Abstracts tagged "bone biology"

Abstract Number: 2131 • ACR Convergence 2024
Role of LECT2 in the Regulation of Bone Metabolism In Vitro and In Vivo
Myeung-Su Lee¹, Chang-hoon Lee², CHONG HYUK CHUNG¹, Ju-Young Kim³, Yoon-Hee Cheon⁴, So Young Eun³ and Gyeung Do Park³, ¹Wonkwang University Hospital, Iksan, South Korea, ²Wonkwang University Hospital, Iksan Jeonbuk, South Korea, ³Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Republic of Korea, ⁴Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Cholla-bukto, Republic of Korea
Background/Purpose: Leucocyte cell derived chemotaxin 2 (LECT2) is a hepatokine produced in liver cells, secreted into the circulation, and acts as a hormone throughout the…
Abstract Number: 2133 • ACR Convergence 2024
Unveiling the Association Between Low-Density Lipoprotein Cholesterol Lowering and Fracture Risk Among Patients with Hyperlipidaemia in a Population-Based Cohort Study: The Lower, the Better
Zeqin Wen¹, Yilun Wang¹, Xiaoxiao Li², Yuqing Zhang³, Junqing Xie⁴, Houchen Lyu⁵, Changjun Li², Jie Wei⁶, Guanghua Lei⁷ and Chao Zeng⁸, ¹Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China (People's Republic), ²Central South University, Changsha, China (People's Republic), ³Massachusetts General Hospital, Quincy, MA, ⁴University of Oxford, Oxford, United Kingdom, ⁵Central South University, Beijing, China, ⁶Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China (People's Republic), ⁷Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China (People's Republic), ⁸Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China (People's Republic)
Background/Purpose: High low-density lipoprotein cholesterol (LDL-C) is a major risk factor for fracture; however, whether LDL-C lowering induced by statins is associated with decreased fracture…
Abstract Number: 2134 • ACR Convergence 2024
PEX5 Acts as a Negative Regulator of RANKL-induced Osteoclastogenesis In Vitro and Inflammatory Calvarial Bone Destruction In Vivo
CHONG HYUK CHUNG¹, Myeung-Su Lee¹, Chang-hoon Lee², Ju-Young Kim³, Yoon-Hee Cheon⁴, So Young Eun³ and Gyeung Do Park³, ¹Wonkwang University Hospital, Iksan, South Korea, ²Wonkwang University Hospital, Iksan Jeonbuk, South Korea, ³Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Republic of Korea, ⁴Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Cholla-bukto, Republic of Korea
Background/Purpose: Peroxisomal biogenesis factor 5 (PEX5) is essential for regulating peroxisome function by recognizing and transporting peroxisome target sequence receptor substrate proteins to peroxisomes. PEX5…
Abstract Number: 2145 • ACR Convergence 2024
Study of Bone Metabolism in Patients Diagnosed with Osteogenesis Imperfecta.
Daniel Ramos Castro¹, SAMUEL LEAL², Elena Grau García³, JOSE ELOY OLLER RODRIGUEZ⁴, José Ivorra-Cortés⁵, Carmen Riesco Barcena⁶, Anderson Huaylla Quispe⁷, Pablo Muñoz Martínez⁸, Laura Mas Sánchez⁹, Alba Torrat noves¹⁰, Belén Villanueva Mañés¹¹, Iago Alcántara Álvarez¹², Andrés Pérez Hurtado¹, Miguel Simeo Vinaixa¹¹ and Jose A Román-Ivorra¹³, ¹Rheumatology Department. HUP La Fe, Valencia, Spain, ²Hospital La Fe, Valencia, Spain, ³HUP La Fe, Valencia, Spain, ⁴HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE, VALENCIA, Spain, ⁵Hospital Universitario La Fe, PALMA DE MALLORCA, Spain, ⁶Hospital Universitario i Politecnic La Fe (Valencia-Spain), Valéncia, Spain, ⁷Medicina, Valéncia, Spain, ⁸Hospital Universitario y Politècnico La Fe, Sagunto, Spain, ⁹Resident at Hospital Universitari i Politecnic La Fe, Valéncia, Spain, ¹⁰Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Comunidad Valenciana, Spain, ¹¹Rheumatology Department. HUP La Fe, Valencia, Comunidad Valenciana, Spain, ¹²Hospital Universitari i Politècnic La Fe, Valéncia, Comunidad Valenciana, Spain, ¹³Hospital Universitari i Politècnic la Fe, Valencia, Comunidad Valenciana, Spain
