ACR Meeting Abstracts

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Abstracts tagged "Biostatistics"

  • Abstract Number: 1533 • ACR Convergence 2022

    Use of Body Mass Index in Prediction of Interstitial Lung Disease Related to Systemic Sclerosis Revealed by Decision Trees

    Alexandru Garaiman1, Carina Mihai1, Rucsandra Dobrota1, cosimo bruni2, Muriel Elhai1, Suzana Jordan1, Lea Stamm3, Anna-Maria Hoffmann-vold4, Oliver Distler1 and Mike Becker1, 1Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 2University of Florence, Florence, Italy, 3Department of Rheumatology, University Hospital Zurich, Zürich, Switzerland, 4Oslo University Hospital, Oslo, Norway

    Background/Purpose: Some gastrointestinal (GI) and nutritional factors are associated with the presence of interstitial lung disease related to systemic sclerosis (SSc-ILD). However, there are many…
  • Abstract Number: 1635 • ACR Convergence 2022

    Safety Profile of Hydroxychloroquine in a Large Cohort of Rheumatology Patients Within the US Department of Defense Military Healthcare System

    Toni Rush1, Rachel Robbins2, Angelique Collamer2 and Jess Edison3, 1Health Research Tx, Trevose, PA, 2Walter Reed National Military Medical Center, Bethesda, MD, 3Uniformed Services University of the Health Sciences / National Capital Consortium- Walter Reed Bethesda, Bethesda, MD

    Background/Purpose: Hydroxychloroquine (HCQ) is a well-established conventional synthetic DMARD for many rheumatologic conditions. While generally believed to be safe, HCQ use is associated with a…
  • Abstract Number: 1777 • ACR Convergence 2022

    A Symptom Checker App Is Better at Classifying Inflammatory Disease Than Physicians Who Are Presented Identical Information

    markus Gräf1, Johannes Knitza2, Jan Leipe3, Martin Krusche4, Martin Welcker5, Sebastian Kuhn6, Johanna Mucke7, Axel Hueber8, Johannes Hornig9, Philipp Klemm10, stefan Kleinert11, Peer Aries12, Nicolas Vuillerme13, Arnd Kleyer2, Georg Schett14 and Johanna Callhoff15, 1Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 2Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 3Division of Rheumatology, Department of Medicine V, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Heidelberg, Germany, 4University Hospital Hamburg-Eppendorf, Hamburg, Germany, 5GBR, Planegg, Germany, 6Department of Digital Medicine, Medical Faculty OWL, Bielefeld University, Bielefeld, Germany, 7Policlinic and Hiller Research Center, Heinrich-Heine-University Duesseldorf, Neuss, Germany, 8Paracelsus University Nürnberg, Erlangen, Germany, 9Rheumatologische Schwerpunktpraxis, Osnabrück, Germany, 10Campus Kerckhoff of Justus Liebig University Giessen, Bad Nauheim, Germany, 11Praxisgemeinschaft Rheumatologie - Nephrologie (PGRN), Erlangen, Germany, 12Rheumatologie im Struenseehaus, Hamburg, Germany, 13Université Grenoble Alpes, AGEIS, Grenoble, France, 14Universitätsklinikum Erlangen, Erlangen, Germany, 15German Rheumatism Research Centre, Berlin, Germany

    Background/Purpose: The purpose of this study was to compare the ability of an artificial intelligence-based symptom checker app (Ada) and physicians to determine the presence/absence…
  • Abstract Number: 2003 • ACR Convergence 2022

    Anti-rheumatic Treatment Modulates Expression of the Glycolytic Enzyme PFKFB3 in CD14+ Monocytes of Patients with Rheumatoid Arthritis, Which Contributes to Dissimilarities of the IFN Signature

    Malin Erlandsson1, Karin Andersson1, Sofia Töyrä Silfverswärd2, Rille pullerits2 and Maria Bokarewa2, 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden, 2Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

    Background/Purpose: Combination of IFN-stimulated genes known as IFN signature, helps to predict disease activity and treatment response in several autoimmune diseases, including rheumatoid arthritis (RA).…
  • Abstract Number: 2221 • ACR Convergence 2022

