ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2025
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • 2020-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "bone biology"

  • Abstract Number: 0925 • ACR Convergence 2024

    Macrophages Produce Bone Anabolic Factors in Settings of Inflammation-Induced Bone Formation

    Jia (Sijia) Chen1, Megan Hanlon2, Catherine Manning3, Susan MacLauchlan1, Paul Hoover4, Christian Jacome-Galarza5 and Ellen Gravallese6, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women’s Hospital, Boston, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Brigham and Women's Hospital, SWAMPSCOTT, MA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Understanding the pathogenesis of inflammation-induced pathologic bone formation remains a significant challenge in spondyloarthritis patients. We thought to uncover the pivotal events driving the…
  • Abstract Number: 0936 • ACR Convergence 2024

    Schnurri-3 Inhibition Protects from NF-kB-induced Bone Loss in Inflammatory Arthritis

    Priyanka Kushwaha1, Catherine Manning2, Tadatoshi Sato3, Yeon-Suk Yang3, Jae-Hyuck Shim4 and Ellen Gravallese5, 1Department of Medicine/Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Boston, MA, 2Brigham and Women's Hospital, Dedham, MA, 3Department of Medicine/Division of Rheumatology, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, 4University of Massachusetts, Worcester, MA, 5Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: In rheumatoid arthritis (RA), production of TNF promotes osteoclast activity and inhibits osteoblasts (OBs) and bone healing. Schnurri-3 (SHN3) is a potent suppressor of…
  • Abstract Number: 1429 • ACR Convergence 2024

    Association of Bone Erosion and Microarchitecture with Disease Activity and Damage in Sjögren’s Disease

    Andre Franco1, Igor Murai2, Thomas Yang2, Valeria Caparbo3, Virginia Bonoldi2, Diogo Domiciano1, Lissiane Guedes2, Sandra Pasoto1, Camille Figueiredo3 and Rosa M R Pereira3, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, 2Hospital das Clinicas HCFMUSP, Faculdade de Medicina da USP, São Paulo, SP, Brazil, 3Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, SP, Brazil

    Background/Purpose: Sjögren's disease (SjD) is a chronic multisystem autoimmune condition characterized by sicca syndrome and inflammatory arthralgia, more common in women. Bone involvement can result…
  • Abstract Number: 1710 • ACR Convergence 2024

    Extl3 Involved in the Regulation of Endochondral Ossification in Axial SpA

    Stéphane Hilliquin1, OLIVIER FOGEL2, Mathilde Tissier3, Chahrazad Cherifi4, Karim Ibrahim5, Judith Melki6, Robert Olaso7, Brigitte Baroukh5, Philippe Dieudé8, Lars Rogge3, Elisabetta Bianchi3, Marcio Do Cruzeiro9, Frederique Cornelis10, Rik Lories10, Patricia Albanese4, Xavier Houard11, Claire Bardet5 and Corinne MICELI12, 1Département de Rhumatologie, Hôpital Cochin, Assistance publique des Hôpitaux de Paris, Université Paris-Cité, Paris, France, PARIS, France, 2AP-HP, Paris, France, 3Institut Pasteur, Université Paris Cité, Immunoregulation Unit, F-75015 Paris, France, PARIS, France, 4Laboratoire Gly-CREET, Université Paris-Est Créteil Val de Marne (UPEC) Faculté des sciences et technologies, Créteil, France, 5Université Paris Cité, Institut des maladies musculo-squelettiques, Laboratory Orofacial Pathologies, Imaging and Biotherapies URP2496 and FHU-DDS-Net, Dental School, and Plateforme d’Imagerie du Vivant (PIV), Montrouge, France,, Montrouge, France, 6Université Paris-Saclay, Laboratory Diseases and Hormones of the Nervous Systems, Inserm U1195, Le Kremlin Bicêtre, France, Le Kremlin Bicêtre, France, 7Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, Evry, France, 8Departement of Rheumatology, AP-HP, Bichat Hospital, Paris, France, 9Plateformes PDA et MouseT'IC, Institut Cochin, Université Paris Cité, Paris, France, PARIS, France, 10Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, 11Centre de Recherche Saint-Antoine, UMR_S938 INSERM /Sorbonne Université, Paris, France, Paris, France, 12Université de Paris Cité, APHP, Paris, France

