Abstracts tagged "Biomarkers"

Abstract Number: 2262 • 2013 ACR/ARHP Annual Meeting
Antibody To Malondialdehyde-Acetaldehyde Adducts (MAA) Is a Biomarker Of Inflammation and Is Correlated With The Disease Activity In Rheumatoid Arthritis
Kathleen Young¹, Dathe Benissan-Messan², Michael J. Duryee³, Daniel Anderson⁴, Liron Caplan^5,6, Lisa A. Davis^7,8,9, Harlan Sayles⁴, Carlos D. Hunter³, Lynell W. Klassen¹⁰, James R. O'Dell¹¹, Ted R. Mikuls⁴ and Geoffrey M Thiele¹², ¹Int Med/Sec of Rheum/Immun, University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Department of Medicine, Denver Veterans Affairs Medical Center, Denver, CO, ⁶Department of Medicine, University of Colorado School of Medicine, Aurora, CO, ⁷Division of Rheumatology, Univ. of Colorado Sch. of Medicine, Aurora, CO, ⁸Division of Rheumatology, Denver Health and Hospital Authority, Denver, CO, ⁹Denver Veterans Affairs Medical Center, Denver, CO, ¹⁰Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹¹Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ¹²Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with rheumatoid arthritis (RA). While there are many markers used…
Abstract Number: 1809 • 2013 ACR/ARHP Annual Meeting
Topline Results Of The Biomarkers Of Lupus Disease (BOLD) Study: Clinical and Mechanistic Perplexities Of Lupus Treatment Trials Can Be Mitigated By Eliminating Background Immune Suppressants
Joan T. Merrill¹, Frederick W. Immermann², Tianhui Zhou³, Margot O'Toole⁴, Maryann Whitley⁵, Andrew A. Hill⁵, Ying Zhang⁵, David von Schack⁵, Padmalatha S. Reddy⁵, Jaime L. Masferrer⁴, Stan Kamp¹, Joel M. Guthridge⁶, Aikaterini Thanou⁷, Paul Wu⁵, Theresa Paradis⁵, William M. Mounts⁵, Judith A. James⁸ and Sudhakar T. Sridharan², ¹Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²BioTherapeutics R&D, Pfizer Inc, Collegeville, PA, ³BioTherapeutics R&D, Bristol Myers Squibb, Princeton, NJ, ⁴independent consultant, Cambridge, MA, ⁵Pfizer Inc, Cambridge, MA, ⁶Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Arthritis and Clinical Immmunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: The BOLD study was designed to test the discriminatory capacity and safety of a trial design eliminating background immune suppressants (IS) in SLE patients…
Abstract Number: 1253 • 2013 ACR/ARHP Annual Meeting
Studies On The Relationship Between Intraplantar Carrageenan-Induced Bradykin B1 Receptor Messenger Ribonucleic Acid Expression and Oedema and Hyperalgesia In Rats: Effects Of Dexamethasone and a B1 Receptor Antagonist, BI-113823
Guy Kennett¹, Jessica Arlott¹, Phil Butler², Mike Comer¹, Andrew Clarkson², Alex Coulthard¹, Sean Lightowler¹, Rachel Upcott-Gill², Rebecca Upton¹, Louise Wray², Philipp Wabnitz³, Sven Kühnert³ and Simon Cruwys³, ¹Saretius Ltd, Reading, United Kingdom, ²Cyprotex Ltd, Macclesfield, United Kingdom, ³Grunenthal GmbH, Aachen, Germany
Background/Purpose: Kinins are a group of peptides formed in plasma and tissues in response to infection, tissue trauma or inflammation (inflamm) whose actions are mediated…
Abstract Number: 248 • 2013 ACR/ARHP Annual Meeting
Hand Osteoarthritis Is Associated With Increased Type II Collagen Degradation In Women: The Ofely Study
Jean-Charles Rousseau¹, Elisabeth Sornay-Rendu¹, Cindy Bertholon¹, Patrick Garnero² and Roland Chapurlat³, ¹INSERM UMR 1033, Lyon, France, ²INSERM, UMR 1033, Lyon and Cisbio Bioassays, Bagnols/Cèze, France, ³Service de Rhumatologie et Pathologie Osseuse, INSERM UMR 1033 and Université de Lyon, Hôpital Edouard Herriot, Lyon, France
Background/Purpose: Hand osteoarthritis (OA) is one of the most common sites of OA and predominantly affects women. Patients with knee, hip or spine OA exhibit…
Abstract Number: 2914 • 2013 ACR/ARHP Annual Meeting
Serum Proteins and Whole Blood Transcripts Suppressed By An Anti-Type I Interferon Receptor Monoclonal Antibody In Subjects With Systemic Sclerosis
