ACR Meeting Abstracts

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Abstracts tagged "bone biology"

  • Abstract Number: 652 • 2017 ACR/ARHP Annual Meeting

    Investigating the Role of Mechanical Stress in Spondyloarthritis Pathogenesis

    Breanna Nguyen1, Robert Colbert2 and Gerlinde Layh-Schmitt1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD

    Background/Purpose: Mechanotransduction is a cell’s ability to translate mechanical stimuli into biochemical signals and has been implicated in signaling pathways involving differentiation and proliferation. Mechanical…
  • Abstract Number: 1932 • 2017 ACR/ARHP Annual Meeting

    A2A Adenosine Receptor (A2AR) Stimulation Modulates NR4A2 Orphan Receptor Expression during Osteoclast Differentiation

    Carmen Corciulo1, Tuere Wilder1 and Bruce Cronstein2, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Orphan receptors comprise a large number of evolutionarily conserved molecules that have unknown ligands but may have potent biologic effects. Among these receptors are…
  • Abstract Number: 1936 • 2017 ACR/ARHP Annual Meeting

    Bimekizumab Blocks T Cell-Mediated Osteogenic Differentiation of Periosteal Stem Cells: Coupling Pathological Bone Formation to IL-17A and IL-17F Signaling

    Mittal Shah1,2, Ash Maroof1, Rawiya Al-Hosni2, Panagiotis Gikas3, Neil Gozzard1, Stevan Shaw1 and Scott Roberts1,2, 1UCB Pharma, Slough, United Kingdom, 2University College London, London, United Kingdom, 3The Royal National Orthopaedic Hospital, London, United Kingdom

    Background/Purpose: Structural tissue damage, as a result of pathological bone formation, is a major cause of disability in spondyloarthritis (SpA). A paucity of in vitro…
  • Abstract Number: 323 • 2016 ACR/ARHP Annual Meeting

    Effect of 10 Years of Denosumab Treatment on Bone Histology and Histomorphometry in the Freedom Extension Study

    David W Dempster1,2, NS Daizadeh3, A Fahrleitner-Pammer4, Jens-Erik Beck Jensen5, DL Kendler6, Ivo Valter7, Rachel B Wagman3, Susan Yue3 and Jacques P Brown8, 1Columbia University, New York, NY, 2Helen Hayes Hospital, West Haverstraw, NY, 3Amgen Inc., Thousand Oaks, CA, 4Medical University, Graz, Austria, 5Hvidovre University Hospital, Hvidovre, Denmark, 6University of British Columbia, Vancouver, BC, Canada, 7Center for Clinical and Basic Research, Tallinn, Estonia, 8Centre Hospitalier de l'Université Laval (CHUL), Quebec City, QC, Canada

    Background/Purpose: Denosumab (DMAb) has been associated with low incidence of spine and non-spine, including hip, fractures through 10 years of treatment (Bone ASBMR 2015). Questions…
  • Abstract Number: 1097 • 2016 ACR/ARHP Annual Meeting

    Tankyrase Regulates Osteoclastogenesis Via SH3BP2

    Shunichi Fujita, Tomoyuki Mukai, Takafumi Mito, Shoko Kodama, Akiko Nagasu, Hiroyasu Hirano and Yoshitaka Morita, Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan

    Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Axin, a regulatory protein of Wnt/β-catenin signaling, is one…
  • Abstract Number: 2137 • 2016 ACR/ARHP Annual Meeting

    Subchondral Bone Structure and Pain Behaviors in Collagenase Induced Noninflammatory Monoarthritis in Mice

    Hollis E. Krug1,2, Christopher W. Dorman3, Sandra Frizelle3, Peter A. Valen2,4 and Maren L. Mahowald1,2, 1Medicine, University of Minnesota Medical School, Minneapolis, MN, 2Medicine, Minneapolis VA Health Care System, Minneapolis, MN, 3Research, Minneapolis VA Health Care System, Minneapolis, MN, 4Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN

    Background/Purpose:   Bone histomorphometry can define OA changes in rodents and in Antigen-Induced arthritis in rats. We previously found that pain from inflammatory monoarthritis in mouse…
  • Abstract Number: 543 • 2015 ACR/ARHP Annual Meeting

    The IL-20 Receptor Axis in Early Rheumatoid Arthritis: Novel Inflammation-Independent Links Between Autoantibody Positivity and Radiographic Progression

    Tue Wenzel Kragstrup1,2,3, Stinne Greisen1, Morten Aagaard Nielsen1, Chris Rhodes2, Kristian Stengaard-Pedersen3, Merete Lund Hetland4, Kim Hørslev-Petersen5, Peter Junker6, Mikkel Østergaard7, Malene Hvid1,8, Thomas Vorup-Jensen1, William H. Robinson2,9, Jeremy Sokolove2,10 and Bent Deleuran1,3,8, 1Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 4DANBIO, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 5Rheumatology, Rheumatology King Christian X's Hospital, Graasten, Denmark, 6University of Southern Denmark, Odense, Denmark, 7Copenhagen University Hospital Glostrup, Copenhagen, Denmark, 8Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 9Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 10Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs) and bone erosions. Successful treatment can compromise…
  • Abstract Number: 1941 • 2015 ACR/ARHP Annual Meeting

    Senescent T-Cells Expedite RANKL-Dependent Bone Loss in Rheumatoid Arthritis

    Johannes Fessler1, Rusmir Husic2, Elisabeth Lerchbaum3, Verena Schwetz3, Claudia Stiegler3, Barbara Obermayer-Pietsch3, Winfried B. Graninger4 and Christian Dejaco5, 1Rheumatology and Immunology, Medical University Graz, Graz, Austria, 2Rheumatology, Medical University Graz, Graz, Austria, 3Division of Endocrinology and Metabolism, Medical University Graz, Graz, Austria, 4Internal Medicine/Rheumatology, Medical University Graz, Graz, Austria, 5Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria

    Background/Purpose: To study the influence of senescent CD28-T-cells on systemic osteoporosis in rheumatoid arthritis (RA) and patients with primary osteoporosis. Methods: Prospective, cross-sectional study on…
  • Abstract Number: 2084 • 2015 ACR/ARHP Annual Meeting

    Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Modulates Bone Resorption in Inflammatory Arthritis and Fracture Repair

    Yahui Grace Chiu1, Tzong-Ren Sheu2, Jinbo Li3, Dongge Li4, Michael Thullen2, Brendan Boyce5, Christopher T. Ritchlin6 and Javier Rangel-Moreno7, 1Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Pathology, University of Rochester, Rochester, NY, 4Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 5University of Rochester, Rochester, NY, 6Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, 7Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY

    Background/Purpose: Osteoclasts (OC) direct pathologic bone resorption in osteoporosis and inflammatory arthritis. We previously demonstrated that DC-STAMP (Dendritic Cell-Specific Transmembrane protein), a 7-pass transmembrane protein,…
  • Abstract Number: 2207 • 2015 ACR/ARHP Annual Meeting

    Interleukin-32γ Exhibited Protective Effects on Osteoporosis

    Seokchan Hong1, Eun-Jin Lee2, Sang-Min Kim3, Eun-Ju Chang2, Doo-Ho Lim4, Byeongzu Ghang5, Wookjang Seo6, Yong-Gil Kim4, Chang-Keun Lee1 and Bin Yoo4, 1Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 2Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 3Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Univerisy of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 6Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea

    Background/Purpose: Interleukin-32 (IL-32) has been known to be implicated in the pathogenesis of various inflammatory diseases. Osteoporosis, characterized by low bone density and increases the…
  • Abstract Number: 2568 • 2015 ACR/ARHP Annual Meeting

    The Osteoimmunological Mechanistic Basis of Low-Dose Radiotherapy in TNF Driven Arthritis

    Lisa Deloch1, Anja Derer1, Axel J. Hueber2, Barbara Happich3, Rainer Fietkau1, Benjamin Frey1 and Udo S. Gaipl1, 1Department of Radiation Oncology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Today many treatment options for Rheumatoid Arthritis (RA) and degenerative inflammatory musculoskeletal diseases are available, however, not all patients respond properly or have to…
  • Abstract Number: 25 • 2014 ACR/ARHP Annual Meeting

    DC-STAMP Modulates Osteoblast Differentiation and Regulates Bone Repair

    Yahui Grace Chiu1, Tzong-Ren Sheu2, Jinbo Li3, Dongge Li1, Michael Thullen2, Brendan Boyce4, Edward Puzas2 and Christopher T. Ritchlin5, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Pathology, University of Rochester, Rochester, NY, 4Pathology, University of Rochester, Rocehster, NY, 5Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose Patients with osteoporosis and the elderly have an increased risk of bone fracture. Currently, no biomarker is available to assess bone healing status in…
  • Abstract Number: 24 • 2014 ACR/ARHP Annual Meeting

    Netrin1 Is Highly Expressed and Required in Inflammatory Infiltrates in Wear Particle-Induced Osteolysis

    Aranzazu Mediero1, Bhama Ramkhelawon2, Ed Purdue3, Steven R. Goldring4, Kathryn Moore2 and Bruce N. Cronstein5, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, 3535 East 70th Street, Hospital for Special Surgery, New York, NY, 4Hospital for Special Surgery, New York, NY, 5NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose Osteoclasts play a critical role in homeostatic bone turnover and pathologic bone destruction. Netrin-1, expressed in the marrow only by osteoclast precursors, acts in…
  • Abstract Number: 23 • 2014 ACR/ARHP Annual Meeting

    Activation of EPAC1/2 Is Essential for Osteoclast Formation By Modulating NFkB Nuclear Translocation and Actin Cytoskeleton Rearrangements

    Aranzazu Mediero1, Miguel Perez-Aso2 and Bruce N. Cronstein3, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2545 1st Ave., New York University, New York City, NY, 3NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose Bisphosphonates inhibit osteoclast differentiation/function via inhibition of Rap1A isoprenylation and cytoskeletal assembly. As Rap1 is the effector of EPAC proteins (exchange protein directly activated…
  • Abstract Number: 1010 • 2014 ACR/ARHP Annual Meeting

    Catecholaminergic-to-Cholinergic Transition of Sympathetic Nerve Fibers in Arthritis and in a Co-Culture System of Sympathetic Ganglia in Vitro

    Hubert Stangl1, Hans Robert Springorum2, Dominique Muschter2, Susanne Graessel2 and Rainer Straub3, 1Department of Internal Medicine 1, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany, 2Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital Regensburg, Regensburg, Germany, 3Internal Medicine, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany

    Background/Purpose: Sympathetic nerve fibers play an important role in bone and tissue homeostasis of joints. However sympathetic nerve fibers are able to switch their phenotype…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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