Background/Purpose: Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder (90% autosomal dominant) characterized by a disruption in type 1 collagen or proteins associated with…
Abstract Number: 2528 • ACR Convergence 2024
Activation of the Hes1/Piezo1 Pathway Promotes Mechanical Stress Response and Prevents Glucocorticoid-induced Osteoporosis
Nagahiro Ochiai¹, Yuki Etani², Takaaki Noguchi², Taihei Miura², Takuya Kurihara², Yuji Fukuda², Hidetoshi Hamada², Keisuke Uemura², Kazuma Takashima², Masashi Tamaki², Teruya Ishibashi², Shohei Ito³, Satoshi Yamakawa², Takashi Kanamoto², Seiji Okada², Ken Nakata² and Kosuke Ebina², ¹Taisho Pharmaceutical Co., Ltd., Saitama, Saitama, Japan, ²Osaka University, Suita, Japan, ³Taisho Pharmaceutical, Co., Ltd., Saitama, Japan
Background/Purpose: This study investigated the diminished expression of Piezo1 (Piezo-type mechanosensitive ion channel component 1), a mechanosensitive receptor, in bone tissues of both patients and…
Abstract Number: 2567 • ACR Convergence 2024
Gene Expression in Osteonecrosis of the Femoral Head: A Region-matched RNA-sequencing Study
Lucy Eunju Lee¹, Seung Hwan Lee², Miri Kim², Jieun Kim², Joo Sung Shim², Eun Gyel Shin², Tae Sung Lee², Hyuck Min Kwon², Young Han Lee², Hun-Mu Yang², Kwan Kyu Park² and Jason Jungsik Song², ¹Yonsei University, Seoul, South Korea, ²Yonsei University College of Medicine, Seoul, Republic of Korea
Background/Purpose: Osteonecrosis of the femoral head (ONFH) is linked to diverse risk factors like glucocorticoid use and excessive alcohol consumption. Various cells may influence bone…
Abstract Number: 0027 • ACR Convergence 2024
Cation Channel TRPC1 Regulates Mesenchymal Stem Cell Differentiation and Bone Formation
Jyoti Yadav¹, Shivmurat Yadav², Jeremy Houser¹, Marta Onopuik³, Leonidas Tsiokas³ and Mary Beth Humphrey¹, ¹University of Oklahoma College of Medicine, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³University of Oklahoma College of Medicine, Oklahoma City
Background/Purpose: Transient receptor potential canonical 1 (TRPC1), a non-selective cation channel, is characterized by its high permeability to calcium ions (Ca2+), a vital second messenger…
Abstract Number: 0068 • ACR Convergence 2024
Enhanced Expression of GPR65 in Inflammatory Sites and Bone Formation Regions in Ankylosing Spondylitis: Evidence from ScRNA-seq Analysis
Yong-Wook Park¹, Ki-Jeong Park², Sungsin Jo³, Tae-Hwan Kim⁴ and Tae-Jong Kim¹, ¹Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, ²Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, ³Hanyang University Institute for Rheumatology Research, Seoul, Republic of Korea, ⁴Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton. T helper 17 (Th17) cells play a pivotal role in the…
Abstract Number: 0846 • ACR Convergence 2023
Preosteoclast Plays a Pathogenic Role in Syndesmophyte Formation of Ankylosing Spondylitis Through the Secreted PDGFB – GRB2/ERK/RUNX2 Pathway
Yulong Tang¹, Qingmei Liu¹, Kunhai Tang¹, Chengchun Geng¹, Jiangnan Xie¹, Jiucun Wang², Qi Zhu³ and Jing Liu¹, ¹Fudan University, Shanghai, China, ²Shanghai, Shanghai, China, ³Guanghua Integrative Medicine Hospital, Shanghai, China
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting…
Abstract Number: 1139 • ACR Convergence 2023
From Skin to Bone Lesions: A Pioneer Study Unraveling the Underdiagnosis of SAPHO Syndrome in the Dominican Republic
Leeany Maletta¹, Diana Jimenez² and Rosanna de Jesus³, ¹UNIBE School of Medicine, San Antonio, TX, ²UNIBE School of Medicine, Miami, FL, ³Hospital General Plaza de la Salud, Distrito Nacional, Dominican Republic
