Abstracts tagged "Biomarkers"

Abstract Number: 2973 • 2014 ACR/ARHP Annual Meeting
The Multi-Biomarker Disease Activity Score As a Predictor of Radiographic Progression in a Registry of Patients with Rheumatoid Arthritis
Eric H. Sasso¹, George Wu², CC Hwang², Michael E. Weinblatt³, Nancy A. Shadick⁴, Claire Alexander⁵ and Oscar Segurado¹, ¹Crescendo Bioscience Inc., South San Francisco, CA, ²Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA, ³Division of Rheumatology & Immunology, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA, ⁵Clinical Operations, Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose This study evaluated the association between baseline disease activity, as assessed with the multi-biomarker disease activity (MBDA) blood test, CRP or clinical measures, and…
Abstract Number: 2088 • 2014 ACR/ARHP Annual Meeting
Association of TNFAIP3 Gene Polymorphisms with the Risk for RA and Prediction of Therapy Outcome of TNFα-Blocker Treatment
Susanne Drynda¹, Marietta Gloetzner² and Joern Kekow¹, ¹Clinic of Rheumatology, Univ of Magdeburg, Clinic of Rheumatology, Vogelsang-Gommern, Germany, ²Univ of Magdeburg, Clinic of Rheumatology, Vogelsang-Gommern, Germany
Background/Purpose: The TNFα inducible protein 3 (TNFAIP3=A20) is an important regulatory protein for the inhibition of NFkB activation in TNFaR and TLR pathways. It belongs…
Abstract Number: 1467 • 2014 ACR/ARHP Annual Meeting
Do G-CSF and Neutrophils Contribute to the Pathophysiology of Rheumatoid Arthritis?
Gabrielle Goldberg¹, Simon Chatfield^2,3, Jane Murphy¹, Ee Shan Pang¹, Yunshun Chen⁴, Gordon Smyth⁴, Milica Ng⁵, Michael Wilson⁵, Clare O'Neill³, Samantha Busfield⁵, Arna Andrews⁵ and Ian P. Wicks^3,6,7, ¹Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, ²Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, ³Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia, ⁴Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, ⁵Research, CSL Limited, Melbourne, Australia, ⁶Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, ⁷Medical Biology, The University of Melbourne, Melbourne, Australia
Background/Purpose Rheumatoid arthritis (RA) is characterised by a persistent, but poorly understood interplay between innate and adaptive immunity. Neutrophils are the predominant cell type in…
Abstract Number: 988 • 2014 ACR/ARHP Annual Meeting
Serum CXCL13 As a Biomarker of Disease Activity and Severity in Rheumatoid Arthritis: Comparison with Acute Phase Reactants and the Autoantibody Profile
Antonio Manzo¹, Serena Bugatti¹, Barbara Vitolo¹, Francesca Benaglio¹, Elisa Binda¹, Martina Scarabelli¹, Roberto Caporali² and Carlomaurizio Montecucco¹, ¹Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy, ²Division of Rheumatology, Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy
Background/Purpose The B cell chemoattractant CXCL13 has recently emerged as a new candidate biomarker of disease activity capable of identifying patients with persistent synovitis and…
Abstract Number: 489 • 2014 ACR/ARHP Annual Meeting
Rosuvastatin Improves Arterial Stiffness in Patients with Inflammatory Joint Diseases
Eirik Ikdahl¹, Silvia Rollefstad¹, Jonny Hisdal², Inge C. Olsen³, Ingar Holme⁴, Terje R. Pedersen⁵, Tore Kvien⁶ and Anne Grete Semb¹, ¹Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Section of Vascular Investigations, Oslo University Hospital Aker, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of biostatistics, epidemiology and health economics, Oslo University Hospital, Oslo, Norway, ⁵Faculty of Medicine, University of Oslo, Oslo, Norway, ⁶Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose Arterial stiffness, as pulse wave velocity (PWV) and augmentation index (AIx) has emerged as early risk markers of cardiovascular disease (CVD) in patients with…
Abstract Number: 75 • 2014 ACR/ARHP Annual Meeting
Robust Identification of Anti-TNF Non-Responders in RA from Blood
