Abstracts tagged "bone biology"

Abstract Number: 25 • 2014 ACR/ARHP Annual Meeting
DC-STAMP Modulates Osteoblast Differentiation and Regulates Bone Repair
Yahui Grace Chiu¹, Tzong-Ren Sheu², Jinbo Li³, Dongge Li¹, Michael Thullen², Brendan Boyce⁴, Edward Puzas² and Christopher T. Ritchlin⁵, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Pathology, University of Rochester, Rochester, NY, ⁴Pathology, University of Rochester, Rocehster, NY, ⁵Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose Patients with osteoporosis and the elderly have an increased risk of bone fracture. Currently, no biomarker is available to assess bone healing status in…
Abstract Number: 24 • 2014 ACR/ARHP Annual Meeting
Netrin1 Is Highly Expressed and Required in Inflammatory Infiltrates in Wear Particle-Induced Osteolysis
Aranzazu Mediero¹, Bhama Ramkhelawon², Ed Purdue³, Steven R. Goldring⁴, Kathryn Moore² and Bruce N. Cronstein⁵, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, ³535 East 70th Street, Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Osteoclasts play a critical role in homeostatic bone turnover and pathologic bone destruction. Netrin-1, expressed in the marrow only by osteoclast precursors, acts in…
Abstract Number: 23 • 2014 ACR/ARHP Annual Meeting
Activation of EPAC1/2 Is Essential for Osteoclast Formation By Modulating NFkB Nuclear Translocation and Actin Cytoskeleton Rearrangements
Aranzazu Mediero¹, Miguel Perez-Aso² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²545 1st Ave., New York University, New York City, NY, ³NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Bisphosphonates inhibit osteoclast differentiation/function via inhibition of Rap1A isoprenylation and cytoskeletal assembly. As Rap1 is the effector of EPAC proteins (exchange protein directly activated…

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