    The Molecular Endotypes of Type 1 and Type 2 SLE

    Robert Robl1, Amanda Eudy2, Prathyusha Bachali3, Jennifer L Rogers4, Megan Clowse5, David Pisetsky6 and Peter lipsky1, 1AMPEL BioSolutions, Charlottesville, VA, 2Duke University, Raleigh, NC, 3AMPEL BioSolutions, Redmond, WA, 4Duke University School of Medicine, Division of Rheumatology & Immunology, Durham, NC, 5Duke University, Durham, NC, 6Duke University Medical Center, Durham, NC

    Background/Purpose: To characterize the molecular landscape of patients with Type 1 and Type 2 systemic SLE erythematosus (SLE) by analyzing gene expression profiles from peripheral…
  • Abstract Number: 0174 • ACR Convergence 2022

    Intra-rater Validation of Calcinosis Durometer Measurements in Juvenile and Adult Dermatomyositis

    Meghan Nelson1, Adam Schiffenbauer2, Hanna Kim3, Scott Gillespie4, Vy Do5, Julie Fuller6, Lisa G Rider7 and Kelly Rouster-Stevens8, 1Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine; Children's Healthcare of Atlanta, Atlanta, GA, 2National Institutes of Health, Bethesda, MD, 3Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences; Juvenile Myositis Therapeutic and Translation Studies Unit, PTRB, NIAMS, NIH, Bethesda, MD, 4Emory University, Atlanta, GA, 5UT Austin Dell Medical School, Austin, TX, 6UT Southwestern, Frisco, TX, 7Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, 8Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine; Children’s Healthcare of Atlanta, Atlanta, GA

    Background/Purpose: Dermatomyositis (DM) and juvenile dermatomyositis (JDM) are idiopathic inflammatory myopathies primarily affecting proximal skeletal muscle and skin. Calcinosis, a known complication of DM, is…
  • Abstract Number: 0621 • ACR Convergence 2022

    Altered Immunological Circadian Rhythms and the Effect of Treatment with Glucocorticoids on Circadian Rhythms of Immune Cells in Patients with Rheumatoid Arthritis: Bring Back the Rhythm

    Siska Wilantri1, Cindy Strehl1, Dimas Abdirama1, Timo Gaber1, Robert Biesen2 and Frank Buttgereit1, 1Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany, 2Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

    Background/Purpose: Clinical symptoms of rheumatoid arthritis (RA), including pain, joint stiffness, and swelling, exhibit a distinct circadian rhythm that exacerbates in the early morning in…
  • Abstract Number: 0708 • ACR Convergence 2022

    The Impact of Early Antimalarial Adherence on Future Acute Care Utilization Among Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients: A Population-based Study

    Md Rashedul Hoque1, J. Antonio Avina-Zubieta2, Diane Lacaille2, Mary De Vera3, Yi Qian3, John Esdaile4 and Hui Xie5, 1Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada, 2Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada, 3University of British Columbia, Vancouver, BC, Canada, 4Arthritis Research Canada, Vancouver, BC, Canada, 5Simon Fraser University, Vancouver, BC, Canada

    Background/Purpose: To examine the association between antimalarial (AM) adherence and acute care utilization among newly diagnosed rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients.Methods:…
  • Abstract Number: 1406 • ACR Convergence 2022

    Integrative Multi-omic Phenotyping in Blood Identifies Molecular Signatures and Candidate Biomarkers of ACPA-negative Rheumatoid Arthritis

    Benjamin Hur1, Kevin Cunningham2, John Davis1 and Jaeyun Sung1, 1Mayo Clinic, Rochester, MN, 2University of Minnesota, Rochester, MN

    Background/Purpose: ACPA detection assays are often used for RA diagnosis due to their high specificity ( >90%). However, current ACPA assays (e.g., anti-CCP2 ELISA) have…
  • Abstract Number: 1473 • ACR Convergence 2022

    Unsupervised Clustering of Lupus Patient-Reported Outcome Data Identifies Patient Groups with Differences in SLEDAI and Physician Global Assessment

    Jack Zent1, Kristy Bell2, Brooke Williams2, Prathyusha Bachali3 and Peter Lipsky4, 1AMPEL BioSolutions LLC, Leesburg, VA, 2AMPEL BioSolutions LLC, Charlottesville, VA, 3AMPEL BioSolutions, Redmond, WA, 4AMPEL BioSolutions, Charlottesville, VA

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous clinical presentations. Patient-reported outcomes (PROs) can aid in the measurement of the burden of…
  • Abstract Number: 0324 • ACR Convergence 2021

    Machine Learning: Identifying Lupus Nephritis Within Systemic Lupus Erythematosus in the Real World