Ty Thomson, Reynald Lescarbeau, David Drubin, David Fryburg, David de Graaf, Renée Deehan, Daphna Laifenfeld and Aaron Van Hooser, Selventa, Cambridge, MA
Background/Purpose: The number of biologic therapies approved for use in treating rheumatoid arthritis (RA) has grown steadily over the past 15 years. While many patients…
Abstract Number: 162 • 2013 ACR/ARHP Annual Meeting
Genotypic and Haplotypic Effects Of 7 Single-Nucleotide Polymorphisms In the CRP Gene On Levels Of C-Reactive Protein and DAS28 In a Cohort Of 180 Untreated Newly Diagnosed Rheumatoid Arthritis Patients (OPERA Study)
Christian G. Ammitzbøll¹, Rudi Steffensen², Peter Junker³, Mikkel Østergaard⁴, Julia Johansen⁵, Jan Pødenphant⁶, Merete Lund Hetland^7,8, Hanne M. Lindegaard⁹, Torkell Ellingsen¹⁰ and Kristian Stengaard-Pedersen¹, ¹Arhus University Hospital, Aarhus, Denmark, ²Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ³University of Southern Denmark, Odense, Denmark, ⁴Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁵Copenhagen University and Glostrup Hospital, Copenhagen, Denmark, ⁶Copenhagen University at Gentofte, Hellerup, Denmark, ⁷Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ⁸Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark, ⁹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁰Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark
Background/Purpose: Single nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the basal C-reactive protein (CRP) expression and its response to…
Abstract Number: 2604 • 2013 ACR/ARHP Annual Meeting
Longitudinal Assessment Of Scleroderma Skin By Optical Coherence Tomography: Preliminary Validation Of Sensitivity To Change Over-Time
Giuseppina Abignano¹, Lesley-Anne Bissell¹, Jason Britton², Daniel Woods³, Maya H. Buch¹, Dennis McGonagle¹, Paul Emery¹ and Francesco Del Galdo¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ²Medical Physics Department, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Michelson Diagnostics Ltd, Kent, United Kingdom
Background/Purpose: Optical coherence tomography (OCT) has been shown to be a quantitative reliable tool to assess skin involvement in Systemic Sclerosis (SSc) (1). However the…
Abstract Number: 2039 • 2013 ACR/ARHP Annual Meeting
Micro and Nanoparticles As Possible Causative-Prognostic Co-Factors Of Mixed Cryoglobulinemia Syndrome
Erica Artoni¹, Gian Luca Sighinolfi¹, Daniele Campioli², Marco Sebastiani³, Dilia Giuggioli³ and Clodoveo Ferri⁴, ¹Life Sciences, University of Modena and Reggio Emilia, Modena, Italy, ²Laboratory of Clinical Chemistry, Azienda Ospedaliera - Policlino di Modena, Modena, Italy, ³Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy, ⁴Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
Background/Purpose: We previously demonstrated that patients affected by membranoproliferative glomerulonephritis and mixed cryoglobulinemia syndrome (MCs) show the presence of circulating micro and nanoparticles (MPs and…
Abstract Number: 1384 • 2013 ACR/ARHP Annual Meeting
Estimation Of The Effect Of Denosumab On Bone Loss From The Results Of The 12-Month Phase II Study In Patients With Rheumatoid Arthritis (RA) On Background Methotrexate (MTX)
Yoshiya Tanaka¹, Tsutomu Takeuchi², Naoki Ishiguro³, Hisashi Yamanaka⁴, Toshiyuki Yoneda⁵, Harry K. Genant⁶ and Désiréé van der Heijde⁷, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²Keio University, Tokyo, Japan, ³Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁴Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁵Indiana University School of Medicine, Indianapolis, IN, ⁶University of California, San Francisco, CCBR-Synarc, Newark, Tiburon, CA, ⁷Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: RANKL is an essential factor for osteoclast differentiation and activation. Denosumab, a fully human monoclonal IgG2 antibody, is a potent inhibitor of RANKL and…