Xiang Guo¹, Brandon W. Higgs², Christopher Kane³, Chris, A. Morehouse², Zheng Liu², Liangwei Wang⁴, Stephen Yoo⁵, Yihong Yao², Lorin Roskos⁶ and Wendy White⁷, ¹Translational Sciences, MedImmune LLC, Gaithersburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³MedImmune, LLC, Gaithersburg, MD, ⁴Biostatistics, MedImmune, LLC, Gaithersburg, MD, ⁵Clinical Development, MedImmune, LLC, Gaithersburg, MD, ⁶One MedImmune Way, Medimmune, Gaithersburg, MD, ⁷Translational Sciences, MedImmune, Gaithersburg, MD
Background/Purpose: To identify serum markers that are modulated by an investigational human IgG1κ monoclonal antibody directed against subunit 1 of the type I interferon receptor…
Abstract Number: 2205 • 2013 ACR/ARHP Annual Meeting
Galectin-3 and Transforming Growth Factor-β Signaling In The Pathogenesis Of Coronary Artery Aneurysms In Kawasaki Disease
Fujito Numano¹, Matthew Vejar², Chisato Shimizu¹, Susan Jimenez-Fernandez¹, Adriana H. Tremoulet³, Jane C. Burns¹ and Lori B. Daniels², ¹Pediatrics, UC San Diego, School of Medicine, La Jolla, CA, ²Departments of Medicine, UC San Diego, School of Medicine, La Jolla, CA, ³Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA
Background/Purpose: Kawasaki disease (KD) is a self-limited acute vasculitis of young children, and coronary artery aneurysms (CAA) are the most significant complication. Despite appropriate treatment…
Abstract Number: 1777 • 2013 ACR/ARHP Annual Meeting
Antibodies Against TIF1-Gamma In Cancer Associated Myositis May Precede Cancer Symptoms and Persist After Cancer Removal
Ingrid E. Lundberg¹, Lara Dani², Maryam Dastmalchi², Maria Angeles Martinez³, Moises Labrador-Horrillo⁴ and Albert Selva O'Callaghan⁴, ¹Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ³Sant Pau Hospital, Barcelona, Spain, ⁴Vall d'Hebron General Hospital, Barcelona, Spain
Background/Purpose: Antibodies against TIF1-gamma have been detected in patients with cancer associated myositis (CAM) but it is not known whether the antibodies precede the diagnosis…
Abstract Number: 1135 • 2013 ACR/ARHP Annual Meeting
Synovial Fluid Vascular Endothelial Growth Factor Could Predict Progression Of Osteoarthritis According To Radiological and Ultrasonographic Findings
Sang-Heon Lee, Hae-Rim Kim and Ho-Youn Kim, Division of Rheumatology, Konkuk University Medical Center, Seoul, South Korea
Background/Purpose: Vascular endothelial growth factor (VEGF) may have important contribution in the pathogenesis of knee osteoarthritis. MMP-13 is expressed by chondrocytes and synovial cells, and…
Abstract Number: 249 • 2013 ACR/ARHP Annual Meeting
Biomarkers Reflect Differences In Osteoarthritis Phenotypes Of The Lumbar Spine: The Johnston County Osteoarthritis Project
Adam P. Goode¹, Amanda E. Nelson², Virginia B. Kraus³, Jordan B. Renner⁴ and Joanne M. Jordan⁵, ¹Community and Family Medicine, Duke University, Durham, NC, ²University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ³Medicine/Rheumatology, Duke University Medical Center, Durham, NC, ⁴University of North Carolina Department of Radiology, Chapel Hill, NC, ⁵Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: We have previously identified differences in associations between joint metabolism biomarkers and radiographic features of the lumbar spine (disc space narrowing (DSN) and osteophytes…
Abstract Number: 2894 • 2013 ACR/ARHP Annual Meeting
Triggering Receptor Expressed on Myeloid Cells 1 In Systemic Lupus Erythematosus
Laurie Davis¹, Yong Du², Tianfu Wu³ and Chandra Mohan⁴, ¹Internal Medicine, UT Southwestern Medical Center, Dallas, TX, ²Internal Medicine - Rheumatic Diseases, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, ³Division of Rheumatology/Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, ⁴University of Houston, Houston, TX
Background/Purpose: In healthy individuals, TREM-1 proteins are cell surface receptors expressed by hematopoietic cells of the myeloid lineage. TREM-1 is a potent amplifier of proinflammatory…
Abstract Number: 2207 • 2013 ACR/ARHP Annual Meeting
Plasma Cytokine Concentrations Are Associated With Folate Perturbations and Methotrexate Polyglutamate Accumulation In The Peripheral Blood Of Juvenile Idiopathic Arthritis Patients Treated With Low-Dose Methotrexate
