea, Seoul, Korea, Republic of (South)

    Background/Purpose: The trabecular bone score (TBS) is a novel tool used to evaluate bone microarchitecture. It is a textural index that evaluates pixel gray-level variations…
  • Abstract Number: 360 • 2016 ACR/ARHP Annual Meeting

    Osteoporosis Prevalence in Lung Transplant Patients

    Mireia Barceló-Bru1, Sandra Farietta-Varela2, Basilio Rodriguez-Díez1, Ernesto Trallero-Araguás1, Mireia López-Corbeto2, Juan Jose De Agustin De Oro2, Roxana Coras2 and Agusti Sellas-Fernandez2, 1Rheumatology, Hospital Universitario Vall d´Hebron, Barcelona, Spain, 2Hospital Universitario Vall d´Hebron, Barcelona, Spain

    Background/Purpose: Osteoporosis prevalence in lung transplantation candidates is between 16-21%. In the last years, the survival rate after lung transplantation has definitely improved, due to…
  • Abstract Number: 1561 • 2015 ACR/ARHP Annual Meeting

    The Effect of TNF Blockers on Bone Mineral Density in Rheumatoid Arthritis Patients Receiving Bisphosphonate

    Doo-Ho Lim1, Seokchan Hong2, Soo Min Ahn2, Byeongzu Ghang3, Wook Jang Seo4, Yong-Gil Kim1, Chang-Keun Lee1 and Bin Yoo1, 1Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Univerisy of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 4Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea

    Background/Purpose: Osteoporosis is more frequently observed in patients with rheumatoid arthritis (RA) than in general population. Bisphosphonate (BP), which suppresses bone resorption by inhibiting osteoclast…
  • Abstract Number: 920 • 2014 ACR/ARHP Annual Meeting

    Randomized Controlled Trial to Assess the Safety and Efficacy of Odanacatib in the Treatment of Men with Osteoporosis

    Eric Orwoll1, Silvano Adami2, Neil Binkley3, Roland Chapurlat4, Bente Langdahl5, Steven Doleckyj6, Hilde Giezek7, Boyd Scott8 and Arthur Santora8, 1Oregon Health and Science University, Portland, OR, 2Rheumatology Department, University of Verona, Verona, Italy, 3University of Wisconsin, Madison, WI, 4Pavillon F Rheumatology, Hopital Edouard Herriot, Lyon, France, 5Aarhus University Hospital, Aarhus, Denmark, 6Merck & Co., Inc., Whitehouse Station, NJ, 7MSD Belgium, Brussels, Belgium, 8Merck Sharp & Dohme Corp., Whitehouse Station, NJ

    Background/Purpose Osteoporosis in men is an important clinical problem, associated with significant morbidity, mortality and societal expense. Men with osteoporosis represent between 20 and 25%…
  • Abstract Number: 727 • 2012 ACR/ARHP Annual Meeting

    Effects of Odanacatib On BMD and Overall Safety in the Treatment of Osteoporosis in Postmenopausal Women Previously Treated with Alendronate

    Roland Chapurlat1, Sydney Bonnick2, Tobias De Villiers3, Alberto Odio4, Santiago Palacios5, Boyd Scott6, Celine Le Bailly De Tilleghem7, Carolyn DaSilva6, Albert Leung8 and Deborah Gurner6, 1Hôpital Edouard Herriot, Lyon, France, 2Director Osteoporosis Services, Cooper Clinic, Dallas, TX, 3Mediclinic Panorama and Department of Obstetrics & Gynecology, University of Stellenbosch, Cape Town, South Africa, 4Alta California Medical Group, Simi Valley, CA, 5Instituto Palacios, Madrid, Spain, 6Merck Sharp & Dohme Corp., Whitehouse Station, NJ, 7MSD Europe Inc., Brussels, Belgium, 8Clinical Research, Merck Sharp and Dohme Corp., Rahway, NJ