    Background/Purpose: Spondyloarthritis (SpA) is an inflammatory rheumatic disease characterized, in its axial form, by lesions affecting the spine and/or sacroiliac joints (SIJ). Severe forms of…
  • Abstract Number: 2117 • ACR Convergence 2024

    The Risk of Medication-related Osteonecrosis of the Jaw (MRONJ) in a Patient with Osteoporosis Treated with Antiresorptive Therapy and Undergoing Dental Care Is Negligible with a CTX Threshold Above 260

    Camille Ghio, Robinson Gravier-Dumonceau, Pierre Lafforgue, Roch Giorgi and Thao Pham, Assistance Publique-Hôpitaux de Marseille, Marseille, France

    Background/Purpose: Although antiresorptive treatments, including bisphosphonates and denosumab, have demonstrated their efficacy in treating osteoporosis. However, osteonecrosis of the jaw has been reported as a…
  • Abstract Number: 2131 • ACR Convergence 2024

    Role of LECT2 in the Regulation of Bone Metabolism In Vitro and In Vivo

    Myeung-Su Lee1, Chang-hoon Lee2, CHONG HYUK CHUNG1, Ju-Young Kim3, Yoon-Hee Cheon4, So Young Eun3 and Gyeung Do Park3, 1Wonkwang University Hospital, Iksan, South Korea, 2Wonkwang University Hospital, Iksan Jeonbuk, South Korea, 3Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Republic of Korea, 4Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Cholla-bukto, Republic of Korea

    Background/Purpose: Leucocyte cell derived chemotaxin 2 (LECT2) is a hepatokine produced in liver cells, secreted into the circulation, and acts as a hormone throughout the…
  • Abstract Number: 2133 • ACR Convergence 2024

    Unveiling the Association Between Low-Density Lipoprotein Cholesterol Lowering and Fracture Risk Among Patients with Hyperlipidaemia in a Population-Based Cohort Study: The Lower, the Better

    Zeqin Wen1, Yilun Wang1, Xiaoxiao Li2, Yuqing Zhang3, Junqing Xie4, Houchen Lyu5, Changjun Li2, Jie Wei6, Guanghua Lei7 and Chao Zeng8, 1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China (People's Republic), 2Central South University, Changsha, China (People's Republic), 3Massachusetts General Hospital, Quincy, MA, 4University of Oxford, Oxford, United Kingdom, 5Central South University, Beijing, China, 6Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China (People's Republic), 7Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China (People's Republic), 8Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China (People's Republic)

    Background/Purpose: High low-density lipoprotein cholesterol (LDL-C) is a major risk factor for fracture; however, whether LDL-C lowering induced by statins is associated with decreased fracture…
  • Abstract Number: 2134 • ACR Convergence 2024

    PEX5 Acts as a Negative Regulator of RANKL-induced Osteoclastogenesis In Vitro and Inflammatory Calvarial Bone Destruction In Vivo

    CHONG HYUK CHUNG1, Myeung-Su Lee1, Chang-hoon Lee2, Ju-Young Kim3, Yoon-Hee Cheon4, So Young Eun3 and Gyeung Do Park3, 1Wonkwang University Hospital, Iksan, South Korea, 2Wonkwang University Hospital, Iksan Jeonbuk, South Korea, 3Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Republic of Korea, 4Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Cholla-bukto, Republic of Korea

    Background/Purpose: Peroxisomal biogenesis factor 5 (PEX5) is essential for regulating peroxisome function by recognizing and transporting peroxisome target sequence receptor substrate proteins to peroxisomes. PEX5…
  • Abstract Number: 1139 • ACR Convergence 2023

    From Skin to Bone Lesions: A Pioneer Study Unraveling the Underdiagnosis of SAPHO Syndrome in the Dominican Republic

    Leeany Maletta1, Diana Jimenez2 and Rosanna de Jesus3, 1UNIBE School of Medicine, San Antonio, TX, 2UNIBE School of Medicine, Miami, FL, 3Hospital General Plaza de la Salud, Distrito Nacional, Dominican Republic

    Background/Purpose: SAPHO syndrome is a rare chronic inflammatory condition that affects the skin and osteoarticular structures. Despite being first described over 30 years ago, it…
  • Abstract Number: 1794 • ACR Convergence 2023

    The Role of the Deubiquitinase ZRANB1/TRABID in Inflammation and Bone Formation in Spondyloarthritis

