ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "bone biology"

  • Abstract Number: 0925 • ACR Convergence 2024

    Macrophages Produce Bone Anabolic Factors in Settings of Inflammation-Induced Bone Formation

    Jia (Sijia) Chen1, Megan Hanlon2, Catherine Manning3, Susan MacLauchlan1, Paul Hoover4, Christian Jacome-Galarza5 and Ellen Gravallese6, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women’s Hospital, Boston, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Brigham and Women's Hospital, SWAMPSCOTT, MA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Understanding the pathogenesis of inflammation-induced pathologic bone formation remains a significant challenge in spondyloarthritis patients. We thought to uncover the pivotal events driving the…
  • Abstract Number: 0936 • ACR Convergence 2024

    Schnurri-3 Inhibition Protects from NF-kB-induced Bone Loss in Inflammatory Arthritis

    Priyanka Kushwaha1, Catherine Manning2, Tadatoshi Sato3, Yeon-Suk Yang3, Jae-Hyuck Shim4 and Ellen Gravallese5, 1Department of Medicine/Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Boston, MA, 2Brigham and Women's Hospital, Dedham, MA, 3Department of Medicine/Division of Rheumatology, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, 4University of Massachusetts, Worcester, MA, 5Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: In rheumatoid arthritis (RA), production of TNF promotes osteoclast activity and inhibits osteoblasts (OBs) and bone healing. Schnurri-3 (SHN3) is a potent suppressor of…
  • Abstract Number: 1429 • ACR Convergence 2024

    Association of Bone Erosion and Microarchitecture with Disease Activity and Damage in Sjögren’s Disease

    Andre Franco1, Igor Murai2, Thomas Yang2, Valeria Caparbo3, Virginia Bonoldi2, Diogo Domiciano1, Lissiane Guedes2, Sandra Pasoto1, Camille Figueiredo3 and Rosa M R Pereira3, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, 2Hospital das Clinicas HCFMUSP, Faculdade de Medicina da USP, São Paulo, SP, Brazil, 3Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, SP, Brazil

    Background/Purpose: Sjögren's disease (SjD) is a chronic multisystem autoimmune condition characterized by sicca syndrome and inflammatory arthralgia, more common in women. Bone involvement can result…
  • Abstract Number: 1710 • ACR Convergence 2024

    Extl3 Involved in the Regulation of Endochondral Ossification in Axial SpA

    Stéphane Hilliquin1, OLIVIER FOGEL2, Mathilde Tissier3, Chahrazad Cherifi4, Karim Ibrahim5, Judith Melki6, Robert Olaso7, Brigitte Baroukh5, Philippe Dieudé8, Lars Rogge3, Elisabetta Bianchi3, Marcio Do Cruzeiro9, Frederique Cornelis10, Rik Lories10, Patricia Albanese4, Xavier Houard11, Claire Bardet5 and Corinne MICELI12, 1Département de Rhumatologie, Hôpital Cochin, Assistance publique des Hôpitaux de Paris, Université Paris-Cité, Paris, France, PARIS, France, 2AP-HP, Paris, France, 3Institut Pasteur, Université Paris Cité, Immunoregulation Unit, F-75015 Paris, France, PARIS, France, 4Laboratoire Gly-CREET, Université Paris-Est Créteil Val de Marne (UPEC) Faculté des sciences et technologies, Créteil, France, 5Université Paris Cité, Institut des maladies musculo-squelettiques, Laboratory Orofacial Pathologies, Imaging and Biotherapies URP2496 and FHU-DDS-Net, Dental School, and Plateforme d’Imagerie du Vivant (PIV), Montrouge, France,, Montrouge, France, 6Université Paris-Saclay, Laboratory Diseases and Hormones of the Nervous Systems, Inserm U1195, Le Kremlin Bicêtre, France, Le Kremlin Bicêtre, France, 7Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, Evry, France, 8Departement of Rheumatology, AP-HP, Bichat Hospital, Paris, France, 9Plateformes PDA et MouseT'IC, Institut Cochin, Université Paris Cité, Paris, France, PARIS, France, 10Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, 11Centre de Recherche Saint-Antoine, UMR_S938 INSERM /Sorbonne Université, Paris, France, Paris, France, 12Université de Paris Cité, APHP, Paris, France

    Background/Purpose: Spondyloarthritis (SpA) is an inflammatory rheumatic disease characterized, in its axial form, by lesions affecting the spine and/or sacroiliac joints (SIJ). Severe forms of…
  • Abstract Number: 2117 • ACR Convergence 2024

    The Risk of Medication-related Osteonecrosis of the Jaw (MRONJ) in a Patient with Osteoporosis Treated with Antiresorptive Therapy and Undergoing Dental Care Is Negligible with a CTX Threshold Above 260

