ACR Meeting Abstracts

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Abstracts tagged "Biostatistics"

  • Abstract Number: 1717 • ACR Convergence 2024

    Early Antimalarial Adherence Reduces Future Hospitalization Cost in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients: Evidence from a Population-based Study

    Md Rashedul Hoque1, Diane Lacaille2, J. Antonio Avina-Zubieta2, Mary A. De Vera3, Yi Qian4, John Esdaile5 and Hui Xie6, 1Simon Fraser University, Vancouver, BC, Canada, 2Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada, 3University of British Columbia, Faculty of Pharmaceutical Sciences, Vancouver, BC, Canada, 4University of British Columbia, Vancouver, Canada, 5Arthritis Research Canada, Vancouver, BC, Canada, 6Arthritis Research Canada, Simon Fraser University, Vancouver, BC, Canada

    Background/Purpose: To examine the association between antimalarial (AM) adherence and hospitalization costs among newly diagnosed rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients.Methods: We…
  • Abstract Number: 1723 • ACR Convergence 2024

    Clustering Analysis with Unsupervised Machine Learning Process to Phenotype the Cardiovascular Risk of Patients with Rheumatoid Arthritis Beyond the 10-year Prediction Algorithm

    Fabio Cacciapaglia1, Vincenzo Venerito2, Gian Luca Erre3, Matteo Piga4, Andreina Manfredi5, Garifallia Sakellariou6, Ombretta Viapiana7, Elisa Gremese8, Elena Bartoloni Bocci9, Francesca Romana Spinelli10 and Fabiola Atzeni11, and "Cardiovascular Obesity and Rheumatic DISeases" Study Group of the Italian Society of Rheumatology, 1Rheumatology Unit DiMePRe-J, University and AOU Policlinico of Bari, Italy, Bari, Italy, 2Rheumatology Unit, DiMePRe-J University of Bari, Bari, Italy, 3Rheumatology Unit - University of Sassari, Sassari, Italy, 4Rheumatology Unit - University of Cagliari, Cagliari, Italy, 5University of Modena and Reggio Emilia, Modena, 6Department of Internal Medicine and Medical Therapy, University of Pavia, and Istituti Clinici Scientifici Maugeri IRCCS Pavia,, Pavia, Italy, 7Rheumatology Unit, University of Verona, Verona, Italy, 8Catholic University of the Sacred Heart, Rome, Rome, Italy, 9Rheumatology Unit. Department of Medicine, Perugia, Perugia, Italy, 10Sapienza University of Rome, Rome - Italy, Roma, Rome, Italy, 11University of Messina, Italy, Messina, Italy

    Background/Purpose: Rheumatoid arthritis (RA) patients are at increased cardiovascular (CV) risk, but traditional CV risk factors and available 10-year CV risk estimation models may not…
  • Abstract Number: 1906 • ACR Convergence 2024

    Bayesian Algorithm to Identify Osteoarthritis in Administrative Health Data Without Requiring Chart Review

    S. Reza Jafarzadeh1, Sarah Tilley1, Anup Arvind1 and David Felson2, 1Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 2Boston University, Boston, MA

    Background/Purpose: Osteoarthritis (OA) is the most prevalent arthritis and a significant contributor to Years Lived with Disability. Administrative health data are widely used to study…
  • Abstract Number: 2400 • ACR Convergence 2024

    Predicting Adverse Pregnancy Outcomes in Women with Systemic Lupus Erythematosus: External Validation of the PROMISSE Model Using Multiple Independent Cohorts

