Abstracts tagged "Biomarkers"

Abstract Number: 2611 • 2015 ACR/ARHP Annual Meeting
Circulating Monocyte Count Is Significantly Associated with Interstitial Pneumonia in Biologic-Naive Patients with Rheumatoid Arthritis: A Single-Center Prospective Cohort Study (Keio First-Bio Cohort Study)
Keisuke Izumi¹, Misato Hashizume², Yuko Kaneko³, Keiko Yoshimoto¹ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ³Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose : Interstitial pneumonia (IP) is one of the most critical complications in rheumatoid arthritis (RA). Severe IP is developed in zymosan-treated SKG mice, and…
Abstract Number: 3034 • 2015 ACR/ARHP Annual Meeting
A Comparative Metabolomic Evaluation of Behcet’s Disease with Arthritis and Seronegative Arthritis Using Synovial Fluid
Joong Kyong Ahn¹, Sooah Kim², Jungyeon Kim², Jiwon Hwang³, Hyungjin Kim⁴, Hyemin Jeong⁵, Yeong Hee Eun⁶, Chan Hong Jeon⁷, Jaejoon Lee⁵, Eun-Mi Koh⁵, Kyoung Heon Kim² and Hoon-Suk Cha⁸, ¹Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Biotechnology, Korea University Graduate School, Seoul, South Korea, ³Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁵Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁶Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁷Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ⁸Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Behcet’s disease (BD) is a chronic, complex systemic vasculitis of unknown etiology characterized by orogenital ulcers, uveitis, and arthritis. Arthritis and arthralgias in BD…
Abstract Number: 2652 • 2014 ACR/ARHP Annual Meeting
Headache in Patients with Systemic Lupus Erythematosus Is Associated with Reduced Cerebral Grey Matter Volume, but not with Measures of Glial Activation, Anti-NR2-, or Anti-P Antibodies
Anne B Tjensvoll¹, Maria B Lauvsnes², Shunsei Hirohata³, Jan T Kvaløy⁴, Mona K Beyer⁵, Erna Harboe⁶, Lasse G Gøransson⁶, Ole J Greve⁷ and Roald Omdal⁸, ¹Department of Neurology, Stavanger University Hospital, Stavanger, Norway, ²Department of Internal Medicine, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway, ³Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ⁴Research Department, Stavanger University Hospital, Stavanger, Norway, ⁵Department of Radiology and Nuclear medicine, Oslo University Hospital, National Hospital, Oslo, Norway, ⁶Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁷Department of Radiology, Stavanger University Hospital, Stavanger, Norway, ⁸Department of Internal Medicin, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Headache, especially migraine, is frequent and one of the most common neuropsychiatric manifestations in systemic lupus erythematosus (SLE). A possible mechanism for this is…
Abstract Number: 1666 • 2014 ACR/ARHP Annual Meeting
The Relevance of Urinary Podocyte Number and Urinary Podocalyxin Level with Response to Treatment and 1 Year Renal Prognosis in Systemic Lupus Erythematosus
Hiroshi Kajiyama¹, Keiju Hiromura², Daisuke Ikuma¹, Hidekazu Ikeuchi², Hiroyuki Kurosawa³, Yoshiaki Hirayama³, Fumio Gondaira³, Masanori Hara⁴, Yoshihisa Nojima² and Toshihide Mimura⁵, ¹Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, ²Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, ³Department of reagent research and development, Denka Seiken Co. Ltd., Niigata, Japan, ⁴Department of Pediatrics, Yoshida Hospital, Niigata, Japan, ⁵Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose Podocytes are glomerular visceral epithelial cells, whose number decrease due to death and/or detachment from capillary wall leads to severe proteinuria and end stage…
Abstract Number: 1266 • 2014 ACR/ARHP Annual Meeting
Anti-MDA5 Is Associated with Rapidly-Progressive Interstitial Lung Disease and Poor Survival in U.S. Patients with Amyopathic and Myopathic Dermatomyositis
Siamak Moghadam-Kia¹, Chester V. Oddis², Shinji Sato³, Masataka Kuwana⁴ and Rohit Aggarwal¹, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, ⁴Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose : Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash(es) of DM without objective muscle weakness. Asian studies…
Abstract Number: 730 • 2014 ACR/ARHP Annual Meeting
Prediction of Cardiac and Vascular Events in Systemic Sclerosis: Input from Endothelin-1 Type a Receptor Antibodies
Jerome Avouac¹, Gabriela Riemekasten², Christophe Meune³, Barbara Ruiz⁴ and Yannick Allanore¹, ¹Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ²Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ³Paris 13 University, University Hospital of Paris-Seine-Saint-Denis, Cardiology Department, Bobigny, France, ⁴Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France
Background/Purpose: Cardiac and peripheral microvascular alterations are key features of systemic sclerosis (SSc). We have previously reported that angiogenic markers can predict the cardiovascular outcomes…
Abstract Number: 317 • 2014 ACR/ARHP Annual Meeting
Myeloid Related Proteins 8 and 14 (MRP 8/14) – Potential Biomarkers of Disease Activity of Arthritis in Children with Trisomy 21
Charlene Foley, Orla Killeen and Emma Jane MacDermott, The National Centre for Paediatric Rheumatology, Dublin, Ireland
Background/Purpose JIA is an umbrella term used to describe a heterogeneous group of diseases.To date no specific markers exist in clinical practice to predict disease…
Abstract Number: 2540 • 2014 ACR/ARHP Annual Meeting
Sjö™, an Advanced Diagnostic Panel for Detection of Sjögren’s Syndrome Autoantibodies