Abstract Number: 612 • 2013 ACR/ARHP Annual Meeting
Increased Expression Of Membrane Endothelial Protein C Receptor Associates With Poor Response In Lupus Nephritis Independent Of Chronicity Index
Barbara Mendez¹, Ming Wu², Dominick Santoriello², Laura Barisoni³, Peter M. Izmirly¹, Jill P. Buyon¹ and Robert M. Clancy⁴, ¹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Pathology, New York University School of Medicine, New York, NY, ³Pathology, University of Miami Hospital, Miami, FL, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: While a consensus is that a high chronicity index (CI) is associated with a greater risk for progression to renal failure in lupus nephritis…
Abstract Number: 164 • 2013 ACR/ARHP Annual Meeting
Haptoglobin Chains As Potential Biomarkers In Serum Of Osteoarthritis Disease
Carolina Fernandez-Costa¹, Valentina Calamia¹, Patricia Fernandez-Puente¹, Jesus Mateos¹, Beatriz Rocha², Lucia Lourido¹, Jose Luis Capelo³, Cristina Ruiz-Romero^1,4 and Francisco J. Blanco¹, ¹Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³BIOSCOPE Group, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa,, Caparica, Portugal, ⁴CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: The aim of this study is to search for osteoarthritis (OA) biomarkers in human serum using an easy and fast approach and the validation…
Abstract Number: 2557 • 2013 ACR/ARHP Annual Meeting
Fluctuations In sVCAM-1 and Adiponectin Mirror Fluctuations In Disease Activity In Lupus, But Cannot Be Use To Accurately Predict Impending Changes In Disease State
Carolina landolt-Marticorena¹, Stephenie Prokopec², Stacey Morrison³, Heather Reich⁴, James Scholey⁴, Dafna D. Gladman⁵, Murray B. Urowitz⁵, Paul Boutros², Paul R. Fortin⁶ and Joan E. Wither⁷, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Ontario Institute for Cancer Research, Toronto, ON, Canada, ³Div Rheumatology Rm MP-10-304, The Toronto Western Hospital, Toronto, ON, Canada, ⁴Department of Medicine, The Toronto Western Hospital, Toronto, ON, Canada, ⁵Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶University of Laval, Quebec, QC, Canada, ⁷1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Previous reports have identified a number of pro-inflammatory cyto/chemokines as candidate activity-specific SLE biomarkers. In our preliminary studies we found that out of a…
Abstract Number: 1974 • 2013 ACR/ARHP Annual Meeting
Assessing Validity Of Low Field Magnetic Resonance Imaging (MRI) for Joint Inflammation and Damage In Wrist/Hand Rheumatoid Arthritis (RA) – A Systematic Literature Review (SLR)
OM Troum¹, OL Pimienta¹, TG Woodworth², O Morgacheva³, V Ranganath⁴ and Daniel Furst⁵, ¹Keck School of Medicine, University of Southern California, Los Angeles, CA, ²Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA, ³Medicine/Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA, ⁴Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁵David Geffen School of Medicine, University of California, Los Angeles, CA
Background/Purpose: Radiographic scoring of erosions and joint space narrowing (JSN) of the hand/wrist is standard to evaluate RA joint damage for regulatory approval of DMARDs;…
Abstract Number: 1388 • 2013 ACR/ARHP Annual Meeting
Multiplex Cytokine Analyses In Patients With Rheumatoid Arthritis Require Use Of Agents Blocking Heterophilic Antibody Activity
Peter Olsson¹, Elke Theander², Ulf Bergström³, Stefan Jovinge⁴, Lennart Jacobsson³ and Carl Turesson², ¹Section of Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden, ²Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
Background/Purpose: Rheumatoid factor (RF) and other circulating heterophilic antibodies have been shown to interfere with antibody-based immunoassays, in particular with multiplex protein detection platforms. Previous…

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