    Melissa Fazzari1, Jane Salmon2, Marta Guerra2, Nathalie Costedoat-Chalumeau3, Veronique LE GUERN4, Gaëlle Guettrot-Imbert4, Marta Mosca5, Dina Zucchi6, Chiara Tani7, Rebecca Fischer-Betz8, Isabell Haase9, Anna Broder10, Navneet Kaur11, Jill Buyon12, Brooke Cohen12, Diane Kamen13, Jessica English14, Anna Arar13 and Mimi Kim15, 1Albert Einstein College of Medicine, Bronx, NY, 2Hospital for Special Surgery, New York, NY, 3Inserm DR Paris 5, Paris, France, 4Cochin hospital, Paris, France, 5University of Pisa, Department of Clinical and Experimental Medicine - Rheumatology Unit, Pisa, Italy, 6Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 7University of Pisa, Pisa, Italy, 8Uniklinik Düsseldorf, Düsseldorf, Germany, 9Heinrich-Heine University Duesseldorf, Düsseldorf, Germany, 10Hackensack Network, Hackensack, NJ, 11Touro University Medical Group, Sacramento, CA, 12NYU Grossman School of Medicine, New York, NY, 13Medical University of South Carolina, Charleston, SC, 14Medical University of South Carolina, Johns Island, SC, 15Albert Einstein College of Medicine, Larchmont, NY

    Background/Purpose: Nearly 20% of pregnancies in systemic lupus erythematosus (SLE) patients result in an adverse pregnancy outcome (APO); early identification of those at high APO…
  • Abstract Number: 0157 • ACR Convergence 2024

    Knowledge and Attitudes About Delta-9-tetrahydrocannabinol (THC) Impact Real-world Practice in an International Group of Rheumatologists

    Joanna Zeiger1, Patti Katz2, Mary-Ann Fitzcharles3, Stuart Kassan4, Teresa Simon5 and Kaleb Michaud6, 1Canna Research Foundation, Boulder, CO, 2UCSF, San Rafael, CA, 3McGill University, Montreal-West, Canada, 4National Jewish Health, Denver, CO, 5Physicians Research Center Consultant to ForWard, Toms River, NJ, 6University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatologists care for difficult to manage chronic diseases, necessitating adjustments to new treatments and evolving patient views. When making treatment decisions, rheumatologists incorporate clinical…
  • Abstract Number: 0657 • ACR Convergence 2024

    Data-driven Bayesian Network Analysis for Predicting Difficult-to-treat (DTT) Lupus Nephritis

    Jagan K L1, Augustine Jose2, Vishnupriya G1, Dellan S1, Dhanush S1, Samskruthi Reddy Tokala1, Bhavana Mashetty1, Chengappa Kavadichanda3, Sachith ganapathy1, Aishwarya Gopal4, Rithik Roshan1, Sareddy Sai vignesh Reddy1, Sonal Mehra5, Molly Thabah1 and Vir Singh Negi6, 1Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Puducherry, India, 2Jawaharlal Institute of Postgraduate Medical Education and Research, Gorimedu, Puducherry, India, 3Jawaharlal Institute of Postgraduate Medical Education and Research, pondicherry, Puducherry, India, 4Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Puducherry, India, 5JAYPEE HOSPITAL, Noida, Uttar Pradesh, India, 6AIIMS, Bilaspur, Puducherry, Puducherry, India

    Background/Purpose: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus (SLE), with 14-33% failing to respond to standard treatments. This study assesses treatment…
  • Abstract Number: 0724 • ACR Convergence 2024

    Incidence of ANCA-Associated Vasculitis in a Northern Spanish Health Region Between 2000-2023: A Populatio-based Study

    Fabricio Benavides1, Alba Herrero-Morant2, Salma Al Fazazi3, Vanesa Calvo-Rio4, Mónica Renuncio-García5, Adrián Martín-Gutiérrez6, Amparo Sánchez-López7, Claudia Poo-fernandez7, Clara Escagedo-Cagigas7, Maria Rodríguez-Vidriales1 and Ricardo Blanco-Alonso8, 1Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, Ontinyent, Cantabria, Spain, 3Hospital Universitario Virgen de la Victoria, Málaga, Andalucia, Spain, 4Valdecilla Hospital, Santander, Cantabria, Spain, 5Division of Immunology, Hospital Universitario Marqués de Valdecilla, Immunopathology Group, IDIVAL, Santander, Spain, 6Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 7Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 8Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) is a group of vasculitis that affect small vessels. Includes Granulomatosis with polyangiitis (GPA), Eosinophilic granulomatosis with…
  • Abstract Number: 0735 • ACR Convergence 2024

    ANCA-associated Vasculitis (AAV) and Long-term Risk of Cardiovascular Disease: Large-scale Propensity-matched Global Retrospective Cohort Study

    Sebastian Klapa1, Henry Nording2, Marlene Ludwig3, Sabrina Arnold4, Khalaf Kridin5, Anja Staehle6, Ralf Ludwig7 and Peter Lamprecht4, 1University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, 2University of Lübeck, Cardioimmunology Research Group, Lübeck, Germany, 3Independent Researcher, Groß Grönau, Germany, 4University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, 55. Bar-Ilan University, Azrieli Faculty of Medicine, Safed, Israel, 6University of Lübeck, Department of Rheumatology and Immunology, Lübeck, Germany, 7University of Lübeck, Lübeck Institute of Experimental Dermatology, Lübeck, Germany

    Background/Purpose: In spite of significantly improved therapy during the last years, long-term morbidity and mortality has remained high in ANCA-associated vasculitis (AAV). The main causes…
  • Abstract Number: 0796 • ACR Convergence 2024

    Development and Evaluation of Machine Learning Prediction Models for Hospitalizations Due to Opioid-Related Harms Among New Users with Rheumatic and Musculoskeletal Diseases

    Carlos Raul Ramirez Medina1, Mark Lunt2, David Jenkins2, William Dixon2, Niels Peek3 and Meghna Jani2, 1The University of Manchester, Warrington, United Kingdom, 2University of Manchester, Manchester, United Kingdom, 3THIS Institute , University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: England has seen a notable rise in prescription opioid use over the past two decades, leading to some of Europe's highest opioid-related hospital admissions.…
  • Abstract Number: 1114 • ACR Convergence 2024

    Nintedanib in Autoimmune Disease-related Interstitial Lung Disease: Real-life Effectiveness, Safety and Tolerance in a Spanish Multicenter Study

    paula pérez garcía1, Miriam Retuerto Guerrero2, yanira chuquimia mendoza3, Jesús Loarce4, Belén Atienza-Mateo5, Carolina Merino6, marina pavia pascual7, cristiana sieiro santos8, Clara Moriano9 and elvira Diez álvarez10, 1Complejo Asistencial Universitario de León, león, Spain, 2Complejo Asistencial Universitario de León, Leon, Spain, 3Complejo asistencial univeritario de león, león, Spain, 4Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 5Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, 6Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda (Madrid), Spain, 7Hospital General Universitario Gregorio Marañon, madrid, Spain, 8Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 9Hospital León, LEON, Spain, 10Complejo Asistencial Universitario de Leon, Leon

    Background/Purpose: Interstitial lung disease (ILD) is a severe complication of autoimmune diseases (AD). In recent years, new strategies for the treatment of progressive pulmonary fibrosis…
  • Abstract Number: 0131 • ACR Convergence 2023

    Identifying Antinuclear Antibody Positive Individuals at Risk for Systemic Autoimmune Disease: Development and Validation of a Real-Time Risk Model

    April Barnado, Ryan Moore, Hank Domenico, Sarah Green, Alex Camai, Ashley Suh, Bryan Han, Katherine Walker, Audrey Anderson, Lannawill Caruth, Anish Katta, Allison McCoy and Daniel W. Byrne, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Up to 20% of the general population has a positive ANA without having autoimmune disease. Currently, no tools exist to help clinicians interpret the…
  • Abstract Number: 0132 • ACR Convergence 2023

    Feasibility of a Real-Time Risk Model to Identify Antinuclear Antibody Positive Individuals at Risk for Systemic Autoimmune Disease