    Camille Ghio, Robinson Gravier-Dumonceau, Pierre Lafforgue, Roch Giorgi and Thao Pham, Assistance Publique-Hôpitaux de Marseille, Marseille, France

    Background/Purpose: Although antiresorptive treatments, including bisphosphonates and denosumab, have demonstrated their efficacy in treating osteoporosis. However, osteonecrosis of the jaw has been reported as a…
  • Abstract Number: 2131 • ACR Convergence 2024

    Role of LECT2 in the Regulation of Bone Metabolism In Vitro and In Vivo

    Myeung-Su Lee1, Chang-hoon Lee2, CHONG HYUK CHUNG1, Ju-Young Kim3, Yoon-Hee Cheon4, So Young Eun3 and Gyeung Do Park3, 1Wonkwang University Hospital, Iksan, South Korea, 2Wonkwang University Hospital, Iksan Jeonbuk, South Korea, 3Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Republic of Korea, 4Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Cholla-bukto, Republic of Korea

    Background/Purpose: Leucocyte cell derived chemotaxin 2 (LECT2) is a hepatokine produced in liver cells, secreted into the circulation, and acts as a hormone throughout the…
  • Abstract Number: 2133 • ACR Convergence 2024

    Unveiling the Association Between Low-Density Lipoprotein Cholesterol Lowering and Fracture Risk Among Patients with Hyperlipidaemia in a Population-Based Cohort Study: The Lower, the Better

    Zeqin Wen1, Yilun Wang1, Xiaoxiao Li2, Yuqing Zhang3, Junqing Xie4, Houchen Lyu5, Changjun Li2, Jie Wei6, Guanghua Lei7 and Chao Zeng8, 1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China (People's Republic), 2Central South University, Changsha, China (People's Republic), 3Massachusetts General Hospital, Quincy, MA, 4University of Oxford, Oxford, United Kingdom, 5Central South University, Beijing, China, 6Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China (People's Republic), 7Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China (People's Republic), 8Department of Orthopaedics, Xiangya Hospital, Central South University; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China (People's Republic)

    Background/Purpose: High low-density lipoprotein cholesterol (LDL-C) is a major risk factor for fracture; however, whether LDL-C lowering induced by statins is associated with decreased fracture…
  • Abstract Number: 2134 • ACR Convergence 2024

    PEX5 Acts as a Negative Regulator of RANKL-induced Osteoclastogenesis In Vitro and Inflammatory Calvarial Bone Destruction In Vivo

    CHONG HYUK CHUNG1, Myeung-Su Lee1, Chang-hoon Lee2, Ju-Young Kim3, Yoon-Hee Cheon4, So Young Eun3 and Gyeung Do Park3, 1Wonkwang University Hospital, Iksan, South Korea, 2Wonkwang University Hospital, Iksan Jeonbuk, South Korea, 3Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Republic of Korea, 4Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Cholla-bukto, Republic of Korea

    Background/Purpose: Peroxisomal biogenesis factor 5 (PEX5) is essential for regulating peroxisome function by recognizing and transporting peroxisome target sequence receptor substrate proteins to peroxisomes. PEX5…
  • Abstract Number: 2145 • ACR Convergence 2024

    Study of Bone Metabolism in Patients Diagnosed with Osteogenesis Imperfecta.

    Daniel Ramos Castro1, SAMUEL LEAL2, Elena Grau García3, JOSE ELOY OLLER RODRIGUEZ4, José Ivorra-Cortés5, Carmen Riesco Barcena6, Anderson Huaylla Quispe7, Pablo Muñoz Martínez8, Laura Mas Sánchez9, Alba Torrat noves10, Belén Villanueva Mañés11, Iago Alcántara Álvarez12, Andrés Pérez Hurtado1, Miguel Simeo Vinaixa11 and Jose A Román-Ivorra13, 1Rheumatology Department. HUP La Fe, Valencia, Spain, 2Hospital La Fe, Valencia, Spain, 3HUP La Fe, Valencia, Spain, 4HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE, VALENCIA, Spain, 5Hospital Universitario La Fe, PALMA DE MALLORCA, Spain, 6Hospital Universitario i Politecnic La Fe (Valencia-Spain), Valéncia, Spain, 7Medicina, Valéncia, Spain, 8Hospital Universitario y Politècnico La Fe, Sagunto, Spain, 9Resident at Hospital Universitari i Politecnic La Fe, Valéncia, Spain, 10Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Comunidad Valenciana, Spain, 11Rheumatology Department. HUP La Fe, Valencia, Comunidad Valenciana, Spain, 12Hospital Universitari i Politècnic La Fe, Valéncia, Comunidad Valenciana, Spain, 13Hospital Universitari i Politècnic la Fe, Valencia, Comunidad Valenciana, Spain

