Abstracts tagged "bone biology"

Abstract Number: 543 • 2015 ACR/ARHP Annual Meeting
The IL-20 Receptor Axis in Early Rheumatoid Arthritis: Novel Inflammation-Independent Links Between Autoantibody Positivity and Radiographic Progression
Tue Wenzel Kragstrup^1,2,3, Stinne Greisen¹, Morten Aagaard Nielsen¹, Chris Rhodes², Kristian Stengaard-Pedersen³, Merete Lund Hetland⁴, Kim Hørslev-Petersen⁵, Peter Junker⁶, Mikkel Østergaard⁷, Malene Hvid^1,8, Thomas Vorup-Jensen¹, William H. Robinson^2,9, Jeremy Sokolove^2,10 and Bent Deleuran^1,3,8, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴DANBIO, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁵Rheumatology, Rheumatology King Christian X's Hospital, Graasten, Denmark, ⁶University of Southern Denmark, Odense, Denmark, ⁷Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁸Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁹Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ¹⁰Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs) and bone erosions. Successful treatment can compromise…
Abstract Number: 1941 • 2015 ACR/ARHP Annual Meeting
Senescent T-Cells Expedite RANKL-Dependent Bone Loss in Rheumatoid Arthritis
Johannes Fessler¹, Rusmir Husic², Elisabeth Lerchbaum³, Verena Schwetz³, Claudia Stiegler³, Barbara Obermayer-Pietsch³, Winfried B. Graninger⁴ and Christian Dejaco⁵, ¹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ²Rheumatology, Medical University Graz, Graz, Austria, ³Division of Endocrinology and Metabolism, Medical University Graz, Graz, Austria, ⁴Internal Medicine/Rheumatology, Medical University Graz, Graz, Austria, ⁵Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria
Background/Purpose: To study the influence of senescent CD28-T-cells on systemic osteoporosis in rheumatoid arthritis (RA) and patients with primary osteoporosis. Methods: Prospective, cross-sectional study on…
Abstract Number: 2084 • 2015 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Modulates Bone Resorption in Inflammatory Arthritis and Fracture Repair
Yahui Grace Chiu¹, Tzong-Ren Sheu², Jinbo Li³, Dongge Li⁴, Michael Thullen², Brendan Boyce⁵, Christopher T. Ritchlin⁶ and Javier Rangel-Moreno⁷, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Pathology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵University of Rochester, Rochester, NY, ⁶Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁷Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Osteoclasts (OC) direct pathologic bone resorption in osteoporosis and inflammatory arthritis. We previously demonstrated that DC-STAMP (Dendritic Cell-Specific Transmembrane protein), a 7-pass transmembrane protein,…
Abstract Number: 2207 • 2015 ACR/ARHP Annual Meeting
Interleukin-32Î³ Exhibited Protective Effects on Osteoporosis
Seokchan Hong¹, Eun-Jin Lee², Sang-Min Kim³, Eun-Ju Chang², Doo-Ho Lim⁴, Byeongzu Ghang⁵, Wookjang Seo⁶, Yong-Gil Kim⁴, Chang-Keun Lee¹ and Bin Yoo⁴, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Univerisy of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ⁶Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea
Background/Purpose: Interleukin-32 (IL-32) has been known to be implicated in the pathogenesis of various inflammatory diseases. Osteoporosis, characterized by low bone density and increases the…
Abstract Number: 2568 • 2015 ACR/ARHP Annual Meeting
The Osteoimmunological Mechanistic Basis of Low-Dose Radiotherapy in TNF Driven Arthritis
Lisa Deloch¹, Anja Derer¹, Axel J. Hueber², Barbara Happich³, Rainer Fietkau¹, Benjamin Frey¹ and Udo S. Gaipl¹, ¹Department of Radiation Oncology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Today many treatment options for Rheumatoid Arthritis (RA) and degenerative inflammatory musculoskeletal diseases are available, however, not all patients respond properly or have to…
Abstract Number: 37 • 2014 ACR/ARHP Annual Meeting
Regulation of Osteoclast and T Cell Differentiation By DC-STAMP and TRAF3
Yahui Grace Chiu¹, Jinbo Li², Dongge Li¹, Brendan Boyce² and Christopher T. Ritchlin³, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose DC-STAMP (Dendritic Cell-Specific Transmembrane Protein) is a 7-pass transmembrane protein essential for cell-to-cell fusion during OC differentiation. We have previously shown that DC-STAMP is…
Abstract Number: 19 • 2014 ACR/ARHP Annual Meeting
Adenosine Receptors Stimulate Bone Regeneration
Aranzazu Mediero¹, Tuere Wilder² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ³NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Such orthopedic procedures as spinal fusion and repair of bone defects due to trauma, infection or metastatic disease, require formation of new bone. Adenosine,…
Abstract Number: 29 • 2014 ACR/ARHP Annual Meeting
Impaired Bone Healing in Patients Suffering from Rheumatoid Arthritis – Anti-Inflammatory Therapy As Confounder
Annemarie Lang¹, Sarah Fuegener², Paula Hoff², Anastasia Rakow³, Manuela Jakstadt⁴, Timo Gaber⁴, Gerd Burmester², Carsten Perka³ and Frank Buttgereit⁵, ¹Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ³Center for Musculoskeletal Surgery, Orthopedic Department, Charité University Medicine, Berlin, Germany, ⁴Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany, ⁵Charité University Hospital, Berlin, Germany
Background/Purpose Anti-inflammatory treatment of rheumatoid arthritis (RA) with glucocorticoids (GC) and/or non-steroidal anti-inflammatory drugs (NSAIDs) is supposed to negatively influence bone metabolism and healing. It…
Abstract Number: 25 • 2014 ACR/ARHP Annual Meeting
DC-STAMP Modulates Osteoblast Differentiation and Regulates Bone Repair
Yahui Grace Chiu¹, Tzong-Ren Sheu², Jinbo Li³, Dongge Li¹, Michael Thullen², Brendan Boyce⁴, Edward Puzas² and Christopher T. Ritchlin⁵, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Pathology, University of Rochester, Rochester, NY, ⁴Pathology, University of Rochester, Rocehster, NY, ⁵Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose Patients with osteoporosis and the elderly have an increased risk of bone fracture. Currently, no biomarker is available to assess bone healing status in…
Abstract Number: 24 • 2014 ACR/ARHP Annual Meeting
Netrin1 Is Highly Expressed and Required in Inflammatory Infiltrates in Wear Particle-Induced Osteolysis
Aranzazu Mediero¹, Bhama Ramkhelawon², Ed Purdue³, Steven R. Goldring⁴, Kathryn Moore² and Bruce N. Cronstein⁵, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, ³535 East 70th Street, Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Osteoclasts play a critical role in homeostatic bone turnover and pathologic bone destruction. Netrin-1, expressed in the marrow only by osteoclast precursors, acts in…
Abstract Number: 23 • 2014 ACR/ARHP Annual Meeting
Activation of EPAC1/2 Is Essential for Osteoclast Formation By Modulating NFkB Nuclear Translocation and Actin Cytoskeleton Rearrangements
Aranzazu Mediero¹, Miguel Perez-Aso² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²545 1st Ave., New York University, New York City, NY, ³NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Bisphosphonates inhibit osteoclast differentiation/function via inhibition of Rap1A isoprenylation and cytoskeletal assembly. As Rap1 is the effector of EPAC proteins (exchange protein directly activated…
Abstract Number: 1010 • 2014 ACR/ARHP Annual Meeting
Catecholaminergic-to-Cholinergic Transition of Sympathetic Nerve Fibers in Arthritis and in a Co-Culture System of Sympathetic Ganglia in Vitro
Hubert Stangl¹, Hans Robert Springorum², Dominique Muschter², Susanne Graessel² and Rainer Straub³, ¹Department of Internal Medicine 1, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany, ²Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital Regensburg, Regensburg, Germany, ³Internal Medicine, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: Sympathetic nerve fibers play an important role in bone and tissue homeostasis of joints. However sympathetic nerve fibers are able to switch their phenotype…

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