    April Barnado, Ryan Moore, Hank Domenico, Sarah Green, Alex Camai, Ashley Suh, Bryan Han, Katherine Walker, Audrey Anderson, Lannawill Caruth, Anish Katta, Allison McCoy and Daniel W. Byrne, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Positive antinuclear antibodies (ANAs) cause diagnostic dilemmas for clinicians across multiple specialties. We previously developed and validated a risk model using a de-identified electronic…
  • Abstract Number: 0550 • ACR Convergence 2023

    Harnessing Machine Learning to Predict Neuropsychiatric Events in Systemic Lupus Erythematosus

    Nursen Cetrez1, Julius Lindblom1, Raffaele Da Mutten2, Dionysis Nikolopoulos2 and Ioannis Parodis1, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is linked to increased morbidity, mortality, and adverse health-related quality of life. Early disease, a history of NPSLE, aPL…
  • Abstract Number: 0971 • ACR Convergence 2023

    Network Meta Analyses of the Effectiveness and Safety Profiles of Janus Kinase Inhibitors and Biologic Agents in Treating Children with Non-systemic Juvenile Idiopathic Arthritis (nsJIA)

    Bin Huang1, Yuxiang Li2, Xiaomeng Yue3, Sandra Andorf2, Daniel J Lovell4 and Hermine Brunner5, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3James L. Winkle College Pharmacy, Cincinnati, OH, 4UC Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH, 5Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH

    Background/Purpose: Tofacitinib (TOFA, NCT02592434) and Baricitinib (BARI, NCT03773978) are Janus kinase inhibitors (JAKi) that are approved for or being tested for nsJIA treatment. We aim…
  • Abstract Number: 0978 • ACR Convergence 2023

    Identifying Important Clinical Features for Predicting Remission in Patients with Rheumatoid Arthritis Treated with Biologics Using Machine Learning Model

    Ahmad Alsaber1, Adeeba AlHerz2, Balqees Alawadhi3, Parul Setiya4, KHULOUD MOHAMMED5, Adel Al-Awadhi6, Waleed Al-Kandari7, Eman Hasan8, Khaled Mokaddem9, Aqeel Ghanem10, Youssef Bartella11, Mohammed Hussain8, Naser Alhadhood12, Yaser Ali13, Ebrahim Nahar13, Ali Aldei8, Ahmad Alenizi14, Sawsan Hayat15, Fatemah Abutiban16 and Fatemah Abutiban11, 1American University of Kuwait, Kuwait City, Kuwait, 2Al-Amiri Hospital, Al Asimah Governate, Kuwait, 3The Public Authority for Applied Education and Training, Kuwait City, Kuwait, 4GBPUAT, Department of Agrometerology, Pantnagar, India, 5Farwaniya Hospital, Kuwait, Kuwait, 6Kuwait University, Kuwait City, Kuwait, 7Farwaniya Hospital, Division of Rheumatology, Ministry of Health, Kuwait, Kuwait, 8Amiri Hospital, Division of Rheumatology, Kuwait City, Kuwait, 9Al-Amiri Hospital, Rheumatoid, Al Kuwayt, Kuwait City, Kuwait, 10Mubarak Al-Kabeer Hospital, Division of Rheumatology, Kuwait City, Kuwait, 11Farwaniya Hospital, Department of Rheumatology, Kuwait, Kuwait, 12Farwaniya Hospital, Kuwait City, Kuwait, 13Mubarak Al-Kabeer Hospital, Department of Rheumatology, Jabriya, Kuwait, 14Jahra Hospital, Al Jahra, NY, Kuwait, 15Ministry of Health - Kuwait, Jabriya, Kuwait, 16Jahra Hospital, Department of Medicine, Al Jahra, Kuwait

    Background/Purpose: Biologic disease-modifying antirheumatic drugs (bDMARDs) offer promising results for rheumatoid arthritis (RA) patients in general, but a substantial percentage of patients do not respond…
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