    Archita Srinath1, Daniele Mauro2, Francesco Ciccia3 and Nigil Haroon4, 1University of Toronto, Toronto, ON, Canada, 2University of Campania, Naples, Italy, 3University of Campania - Luigi Vanvitelli, Naples, Italy, 4University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Medicine/Rheumatology, Toronto, ON, Canada

    Background/Purpose: Inflammation and new bone formation are important disease mediators in ankylosing spondylitis (AS). Recent studies in mice show that the deubiquitinase molecule TRABID epigenetically…
  • Abstract Number: 2015 • ACR Convergence 2023

    Synergistic Effect Between Denosumab and Immune Checkpoint Inhibitors : A Retrospective Study of 268 Patients with Bone Metastases

    Emmanuel Massy1, Etienne Mabrut1, Sabine Mainbourg2 and Cyrille Confavreux1, 1Centre Expert des Métastases Osseuses (CEMOS) - Service de Rhumatologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Université de Lyon, INSERM UMR 1033-LYOS, Lyon, France, 2Service de médecine interne et vasculaire, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, F-69495 Pierre-Bénite, Laboratoire de Biométrie et Biologie Evolutive, Université Lyon 1; CNRS, UMR 5558, 69622 Villeurbanne, Lyon, France

    Background/Purpose: Bone is the third site of metastasis. Bone metastases are associated with poorer survival of patients and impaired quality of life with the occurrence…
  • Abstract Number: 2016 • ACR Convergence 2023

    Generation of a Human 3D in Vitro Bone Model That Mimics Glucocorticoid-induced Osteoporosis

    Moritz Pfeiffenberger1, Johannes Plank1, Alexandra Damerau1, Timo Gaber1 and Frank Buttgereit2, 1Charité Universitatsmedizine - Berlin, Berlin, Germany, 2Charité Universitätsmedizin, Dept. Rheumatology, Berlin, Germany

    Background/Purpose: Osteoporosis is a bone disease characterized by low bone mass and changes in bone architecture, leading to pain and reduced mobility in patients. Glucocorticoid-induced…
  • Abstract Number: 2150 • ACR Convergence 2023

    Novel Biologic IRL201805 Inhibits Osteoclastogenesis in Monocytic Cells from RA Patients

    Yuriko Yamamura1, Valerie Corrigall2, Lara Ravanetti3, Jorge De Alba3, Roly Foulkes4, Paul Eggleton5 and Carl Goodyear6, 1School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom, 2Revolo Biotherapeutics, Tadworth, United Kingdom, 3Revolo Biotherapeutics, London, United Kingdom, 4Revolo Biotherapeutics, Slough, United Kingdom, 5Revolo Biotherapeutics, Exeter, United Kingdom, 6University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: In Rheumatoid arthritis (RA), osteoclasts derived from CD14+ Monocytes are associated with a risk of progressive bone and joint destruction, which fundamentally impacts quality-of-life.…
  • Abstract Number: 0846 • ACR Convergence 2023

    Preosteoclast Plays a Pathogenic Role in Syndesmophyte Formation of Ankylosing Spondylitis Through the Secreted PDGFB – GRB2/ERK/RUNX2 Pathway

    Yulong Tang1, Qingmei Liu1, Kunhai Tang1, Chengchun Geng1, Jiangnan Xie1, Jiucun Wang2, Qi Zhu3 and Jing Liu1, 1Fudan University, Shanghai, China, 2Shanghai, Shanghai, China, 3Guanghua Integrative Medicine Hospital, Shanghai, China

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting…
  • Abstract Number: L11 • ACR Convergence 2022

    Romosozumab versus Denosumab in High-risk Patients with Glucocorticoid-induced Osteoporosis: A Pilot Randomized Controlled Trial

    Wai Han Ma1, Chi Chiu Mok2, Ling Yin Ho2, Kar Li Chan3, Sau Mei Tse4 and Sammy Chen5, 1Department of Nuclear Medicine, Hong Kong, Hong Kong, 2Tuen Mun Hospital, Hong Kong, Hong Kong, 3Tuen Mun Hospital, Tsing Yi, Hong Kong, 4Department of Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, 5Department of Pathology, Hong Kong, Hong Kong

    Background/Purpose: To compare the efficacy and safety of romozosumab (ROMO) and denosumab (DEN) in high-risk patients with glucocorticoid -induced osteoporosis (GIOP)Methods: Adult patients (≥18 years)…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
  • 5
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

Embargo Policy

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2026 American College of Rheumatology