Ryan S. Funk¹, Leon van Haandel¹, Marcia Chan², Lanny J. Rosenwasser², Andrew Lasky³, Maria F. Ibarra⁴, Mark F. Hoeltzel⁵, J.S. Leeder¹ and Mara L Becker⁶, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Pediatric Immunology Research, Children's Mercy Hospital, Kansas City, MO, ³Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁴Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ⁵Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, ⁶Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Methotrexate inhibits the production of inflammatory cytokines, but is also an antifolate. The activity of MTX is thought to depend on the formation of…
Abstract Number: 1747 • 2013 ACR/ARHP Annual Meeting
Plasma MCP-1 and IL-10 Levels Predict Long-Term Progression Of Interstitial Lung Disease In Patients With Early Systemic Sclerosis
Minghua Wu¹, Claudia Pedroza², Gloria Salazar¹, Xiaodong Zhou¹, John D. Reveille¹, Maureen D. Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: The currently available clinical markers are not reliable predictors of long-term progression of systemic sclerosis (SSc) related interstitial lung disease (ILD). SSc patients have…
Abstract Number: 876 • 2013 ACR/ARHP Annual Meeting
Prediction Of TNF Inhibitor Response In Rheumatoid Arthritis Patients Using Single Cell Network Profiling Of Intracellular Immune Signaling
Jason Ptacek¹, Rachael Hawtin², Brent Louie¹, Erik Evensen¹, James Cordeiro¹, Barbara Mittleman¹, Michelle Atallah¹, Alessandra Cesano², Clifton O. Bingham III³, Stacey Cofield⁴, Jeffrey R. Curtis⁵, Maria I. Danila⁴, Richard A. Furie⁶, MC Genovese⁷, Marc C. Levesque⁸, Larry W. Moreland⁸, Peter A. Nigrovic⁹, James R. O'Dell¹⁰, William H. Robinson¹¹, Nancy A. Shadick⁹, E. William St Clair¹², Christopher C. Striebich¹³, Geoffrey M Thiele¹⁴, Peter K. Gregersen⁶ and S. Louis Bridges Jr.⁴, ¹Nodality, Inc., South San Francisco, CA, ²Nodality Inc., South San Francisco, CA, ³Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶The Feinstein Institute for Medical Research and North Shore-Long Island Jewish Health System, Lake Success, NY, ⁷Stanford University, Palo Alto, CA, ⁸University of Pittsburgh, Pittsburgh, PA, ⁹Brigham and Women's Hospital/Harvard University, Cambridge, MA, ¹⁰Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ¹¹VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ¹²Medicine, Duke Unversity Medical Center, Durham, NC, ¹³University of Colorado Denver, Aurora, CO, ¹⁴Omaha VA and the University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Biomarkers predictive of drug efficacy are lacking in rheumatoid arthritis (RA) and would be useful in clinical practice and clinical trials. Single cell…
Abstract Number: 83 • 2013 ACR/ARHP Annual Meeting
Oleuropein Or Rutin Consumption Decreases The Spontaneous Development Of OA In Hartley Guinea Pig
Christelle Sanchez¹, Marie-Noëlle Horcajada², Fanny Membrez Scalfo², Pierre Drion³, Fanny Comblain⁴, Elizabeth Offord² and Yves Henrotin⁴, ¹Bone and Cartilage Research Unit, University of Liège, Liege, Belgium, ²Nutrition and Health Department, Nestle Research Center, Lausanne, Switzerland, ³GIGA CHU animal facilities, University of Liège, Liège, Belgium, ⁴Bone and Cartilage Research Unit, University of Liège, Liège, Belgium
Background/Purpose: To assess the potential protective effect of oleuropein and rutin, two polyphenols found in olive oil, fruits or vegetables, on osteoarthritis development Methods: Sixty…
Abstract Number: 2862 • 2013 ACR/ARHP Annual Meeting
Autoantigen Microarray Analysis Of Sera From New-Onset Pediatric Systemic Lupus Erythematosus Patients: A Distinct Autoantibody Profile Associated With Class III/IV Lupus Nephritis
Imelda Balboni¹, David Haddon², Vivian Diep², Cindy Limb² and Paul Utz², ¹Pediatrics, Stanford University School of Medicine, Palo Alto, CA, ²Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous systemic autoimmune disease characterized by the production of autoantibodies directed against highly-conserved nuclear antigens. 15-20% of SLE…

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