    Background/Purpose: Odanacatib (ODN) is a potent, orally-active cathepsin K inhibitor being developed for the treatment of postmenopausal osteoporosis. This study evaluated the effects of ODN…
  • Abstract Number: 1981 • 2012 ACR/ARHP Annual Meeting

    Low Body Mass Index, Medication Use and Social Factors Such As Smoking but Not Secondary Medical Disorders or Older Age May Be More Prevalent in Males with Low Bone Mineral Density

    Vandana J. Vedanarayanan, Allison V. Jones and Vikas Majithia, Div of Rheumatology, University of Mississippi Medical Center, Jackson, MS

    Background/Purpose: Osteoporosis (OP) in Males is prevalent and frequently under-recognized. There are a number of known demographic factors such as age, race and BMI as…
  • Abstract Number: 1994 • 2012 ACR/ARHP Annual Meeting

    The Influence of Percentage Body Fat On Bone Mineral Density in Thin Patients

    Andrew Blanshard1 and Marwan Bukhari2, 1Department of Rheumatology, Lancaster University, Lancaster, United Kingdom, 2Department of Rheumatology, Royal Lancaster Infirmary, Lancaster, United Kingdom

    Background/Purpose: Low Body Mass Index (BMI) is associated with low Bone Mineral Density (BMD) and subsequent risk of fragility fracture. Percentage body fat (%BF), which…
  • Abstract Number: 1959 • 2012 ACR/ARHP Annual Meeting

    Low Fracture Incidence Is Maintained in Postmenopausal Women ≥75 Years with Osteoporosis with Long-Term Denosumab Treatment

    Socrates Papapoulos1, Michael McClung2, Nathalie Franchimont3, Jonathan D. Adachi4, Henry G. Bone5, Claude-Laurent Benhamou6, Jordi Farrerons7, JC Gallagher8, Johan Halse9, Kurt Lippuner10, Salvatore Minisola11, Ove Törring12, Nadia Daizadeh3, Andrea Wang3, Rachel B. Wagman3 and Steven Boonen13, 1Leiden University Medical Center, Leiden, Netherlands, 2Oregon Osteoporosis Center, Portland, OR, 3Amgen Inc., Thousand Oaks, CA, 4St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 5Michigan Bone and Mineral Clinic, Detroit, MI, 6Centre Hospitalier Régional d'Orléans, Orleans, France, 7Hospital de la Santa Creu I Sant Pau, Barcelona, Spain, 8Creighton University Medical Center, Omaha, NE, 9Osteoporoseklinikken, Oslo, Norway, 10Bern University Hospital, Bern, Switzerland, 11Sapienza, Università di Roma, Rome, Italy, 12Karolinska Institutet Sodersjukhuset, Stockholm, Sweden, 13Leuven University, Leuven, Belgium

    Background/Purpose: In the pivotal fracture trial, FREEDOM, denosumab increased bone mineral density (BMD) and reduced the incidence of new vertebral, nonvertebral, and hip fractures in…
  • Abstract Number: 1971 • 2012 ACR/ARHP Annual Meeting

    Resolution of Effects On Bone Turnover Markers and Bone Mineral Density After Discontinuation of Long-Term Bisphosphonate Use

    Kenneth G. Saag1, Claude-Laurent Benhamou2, Tobias De Villiers3, C. Conrad Johnston Jr.4, Bente Langdahl5, Andrew Denker6, Annpey Pong6, John P. McGinnis6, Elizabeth Rosenberg6 and Arthur Santora6, 1Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, 2Centre Hospitalier Régional d'Orléans, Orleans, France, 3Mediclinic Panorama and Department of Obstetrics & Gynecology, University of Stellenbosch, Cape Town, South Africa, 4Indiana University School of Medicine, Indianapolis, IN, 5Aarhus University Hospital, Aarhus, Denmark, 6Merck Sharp & Dohme Corp., Whitehouse Station, NJ

    Background/Purpose: While bisphosphonates (BP) have been well studied in long-term trials of up to 4 years' duration, relatively less is known about the immediate consequences…
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