Mark Jasek¹, Kishore Malyavantham², Lakshmanan Suresh³, Julian Ambrus⁴ and Dennis Pardo⁵, ¹Medical and Scientific Affairs, Nicox Inc, Fort Worth, TX, ²Office of Science & Technology, IMMCO Diagnostics Inc., Amherst, NY, ³60 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, ⁴Division of Allergy, Immunology and Rheumatology, Department of Medicine, State University of New York at Buffalo, Buffalo, NY, ⁵Professional Affairs, Nicox Inc, Fort Worth, TX
Background/Purpose Sjögren’s syndrome (SS) is a complex autoimmune disease involving the salivary and lacrimal glands along with various systemic manifestations. It is a difficult disease to…
Abstract Number: 1653 • 2014 ACR/ARHP Annual Meeting
Serum Cystatin C As a Biomarker for Clinical Practice in Patients with Lupus Nephritis
Hua Zhou¹, Di Lu², Hairong Tang² and Lining Wang², ¹Nephrology, The First Hospital of China Medical University, Shenyang, China, ²The First Hospital of China Medical University, Shenyang, China
Background/Purpose: Cystatin C has been developed as a novel biomarker of renal function in last decade and thought as more sensitive than serum creatinine (sCr).…
Abstract Number: 1257 • 2014 ACR/ARHP Annual Meeting
A New Multianalyte Assay for Detection of Dermatomyositis-Specific Autoantibodies Undetectable By Commercially Available Immunoassays
Masataka Kuwana¹, Yuka Okazaki² and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: The disease expression of dermatomyositis (DM) is highly variable among patients, ranging form those with severe muscle weakness in the absence of internal organ…
Abstract Number: 630 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Bone Remodeling Are Elevated in Psoriatic Arthritis
Fatima Abji¹, Arane Thavaneswaran¹, Vinod Chandran^1,2 and Dafna D. Gladman^1,3, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis that develops in about a third of patients with cutaneous psoriasis (PsC). The identification of biomarkers to…
Abstract Number: 313 • 2014 ACR/ARHP Annual Meeting
Elevated Cardiovascular Disease Burden and Inflammatory Biomarker Levels in Adults with Juvenile Idiopathic Arthritis
Siobhan Crittenden¹, Elizabeth Coulson^1,2, Vijay Kunadian^3,4,5, Wan-Fai Ng^1,2,6 and H. E. Foster^7,8,9, ¹Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ²Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ³Faculty of Medical Sciences, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ⁴Cardiology, Freeman Hospital, Newcastle upon Tyne, United Kingdom, ⁵Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ⁶Musculoskeletal Directorate, The Freeman Hospital, Newcastle upon Tyne, United Kingdom, ⁷Paediatric Rheumatology, Newcastle Hospitals NHS Trust and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom, ⁸Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle Upon Tyne, United Kingdom, ⁹Paediatric Rheumatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
Background/Purpose: Rheumatoid Arthritis (RA) is associated with a 50 % greater cardiovascular mortality rate than the general population, attributable to the increased prevalence of traditional…
Abstract Number: 2159 • 2014 ACR/ARHP Annual Meeting
Human T-Lymphotropic Virus Type 1 Biomarkers in Patients with Rheumatoid Arthritis
Akihiko Okayama¹, Masako Iwanaga², Yasuko Sagara³, Toshihiko Hidaka⁴, Kunihiko Umekita⁵, Kazumi Nakano⁶, Toshiki Watanabe⁶, Yoshihisa Yamano⁷, Yoshiro Horai⁸, Hideki Nakamura⁹ and Atsushi Kawakami⁹, ¹Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan, ²The Jikei University of School of Medicine, Tokyo, Japan, ³Japanese Red Cross Kyushu Block Blood Center, Fukuoka, Japan, ⁴Zenjinkai Shimin-No-Mori Hospital, Miyazaki, Japan, ⁵University of Miyazaki, Miyazaki, Japan, ⁶Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan, ⁷Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ⁸Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). It has been debated recently whether or not immunosuppressive…
Abstract Number: 1632 • 2014 ACR/ARHP Annual Meeting
Is Liopxin A4 a Biomarker for Systemic Lupus Erythematosus?
Manal Sedky Abdou¹, Dina Effat², Lamiaa Mansour³, Mona mohsen Abdul Salam³ and Noha abd El Baky⁴, ¹rheumatology and rehabilitation kasr el aini hospital, faculty of medicin, cairo university, cairo, Egypt, ²rheumatology and rehabilitation, faculty of medicin, cairo university, giza, Egypt, ³clinical and chemical pathology, faculty of medicin, cairo university, cairo, Egypt, ⁴rheumatology and rehabilitation, faculty of medicin, cairo university, cairo, Egypt
Background/Purpose : Systemic lupus erythematosus (SLE) is characterized by autoantibody production and immune complex deposition which trigger both a local and systemic inflammatory response. The…
Abstract Number: 1138 • 2014 ACR/ARHP Annual Meeting
Vasoactive Intestinal Peptide (VIP) Genetic Variants Determine VIP Serum Levels and Could be Used As a Prognosis Biomarker
Amalia Lamana¹, Iria Valino-Seoane², Luis Rodriguez-Rodriguez³, Javier Leceta², Yasmina Juarranz², Ana M. Ortiz Garcia¹, Carmen Martinez-Mora⁴, Benjamín Fernández-Gutiérrez³, Isidoro González-Alvaro⁵, Rosa P Gomariz² and Rosario Garcia-Vicuña⁵, ¹Rheumatology, Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain, ²Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, ³Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, ⁴Cellular Biology, School of Medicine. Universidad Complutense de Madrid, Madrid, Spain, ⁵Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain
Background/Purpose: VIP has shown immunoregulatory properties in assays performed with human or murine cells. VIP has demonstrated a therapeutic effect in a murine model of…

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