    Bruno Teixeira, David Bell, Tim Holbrook and Ben Hoskin, Adelphi Real World, Bollington, United Kingdom

    Background/Purpose: Around 40-70% of patients with systemic lupus erythematosus (SLE) develop lupus nephritis (LN). LN is often underdiagnosed and early diagnosis is crucial for reducing…
  • Abstract Number: 0401 • ACR Convergence 2021

    Item Reduction for the Assessment of Systemic Sclerosis-associated RAynaud’s Phenomenon (ASRAP) Questionnaire Using Data from the International Multicentre ASRAP Validation Study

    John Pauling1, Lan Yu2, Christopher Denton3, Tracy Frech4, Ariane Herrick5, Laura Hummers6, Lesley Ann Saketkoo7, Ami Shah8, Dinesh Khanna9 and Robyn Domsic2, 1Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2University of Pittsburgh, Pittsburgh, PA, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 4University of Utah, Salt Lake City, UT, 5University of Manchester, Salford, United Kingdom, 6Johns Hopkins Univerisity, Baltimore, MD, 7University Medical Center - Comprehensive Pulmonary Hypertension Center, New Orleans, LA, 8Johns Hopkins Rheumatology, Baltimore, MD, 9University of Michigan, Ann Arbor, MI

    Background/Purpose: The Assessment of Systemic sclerosis-associated RAynaud’s Phenomenon (ASRAP) questionnaire is a novel patient-reported outcome (PRO) instrument devised to assess the severity and impact of…
  • Abstract Number: 0499 • ACR Convergence 2021

    Preliminary Assessment of Internal Reliability and Construct Validity of Long and Short-form Assessment of Systemic Sclerosis-associated RAynaud’s Phenomenon (ASRAP) Questionnaires

    John Pauling1, Lan Yu2, Christopher Denton3, Tracy Frech4, Ariane Herrick5, Laura Hummers6, Lesley Ann Saketkoo7, Ami Shah8, Dinesh Khanna9 and Robyn Domsic2, 1Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2University of Pittsburgh, Pittsburgh, PA, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 4University of Utah, Salt Lake City, UT, 5University of Manchester, Salford, United Kingdom, 6Johns Hopkins Univerisity, Baltimore, MD, 7University Medical Center - Comprehensive Pulmonary Hypertension Center, New Orleans, LA, 8Johns Hopkins Rheumatology, Baltimore, MD, 9University of Michigan, Ann Arbor, MI

    Background/Purpose: The Assessment of Systemic sclerosis-associated RAynaud’s Phenomenon (ASRAP) questionnaire is a novel patient-reported outcome instrument devised to assess the severity and impact of SSc-RP.…
  • Abstract Number: 0982 • ACR Convergence 2021

    B Cells Repertoire Repartition Predicts Response to Methotrexate at 6 and 12 Months in Naïve RA: A Machine Learning Driven Approach

    Aurelie Najm1, Shrutii Sarda2, Michelle Toro3, Loni Pickle3, Stephanie Ostresh3, Fraser Morton4, Geoffrey Lowman3, Andrew Felton5 and Carl Goodyear4, 1Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 2Clinical Sequencing Division, Specialty Diagnostics Group, Thermo Fisher Scientific, South San Francisco-CA, United States, San Francisco, 3Clinical Sequencing Division, Specialty Diagnostics Group, Thermo Fisher Scientific, Carlsbad, CA, 4University of Glasgow, Glasgow, United Kingdom, 5VP, Platforms, Research & Applied, Specialty Diagnostics Group, South San Francisco, CA

    Background/Purpose: The adaptive immune system plays a central role in Rheumatoid Arthritis (RA) pathogenesis. Moreover, the composition of the B cell repertoire and its perturbation…
  • Abstract Number: 1268 • ACR Convergence 2021

    Predicting Adverse Pregnancy Outcomes in Women with Systemic Lupus Erythematosus: A Comparison of Machine Learning Methods

    Melissa Fazzari1, Marta Guerra2, Jane Salmon2 and Mimi Kim3, 1Albert Einstein College of Medicine, Bronx, NY, 2Hospital for Special Surgery, New York, NY, 3Albert Einstein College of Medicine, Larchmont, NY

    Background/Purpose: Nearly 20% of pregnancies in patients with Systemic lupus erythematosus (SLE) result in an adverse pregnancy outcome (APO); early identification of women with SLE…
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