Background/Purpose: SAPHO syndrome is a rare chronic inflammatory condition that affects the skin and osteoarticular structures. Despite being first described over 30 years ago, it…
Abstract Number: 1794 • ACR Convergence 2023
The Role of the Deubiquitinase ZRANB1/TRABID in Inflammation and Bone Formation in Spondyloarthritis
Archita Srinath¹, Daniele Mauro², Francesco Ciccia³ and Nigil Haroon⁴, ¹University of Toronto, Toronto, ON, Canada, ²University of Campania, Naples, Italy, ³University of Campania - Luigi Vanvitelli, Naples, Italy, ⁴University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Medicine/Rheumatology, Toronto, ON, Canada
Background/Purpose: Inflammation and new bone formation are important disease mediators in ankylosing spondylitis (AS). Recent studies in mice show that the deubiquitinase molecule TRABID epigenetically…
Abstract Number: 2015 • ACR Convergence 2023
Synergistic Effect Between Denosumab and Immune Checkpoint Inhibitors : A Retrospective Study of 268 Patients with Bone Metastases
Emmanuel Massy¹, Etienne Mabrut¹, Sabine Mainbourg² and Cyrille Confavreux¹, ¹Centre Expert des Métastases Osseuses (CEMOS) - Service de Rhumatologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Université de Lyon, INSERM UMR 1033-LYOS, Lyon, France, ²Service de médecine interne et vasculaire, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, F-69495 Pierre-Bénite, Laboratoire de Biométrie et Biologie Evolutive, Université Lyon 1; CNRS, UMR 5558, 69622 Villeurbanne, Lyon, France
Background/Purpose: Bone is the third site of metastasis. Bone metastases are associated with poorer survival of patients and impaired quality of life with the occurrence…
Abstract Number: 2016 • ACR Convergence 2023
Generation of a Human 3D in Vitro Bone Model That Mimics Glucocorticoid-induced Osteoporosis
Moritz Pfeiffenberger¹, Johannes Plank¹, Alexandra Damerau¹, Timo Gaber¹ and Frank Buttgereit², ¹Charité Universitatsmedizine - Berlin, Berlin, Germany, ²Charité Universitätsmedizin, Dept. Rheumatology, Berlin, Germany
Background/Purpose: Osteoporosis is a bone disease characterized by low bone mass and changes in bone architecture, leading to pain and reduced mobility in patients. Glucocorticoid-induced…
Abstract Number: 2150 • ACR Convergence 2023
Novel Biologic IRL201805 Inhibits Osteoclastogenesis in Monocytic Cells from RA Patients
Yuriko Yamamura¹, Valerie Corrigall², Lara Ravanetti³, Jorge De Alba³, Roly Foulkes⁴, Paul Eggleton⁵ and Carl Goodyear⁶, ¹School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom, ²Revolo Biotherapeutics, Tadworth, United Kingdom, ³Revolo Biotherapeutics, London, United Kingdom, ⁴Revolo Biotherapeutics, Slough, United Kingdom, ⁵Revolo Biotherapeutics, Exeter, United Kingdom, ⁶University of Glasgow, Glasgow, United Kingdom
Background/Purpose: In Rheumatoid arthritis (RA), osteoclasts derived from CD14+ Monocytes are associated with a risk of progressive bone and joint destruction, which fundamentally impacts quality-of-life.…
Abstract Number: L11 • ACR Convergence 2022
Romosozumab versus Denosumab in High-risk Patients with Glucocorticoid-induced Osteoporosis: A Pilot Randomized Controlled Trial
Wai Han Ma¹, Chi Chiu Mok², Ling Yin Ho², Kar Li Chan³, Sau Mei Tse⁴ and Sammy Chen⁵, ¹Department of Nuclear Medicine, Hong Kong, Hong Kong, ²Tuen Mun Hospital, Hong Kong, Hong Kong, ³Tuen Mun Hospital, Tsing Yi, Hong Kong, ⁴Department of Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ⁵Department of Pathology, Hong Kong, Hong Kong
Background/Purpose: To compare the efficacy and safety of romozosumab (ROMO) and denosumab (DEN) in high-risk patients with glucocorticoid -induced osteoporosis (GIOP)Methods: Adult patients (≥18 years)…

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