    Background/Purpose: Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder (90% autosomal dominant) characterized by a disruption in type 1 collagen or proteins associated with…
  • Abstract Number: 2528 • ACR Convergence 2024

    Activation of the Hes1/Piezo1 Pathway Promotes Mechanical Stress Response and Prevents Glucocorticoid-induced Osteoporosis

    Nagahiro Ochiai1, Yuki Etani2, Takaaki Noguchi2, Taihei Miura2, Takuya Kurihara2, Yuji Fukuda2, Hidetoshi Hamada2, Keisuke Uemura2, Kazuma Takashima2, Masashi Tamaki2, Teruya Ishibashi2, Shohei Ito3, Satoshi Yamakawa2, Takashi Kanamoto2, Seiji Okada2, Ken Nakata2 and Kosuke Ebina2, 1Taisho Pharmaceutical Co., Ltd., Saitama, Saitama, Japan, 2Osaka University, Suita, Japan, 3Taisho Pharmaceutical, Co., Ltd., Saitama, Japan

    Background/Purpose: This study investigated the diminished expression of Piezo1 (Piezo-type mechanosensitive ion channel component 1), a mechanosensitive receptor, in bone tissues of both patients and…
  • Abstract Number: 2567 • ACR Convergence 2024

    Gene Expression in Osteonecrosis of the Femoral Head: A Region-matched RNA-sequencing Study

    Lucy Eunju Lee1, Seung Hwan Lee2, Miri Kim2, Jieun Kim2, Joo Sung Shim2, Eun Gyel Shin2, Tae Sung Lee2, Hyuck Min Kwon2, Young Han Lee2, Hun-Mu Yang2, Kwan Kyu Park2 and Jason Jungsik Song2, 1Yonsei University, Seoul, South Korea, 2Yonsei University College of Medicine, Seoul, Republic of Korea

    Background/Purpose: Osteonecrosis of the femoral head (ONFH) is linked to diverse risk factors like glucocorticoid use and excessive alcohol consumption. Various cells may influence bone…
  • Abstract Number: 0027 • ACR Convergence 2024

    Cation Channel TRPC1 Regulates Mesenchymal Stem Cell Differentiation and Bone Formation

    Jyoti Yadav1, Shivmurat Yadav2, Jeremy Houser1, Marta Onopuik3, Leonidas Tsiokas3 and Mary Beth Humphrey1, 1University of Oklahoma College of Medicine, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3University of Oklahoma College of Medicine, Oklahoma City

    Background/Purpose: Transient receptor potential canonical 1 (TRPC1), a non-selective cation channel, is characterized by its high permeability to calcium ions (Ca2+), a vital second messenger…
  • Abstract Number: 0068 • ACR Convergence 2024

    Enhanced Expression of GPR65 in Inflammatory Sites and Bone Formation Regions in Ankylosing Spondylitis: Evidence from ScRNA-seq Analysis

    Yong-Wook Park1, Ki-Jeong Park2, Sungsin Jo3, Tae-Hwan Kim4 and Tae-Jong Kim1, 1Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, 2Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, 3Hanyang University Institute for Rheumatology Research, Seoul, Republic of Korea, 4Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton. T helper 17 (Th17) cells play a pivotal role in the…
  • Abstract Number: 0924 • ACR Convergence 2024

    The Cytosolic DNA Sensor AIM2 Regulates Bone Homeostasis Through Bone Progenitor Cell Differentiation

    Jia (Sijia) Chen1, Yukiko Maeda2, Catherine Manning3, Victor Le4, Jae-Hyuck Shim5, Katherine A. Fitzgerald6 and Ellen Gravallese7, 1Brigham and Women's Hospital, Boston, MA, 2Sanofi, worcester, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Digital Biology, Boston, MA, 5University of Massachusetts, Worcester, MA, 6UMass Chan Medical School, Worchester, MA, 7Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Innate sensing pathways and inflammasomes play an important role in autoimmunity and aging. AIM2 is a DNA sensor that triggers inflammasome assembly in myeloid…
  • Abstract Number: 0846 • ACR Convergence 2023

    Preosteoclast Plays a Pathogenic Role in Syndesmophyte Formation of Ankylosing Spondylitis Through the Secreted PDGFB – GRB2/ERK/RUNX2 Pathway

    Yulong Tang1, Qingmei Liu1, Kunhai Tang1, Chengchun Geng1, Jiangnan Xie1, Jiucun Wang2, Qi Zhu3 and Jing Liu1, 1Fudan University, Shanghai, China, 2Shanghai, Shanghai, China, 3Guanghua Integrative Medicine Hospital, Shanghai, China

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting…
  • 1
  • 2
  • 3
  • …
  • 5
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology